Top 10 principles of success


Do you want to achieve the goals that you have set for yourself? Are you passionate and determined to change your dreams to reality? have you been thinking of how to stop struggling unsuccessfully and start scoring? if your answer is yes, then this 10 insights are for you!

#1 Have a definite goal; To arrive to your destiny, you have to; know where you want to go, start from where you are, never stop, never change direction and never change the purpose of going there.
#2 Be grateful; Thank God for sustaining your life to this time, if he gives you more life, be sure to spend it doing what you love and what you are best at. If you do what you love, life will never be boring, if you do what you are best at, you will never fail. When life is not boring and you are successful you will always be thanking him and that is the meaning of life, to always give glory to almighty.
#3 Faith; Success is a combination of many things eg hard work, persistence, determination… but faith is the one metric that matters (OMTM), without total believe in your ability to deliver, all the other metrics will not help. It is true that you have to be sure of yourself before you ever win a prize!
#4 Apply ignorance as your survival technique; When you start living your dreams, many people will have reasons why you will not make it, the truth is, sometime they are right and sometime they are wrong but by ignoring all this reasons, you will always be right.
#5 Listen to yourself; While listening to what others have to say is integrity, listening to yourself, especially when you are listening to your instinct not ego, is nobility. Sometime you have to break the norm, sometime you have to break the rule. If the shortcut is save enough, do not call it wrong cut just because so and so think it is.
#6 Never wait to be ready; Start where you are with what you have and believe you will get the rest along the way, history is full of people who have arrived to their destinies without ever having all they thought was necessary for a start, yet others have more than what is needed for a completion but have not yet started, and the chances are they will never start. If you think the journey is worth the efforts, then get going.
#7 Concentrate; You have to find what you are best at and how you can get the best from it. The great have been successful in letting only this thoughts ring in their minds.
#8 Do not coppy paste the successful; The difference between the successful man and the failure is that the successful man is playing with his hobbies and the failure is coping him. Choose to follow your heart and you will realize that every calling has its highest level of rewards only enjoyed by those at home.
#9 Accept failure; a detailed study of life reveals that you do not have to be right always, sometime, one major breakthrough can make the all difference, Every dog has its own day, while I could not explain why yours has delayed, I can give you the secret that will ensure you will not miss it when it emerge and that secret is, the winning odds are those that say you have to remain waiting and wanting.
#10 Advice others;When the all world is silent, great talents and dreams can perish, do not undermine your words of hope and courage even if you think it is a lie, See strength in others. Just tell someone how great they are and you will be amazed by the great giants of talents that you will awake.

In conclusion,Learn from every experience. Every situation is an oppotunity for learning something new.

Have you ever applied some of these principles? Tell us in the comments below how it help you achieve your goals.

25 books by billionaires that will teach you how to run the world.


Whether you want to launch an empire or become the best in your field, who better to consult than those who have achieved the peak of professional and financial success?

Bill Gates Summer Books

That’s why we’ve rounded up 25 books by self-made billionaires. From the business insights of Bill Gates to the leadership lessons of Richard Branson, the wisdom collected in these pages extends far beyond the classroom.

Learn how these masters of industry achieved the impossible, in their own words.

Read more. URL:http://www.businessinsider.in/25-books-by-billionaires-that-will-teach-you-how-to-run-the-world/articleshow/55654397.cms

We now have more evidence that fat fuels cancer’s spread.


Scientists have stopped metastasis in mice.

 

Scientists have found that the cells responsible for spreading cancer around the bodies of mice have a big weakness – they need certain fats to fuel their growth.

Now a team of researchers has shown that by blocking these cells from absorbing fat they can actually stop cancer from metastasising in mice – and they’re hoping the results might help them do the same in humans.

Metastasis is the leading cause of cancer-related deaths in the world, but until now, scientists have struggled to understand exactly how and why cancer cells go through the energy-intensive process of splitting off, travelling through the bloodstream, and taking root somewhere else in the body.

In the past, it was assumed that sugar was cancer’s main fuel source, but a study earlier this year suggested that we’d been looking at metastasis entirely wrong – what if fat was actually driving the spread of cancer?

Now a new study adds more weight to this hypothesis.

A team of researchers identified the cells responsible for the spread of oral cancer in mice, and showed that they rely on fatty acids – including palmitic acid, a major component of common food additive palm oil – to spread around the body.

They figured this out after noticing that many of the metastasising cells expressed high levels of a receptor protein called CD36, which helps cells absorb lipids.

High expression of CD36 has also been linked to poor medical outcomes in cancer patients, so the team decided to see what would happen if the receptor was blocked.

Incredibly, the researchers showed that when they blocked CD36 expression in a range of human cancer cells, they were able to stop the cancer from spreading altogether in mice – although it didn’t stop primary tumours from forming.

“We hypothesise that metastatic cells rely so much on the availability of certain fatty acids, that they cannot cope without them,” lead researcher Salvador Aznar Benitah told Research Gate.

“However, we still do not know the precise mechanism of why blocking CD36 results in such a strong effect on metastasis.”

While the team still has more work to do, their results so far show that the approach might also work after cancer has metastasised.

In mice, blocking CD36 with antibodies eradicated metastatic tumours 15 percent of the time, and the remaining tumours that had spread shrunk by at least 80 percent.

The study also showed that mice fed high-fat diet had more and larger tumours in their lymph nodes and lungs – which is a sign of them spreading – compared to mice on normal diets.

To be clear, this research has only been done on human cancer cells in mice, so there’s no guarantee the same thing will work in human patients.

And at this stage, no one is recommending anyone cut fats from their diets to avoid cancer spread – especially seeing as many cancer patients need high-energy diets in order to stay healthy.

But the team is working on creating antibodies that work against CD36 in humans, and hope to test them in clinical trials within the next five years.

“This is an important and exciting first step,” said Benitah. “Now that we have been able to identify these cells responsible for metastasis, we can study their behaviour in much more detail.”

“Also, it opens the possibility of a new anti-metastatic therapy based on blocking the ability of these cells to uptake fatty acids,” he added.

We’re looking forward to seeing what comes of this research, because while we’re closing in on many revolutionary new treatments for cancer, being able to stop it from spreading in the first place would be incredible.

Yale Neuroscientists Can Now Determine Human Intelligence Through Brain Scans.


Article Image
The human connectome. By Andreashorn

Do you feel like you were born to do something? There is just a certain skill like playing an instrument or sport, or a certain subject, like math, which you naturally excel in? It might have to do with the way your brain is wired. Different people have different aptitudes. The repositories for these lie in different parts of the brain and, as scientists are learning more and more, in the connectome or the connections between regions.

Today, neuroscientists can determine one’s intelligence through a brain scan, as sci-fi as that sounds. Not only that, it’s only a matter of time before they are able to tell each individual’s set of aptitudes and shortcomings, simply from scanning their brain. Researchers at Yale led the study. They interpreted intelligence in this case as abstract reasoning, also known as fluid intelligence. This is the ability to recognize patterns, solve problems, and identify relationships. Fluid intelligence is known to be a consistent predictor of academic performance. Yet, abstract reasoning is difficult to teach, and standardized tests often miss it.

Researchers in this study could accurately predict how a participant would do on a certain test by scanning their brain with an fMRI. 126 participants, all a part of the Human Connectome Project, were recruited. The Human Connectome Project is the mapping of all the connections inside the brain, to get a better understanding of how the wiring works and what it means for things like intellect, the emotions, and more. For this study, researchers at Yale put participants through a series of different tests to assess memory, intelligence, motor skills, and abstract thinking.

They were able to map the connectivity in 268 individual brain regions. Investigators could tell how strong the connections were, how active, and how activity was coordinated between regions. Each person’s connectome was as unique as their fingerprint, scientists found. They could identify one participant from another with 99% accuracy, from their brain scan. Yale researchers could also tell whether the person was engaged in the assessment they were taking or if they were aloof about it.

Emily Finn was a grad student and co-author of this study. She said, “The more certain regions are talking to one another, the better you’re able to process information quickly and make inferences.” Mostly, fluid intelligence had to do with the connections between the frontal and parietal lobes. The stronger and swifter the communication between these two regions, the better one’s score in the abstract thinking test. These are some of the latest regions to have evolved in the brain. They house the higher level functions, such as memory and language, which are essentially what make us human.

Axonal nerve fibers in the real brain, by jgmarcelino from Newcastle upon Tyne, UK

Yale researchers believe that by learning more about the human connectome, they might find novel treatments for psychiatric disorders. Things like schizophrenia vary widely from one patient to the next. By finding what’s unique to a particular patient, a psychiatrist can tailor treatment to suit their needs. Understanding one’s connectome could give insight into how the disease progresses, and if and how the patient might respond to certain therapies or medications. But there are other uses which we may or may not feel comfortable with.

For instance, your child could have their brain scanned to track them at school, according to study author Todd Constable. It might be used to say whether or not a candidate is qualified for a job or should pursue a certain career. Brain scans could tell who might be prone to addiction, or what sort of learning environment a student might flourish in. School curriculum could even be changed on a day-to-day basis to fit student’s needs. And the dreaded SAT might even be shelved too, in favor of a simple brain scan.

Peter Bandettini is the chief of functional imaging methods at the National Institute of Mental Health (NIMH). He told PBS that barring ethical issues, brain scans could someday be used by employers to tell which potential candidate possesses desirable aptitudes or personality traits, be they diligent, hardworking, or what-have-you. Richard Haier, an intelligence researcher at UC Irvine, foresees prison officials using such scans on inmates to tell who might be prone to violence.

We may even someday learn how to augment human intelligence from studies such as this. It’s important to remember that intelligence research is still in its infancy. Yet, according to Yale scientists, we are moving in this direction.

Some fear a Minority Report-like misuse of said technology. Neuroethicist Laura Cabrera at Michigan State University enumerated for WIRED her concerns. What if insurance companies denied coverage based on such a scan, due to a tendency toward addiction or some other predisposition. Of course, just because someone has a higher risk of something, doesn’t mean they will develop it. Without proper guidelines in place and oversight, we could quickly see banks, schools, universities, and other institutions taking part in “neuro-discrimination.” Strong laws will have to be put in place to defend against misuse.

There are limits to what we now know about the human connectome that have yet to be overcome. For instance, we can only look at the connections as they are now. We don’t know how they form or develop over time. And fluid intelligence is merely one type out of several different kinds. We are still far from applying such technology in the real world. But the potential is there.

Watch the video. URL:https://youtu.be/2nzLxAoUuts