Clostridium botulinum

Secret Botulism Paper Published.

Posted by

0


The discovery of a new form of the deadly botulinum toxin gets published, but its sequence is kept under wraps until an antidote is developed.

In a publishing first, the sequence of a newly discovered protein is not divulged in papers announcing the finding. Researchers at the California Department of Public Health in Sacramento discovered the protein, a new type of the extremely dangerous botulinum toxin, lurking in the feces of a child who displayed the symptoms of botulism. They published their findings in two reports on the website of The Journal of Infectious Diseases, but absent from either paper was the DNA sequence of the protein, the eighth form of botulinum toxin recovered from the bacteriumClostridium botulinum. The move represents the first time that a DNA sequence has been omitted from such a paper. “Because no antitoxins as yet have been developed to counteract the novel C. Botulinum toxin,” wrote editors at The Journal of Infectious Diseases, “the authors had detailed consultations with representatives from numerous appropriate US government agencies.”

These agencies, which included the Centers for Disease Control and Prevention and the Department of Homeland Security, approved publication of the papers so long as the gene sequence that codes for the new protein was left out. According to New Scientist, the sequence will be published as soon as antibodies are identified that effectively combat the toxin, which appears to be part of a whole new branch on the protein’s family tree.

The New Deadliest Substance Known to Man Is Top Secret (For Now)

Posted by

0


Scientists recently discovered a new type of botulinum toxin (a.k.a. botox) that they believe is the deadliest substance known to man. Because they’ve yet to discover an antitoxin, researchers won’t publish the details of gene sequence due to security concerns—a first for the scientific community. Thank God.

When scientists say this stuff is deadly, they mean it. It takes an injection of just 2 billionths of a gram or inhaling 13 billionths of a gram to kill an adult. A spoonful of the stuff in a city’s water supply could be catastrophic. The toxin, which comes from the bacterium Clostridium botulinum, blocks the chemical that makes nerves work, causing botulism and death by paralysis. In a comment accompanying a newly published journal article on the new botox, Stanford Medical School professor David Relman said the substance posed “an immediate and unusually serious risk to society.”

You’d be right to wonder: If this stuff is so dangerous, why do we have it in the first place? Well, it’s not manmade if that’s what you’re thinking. Before this new discovery, there were seven known branches on the botulinum family tree, but researchers recently found an eighth type of toxin in stool samples of an infant with botulism. It just so turns out that eighth type, known as type H, is the deadliest substance in the world. Scientists are withholding the genetic sequence so that terrorists, for instance, can’t synthesize it and do something terrible. Terrorists do like botox, too. It was one of these toxins that the Japanese cult Aum Shinrikyo tried to release in downtown Tokyo in the 1990s.

Despite the somewhat sensational nature of this latest discovery, everything is okay for now. This is, however, a rude reminder of how scientific discoveries can always be twisted into weapons of warfare. Unless we keep them secret, that is.