Why Walking, Yoga, and Strength Training May Help Ease Depression


New research finds that simple exercises like walking, jogging, yoga, and strength training can help ease symptoms of depression. enigma_images/Getty Images

  • A review of 218 scientific trials has found that walking, jogging, yoga, and strength training may be the most effective exercises for relieving symptoms of depression.
  • The more vigorous the exercise, the greater the mental health benefits are likely to be.
  • Experts say this is likely due to the release of feel-good hormones, engagement in a routine, and the social interaction exercise often provides.
  • It can be difficult to exercise when you’re depressed, so experts recommend starting slow and finding something you enjoy.

Have you ever noticed that your mood improves when you exercise?

New research has found that certain kinds of exercise – specifically walking, jogging, yoga, and strength training – seem to be the most effective at easing symptoms of depression.

The research published in The BMJ found that these exercises were effective at reducing depression when used alone or alongside established treatments such as psychotherapy and medication.

Furthermore, the results suggest that, while low intensity exercise is beneficial, the more vigorous the activity, the greater the benefits are likely to be.

To assess the existing data, the study authors reviewed 218 relevant trials involving 14,170 participants that compared exercise as a treatment for depression with established treatments, like antidepressants and cognitive behavioral therapy.

Moderate reductions in depression were found in walking or jogging, yoga, strength training, mixed aerobic exercises, and tai chi or qi gong.

Moderate effects were also found when exercise was combined with SSRI antidepressants or aerobic exercise was combined with psychotherapy, which suggests that exercise could provide added benefit alongside these established treatments.

While the authors acknowledge that the quality of evidence is low and very few trials monitored participants for one year or more, they say the results suggest that these forms of exercise “could be considered alongside psychotherapy and drugs as core treatments for depression.”

In particular, they note that a combination of social interaction, mindfulness, and immersion in green spaces may help explain the positive effects.

The link between exercise and mental health

Clinical psychologist Charlotte Russell, who was not involved int the study, isn’t surprised by these findings and says there are likely several mechanisms that explain the effect exercise has on mood.

One of these is the impact of neurochemicals, including dopamine, serotonin, and endorphins, which are released when we exercise.

Serotonin stabilizes mood, dopamine contributes to feelings of happiness, and endorphins can provide a natural high.

Additionally, Russell says exercise can provide a sense of meaning and engagement in routine. There is often a social element as well, and all of these factors can positively influence our mental health.

“Building exercise into your routine also breaks the cycle of worsening mood and decreased activity that we commonly see in depression,” Russell adds.

“When we are inactive and not using our body, this can contribute to a sense of sluggishness and low motivation, which can quickly lead to a downward spiral. Regular exercise breaks this and maintains a sense of well-being,” she explains.

How different kinds of exercise can affect depression

You might be wondering why walking, jogging, yoga, and strength training appear to be particularly effective at relieving symptoms of depression.

With walking and jogging, Russell says the benefits may lie in the fact that these exercises are often done outside.

“This typically offers a feeling of connection with nature, and we know that this can be beneficial for us psychologically,” she explains.

Yoga, meanwhile, teaches you to focus on your breathing, something Russell says can lessen feelings of anxiety and create an awareness of our internal state.

“The latter is a skill that can be very beneficial in terms of managing difficult thoughts and feelings,” she notes.

What about the benefits of strength training?

Russell says strength training can help you feel stronger in your body and allow you to complete everyday tasks more easily.

“This has a protective effect on our sense of self and mood,” she notes.

Why does vigorous exercise seem to be best?

Clinical hypnotherapist and wellness coach Geraldine Joaquim, who was not involved in the study, says the more vigorous the exercise, the more you’ll feel those high-achievement hormones, which can have a huge internal effect.

But, she says, taking things at your own pace is more important.

How to safely get started with a new exercise routine

If you live with depression, it isn’t always easy to find your get-up-and-go.

“It takes more effort to move forward when you’re depressed because you’re on an uphill battle to create hormonal activity,” Joaquim explains.

“That’s why it’s important to start where you are and build slowly. That might mean simply putting trainers on and walking to the end of your garden. Doing it again. And again. Then expanding, going to the end of the road, for example.”

By working slowly and being kind to yourself, Joaquim says you are gently promoting the production and release of hormones like serotonin, dopamine, and oxytocin that make you feel good.

Joaquim advises aiming for around 80% of your capacity rather than going all out and exhausting yourself if you’re not sure how much is too much when you’re exercising.

“Notice what’s happening in your body as you move, enjoy the feelings of stretching muscles, deep breathing, and feeling strong – and remember, nothing is set in stone. You can change what you’re doing at any time,” she notes.

Meanwhile, Russell points out that many gyms and fitness studios offer classes and exercise courses that are suitable for beginners.

“Choosing this option can be reassuring for many as everyone will be in a similar situation,” she says. “However, if an in-person class seems too daunting, start with an online class to build your confidence.”

Takeaway

Exercising when you are depressed can be challenging, and taking the initiative to move can be daunting.

However, research shows, finding ways to move your body is vital for good mental health.

Even low intensity movement can help.

“The more you feel able to do, the more you want to do. It’s a positive spiral that has real physical changes,” says Joaquim.

Antidepressant Use in Pregnancy


A new mouse study investigated the impact of SSRIs on brain development.

  • A new mouse study found antidepressant use during pregnancy may influence brain development in utero.
  • Most antidepressants are safe to use during pregnancy, according to experts. Depending on the severity of mental illness, withholding medication can lead to more severe health risks.
  • Other treatments for depression include cognitive behavioral therapy, interpersonal psychotherapy, support groups, mindfulness, yoga, and exercise.

A new mouse study found taking antidepressants during pregnancy may affect brain development in utero and be a risk factor for developing mental health disorders later in life.

The findings were published February 16 inNature Communications.Trusted Source

Researchers examined the impact of a chemical called fluoxetine on mice.

Fluoxetine elevates the amount of serotonin in the brain and is typically used in selective serotonin reuptake inhibitors (SSRI) medications such as Prozac and Sarafem which are used to help treat depression and perinatal depression. The researchers looked at how serotonin influences prefrontal cortex development in a fetus – specifically, the effect of deficiency and surplus of serotonin on brain development in mice.

Results showed that serotonin not only impacts overall brain function but also impacts how individual connections between neurons change and adapt. This, in turn, affects the way the brain learns.

“This is certainly a fascinating scientific study on postnatal development in the mouse brain but how it applies to the human brain still remains a question,” said Dr. Michael Cackovic, maternal-fetal medicine physician at Bridgeport Hospital.

Cackovic wasn’t involved in the study.

Most brain development in humans occurs in the first two years of life and 90% before kindergarten so it would make sense that giving “pups” this medication early in life could potentially cause a problem, Cackovic explained.

SSRIs can transmit from parent to child in utero

Researchers looked at the effects of serotonin on the part of a developing brain called prefrontal cortex when it is exposed to fluoxetine.

Fluoxetine goes into the placenta but also into breast milk.

“All known SSRI medications readily pass through the placenta and enter the fetal circulation,” said Dr. Jay Gingrich, professor of developmental psychology at Columbia University Vagelos College of Physicians and Surgeons. “There are several studies that have examined the health and mental health outcomes of children exposed to SSRIs in utero. Because serotonin receptors and pathways are highly conserved through evolution (across distant species), there has been a presumption that findings in rodents may likely be relevant to human brain development.”

Gingrich continued: “This has been difficult to prove unequivocally, but several studies have found increased rates of depression, anxiety, and adjustment disorders in SSRI-exposed children as they age into adolescence. Other studies have found increased rates of autism, but most of those studies have not controlled for maternal mental health and several studies failed to find a similar linkage.”

The risk of exposure through breast milk is expected to be far lower than through placental passage and should not dissuade mothers from breastfeeding or resuming SSRI use during this period, he added.

These findings do not mean that people who wish to become pregnant should stop taking SSRIs immediately, according to experts.

“There is a tremendous amount of data that supports use of an SSRI during pregnancy when it is taken to help the person achieve remission or maintain remission of their depression and/or anxiety,” said Dr. Katherine Campbell, associate professor of obstetrics, reproductive sciences at Yale School of Medicine.

Campbell, who did not work on the study, did clarify that infants can have symptoms if their parent is on SSRIs while pregnant.

“When babies are born to parents who are on fluoxetine (or other SSRI), the baby can have withdrawal symptoms that can start after birth,” Campbell said. “Withdrawal symptoms can include irritability, jitteriness, and fast breathing. There are newer SSRIs on the market that cross the placenta and cross into breast milk in lower concentrations.”

Is it safe to take antidepressants during pregnancy?

While there may be risks in taking SSRIs while pregnant, there are also risks of experiencing mental health disorders. Experts point out that untreated mental illness has significant and well-established consequences to maternal and infant health.

For example, untreated depressionTrusted Source in pregnancy is associated with preterm birth, low birth weight and stillbirthTrusted Source.

“Antidepressants, and selective serotonin reuptake inhibitors (SSRIs) specifically, are the most studied class of medications in pregnancy and the clinical consensus based on the extensive literature (in human studies), is that they are generally safe to use in pregnancy and in lactation when medically indicated (with the exception of paroxetine, which is usually not prescribed or used in pregnancy due to equivocal evidence on possible minor cardiac malformations),” said Dr. Ariadna Forray, associate professor of psychiatry at Yale School of Medicine and Director at the Center for Wellbeing of Women and Mothers, Psychiatry; Yale Medical Director, ACCESS Mental Health for Moms.

Forray was not involved in the study.

“The irony is that both untreated maternal depression and the use of antidepressants both increase the risk for anxiety and depressive disorders in the offspring in later life,” Gingrich said. “This conundrum is what has made it so difficult to discern whether SSRI use in pregnancy is a net positive to the child or whether we are exacerbating what trends were expected based on maternal history.”

Experts say if you are pregnant and taking SSRIs you can speak with your physician about whether or not it would make sense to stop taking the medication.

In many clinical scenarios, it is problematic to withhold medication treatment during pregnancy because of the severity of the mother’s symptoms.

“We have been working in this area for 20 years in attempt to provide a clearer risk-benefit profile to clinicians and their patients to help inform better decisions. This work is ongoing,” Gingrich added.

Other options to treat depression

There are various non-pharmacological interventions to help treat depression symptoms that people can explore after talking to their psychiatrist and physician if they want to avoid SSRIs.

“Evidence-based interventions include cognitive behavioral therapy and interpersonal psychotherapy,” said Forray. “Things like support groups, mindfulness, yoga and exercise can also be helpful additions to evidence-based treatments.”

In addition, “there are several effective psychotherapies for depression during pregnancy and in the post-partum period (IPT, CBT) and there are new non-SSRI medications specifically indicated for post-partum depression (e.g., Zurzuvae or zuranolone),” Gingrich explained. “The US needs to improve the availability and reimbursement of such non-pharmacologic therapies for patients in need. These are often barriers to obtaining appropriate psychotherapy for the expecting mother.”

Takeaway

According to a new mouse study, antidepressant use during pregnancy may affect brain development in utero. However, further research is needed.

The clinical consensus is that most antidepressants are safe to use during pregnancy, according to experts. It is important to note that withholding medication can pose greater health risks for the pregnant person and child.

Aside from medication, there are other ways to help treat symptoms of depression. These include cognitive behavioral therapy, interpersonal psychotherapy, support groups, mindfulness, yoga, and exercise.

A Room-Temperature Superconductor Would Transform the Modern World. Could This Little Gray Rock Get Us There?


Despite controversies last year, scientists are still pursuing LK-99 as a potential a room-temperature superconducting material, because it would allow us to conduct electricity without any loss of energy.By Paul M. SutterPublished: Feb 20, 2024

On the surface it looks like a dullish gray rock, something you might scrape off your boot after a day of hiking. But the rock, known as LK-99, may hold the keys to a future barely imaginable today: the ability to transmit electrical power with no resistance at all.

Unfortunately, this little gray rock is sitting in a storm of controversy, with competing claims and counter-claims arguing about whether it has the magical properties necessary to make it a superconductor. While the superconducting nature of LK-99 seemed to be largely discredited last year, a new team of researchersjust presented evidence that suggests it does fit the bill for a room-temperature superconductor, resurrecting the promise of this material.

Here’s a rundown of what LK-99 is, what it’s supposed to be, and why it matters.

Superconductors Are Already Indispensable

Any bit of material that allows electricity to pass through it relatively easily is called a conductor, and conductors run our lives: they are the wires in everything from the inside of your walls to the inside of your phone’s microprocessors. Conductors are how we get electricity from place to place, but nothing in this world is perfect: every time we transmit electricity, there’s a little bit of resistance in the conductor that we have to work through. That resistance adds up, causing some of the electrical energy to be lost as heat, which is a major pain in the neck.

Enter the magic trick of physics: superconductors. When the conditions are just right—usually when the temperatures drop greatly or the pressures ramp up incredibly high—all electrical resistance within a superconductor vanishes, and along with that, any magnetic fields get pushed outside of it (an important part that we’ll come back to later). This allows it to conduct electricity with no energy loss at all. We already use superconductors in a wide variety of situations, especially when we need a whole lot of electricity in a relatively confined space, because otherwise our equipment would melt in the heat of electrical resistance.

One catch: all existing superconducting materials only work at extremely cold temperatures—over 100 degrees Fahrenheit below zero

For decades, researchers have been attempting to create a superconductor that works at normal temperatures and pressures, known as room-temperature superconductors. In other words, a superconducting material that would work pretty much the same way as a copper wire would: you could just stick it where you needed it to go, and boom, you’re conducting electricity with absolutely no resistance.

Is LK-99 Too Good to Be True?

This is where LK-99 comes in. Last year, a team of researchers based in South Korea released preliminary results that they had identified such a room-temperature superconducting material, which they named LK-99. Their claims were based in part on the material’s response to magnetic fields. They reported that their sample levitated when placed over a magnet, an effect caused when a material pushes magnetic fields away from it. It’s something that superconductors like to do.

Here’s the problem: some other, non-superconducting materials also levitate when placed over a magnet (in one famous experiment, researchers were able to make a living frog float above a magnet). So the claims of the LK-99 team depended on the precise, detailed response of their material to magnetic fields, and the stipulation that their sample behaved in ways that other non-magnetic materials would not.

What we’re seeing with all this back-and-forth is the scientific process playing out in real time.

Cue a flurry of research (and news) over the last few months. Some simulation work suggested that LK-99 could work, but attempts to replicate the Korean team’s findings fell flat. The Korean team argued that the other samples weren’t pure enough. Materials like LK-99 need precise amounts of copper added, and one tiny bit of contamination from other elements could throw the whole thing off. The details of the material’s construction mattered, the Korean team claimed, because if you didn’t have the right geometry, then you wouldn’t achieve superconductivity.

This past winter, the scientific community largely moved past LK-99 and on to other projects. But a Chinese team’s paper, published on the preprint server arXiv on January 2 of this year, claims to have made a replica of LK-99. Though the work has not yet been peer-reviewed, the researchers observed a loss of the magnetic field within their sample—not a slam-dunk, but their experiment provided much stronger evidence than the original Korean team had.

There’s nothing novel about the chemical makeup of the sample in this new research, which is encouraging. If the Chinese team’s work is substantiated, then we could indeed have found a room-temperature superconductor—and it could mean that other teams couldn’t replicate it because it really is hard to get the chemical properties just right

What we’re seeing with all this back-and-forth is the scientific process playing out in real time. Researchers make claims and discoveries all the time, and it’s up to their peers and colleagues to scrutinize those results and attempt to replicate them. Most ideas in science are wrong—that is what we get for searching beyond the horizons of the known.

But no matter what, research into LK-99 will strengthen our understanding of superconductors. One scenario is that enough groups successfully replicate the original results, which brings us many steps closer to a practical room-temperature superconductor. Or, on the other hand, research into LK-99 specifically stalls out, and scientists around the world learn not to look too closely in that direction, or along similar lines. While it’s not as big of a step as a discovery, it’s still useful knowledge that guides and informs us … and brings us ever closer to cracking the case.

Why We Need a Room-Temperature Superconductor

Even if LK-99 doesn’t hold up, there’s a reason that hundreds of scientists around the globe are pursuing room-temperature superconductivity research. Put simply, the ability to transmit electrical energy without any loss of resistance would transform modern society

We could have power stations anywhere we wanted: solar panels floating in equatorial oceans, nuclear power plants in Antarctica, wind farms miles off coastlines, wherever. We could transmit their power directly to our homes and business as if they were right next door. This would cause an explosion in green, sustainable power generation; right now, we have to balance the optimal locations for generating such power with our ability to transmit electricity over long distances.

We could accelerate computing speeds, as we wouldn’t have to deal with the huge microprocessor design problem of cooling all those circuits.

We could have much cheaper, more prolific, and extremely accurate medical diagnostic equipment. Imagine getting an MRI from a machine that sits on a tabletop and is as easy and cheap to use as a doctor’s office X-ray machine.

💡Did You Know? One of the reasons MRI machines are so costly to operate is that they use superconductors to power super-strong flows of electricity, but the guts of the machine need to be cooled down to operate.

Superconductors could be used to control fusion reactions, bringing a brand-new source of renewable power with it. They can be used to levitate trains, allowing them to travel with as little friction as possible (something that we already do, but superconductors would allow them to be much cheaper).

Finally, we could go BIG. Superconducting wires can transmit more than 200 times more electricity than traditional copper wire. Wherever we needed a lot of electricity, for homes and business, work and pleasure, we could have it.

That’s why we keep searching, and that’s why news like LK-99 makes such a big splash. We are always dreaming, always striving for a future that’s better than our present. Room-temperature superconductors are one way to make that kind of future possible.

What have we learned about brain fog in long COVID so far?


The peak of the COVID-19 pandemic may be behind us, but for many people, long COVID continues to cause symptoms weeks, months, or even years after the initial illness. Among the more than 200 symptoms reported for long COVID, brain fog — problems with thinking, understanding, focus and memory — is one of the most widespread and long-lasting.What does the latest research tell us about brain fog in long COVID? Image credit: davit85/Getty Images.

The World Health Organization (WHO) declared COVID-19 a pandemicTrusted Source on March 11, 2020. Since then, the WHO has recorded almost 775 million confirmed cases worldwide. But there have, almost certainly, been many more that have not been confirmed, particularly with the decline in testing in most countries.

According to the Centers for Disease Control and Infection (CDC)Trusted Source, infection with SARS-CoV-2, the virus that causes COVID-19, leads to an illness with some, or all, of the following symptoms, which may be mild or severe:

  • fever or chills
  • cough
  • shortness of breath or difficulty breathing
  • fatigue
  • muscle or body aches
  • headache
  • new loss of taste or smell
  • sore throat
  • congestion or runny nose
  • nausea or vomiting
  • diarrhea.

For most people, these symptoms resolve within 1 to 2 weeks. However, for some people, the acute illness is followed by lingering symptoms, a condition termed long COVID, or post-acute sequelae of COVID-19 (PASC)Trusted Source.

How widespread is long COVID?

Long COVIDTrusted Source can occur in anyone infected by SARS-CoV-2, whether their initial infection was severe, mild, or even asymptomaticTrusted Source.

One study, published in Nature Reviews MicrobiologyTrusted Source in January 2023, suggests that around 10% of people experience long COVID following acute infection, with 50–70% of people who are hospitalized with COVID-19 experiencing lasting symptoms.

According to the United Kingdom’s Office of National Statistics Coronavirus (COVID-19) Infection Survey self-reported data, almost 3% of the U.K. population was experiencing long COVID in March 2023. Of these, 41% were still experiencing symptoms 2 years after initial infection with SARS-CoV-2.

In the United States, the CDC notes that 6.4%Trusted Source of adults have, at some time, reported long COVID symptoms.

These may be a continuation of those experienced in the acute infection, or may change, and can affect almost any part of the body, with one study — published ineClinicalMedicineTrusted Source in 2021 — finding that symptoms “affect multiple organ systems, with significant impacts on morbidity, mortality, and quality of life”.

The study from Nature Reviews Microbiology outlines lasting impacts on the heart, lungs, immune system, pancreas, gastrointestinal tract, kidneys, spleen, liver, blood vessels, reproductive system and neurological system.

Of course, a person with long COVID will not experience all of the 203 symptoms recorded by the wide-ranging international study from eClinicalMedicine. In this study, 91.8% of the cohort reported symptoms that lasted more than 35 weeks after initial infection, the most common and debilitating of which were fatigue, breathing issues and cognitive dysfunction, or brain fog.

This “classic” long COVID, characterized by brain fog, fatigue, dysautonomia, and postexertional malaiseTrusted Source, is more common in younger adults and in females. Older people and those with comorbidities are more likely to experience cardiovascular and metabolic effects.

Neurological symptoms of long COVID

Reports of COVID-19’s effects on the central nervous systemTrusted Source (CNS) started early in the pandemic, and evidence has accumulated since then.

Those who have had more severe COVID-19, with hypoxia, a need for ventilation, and psychological trauma, are at higher risk of lasting psychological effects or cognitive dysfunction.

But anyone who has had COVID-19 has a greater riskTrusted Source of neurological or psychiatric symptoms following their initial illness than someone who has not had a SARS-CoV-2 infection.

Some symptoms, such as mood and anxiety disorders, increase for a short time after infection, but then reduce back to baseline levels. However, others continue for much longer. And one of these is brain fog, which a recent study published in Scientific ReportsTrusted Source found in 89% of people with long COVID.

In this study, 89% of participants also reported fatigue, and 77% difficulty concentrating. When researchers assessed them using the Montreal Cognitive Assessment, they found that 46% had mild cognitive dysfunction.

What is brain fog?

Often the result of, among other things, inflammation, concussion, hormonal changes, or medication, brain fog is one of the most common symptoms reported by people with long COVID.

A person with brain fog may have problems with memory, focus, thinking and understanding, as well as often experiencing stress and fatigue.

Prof. Stephen Griffin, virologist at the University of Leeds School of Medicine, and co-chair of Independent SAGE told Medical News Today:

“Symptoms can vary, but some of the major issues include a lack of recall for things like names, places, events, etc., as well as a general inability to process complex tasks, hold concentration over time and multi-task.”

“In some instances, general alertness can be affected as well which, when combined with the intense fatigue experienced by many, can be extremely debilitating in terms of interacting socially or functioning at school or work,” he added.

The study from eClinicalMedicine, which looked into the lasting effects of COVID-19, recorded brain fog, cognitive dysfunction and memory impairment in 85.1% of respondents. And almost 90% of those who worked reported that brain fog impaired their ability to work to some extent.

Why does COVID-19 cause brain fog?

Research has suggested several potential causes for brain fog in COVID-19, including:

One theory is that SARS-CoV-2 can cross the blood-brain barrier (BBB)Trusted Source and directly affect cells in the CNS, but this has only been demonstrated in vitroTrusted Source, in isolated cells.

This study found that two SARS-CoV-2 variants, the original wild type and Omicron, were best able to induce cell stress and damage components of the BBB.

However, Dr. Giovanni Schifitto, professor of neurology at the University of Rochester Medical Center, NY, believes that the cause of long covid is likely to be multifactorial.

“The physical presence of SARS-CoV-2 in the brain, especially in the chronic phase, is unlikely to be the culprit. However, systemic virus persistence can create a more chronic systemic inflammatory status and that can contribute to multi-organ dysfunction,” he told us.

There is more support for the suggestion that brain fog in long COVID may result from immune dysfunction and inflammation.

One recent study, which appeared in Nature CommunicationsTrusted Source, showed that people with COVID had raised levels of four brain injury biomarkers, and that two of these persisted long after the initial infection, particularly in those who experienced neurological complications during the acute infection.

The authors of this research suggest these abnormal immune responses may be causing ongoing inflammation. And inflammation can lead to brain fog.

They believe that if they can find out why these immune responses are triggered, treatments could be developed to target them.

Brain changes in long COVID

Whether the effects are due to viral invasion or immune dysfunction, research has found that SARS-CoV-2 infection can lead to changes in the brain.

A study — published in NatureTrusted Source in March 2022 — using data from the UK Biobank compared brain scans conducted on people before and after they had COVID-19.

Those who had had SARS-CoV-2 infection had a reduction in grey matter thickness, markers of tissue damage in olfactory regions, and changes in brain volume, as well as slightly lower cognitive abilities than those who had not.

Prof. Griffin explained:

“As with many issues around long COVID, brain fog is likely a combination of persistent infection by SARS-CoV-2 [as reported ina new studyTrusted Sourcepublished in 2023] and host immune/metabolic changes that occur either concomitantly or as a follow-on. Worryingly, changes to the brain, including reductions in grey matter, have been noted even in patients that aren’t necessarily associated with neurological symptoms.”

Research reported in Nature NeuroscienceTrusted Source, which used dynamic contrast-enhanced magnetic resonance imagingTrusted Source (DCE-MRI) on people with long COVID with or without reported brain fog, has backed up these findings. The researchers found not only significantly increased BBB permeability in the group with brain fog, but also reduced global brain volume and white matter volume.

The researchers suggest that “long COVID-derived brain fog is associated with BBB disruption and sustained systemic inflammation,” adding that their “data suggest that BBB disruption occurs during acute infection and long COVID, where it is strongly associated with cognitive impairment.”

Coping with brain fog

General advice for coping with brain fog, from any cause, includes:

  • following a healthy diet, rich in fresh fruits and vegetables and limiting processed food
  • doing regular exercise
  • having good sleep hygiene
  • managing stress.

Dr. Schifitto advised that:

“General principals are avoid deconditioning, thus keep routine physical activity although [this] will need to be titrated to tolerance. Be aware of mental fatigue so spread intellectual work throughout the day. Because often there are also depressive symptoms present, maintain social connections.”

And Prof. Griffin warned that anyone with long COVID brain fog should “ensure that you pace yourself when experiencing this or other long COVID symptoms. Over-exertion can sometimes exacerbate things.”

He suggested that using tech, and setting reminders and alarms can help people cope with the brain fog and fatigue of long COVID.

A long-term problem that needs addressing

As has become increasingly clear, COVID, like many other viral diseases, can have effects long beyond the initial infection, and research is only now starting to discover why.

Avoiding infection is, of course, the best way to avoid long-term effects, but there is increasing evidence that vaccination and antiviral treatment in the early stages of infection reduces the risk of long COVID.

But Prof. Griffin is frustrated about the lack of action taken to prevent infection and counter the long-term effects of COVID-19.

“Like a lot of aspects of SARS-CoV-2 infection, because it [brain fog] doesn’t necessarily manifest during acute disease it tends to be overlooked. This, to me, is another reason why the reluctance of western governments to suppress prevalence of this virus is […] mind-bogglingly negligent,” he told us.

“There are already record numbers of people out of work due to chronic illness, also many that struggle on, plus cognitive impairment on this scale makes for a less productive population as a whole,“ said Prof Griffin.

“Adding brain fog to the already staggering list of longer term problems caused by COVID must surely make us question what we’re allowing to happen to those being exposed to multiple infections with this virus, including our children,” he emphasized.

8 Common Signs You’re Deficient in Vitamins and Minerals


Symptoms of vitamin deficiency include brittle hair and nails, mouth ulcers, hair loss, scaly skin patches, and more. Recognizing these signs can help you adjust your diet accordingly.

A well-balanced and nutritious diet has many benefits. On the other hand, a diet lacking in nutrients may cause various unpleasant symptoms or even serious adverse effects.

These symptoms are your body’s way of communicating potential vitamin and mineral deficiencies.

Learn about 8 common signs of vitamin and mineral deficiencies and how to address them.Aleksandar Nakic/Getty Images

1. Brittle hair and nails

A variety of factors may cause brittle hair and nails. One of them is a lack of biotin.

Biotin, also known as vitamin B7, helps the body convert food into energy. A deficiency in biotin is somewhat rare, but when it occurs, brittle, thinning, or splitting hair and nails are some of the most noticeable symptoms.

Also, the prolonged use of antibiotics and some anti-seizure medications is a risk factor (2Trusted Source).

Eating raw egg whites may cause biotin deficiency as well. That’s because raw egg whites contain avidin, a protein that binds to biotin and can reduce its absorption (1, 3Trusted Source, 4Trusted Source).

Foods rich in biotin include eggs, organ meats, fish, meat, dairy, nuts, seeds, spinach, broccoli, cauliflower, sweet potatoes, yeast, whole grains, and bananas (5Trusted Source).

Adults with brittle hair or nails might consider trying a supplement that provides about 30 micrograms of biotin per day. However, it’s important to speak with a healthcare professional first before beginning any new supplements.

Summary Biotin is a B vitamin involved in many body functions. It plays an
important role in strengthening hair and nails. A deficiency in this vitamin is
generally rare but may occur in certain cases.

2. Mouth ulcers or cracks in the corners of the mouth

Lesions in and around the mouth may partly be linked to an insufficient intake of certain vitamins or minerals.

For instance, canker sores, a type of mouth ulcer, are often the result of deficiencies in iron or B vitamins.

In a small older study, around 28% of patients with recurring mouth ulcers had deficiencies in thiamine (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B6) or a combination of the vitamins. These findings indicate that there may be a link between mouth ulcers recurring and deficiencies in these three vitamins (11Trusted Source).

Foods rich in iron include poultry, meat, fish, legumes, dark leafy greens, nuts, seeds, and whole grains (14Trusted Source).

Good sources of thiamine, riboflavin, and pyridoxine include whole grains, poultry, meat, fish, eggs, dairy, organ meats, legumes, green vegetables, starchy vegetables, nuts, and seeds (15Trusted Source, 16Trusted Source, 17Trusted Source).

If you experience these symptoms, consider speaking with a healthcare professional. They can evaluate your situation and create a treatment plan to address your medical needs.

For example, they may order tests to determine if you have any vitamin or mineral deficiencies. If so, they may recommend adding or increasing the dietary amount of certain foods or starting supplementation. They will likely monitor you to see if your symptoms improve.

Summary People with mouth ulcers or cracks at the corners of the mouth may
want to try consuming more foods rich in thiamine, riboflavin, pyridoxine, and
iron to alleviate symptoms.

3. Bleeding gums

Sometimes a rough tooth brushing technique is at the root of bleeding gums, but a diet lacking in vitamin C can also be a contributing factor.

Vitamin C plays an important role in wound healing and immunity, and it even acts as an antioxidant, helping prevent cell damage.

Your body does not make vitamin C on its own, so the only way to maintain adequate levels of it is through diet (18Trusted Source, 19Trusted Source, 20Trusted Source).

Vitamin C deficiencies are rare in individuals who consume enough fresh fruits and vegetables. That said, many people do not eat enough fruits and vegetables each day.

Consuming very little vitamin C through your dietary selections for long periods can lead to deficiency symptoms, including bleeding gums and tooth lossTrusted Source.

Another serious consequence of severe vitamin C deficiency is scurvy, which depresses the immune system, weakens muscles and bones, and makes you feel fatigued and lethargic.

Other common signs of vitamin C deficiency include easy bruising, slow wound healing, dry skin, which may become scaly, and frequent nosebleeds (22, 24Trusted Source).

To consumeTrusted Source enough vitamin C, it’s important to eat at least 1.5–2 cups of fruit and 2–3 cups of vegetables each day.

Summary Eating little to no fruits and vegetables may cause a vitamin C deficiency. This can lead to unpleasant symptoms like bleeding gums, a weakened immune system, and in severe cases, tooth loss and scurvy.

4. Poor night vision and white growths on the eyes

A low nutrient eating plan can sometimes cause vision problems.

For instance, low intake of vitamin A is often linked to a condition known as night blindness, which reduces your ability to see in low light or darkness.

That’s because vitamin A is necessary to produce rhodopsin, a pigment found in the retina of each eye that helps you see at night.

When left untreated, night blindness can progress to xerophthalmia, a condition that can damage your cornea and ultimately lead to blindness (25Trusted Source).

Another early symptom of xerophthalmia is Bitot’s spots, which are slightly elevated, foamy, white growths that occur on the conjunctiva or white part of the eyes.

Biotot’s spots may improve within 2 weeks of high dose vitamin A therapy, but it’s important to speak with a medical professional before making any significant dietary changes (26Trusted Source).

Vitamin A deficiency is rare in developed countries. If you suspect your vitamin A intake is insufficient, you might consider eating more vitamin-A-rich foods, such as organ meats, dairy, eggs, fish, dark leafy greens, and yellow-orange colored vegetables (27Trusted Source).

Unless you’re diagnosed with a deficiency, it’s typically recommended that you avoid taking vitamin A supplements. That’s because vitamin A is a fat-soluble vitamin, which when consumed in excess, can accumulate in the body’s fat stores and lead to toxicity.

Symptoms of vitamin A toxicity can be serious and include nausea, headaches, skin irritation, joint and bone pain, and in severe cases, even coma or death (28).

Summary Low vitamin A intake may cause poor night vision or growths on the
white part of the eyes. Adding more vitamin-A-rich foods to your diet may help
you avoid or reduce these symptoms.

5. Scaly patches and dandruff

Seborrheic dermatitis (SB) and dandruff are part of the same group of skin disorders that affect the oil-producing areas of your body.

Both involve itchy, flaking skin. Dandruff is mostly restricted to the scalp, whereas seborrheic dermatitis can also appear on the face, upper chest, armpits, and groin.

The likelihood of these skin disorders is highest within the first 3 months of life, during puberty, and in mid-adulthood.

Studies show that both of these conditions are very common. Up to 42% of infants and 50% of adults may experience dandruff or seborrheic dermatitis at one point or another (29Trusted Source, 30Trusted Source).

Many factors can cause dandruff and seborrheic dermatitis. One of which is a nutrient-poor diet. For instance, low blood levels of riboflavin (vitamin B2) and pyridoxine (vitamin B6) may play a role (13, 29Trusted Source, 31).

While the link between a low nutrient diet and these skin conditions is not fully understood, people with dandruff or seborrheic dermatitis might consider consuming more of these nutrients. To confirm whether you have a deficiency, you can talk with a healthcare professional who can order tests to check your vitamin levels.

Foods rich in riboflavin and pyridoxine include poultry, meat, fish, eggs, dairy, oats, nuts, and certain vegetables (16Trusted Source, 17Trusted Source).

Summary Dandruff and scaly patches on the scalp, eyebrows, ears,
eyelids, and chest may be caused by low intake of riboflavin and
pyridoxine. A healthcare professional may order tests to check your blood levels of these vitamins.

6. Hair loss

Hair loss is a very common symptom. In fact, up to 50% of male adults report hair loss by the time they reach 50 years old (33Trusted Source).

A diet rich in the following nutrients may help prevent or slow hair loss (34Trusted Source).

Meat, fish, eggs, legumes, dark leafy greens, nuts, seeds, and whole grains are good sources of iron.

Niacin-rich foods include meat, fish, dairy, whole grains, legumes, nuts, seeds, and leafy greens. These foods are also rich in biotin, which is also found in egg and organ meat.

Leafy vegetables, nuts, whole grains, and vegetable oils are rich in LA, while walnuts, flaxseeds, chia seeds, and soy nuts are rich in ALA.

It’s worth noting that taking vitamin and mineral supplements in the absence of a deficiency may worsen hair loss, rather than help it (44Trusted Source).

For instance, excess selenium and vitamin A, two nutrients often added to hair growth supplements, have both been linked to hair loss (34Trusted Source).

Unless your healthcare professional confirms a deficiency, it’s likely best to opt for diets rich in these nutrients rather than supplements, but speaking with a professional first before making any changes is best.

Summary The vitamins and minerals mentioned above are needed for hair growth,
so diets rich in them may help prevent hair loss. However, the use of
supplements — except in cases of deficiency — may cause more harm than good.

7. Red or white bumps on the skin

Keratosis pilaris is a condition that causes goosebump-like bumps to appear on the cheeks, arms, thighs, or buttocks. These little bumps may also be accompanied by corkscrew or ingrown hairs.

The condition often appears in childhood and naturally disappears in adulthood.

The cause of these little bumps is still not fully understood, but they may appear when too much keratin is produced in hair follicles. This produces red or white elevated bumps on the skin (45Trusted Source).

Keratosis pilaris may have a genetic component, meaning that a person is more likely to have it if a family member has it. That said, it has also been observed in people with diets low in vitamins A and C (22).

Thus, in addition to traditional treatments with medicated creams, people with this condition may consider talking with a medical professional about adding foods rich in vitamins A and C to their diet.

These include organ meats, dairy, eggs, fish, dark leafy greens, yellow-orange colored vegetables, and fruit (24Trusted Source, 27Trusted Source).

Summary Inadequate intake of vitamins A and C may be linked to keratosis
pilaris, a condition that leads to the appearance of red or white bumps on the
skin.

8. Restless leg syndrome

Restless leg syndrome (RLS), also known as Willis-Ekbom disease, is a nerve condition that causes unpleasant or uncomfortable sensations in the legs, as well as an irresistible urge to move them (46).

According to the National Institute of Neurological Disorders and Stroke, RLS affects up to 10% of Americans, with women twice as likely to experience the condition. For most people, the urge to move seems to intensify when they’re relaxing or trying to sleep.

While the exact causes of RLS are not fully understood, there appears to be a link between symptoms of RLS and a person’s blood iron levels.

For instance, several studies link low blood iron stores to an increased severity of RLS symptoms. Several studies also note that symptoms often appear during pregnancy, a time during which women’s iron levels tend to drop (49Trusted Source, 50Trusted Source).

Supplementing with iron might help decrease RLS symptoms, especially in people with a diagnosed iron deficiency. However, research is still limited on the effects of supplementation for managing RLS (51Trusted Source, 52Trusted Source, 53Trusted Source, 54Trusted Source).

Since higher iron intakes may help reduce symptoms, consider speaking with a healthcare professional about increasing your intake of iron-rich foods, such as meat, poultry, fish, legumes, dark leafy greens, nuts, seeds, and whole grains, may also be beneficial (14Trusted Source).

It may be especially beneficial to combine these iron-rich foods with vitamin-C-rich fruits and vegetables, as these can help increase iron absorption (55Trusted Source).

Using cast-iron pots and pansTrusted Source and avoiding tea or coffee at meals can also help boost iron absorption.

It’s helpful to note that unnecessary supplementation can do more harm than good, so it’s important to use caution if you’re considering supplementation (56Trusted Source).

Extremely high iron levels can even be fatal in some cases, so it’s best to consult your healthcare professional before taking any supplements (57Trusted Source).

Finally, some evidence suggests that magnesium may play a role in managing restless leg syndrome symptoms (58Trusted Source).

Summary Restless leg syndrome is often linked to low iron levels. Those with
this condition may want to discuss increasing their intake of iron-rich foods and taking
supplementation with their healthcare professional.

The bottom line

A diet that provides an insufficient intake of vitamins and minerals can cause several symptoms, some of which are more serious than others.

Increasing your intake of foods rich in the appropriate vitamins and minerals may help you manage nutrient-deficient-related symptoms.

However, it’s always helpful to speak with a healthcare professional before making significant dietary changes and if you’re considering supplementation.

Probing the mysteries of neutron stars with a surprising earthly analog


Ever since neutron stars were discovered, researchers have been using their unusual properties to probe our universe. The superdense remnants of stellar explosions, neutron stars pack a mass greater than the Sun’s into a ball about as wide as San Francisco. A single cup of this star matter would weigh about as much as Mount Everest.

These odd celestial bodies could alert us to distant disturbances in the fabric of spacetime, teach us about the formation of elements, and unlock the secrets of how gravity and particle physics work in some of the most extreme conditions in the universe.

“They’re at the center of a lot of open questions in astronomy and astrophysics,” says astrophysicist Vanessa Graber of the Institute of Space Sciences in Barcelona.

But to accurately interpret some of the neutron stars’ signals, researchers must first understand what goes on inside them. They have their hunches, but experimenting directly on a neutron star is out of the question. So scientists need another way to test their theories. The behavior of matter in such a superdense object is so complicated that even computer simulations aren’t up to the task. But researchers think they may have found a solution: an earthly analog.

Though young neutron stars can have temperatures in the millions of degrees in their interior, by one important energetic measure neutrons are considered “cold.” Physicists think that is a characteristic they can exploit to study the inner workings of neutron stars. Instead of looking to the sky, researchers are peering into clouds of ultracold atoms created in laboratories here on Earth. And that might help them finally answer some longstanding questions about these enigmatic objects.

Space oddities

The existence of neutron stars was first proposed in 1934, two years after the discovery of the neutron itself, when astronomers Walter Baade and Fritz Zwicky wondered if a celestial body made entirely of neutrons might remain after a supernova explosion. Though they didn’t get all the details right, their general idea is now widely accepted.

Stars power themselves by fusing the nuclei of lighter atoms into those of heavier atoms. But when stars run out of those lighter atoms, nuclear fusion stops and there is no longer an outward pressure to fight against the inward force of gravity. The core collapses and the star’s outer layer races inward. When this layer hits the dense core, it bounces off and explodes outward, producing a supernova. The dense core that remains afterward is a neutron star.

A composite, falsely colored image shows a small white sphere shooting a filament of white from its center. Surrounded by concentric rings of white gases, blue and purple clouds emanate and twist into the dark sky around it.
The remains of a supernova witnessed in the year 1054, the Crab Nebula contains a rapidly spinning neutron star known as a pulsar.

It wasn’t until the 1960s that Zwicky and Baade’s hypothetical neutron stars were finally detected. Radio astronomer Jocelyn Bell Burnell noticed a strange, regularly pulsed radio wave signal from space while working as a graduate student at the University of Cambridge. She was detecting something that had never been seen before: a special kind of neutron star called a pulsar, which flashes beams of radiation at regular intervals as it spins, like a lighthouse. (Her adviser, along with the director of the observatory — but not Bell Burnell — later received the Nobel Prize for the discovery.)

Since then, thousands of neutron stars have been detected. As some of the densest, highest-pressure objects in the universe, neutron stars might help us learn about what happens to matter at extremely high densities. Understanding their structure and the behavior of the neutron matter composing them is of paramount importance to physicists.

Scientists already know that the neutrons, protons and other subatomic particles that compose a neutron star arrange themselves differently depending on where in the star they are. In certain sections, they pack rigidly like water molecules in a block of ice. In others, they flow and swirl like a frictionless fluid. But exactly where the transition happens and how the different phases of matter behave, physicists aren’t sure.

A superdense star born of a nuclear fireball seems, on its face, to have very little in common with a dilute cloud of ultracold particles. But they can share at least one useful characteristic: They are both below a threshold known as the Fermi temperature that depends on — and is calculated based on — the matter each system is made of. A system that is well above this temperature will largely behave according to the laws of classical physics; if it is well below, its behavior will be ruled by quantum mechanics. Certain ultracold gases and neutron star material can both be well below their Fermi temperatures and consequently can act in similar ways, says Christopher Pethick, a theoretical physicist at the Niels Bohr Institute in Copenhagen and coauthor of an early overview of neutron stars in the 1975 Annual Review of Nuclear Science.

This animation of a pulsar shows how, much like a lighthouse, pulsars flash beams of light at regular intervals as they spin.

Matter that is below its Fermi temperature can obey remarkably universal laws. This universality means that, while we don’t have easy access to several-million-degree neutron star matter, we could learn about some of its behavior by experimenting with ultracold gases that can be created and manipulated in laboratory vacuum chambers on Earth, says theoretical astrophysicist James Lattimer of Stony Brook University in New York, author of a summary of the science of nuclear matter in the 2012 Annual Review of Nuclear and Particle Science.

Of particular interest to Lattimer is a theoretical state called a unitary gas. A gas is unitary when each of its particles’ sphere of influence becomes infinite, meaning that they would influence each other no matter how far apart they are. This is impossible to have in reality, but ultracold atom clouds can get close — and so can the matter inside of neutron stars. “It’s similar to a unitary gas,” Lattimer says, “but it’s not a perfect unitary gas.”

Down to Earth

For a long time, the exact relationship between a gas’s pressure and its density was simply too complex to accurately calculate. But when experimental physicists developed the ability to control clouds of cold atoms and tune them to get very, very close to a unitary gas, this opened a new avenue to determining such a gas’s properties: Simply measure it directly, instead of struggling to wrangle the unwieldy math on a computer.

These ultracold atom clouds are actually closer to being a unitary gas than neutron star matter, so the analogy isn’t perfect. But it’s close enough that Lattimer has been able to take almost-unitary-gas measurements from the cold-atom clouds and apply them to neutron matter to refine some of the theoretical models that describe the internal workings of neutron stars. And experiments with cold atoms can help scientists develop theories about what physics might be at play in some unexplained neutron star phenomena.

In particular, Graber and other scientists are hoping to find clues to one of the biggest mysteries, called pulsar glitches. Generally, the regularly timed ticking of a pulsar “clock” is so reliable that its accuracy rivals that of atomic clocks. But not always: Sometimes, the pulsar’s rate of rotation increases abruptly, causing a glitch. Where that extra oomph comes from is unclear. The answer lies with how that matter moves around inside a neutron star.

Both cold gases and neutron matter in some parts of a neutron star are superfluids — the particles flow without any friction. When a superfluid rotates, little whirlpools, or vortices, develop. How exactly these vortices move and interact with one another and other structures inside a rotating neutron star is still an open question. “It’s probably not this nice, regular lattice of vortices,” says Michael McNeil Forbes, who studies theoretical physics at Washington State University in Pullman. “It might be some tangle of vortices that’s in the entire star. We don’t know.”

Forbes and others suspect that the glitches they observe in the rotation of pulsars have something to do with how these vortices get “pinned” to structures in the star. Generally, a single vortex meanders freely around a fluid. But when the fluid contains a rigidly packed area of matter that obstructs the vortex’s motion, the vortex will stop and sometimes even wrap its swirling arms around the rigid object and position itself so that its center is right on top of it.

Eight microscopic images show a series of white circles with many dark flecks arranged within them. The largest nearly fills the field of view, and the dark spots appear somewhat blurry. In the series, the circles decrease in size and corresponding number of dark spots, which appear more regularly arranged in some of the views.
Superfluid vortices are found in both neutron stars and clouds of cold atoms. Physicists study these in cold atoms using laser light and magnetic traps to manipulate the clouds. Here, scientists studied the formation and decay of vortices (dark spots) in cold-atom clouds over increasing amounts of time (from 25 milliseconds, upper left, to 40 seconds, lower right). Additional studies look at what happens when such vortices move or interact.

Vortices tend to stay pinned in this way, but sometimes they can unpin and migrate away from the object. When this happens, the flow of fluid exerts a torque on the object. If hundreds of thousands of vortices unpin from various structures in a neutron star all at once, they can suddenly speed up the star’s rotation. Forbes explains how so many vortices might all unpin at once: “Like dropping sand onto a sand pile — nothing really happens until … you get a whole avalanche.”

But it’s almost impossible for classical computers to exactly calculate all the intricacies of the dance of so many vortices at once. So Forbes plans to team up with experimental groups that can form these vortices in their clouds of cold atoms and see what happens. The idea is to use “cold atom experiments as analog quantum computers for calculating stuff that we can’t do any other way,” he says.

Researchers are busy examining how other ultracold phenomena they regularly see in the lab can inspire new lines of research into the behavior of neutron stars. Recently, Graber and her colleagues outlined so many possibilities that they needed 125 pages to publish them all. In 2019, dozens of astronomers, nuclear physicists and ultracold atomic physicists from around the world gathered to discuss more of the surprising connections between their fields. Researchers are just beginning to test some of the ideas generated by these brainstorms.

They’re also learning more from the stars themselves, says Pethick. “It’s an exciting field, because at the moment there are a lot of observations coming in.”

With better telescopes and new methods to glean properties about a neutron star’s inscrutable interior, scientists can hope to find out just how far this analogy between cold atoms and neutron stars can be taken.

Pursuing fusion power.


Scientists have been chasing the dream of harnessing the reactions that power the Sun since the dawn of the atomic era. Interest, and investment, in the carbon-free energy source is heating up.

For the better part of a century now, astronomers and physicists have known that a process called thermonuclear fusion has kept the Sun and the stars shining for millions or even billions of years. And ever since that discovery, they’ve dreamed of bringing that energy source down to Earth and using it to power the modern world.

It’s a dream that’s only become more compelling today, in the age of escalating climate change. Harnessing thermonuclear fusion and feeding it into the world’s electric grids could help make all our carbon dioxide-spewing coal- and gas-fired plants a distant memory. Fusion power plants could offer zero-carbon electricity that flows day and night, with no worries about wind or weather — and without the drawbacks of today’s nuclear fission plants, such as potentially catastrophic meltdowns and radioactive waste that has to be isolated for thousands of centuries.

In fact, fusion is the exact opposite of fission: Instead of splitting heavy elements such as uranium into lighter atoms, fusion generates energy by merging various isotopes of light elements such as hydrogen into heavier atoms.

To make this dream a reality, fusion scientists must ignite fusion here on the ground — but without access to the crushing levels of gravity that accomplish this feat at the core of the Sun. Doing it on Earth means putting those light isotopes into a reactor and finding a way to heat them to hundreds of millions of degrees centigrade — turning them into an ionized “plasma” akin to the insides of a lightning bolt, only hotter and harder to control. And it means finding a way to control that lightning, usually with some kind of magnetic field that will grab the plasma and hold on tight while it writhes, twists and tries to escape like a living thing.

Both challenges are daunting, to say the least. It was only in late 2022, in fact, that a multibillion-dollar fusion experiment in California finally got a tiny isotope sample to put out more thermonuclear energy than went in to ignite it. And that event, which lasted only about one-tenth of a nanosecond, had to be triggered by the combined output of 192 of the world’s most powerful lasers.

Side-by-side graphics show two spherical targets, the left one within a metal cylinder. Laser beams are blasting the targets directly (right) and though holes in the bottom and top of cylinder (left).
This approach to fusion starts with a tiny solid target filled with deuterium-tritium fuel that gets hit from every side with intense pulses of energy. This can be done indirectly (left) by surrounding the target with a small metal cylinder. Lasers strike the insides of the cylinder, generating X-rays that heat the fuel pellet. The laser beams can also heat the target directly (right). Either way, the fuel pellet implodes, and the resulting energy release quickly blows the target apart. The indirect approach was used by the National Ignition Facility in the heralded “break even” experiments that produced more energy than the lasers delivered. But this approach to fusion is probably many decades from being a practical way to generate electricity.

Today, though, the fusion world is awash in plans for much more practical machines. Novel technologies such as high-temperature superconductors are promising to make fusion reactors smaller, simpler, cheaper and more efficient than once seemed possible. And better still, all those decades of slow, dogged progress seem to have passed a tipping point, with fusion researchers now experienced enough to design plasma experiments that work pretty much as predicted.

“There is a coming of age of technological capability that now matches up with the challenge of this quest,” says Michl Binderbauer, CEO of the fusion firm TAE Technologies in Southern California.

Indeed, more than 40 commercial fusion firms have been launched since TAE became the first in 1998 — most of them in the past five years, and many with a power-reactor design that they hope to have operating in the next decade or so. “‘I keep thinking that, oh sure, we’ve reached our peak,” says Andrew Holland, who maintains a running count as CEO of the Fusion Industry Association, an advocacy group he founded in 2018 in Washington, DC. “But no, we keep seeing more and more companies come in with different ideas.”

Why green energy finally makes economic sense

None of this has gone unnoticed by private investment firms, which have backed the fusion startups with some $6 billion and counting. This combination of new technology and private money creates a happy synergy, says Jonathan Menard, head of research at the Department of Energy’s Princeton Plasma Physics Laboratory in New Jersey, and not a participant in any of the fusion firms.

Compared with the public sector, companies generally have more resources for trying new things, says Menard. “Some will work, some won’t. Some might be somewhere in between,” he says. “But we’re going to find out, and that’s good.”

Granted, there’s ample reason for caution — starting with the fact that none of these firms has so far shown that it can generate net fusion energy even briefly, much less ramp up to a commercial-scale machine within a decade. “Many of the companies are promising things on timescales that generally we view as unlikely,” Menard says.

But then, he adds, “we’d be happy to be proven wrong.”

With more than 40 companies trying to do just that, we’ll know soon enough if one or more of them succeeds. In the meantime, to give a sense of the possibilities, here is an overview of the challenges that every fusion reactor has to overcome, and a look at some of the best-funded and best-developed designs for meeting those challenges.

Prerequisites for fusion

The first challenge for any fusion device is to light the fire, so to speak: It has to take whatever mix of isotopes it’s using as fuel, and get the nuclei to touch, fuse and release all that beautiful energy.

This means literally “touch”: Fusion is a contact sport, and the reaction won’t even begin until the nuclei hit head on. What makes this tricky is that every atomic nucleus contains positively charged protons and — Physics 101 — positive charges electrically repel each other. So the only way to overcome that repulsion is to get the nuclei moving so fast that they crash and fuse before they’re deflected.

This need for speed requires a plasma temperature of at least 100 million degrees C. And that’s just for a fuel mix of deuterium and tritium, the two heavy isotopes of hydrogen. Other isotope mixes would have to get much hotter — which is why “DT” is still the fuel of choice in most reactor designs.

Graphic shows the light isotopes of four promising types of fusion fuel and their fusion products.
In fusion reactors, light isotopes fuse to form heavier ones and release energy in the process. Shown here are four examples of reactor fuels. The first, D-T, combines two heavy forms of hydrogen (deuterium and tritium). This mix is most common because it begins to fuse at the lowest temperature, but tritium is radioactive, and the generated neutrons can make the reactor radioactive. A reaction between two deuterium nuclei (D-D) proceeds more slowly and requires high temperatures. Using a deuterium-helium-3 mix is also less common, in part because helium-3 is rare and expensive. Perhaps the most tantalizing is a mix of protons and boron-11 (P-11B). Both isotopes are non-radioactive and abundant, while their fusion products are stable and easy to capture for energy extraction. The challenge will be to get the mix to fusion temperatures of more than 1 billion degrees Celsius.

But whatever the fuel, the quest to reach fusion temperatures generally comes down to a race between researchers’ efforts to pump in energy with an external source such as microwaves, or high-energy beams of neutral atoms, and plasma ions’ attempts to radiate that energy away as fast as they receive it.

The ultimate goal is to get the plasma past the temperature of “ignition,” which is when fusion reactions will start to generate enough internal energy to make up for that radiating away of energy — and power a city or two besides.

But this just leads to the second challenge: Once the fire is lit, any practical reactor will have to keep it lit — as in, confine these superheated nuclei so that they’re close enough to maintain a reasonable rate of collisions for long enough to produce a useful flow of power.

In most reactors, this means protecting the plasma inside an airtight chamber, since stray air molecules would cool down the plasma and quench the reaction. But it also means holding the plasma away from the chamber walls, which are so much colder than the plasma that the slightest touch will also kill the reaction. The problem is, if you try to hold the plasma away from the walls with a non-physical barrier, such as a strong magnetic field, the flow of ions will quickly get distorted and rendered useless by currents and fields within the plasma.

Unless, that is, you’ve shaped the field with a great deal of care and cleverness — which is why the various confinement schemes account for some of the most dramatic differences between reactor designs.

Finally, practical reactors will have to include some way of extracting the fusion energy and turning it into a steady flow of electricity. Although there has never been any shortage of ideas for this last challenge, the details depend critically on which fuel mix the reactor uses.

With deuterium-tritium fuel, for example, the reaction produces most of its energy in the form of high-speed particles called neutrons, which can’t be confined with a magnetic field because they don’t have a charge. This lack of an electric charge allows the neutrons to fly not only through the magnetic fields but also through the reactor walls. So the plasma chamber will have to be surrounded by a “blanket”: a thick layer of some heavy material like lead or steel that will absorb the neutrons and turn their energy into heat. The heat can then be used to boil water and generate electricity via the same kind of steam turbines used in conventional power plants.

Graphic of a fusion reactor connected a steam generator and turbine that’s connected to a utility pole in the electrical grid.
A fusion power plant could use one of several different reactor types, but it will turn fusion energy into electricity the same way that fossil-fuel power plants or nuclear-fission reactors do: Heat from the energy source will boil water to make steam, the steam will flow through a steam turbine, and the turbine will turn an electric generator to send power into the grid.

Many DT reactor designs also call for including some lithium in the blanket material, so that the neutrons will react with that element to produce new tritium nuclei. This step is critical: Since each DT fusion event consumes one tritium nucleus, and since this isotope is radioactive and doesn’t exist in nature, the reactor would soon run out of fuel if it didn’t exploit this opportunity to replenish it.

The complexities of DT fuel are cumbersome enough that some of the more audacious fusion startups have opted for alternative fuel mixes. Binderbauer’s TAE, for example, is aiming for what many consider the ultimate fusion fuel: a mix of protons and boron-11. Not only are both ingredients stable, nontoxic and abundant, their sole reaction product is a trio of positively charged helium-4 nuclei whose energy is easily captured with magnetic fields, with no need for a blanket.

But alternative fuels present different challenges, such as the fact that TAE will have to get its proton-boron-11 mix to up fusion temperatures of at least a billion degrees Celsius, roughly 10 times higher than the DT threshold.

A plasma donut

The basics of these three challenges — igniting the plasma, sustaining the reaction, and harvesting the energy — were clear from the earliest days of fusion energy research. And by the 1950s, innovators in the field had begun to come up with any number of schemes for solving them — most of which fell by the wayside after 1968, when Soviet physicists went public with a design they called the tokamak.

Like several of the earlier reactor concepts, tokamaks featured a plasma chamber something like a hollow donut — a shape that allowed the ions to circulate endlessly without hitting anything — and controlled the plasma ions with magnetic fields generated by current-carrying coils wrapped around the outside of the donut.

But tokamaks also featured a new set of coils that caused an electric current to go looping around and around the donut right through the plasma, like a circular lightning bolt. This current gave the magnetic fields a subtle twist that went a surprisingly long way toward stabilizing the plasma. And while the first of these machines still couldn’t get anywhere close to the temperatures and confinement times a power reactor would need, the results were so much better than anything seen before that the fusion world pretty much switched to tokamaks en masse.

Graphic of two donut-shaped devices with yellow plasma flowing through the donuts, which are surrounded by metal coils.
Tokamak reactors (left) and related designs known as stellarator reactors (right) both confine the superhot plasma (yellow) with magnetic fields (purple) that are generated by electromagnetic coils (blue and red). With tokamaks, the most common type of reactor, these coils also start an electric current flowing through the plasma, which helps keep the reaction stable. The stellarator design likewise confines the plasma inside an airtight donut, but eliminates the need for a donut-circling current by controlling the plasma with a much more complex set of external coils (blue).

Since then, more than 200 tokamaks of various designs have been built worldwide, and physicists have learned so much about tokamak plasmas that they can confidently predict the performance of future machines. That confidence is why an international consortium of funding agencies has been willing to commit more than $20 billion to build ITER (Latin for “the way”): a tokamak scaled up to the size of a 10-story building. Under construction in southern France since 2010, ITER is expected to start experiments with deuterium-tritium fuel in 2035. And when it does, physicists are quite sure that ITER will be able to hold and study burning fusion plasmas for minutes at a time, providing a unique trove of data that will hopefully be useful in the construction of power reactors.

But ITER was also designed as a research machine with a lot more instrumentation and versatility than a working power reactor would ever need — which is why two of today’s best-funded fusion startups are racing to develop tokamak reactors that would be a lot smaller, simpler and cheaper.

First out of the gate was Tokamak Energy, a UK firm founded in 2009. The company has received some $250 million in venture capital over the years to develop a reactor based on “spherical tokamaks” — a particularly compact variation that looks more like a cored apple than a donut.

But coming up fast is Commonwealth Fusion Systems in Massachusetts, an MIT spinoff that wasn’t even launched until 2018. Although Commonwealth’s tokamak design uses a more conventional donut configuration, access to MIT’s extensive fundraising network has already brought the company nearly $2 billion.

Both firms are among the first to generate their magnetic fields with cables made of high-temperature superconductors (HTS). Discovered in the 1980s but only recently available in cable form, these materials can carry an electrical current without resistance even at a relatively torrid 77 Kelvins, or -196 degrees Celsius, warm enough to be achieved with liquid nitrogen or helium gas. This makes HTS cables much easier and cheaper to cool than the ones that ITER will use, since those will be made of conventional superconductors that need to be bathed in liquid helium at 4 Kelvins.

But more than that, HTS cables can generate much stronger magnetic fields in a much smaller space than their low-temperature counterparts — which means that both companies have been able to shrink their power plant designs to a fraction of the size of ITER.

As dominant as tokamaks have been, however, most of today’s fusion startups are not using that design. They’re reviving older alternatives that could be smaller, simpler and cheaper than tokamaks, if someone could make them work.

Plasma vortices

Prime examples of these revived designs are fusion reactors based on smoke-ring-like plasma vortices known as the field-reversed configuration (FRC). Resembling a fat, hollow cigar that spins on its axis like a gyroscope, an FRC vortex holds itself together with its own internal currents and magnetic fields — which means there’s no need for an FRC reactor to keep its ions endlessly circulating around a donut-shaped plasma chamber. In principle, at least, the vortex will happily stay put inside a straight cylindrical chamber, requiring only a light-touch external field to hold it steady. This means that an FRC-based reactor could ditch most of those pricey, power-hungry external field coils, making it smaller, simpler and cheaper than a tokamak or almost anything else.

Simplified graphic shows a long metal tube with inward facing guns at each end; each gun has fired a hot plasma vortex toward the center, which also has a hot plasma vortex.
Shown here is a linear reactor concept based on an especially stable plasma vortex that is held together with its own internal currents and magnetic fields. Called the field-reversed configuration (FRC), it is formed from the merger of two simpler vortices that are fired from each end of the reaction chamber by plasma guns. Beams of fresh fuel coming in from the side keep the FRC hot and spinning briskly.

In practice, unfortunately, the first experiments with these whirling plasma cigars back in the 1960s found that they always seemed to tumble out of control within a few hundred microseconds, which is why the approach was mostly pushed aside in the tokamak era.

Yet the basic simplicity of an FRC reactor never fully lost its appeal. Nor did the fact that FRCs could potentially be driven to extreme plasma temperatures without flying apart — which is why TAE chose the FRC approach in 1998, when the company started on its quest to exploit the 1-billion-degree proton-boron-11 reaction.

Binderbauer and his TAE cofounder, the late physicist Norman Rostoker, had come up with a scheme to stabilize and sustain the FRC vortex indefinitely: Just fire in beams of fresh fuel along the vortex’s outer edges to keep the plasma hot and the spin rate high.

It worked. By the mid-2010s, the TAE team had shown that those particle beams coming in from the side would, indeed, keep the FRC spinning and stable for as long as the beam injectors had power — just under 10 milliseconds with the lab’s stored-energy supply, but as long as they want (presumably) once they can siphon a bit of spare energy from a proton-boron-11-burning reactor. And by 2022, they had shown that their FRCs could retain that stability well above 70 million degrees C.

With the planned 2025 completion of its next machine, the 30-meter-long Copernicus, TAE is hoping to actually reach burn conditions above 100 million degrees (albeit using plain hydrogen as a stand-in). This milestone should give the TAE team essential data for designing their DaVinci machine: a reactor prototype that will (they hope) start feeding p-B11-generated electricity into the grid by the early 2030s.

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Plasma in a can

Meanwhile, General Fusion of Vancouver, Canada, is partnering with the UK Atomic Energy Authority to construct a demonstration reactor for perhaps the strangest concept of them all, a 21st-century revival of magnetized target fusion. This 1970s-era concept amounts to firing a plasma vortex into a metal can, then crushing the can. Do that fast enough and the trapped plasma will be compressed and heated to fusion conditions. Do it often enough and a more or less continuous string of fusion energy pulses back out, and you’ll have a power reactor.

In General Fusion’s current concept, the metal can will be replaced by a molten lead-lithium mix that’s held by centrifugal force against the sides of a cylindrical container spinning at 400 RPM. At the start of each reactor cycle, a downward-pointing plasma gun will inject a vortex of ionized deuterium-tritium fuel — the “magnetized target” — which will briefly turn the whirling, metal-lined container into a miniature spherical tokamak. Next, a forest of compressed-air pistons arrayed around the container’s outside will push the lead-lithium mix into the vortex, crushing it from a diameter of three meters down to 30 centimeters within about five milliseconds, and raising the deuterium-tritium to fusion temperatures.

Graphic of a spherical reactor filled with plasma, surrounded by many pistons.
Magnetized target fusion is the 1970s-era name for an approach that amounts to firing a plasma vortex into a metal can, then crushing the can. Shown here is a modern version in which the metal can is replaced by a molten lead-lithium mix that’s held against the sides of a spinning container by centrifugal force. Plasma guns fire vortices of deuterium-tritium plasma into the container’s hollow interior while pistons arrayed around the container’s outside push the lead-lithium mix inwards, crushing the plasma and igniting fusion. The blast pushes the molten lead-lithium mix back out and resets the system.

The resulting blast will then strike the molten lead-lithium mix, pushing it back out to the rotating cylinder walls and resetting the system for the next cycle — which will start about a second later. Meanwhile, on a much slower timescale, pumps will steadily circulate the molten metal to the outside so that heat exchangers can harvest the fusion energy it’s absorbed, and other systems can scavenge the tritium generated from neutron-lithium interactions.

All these moving parts require some intricate choreography, but if everything works the way the simulations suggest, the company hopes to build a full-scale, deuterium-tritium-burning power plant by the 2030s.

It’s anybody’s guess when (or if) the particular reactor concepts mentioned here will result in real commercial power plants — or whether the first to market will be one of the many alternative reactor designs being developed by the other 40-plus fusion firms.

But then, few if any of these firms see the quest for fusion power as either a horse race or a zero-sum game. Many of them have described their rivalries as fierce, but basically friendly — mainly because, in a world that’s desperate for any form of carbon-free energy, there’s plenty of room for multiple fusion reactor types to be a commercial success.

“I will say my idea is better than their idea. But if you ask them, they will probably tell you that their idea is better than my idea,” says physicist Michel Laberge, General Fusion’s founder and chief scientist. “Most of these guys are serious researchers, and there’s no fundamental flaw in their schemes.” The actual chance of success, he says, is improved by having more possibilities. “And we do need fusion on this planet, badly.”

Herpes may double the risk of developing dementia


Scientists have found a link between herpes and dementia risk. istetiana/Getty Images

  • Anyone who has received a herpes diagnosis may be twice as likely to develop dementia than people who have not, according to a new study from Uppsala University in Sweden.
  • HSV-1, the type of the virus that causes cold sores or oral herpes, is most associated with the risk of dementia.
  • Nearly 80% of the adult population in Sweden and 57% to 80% of adults in the United States carries that type.

Anyone who has received a herpes diagnosis may be twice as likely to develop dementia than people who have not, according to a new study from Uppsala University in Sweden.

The study, which was published in the Journal of Alzheimer’s Disease, followed 1,000 70-year-old subjects for 15 years and confirmed previous research about the associations with the herpes virus and dementia.

Herpes results from infection with the herpes simplex virus (HSV), of which there are two types. Herpes simplex virus type 1 (HSV-1) causes oral herpes, affecting the mouth and surrounding skin but also potentially the genital region. Herpes simplex virus type 2 (HSV-2) typically causes genital herpes and is usually sexually transmitted. Nearly 572,000 people have HSV-2 infectionsTrusted Source each year, according to the Centers for Disease Control and Prevention (CDC).

Dementia is a wide term for cognitive decline disorders like Alzheimer’s disease and vascular dementia. It is associated with aging but is not a usual part of getting older.

Erika Vestin, a lead author of the study and a Ph.D. student at Uppsala University, told Medical News Today that the research confirms prior knowledge about the connections between dementia and herpes, but causality is still not concrete.

“We still do not have answers regarding causal mechanisms of this association, whether the virus causes the disease or if there is an indirect link,” Vestin said.

“Further, the association remains to be studied in different social and ethnic groups, and potential effects of herpes drugs on dementia risk need to be investigated in pharmaceutical drug studies,” she added.

How common is herpes and dementia?

According to the World Health Organization (WHO)Trusted Source, more than 55 million people worldwide have dementia and nearly 10 million more will receive a diagnosis of dementia each year. By 2030, it is estimated that the number of people with dementia will reach 78 million.

HSV, which remains for a person throughout their life, is quite common. According to the WHOTrusted Source, around 67% of people under age 50 globally have an HSV-1 infection, and 13% under age 50 have an HSV-2 infection., and 13% under age 50 have an HSV-2 infection. Most people with HSV-2 may not know they have it: Approximately 87.4%Trusted Source of people between the ages of 14 and 49 with genital herpes do not have a clinical diagnosis.

Up to 80% of the adult population in Sweden may have contracted HSV-1 at some point. The statistics are similar in the United States: 57% to 80% of adultsTrusted Source here have oral herpes.

The herpes virus causes sores or blisters in or around the mouth or genitals, alongside other symptoms. There is no cure for herpes, but treatment can help manage symptoms and reduce the likelihood of outbreaks recurring and transmission to partners.

What is the link between herpes and dementia?

Vestin said that the oral form of herpes is most likely the main factor in any connection between HSV and dementia, but that the virus itself can complicate those connections.

“The main culprit seems to be HSV-1, which commonly infects the oral region,” Vestin said. “However, HSV-1 and HSV-2 can both infect either the oral or the genital region, which is important to have in mind when these studies are conducted.”

Dr. Monica Gandhi, MPH, an infectious diseases specialist with the University of California, San Francisco, told MNT that the study does not prove causality.

“There could be important differences between those with or without herpes simplex virus (HSV) IgG status (past exposure) and those who developed dementia or not. It is difficult to control all confounders that have been traditionally associated with dementia (like diabetes, hypertension, history of stroke or myocardial infarction), and the authors state that their entire cohort had relatively low rates of these conditions,” Dr. Gandhi said.

“The authors did not find an association between treatment for HSV and dementia, which would be an interesting observation to see in another study if we wanted to be more convinced of a causal link,” Dr. Gandhi added.

“A good matched study where a group is matched on almost all possible confounders for dementia (hypertension, diabetes, smoking, other risk factors) to another group with the same risk factors but only one difference (HSV IgG status) could be helpful in providing further evidence,” she added.

Should I be worried if I have a herpes diagnosis?

Vestin suggested that getting diagnosed and treated with widely available drugs for the herpes virus would benefit anyone who does have it and indicated that previous research backs this.

“There are indications from large register studies that herpesvirus drug use may be associated with a decreased risk of dementia among symptomatic herpes simplex carriers. However, there are no pharmaceutical trials to confirm this. For now, herpes simplex carriers will have to rely on the same advice as the rest of the population, involving mainly lifestyle factors and cardiovascular health,” she said.

Dr. Gandhi said that the rates of herpes and dementia are different enough — and there are wildly divergent factors for any individual’s susceptibility — to warrant some caution around the study’s findings.

“The prevalence of HSV-1 and HSV-2 is very high in the population (up to 80%) and the rate of dementia is fortunately much lower. Traditional risk factors for strokes (which can induce dementia) include diabetes, hypertension and smoking, so keeping those factors controlled can be helpful for a person’s individual risk of dementia,” Dr. Gandhi said.

“Given how common herpes virus infection is [in] young people, I would not let this study concern you too much,” she added.

Niacin supplements linked to greater risk of heart attacks and strokes


People with higher levels of niacin in their blood may be more at risk of a heart attack or stroke, possibly because too much of the vitamin inflames blood vessels

Niacin, or vitamin B3, is a popular supplement

People with high levels of niacin, also known as vitamin B3, in their blood may be more likely to have a heart attack or stroke than those with lower levels. Excessive amounts of the vitamin, which is routinely added to fortified food and can be taken as a supplement, may inflame blood vessels.

Heart attacks and stroke are leading causes of death worldwide. While researchers have made significant strides over the past few decades in discovering the risk factors for these conditions, they haven’t identified them all.

“If you treat [high] cholesterol and [high] blood pressure and diabetes and all the existing risk factors, you can still suffer a heart attack,” says Stanley Hazen at the Cleveland Clinic in Ohio. “There is something that we are missing.”

In an effort to fill these gaps, Hazen and his colleagues collected blood samples from 2331 adults in the US and 832 adults in Europe who had elected to undergo cardiovascular screenings. The team analysed the samples for substances called metabolites, byproducts of metabolic processes such as digestion. The researchers then tracked incidents of cardiac events, such as heart attacks and strokes, among the participants over three years.

They found that people with elevated levels of a metabolite called 4PY were around 60 per cent more likely, on average, to experience such an event than those with lower levels. This compound only arises when the body breaks down excess niacin.

Further experiments revealed that 4PY inflames blood vessels in rodents. We know that inflammation is a major contributor to the development of heart disease, says Hazen.

It isn’t uncommon for people to have high niacin levels, he says. This is partially due to certain foods, such as cereals and flours, being routinely fortified with the vitamin in countries that include the UK and the US.

Niacin supplements are also increasingly popular as evidence suggests they have anti-ageing benefits, says Hazen. Plus, it wasn’t until recently that doctors stopped prescribing high-dose niacin to people at risk of cardiovascular disease, as it was initially thought the vitamin protected people from these conditions by lowering cholesterol.

“I think this study really shows that sometimes, when it comes to vitamins, you can have too much of a good thing,” says Jenny Jia at Northwestern University in Chicago, Illinois.

However, this research was mainly conducted in people of European ancestry. It is therefore unclear if similar results would occur in people of different racial or ethnic backgrounds, says Jia.

Scientists closer to finding quantum gravity theory after measuring gravity on microscopic level


Scientists are a step closer to unraveling the mysterious forces of the universe after working out how to measure gravity on a microscopic level.

Experts have never fully understood how the force that was discovered by Isaac Newton works in the tiny quantum world. Even Einstein was baffled by quantum gravity and, in his theory of general relativity, said there is no realistic experiment that could show a quantum version of gravity.

But now physicists at the University of Southampton, working with scientists in Europe, have successfully detected a weak gravitational pull on a tiny particle using a new technique.

They claim it could pave the way to finding the elusive quantum gravity theory.

The experiment, published in Science Advances, used levitating magnets to detect gravity on microscopic particles—small enough to border on the quantum realm.

Lead author Tim Fuchs, from the University of Southampton, said the results could help experts find the missing puzzle piece in our picture of reality.

He added, “For a century, scientists have tried and failed to understand how gravity and quantum mechanics work together. Now we have successfully measured gravitational signals at a smallest mass ever recorded, it means we are one step closer to finally realizing how it works in tandem.

“From here we will start scaling the source down using this technique until we reach the quantum world on both sides. By understanding quantum gravity, we could solve some of the mysteries of our universe—like how it began, what happens inside black holes, or uniting all forces into one big theory.”

The rules of the quantum realm are still not fully understood by science—but it is believed that particles and forces at a microscopic scale interact differently than regular-sized objects.

Academics from Southampton conducted the experiment with scientists at Leiden University in the Netherlands and the Institute for Photonics and Nanotechnologies in Italy.

Their study used a sophisticated setup involving superconducting devices, known as traps, with magnetic fields, sensitive detectors and advanced vibration isolation. It measured a weak pull, just 30aN, on a tiny particle 0.43mg in size by levitating it in freezing temperatures a hundredth of a degree above absolute zero—about –273 degrees Celsius.

The results open the door for future experiments between even smaller objects and forces, said Professor of Physics Hendrik Ulbricht also at the University of Southampton.

He added, “We are pushing the boundaries of science that could lead to new discoveries about gravity and the quantum world.

“Our new technique that uses extremely cold temperatures and devices to isolate vibration of the particle will likely prove the way forward for measuring quantum gravity.

“Unraveling these mysteries will help us unlock more secrets about the universe’s very fabric, from the tiniest particles to the grandest cosmic structures.”