Low-dose metronomic cisplatin as an antiangiogenic and anti-inflammatory strategy for cancer


Abstract

Background

Conventional chemotherapy is based on the maximum tolerated dose (MTD) and requires treatment-free intervals to restore normal host cells. MTD chemotherapy may induce angiogenesis or immunosuppressive cell infiltration during treatment-free intervals. Low-dose metronomic (LDM) chemotherapy is defined as frequent administration at lower doses and causes less inflammatory change, whereas MTD chemotherapy induces an inflammatory change. Although several LDM regimens have been applied, LDM cisplatin (CDDP) has been rarely reported. This study addressed the efficacy of LDM CDDP on tumour endothelial cell phenotypic alteration compared to MTD CDDP.

Methods

Tumour growth and metastasis were assessed in bladder cancer-bearing mice treated with LDM or MTD gemcitabine (GEM) and CDDP. To elucidate the therapeutic effects of LDM CDDP, the change of tumour vasculature, tumour-infiltrating immune cells and inflammatory changes were evaluated by histological analysis and mRNA expression in tumour tissues.

Results

Tumour growth and bone metastasis were more suppressed by LDM CDDP + MTD GEM treatment than MTD CDDP + MTD GEM. Myeloid­derived suppressor cell accumulation was reduced by LDM CDDP, whereas inflammatory change was induced in the tumour microenvironment by MTD CDDP.

Conclusion

LDM CDDP does not cause inflammatory change unlike MTD CDDP, suggesting that it is a promising strategy in chemotherapy.

Anti-Inflammatory Golden Milk


(NADKI/Shutterstock)

Golden milk or haldi ka doodh is a warming beverage that dates back to ancient Ayruvedic tradition and was consumed to promote optimal health.  You’ve probably heard of the profound health benefits of turmeric, namely it’s constituent curcumin.   Curcumin, the phytonutrient responsible for turmeric’s vibrant yellow-orange hue is a powerful antioxidant and anti-inflammator.  Because of these powerful properties, curcumin can benefit multiple body systems and relieve many inflammatory symptoms.  It has been shown to support digestion, alleviate pain, aid recovery well as reducing the risk of cancer and diabetes.  Research also shows that it supports  brain, skin, cardiovascular, and ocular health.  The addition of black pepper is critical for ensuring the body absorbs curcumin into the bloodstream as it increases bioavailability by 2,000 percent.

It is important to note that while consuming golden milk is highly beneficial to overall health, we recommend our patients consider supplementing with one of the high quality supplements we have at the clinic.

Ingredients

1 1/2 teaspoons turmeric powder

1/2 teaspoon ground ginger

1/4 teaspoon ground cinnamon

a generous pinch of ground black pepper

a pinch of ground cardamom

a pinch of ground cloves

a pinch of ground nutmeg

8 ounces of coconut milk

1 teaspoon of a wholesome sweetener of your choice (monk fruit sweetener, raw honey, pinch of stevia)

Instructions

Heat the coconut milk in a small saucepan until it begins to simmer.  Remove from the heat and stir in the herbs and sweetener of your choice.  For extra health promoting properties, consider adding coconut oil, MCT oil, and/or Collagen ECM to enhance your beverage.  To achieve a frothy, latte-like consistency, blend in a blender for 15 seconds and serve.

Anti-Inflammatory and Pro-Inflammatory Foods


Harvard Magazine did an excellent review of research on inflammation, showing how pro-inflammatory foods can cause diseases and anti-inflammatory foods can help to prevent them (Harvard Magazine, May-June 2019, 40-52). Chronic inflammation increases risk for heart disease, diabetes, Alzheimer’s disease, certain cancers, and many other diseases. The more anti-inflammatory foods you eat, the greater your protection from chronic inflammation and the diseases it causes.

What is Inflammation?
When germs invade your body, your immune system sends out cells and proteins to kill the invading germs. Your immune system responds with exactly the same cells and proteins in the same way when cells in your body are injured, to remove damaged tissue and start the healing process. As soon as the germs are conquered, or tissues heal, your immune system stops sending out huge amounts of these cells and proteins. However, if your immune system stays overactive, you develop inflammation in which these same cells and proteins attack and damage your own cells. Chronic inflammation damages healthy tissues in the body to cause many diseases and chronic health problems.

How Foods Affect Inflammation
Your immune system is turned on by the surface proteins on the cells of germs that try to invade your body, by anything that damages cells in your body, and by substances in foods that look the same as the surface proteins of germs. The pro-inflammatory foods turn on your immune system to cause these cells and proteins to attack and damage your own normal cells, while the anti-inflammatory foods dampen down this response to protect your cells from damage from an overactive immune system.

The pro-inflammatory foods include sugar-added foods, sugared drinks, unfermented dairy products, mammal meat, processed meats, and fried foods.
• When sugar-added foods and other refined carbohydrates cause a high rise in blood sugar, the excess sugar sticks to the outer membranes of cells and destroys them. Your immune system is turned on by this cell damage (inflammation).
• All drinks with sugar in them, including fruit juices, cause high rises in blood sugar to cause cell damage. However, whole fruits are anti-inflammatory despite their sugar content.
Milk, butter and other non-fermented dairy products contain the pro-inflammatory sugar called galactose.
Mammal meat contains a surface sugar-protein called Neu5Gc that acts just like a germ invading your body to turn on your immune system.
Processed meats usually also contain Neu5Gc, and may have added nitrates that combine with proteins to form nitrosamines that damage cells in your body and increase cancer risk.
• In fried foods and other foods that are cooked at high temperatures without water, sugars bind to fats, proteins and DNA to form chemicals called advanced glycation endproducts (AGEs). AGEs have been shown to turn on your immune system to cause inflammation.

Why Do Plants Have Polyphenols?
A study from the University of Liverpool showed that fruits and vegetables are anti-inflammatory because they contain polyphenols that help to protect you from chronic inflammation (Br J Nutr, May 28, 2016;115(10):1699–1710). The authors showed that inflammation was reduced by substances such as isorhamnetin, resveratrol, curcumin, and vanillic acid found in onions, turmeric, red grapes, green tea and açai berries. Polyphenols such as these are found in virtually all fruits and vegetables.

Since fruits and vegetables cannot run away from their enemies — insects, bacteria, viruses, fungi, animals and humans — they protect themselves by producing large amounts of poisons called oxidants that can harm the invaders. To protect themselves from their own oxidants, plants produce antioxidants called polyphenols. When you eat fruits and vegetables, you get the benefits of these polyphenols, which include helping to protect you from your own immune system and keep it from remaining too active (called inflammation). This particular study showed that the polyphenols tested helped to reduce the release of pro-inflammatory chemicals in people who were at risk of chronic inflammation.

Anti-inflammatory foods include:
• vegetables
• fruits
• nuts
• whole (unground) grains
• beans
• coffee and tea
• oily fish such as salmon, mackerel, tuna, sardines

Pro-inflammatory foods include:
• sweetened beverages and sugar-added foods
• foods made with flour and other refined carbohydrates
• meat from mammals
• processed meats
• milk, butter, margarine, shortening, lard
• fried foods

My Recommendations
A healthful anti-inflammatory diet is high in vegetables, unground whole grains, beans, fruits and nuts; and low in the pro-inflammatory foods (sugar-added foods, sugared drinks, most animal products, and fried foods). Try to follow this pattern most of the time and adapt it to your special needs and preferences.

Food GOLD: Turmeric is just as effective as 14 pharma drugs but suffers from NONE of the side effects


Image: Food GOLD: Turmeric is just as effective as 14 pharma drugs but suffers from NONE of the side effects

What if you could replace all the pills in your medicine cabinet with just one herb? Depending on what you take and why, that may be possible with turmeric. Its main component, curcumin, boasts enough health-enhancing properties to keep pharmaceutical execs up at night.

In fact, this herb is so powerful that it has been at the heart of more than 12,000 peer-reviewed biomedical studies. Researchers have found more than 800 different therapeutic and preventive uses for curcumin. Here is a look at just a few of the drugs to which it compares favorably, as outlined by Green Med Info.

Metformin (for diabetes)

Diabetes numbers continue to climb as Americans grapple with obesity, and that means more and more people are taking Metformin – and taking on its scary risks as well. However, a study in the journal Biochemistry and Biophysical Research Community found that curcumin has value in treating diabetes; it is between 500 and 100,000 times more powerful than Metformin when it comes to activating AMPK, which raises glucose uptake. Studies have also shown that it has a 100 percent efficacy rate in preventing those with pre-diabetes from developing full-fledged diabetes.

Lipitor (for cholesterol)

A 2008 study revealed that curcumin compares favorably to atorvastatin, which you may know as Lipitor, when it comes to dealing with the endothelial dysfunction behind atherosclerosis while reducing inflammation and oxidative stress. Other studies have shown that it can impact triglyceride levels, LDL cholesterol, and total cholesterol. While most of the studies so far have been done in animals, it is believed that it could have the same effect in humans, although the right levels have yet to be established.

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Prozac (for depression)

A study in 2011 found that curcumin compares favorably to the antidepressants fluoxetine (Prozac) and imipramine when it comes decreasing depressive behavior. Best of all, it doesn’t carry the serious side effects that Prozac does, which include sleep problems, tremors, headaches, nausea, a lower sex drive, and suicidal ideation. In addition, it’s well-tolerated by patients.

Researchers believe it works on depression by inhibiting monoamine oxidase, the enzyme that has been linked to depression when it’s present in high amounts in the brain. It also raises levels of calmness-inducing serotonin and dopamine.

Oxaliplatin (for chemotherapy)

A study published in the International Journal of Cancer looked at curcumin’s effects in stopping colorectal cell lines from proliferating. The researchers discovered the herb compared favorably to the chemotherapy drug oxaliplatin. Other studies are underway exploring the impact curcumin has on various types of cancer after animal studies showed it could help prevent illnesses like skin, stomach and colon cancer in rats.

Anti-inflammatory medications

Curcumin is also great for inflammation, which is at the root of many chronic illnesses today such as cancer, metabolic syndrome, Alzheimer’s disease, degenerative diseases, and heart disease. A study published in Oncogene identified it as an effective alternative to drugs like ibuprofen, aspirin and naproxen given its strong anti-inflammatory effects, fighting inflammation at the molecular level. Meanwhile, in a study of patients with rheumatoid arthritis, curcumin worked even better than anti-inflammatory drugs.

Curcumin is so effective at addressing such a vast array of conditions that it’s hard to discuss it without sounding like you’re exaggerating. However, turmeric is truly “food gold” and it’s something well worth making a conscious effort to consume more of. You might not be ready to clean out your entire medicine cabinet, but that doesn’t mean you can’t start adding this spice to your food. It pairs well with a variety of dishes, soups, salads, stews, and smoothies; consuming turmeric with fats is ideal, and make sure you add a pinch of pepper to boost its bioavailability.

Sources for this article include:

GreenMedInfo.com

NaturalNews.com

VeryWellHealth.com

What are the best foods to reverse symptoms of rheumatoid arthritis?


Image: What are the best foods to reverse symptoms of rheumatoid arthritis?

Rheumatoid arthritis is a debilitating disease that causes the joints, usually in the hands, to become inflamed and painful. It usually affects older individuals, although people as young as 30 can suffer from the disease. Like most autoimmune diseases, there is no cure for rheumatoid arthritis, but effectively managing it begins with eating the right food.

There is strong evidence supporting the link between food and the symptoms and effects of rheumatoid arthritis, which can include swollen joints, pain, and disability. In a study published in the journal Frontiers of Nutrition, researchers found that the state of a person’s microflora, the bacteria in the gut, as well as a leaky gut, all contribute to the occurrence of rheumatoid arthritis.

Changes in a person’s diet, they found, can also have pronounced benefits. For instance, fasting produces ketones that help suppress the pro-inflammatory molecules that cause pain in rheumatoid arthritis. Shifting to a plant-based diet has also been found to reduce immune reactivity to antigens found in certain foods.

The Mediterranean diet against rheumatoid arthritis

Because of the close link between rheumatoid arthritis and inflammation, it goes without saying that the best diet for sufferers is one that incorporates a lot of anti-inflammatory foods. When it comes to ingredients that fight inflammation, nothing does it better than the Mediterranean diet.

The Mediterranean diet places a lot of emphasis on fresh fruits and vegetables, high-quality proteins, and whole, unrefined carbohydrates. According to experts, this diet is so healthy that it gives over 1,500 mg of polyphenols every day. Polyphenols are natural compounds with anti-cancer, anti-diabetic, and anti-allergenic properties.

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The Mediterranean diet is linked to a lower incidence of cardiovascular disease. One explanation for this is the liberated use of anti-inflammatory ingredients in almost any dish. Research has proven that many of the staples in this diet can help reduce the expression of pro-inflammatory compounds that may worsen rheumatoid arthritis. (Related: Study finds Mediterranean diet more effective cure for acid reflux than meds.)

Here are some of the pain-relieving and anti-inflammatory nutrients found in many of the foods under the Mediterranean diet:

  • Anthocyanins – These plant pigments are found in blueberries, blackberries, and eggplants. They are powerful antioxidants that reduce oxidative stress and help prevent inflammation.
  • Reservatrol – This antioxidant is abundant in grapes and red wine. Just like anthocyanins, it is a powerful antioxidant that helps protect the joints from inflammation and damage.
  • Mangiferin – Another antioxidant, this time found in mangoes, mangiferin is so powerful that it has been described as having the ability to prevent the destruction of joints.
  • Kaempferol – A compound found in grapefruit, kaempferol reduces the molecules that destroy the bones and the cartilage. The degradation of these parts is one of the main causes of pain of rheumatoid arthritis.
  • Bromelain – This compound from pineapples is known for being a potent anti-inflammatory agent. Studies vouch for its efficacy as a pain reliever that does not cause any adverse effects.
  • Oleic acid – Found in olive oil, this is one of the hallmark ingredients in the Mediterranean diet. This compound is known to provide therapeutic and protective effects from rheumatoid arthritis. When consumed by people without the condition, oleic acid can lower the risk of developing the disease.
  • Curcumin – This compound is found in turmeric and is known for its antioxidant and anti-inflammatory effects. Some studies say that turmeric is best combined with ginger, yet another anti-inflammatory food, to maximize its ability to relieve rheumatoid arthritis pain.
  • Probiotics – These “friendly” bacteria help promote digestion and improve the overall health of the gut. They can help prevent the negative effects of leaky gut and offset bad bacteria that may be causing damage to the body. Probiotics are found in fermented foods. Lactobacillus casei, for instance, is found in yogurt.

Learn which foods you need to eat to relieve body pain at Remedies.news.

Sources include:

NaturalHealth365.com

Arthritis.org

Pomegranates are some of the best foods you can eat to prevent cancer


Image: Pomegranates are some of the best foods you can eat to prevent cancer

Why do you need to make pomegranates a part of your diet? Apart from being refreshingly delicious, pomegranates are packed with vital nutrients and offer many health benefits, among which is protection from cancer.

Fruits are an essential part of a healthy diet. A significant chunk of their nutritional profile is composed of antioxidants. These are compounds that fight free radicals, which are unstable molecules that tend to accumulate in your body because of factors like natural body processes, your diet, the presence of disease, and your environment.

High concentrations of free radicals in your body lead to oxidative stress, which damages your cells and tissues. The effects of oxidative stress can range from prematurely aging skin to serious diseases, including cardiovascular conditions, neurodegenerative diseases, and cancer.

Antioxidants modify free radicals and turn them into harmless substances your body can either process or expel without incident. In this way, they are an essential part of a substantial protection against cancer.

Pomegranates are rich in antioxidants. One cup of its seeds gives you 30 percent of the recommended daily intake (RDI) for vitamin C, known as one of the most powerful antioxidants in nature. Pomegranate peel and juice also have an abundance of punicalagins. These compounds have antioxidant properties that are three times more potent than those of either red wine or green tea, which by themselves are known for being antioxidant powerhouses.

But the cancer-fighting benefits of pomegranates do not stop with their antioxidant load. A review of the fruit’s value in cancer therapy, published in the journal Pharmacological Research, emphasized its anti-inflammatory, antiproliferative, anti-angiogenic, anti-invasive, and anti-metastatic properties as great reasons it is so effective against cancer.

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Inflammation is, under normal circumstances, actually a good thing. As part of your immune response, it tells you that your immune system is up and functional. It becomes problematic when it is prolonged and persistent, becoming a risk factor for cancer and a number of other diseases. The punicalagins and other antioxidant compounds found in pomegranate are linked to reductions in inflammatory activity in breast cancer and colon cancer cells.

Angiogenesis, the formation of new blood vessels, is a key factor in metastasis or the proliferation of cancer cells to other parts of the body. Once cancer has metastasized, it becomes a lot harder to treat, so preventing angiogenesis is an important step in disrupting the disease’s progression. The extracts of pomegranate peel have been confirmed, in a study published in the journal Research in Pharmaceutical Sciences, to have both antiangiogenesis and antiproliferative effects against melanoma.

Pomegranates can also induce apoptosis, or cellular death, according to research published in Growth Hormone & IGF Research. At the end of the day, cancer cells are simply mutated cells. Causing them to undergo the natural process of cellular death by administering substances with apoptotic effects is considered one of the safest ways to kill tumor cells and treat cancer. In the study, pomegranates were shown to cause the death of prostate cancer cells.

Other health benefits of pomegranates

Here are yet more reasons to eat more pomegranates:

  • Pomegranates lower blood pressure – Hypertension increases your risk of dying from a heart attack. Some studies have found that drinking pomegranate juice for two weeks can effectively reduce your systolic blood pressure.
  • Pomegranates reduce joint pain – The discomfort caused by arthritis can be debilitating. The anti-inflammatory compounds in pomegranates can help mitigate the damage caused by osteoarthritis on the joints.
  • Pomegranates treat impotence – Impaired blood flow is considered one of the reasons behind erectile dysfunction. The antioxidants in pomegranates help improve blood flow and may even aid in improving erectile response.
  • Pomegranates protect from infections – The compounds in pomegranates have been shown to protect against bacterial and fungal infections. Among the microorganisms this fruit can boost your resistance to is Candida albicans, the cause of yeast infections.
  • Pomegranates may improve memory – Some studies indicate that pomegranates can help improve the memory of those who have just gone through surgery. Other inquiries found that it can enhance both visual and verbal memory.
  • Pomegranates improve exercise performance – One study found that taking pomegranate extracts 30 minutes before exercise can improve your blood flow. This can delay the onset of fatigue and improve your workout’s efficiency.

 

Sources include:

Science.news

ScienceDirect.com

Cancer.gov

NCBI.NLM.NIH.gov 1

NCBI.NLM.NIH.gov 2

NCBI.NLM.NIH.gov 3

Healthline.com

10 Reasons You Should Be Eating Olives Daily.


Even though more attention is usually given to their delicious oil than the whole food itself, olives are one of the world’s most widely enjoyed fruits. Yes, they are fruits even though most of us think of them as zesty vegetables. Here are 10 reasons why you should be eating these little delicacies every day.
1. Cardiovascular BenefitsWhen free radicals oxidize cholesterol, blood vessels are damaged and fat builds up in arteries, possibly leading to a heart attack. The antioxidant nutrients in black olives impede this oxidation of cholesterol, thereby helping to prevent heart disease. Olives do contain fat, but it’s the healthy monounsaturated kind, which has been found to shrink the risk of atherosclerosis and increase good cholesterol. When diets low in monounsaturated fat are altered to increase the monounsaturated fat content (without becoming too high in total fat), research study participants typically experience a decrease in their blood cholesterol, LDL cholesterol, and LDL:HDL ratio. All of these changes lower our risk of heart disease.Recent research studies have also shown that the monounsaturated fat found in olives (and olive oil) can help to decrease blood pressure. The oleic acid found in olives–once absorbed up into the body and transported to our cells–can change signaling patterns at a cell membrane level (specifically, altering G-protein associated cascades). These changes at a cell membrane level result in decreased blood pressure.
2. Weight LossIt appears that monounsaturated fats, the kind found in olives, when replacing saturated fats, may encourage weight loss. Olive oil consumption has been shown to breakdown fats inside fat cells, get rid of belly fat and reduce insulin insensitivity.People who have the highest olive consumption eat fewer calories overall and are rarely overweight. Blood tests show they have higher levels of serotonin, a so-called satiety hormone that makes us feel full.The aroma extracts from olive oil can leave us feeling fuller, cutting our calorie intake by almost 200 a day, they said.3. Cancer PreventionThe antioxidant and anti-inflammatory properties of olives make them a natural for protection against cancer because chronic oxidative stress and chronic inflammation can be key factors in the development of cancer. If our cells get overwhelmed by oxidative stress (damage to cell structure and cell function by overly reactive oxygen-containing molecules) and chronic excessive inflammation, our risk of cell cancer is increased. By providing us with rich supplies of antioxidant and anti-inflammatory nutrients, olives can help us avoid this dangerous combination of chronic oxidative stress and chronic inflammation.

Black olives are a great source of vitamin E, which has the brilliant ability to neutralize free radicals in body fat. Especially when working with the stable monounsaturated fats found in olives, vitamin E can make cellular processes safer. When such processes such as mitochondrial energy production are not well protected, the free radicals produced can cause oxidation, damaging a cell’s mitochondria, and preventing the cell from producing enough energy to supply its needs. If the DNA of a cell is damaged, it may well mutate and become cancerous. Studies have shown that a diet supplemented with olive oil leads to a lower risk of colon cancer, almost as low a risk as a diet rich in fish oil.

4. Less Pain

Spanish-style green olives, Kalamata-style olives, and many different methods of olive preparation provide us with valuable amounts of many different antioxidant and anti-inflammatory nutrients which can act as a natural Ibuprofen. Their oils contain oleocanthal, a substance with anti-inflammatory agents. Similar to classical NSAIDs, they are a type of non-selective inhibitor of cyclooxygenase (COX). 50g (more than three and a half tablespoons) of a typical virgin olive oil per day contains an amount of oleocanthal with similar anti-inflammatory effect as 1/10 of the adult ibuprofen dose.

5. Skin and Hair Health

Black olives are rich in fatty acids and antioxidants that nourish, hydrate and protect. Chief among those is vitamin E. Whether applied topically or ingested, vitamin E has been shown to protect skin from ultraviolet radiation, thus guarding against skin cancer and premature aging. You can gain a healthy, glowing complexion by washing your face in warm water, applying a few drops of olive oil to vulnerable spots, and letting it work its magic for 15 minutes before rinsing it off. In fact, you can moisturize with olive oil before any bath, and even condition your hair with it by mixing it with an egg yolk and leaving it before rinsing and washing.

6. Less Allergies

New research may help explain how olives work to provide us with anti-inflammatory benefits, especially during circumstances involving allergy. Olive extracts have now been shown to function as anti-histamines at a cellular level. By blocking special histamine receptors (called H1 receptors), unique components in olive extracts may help to lessen a cell’s histamine response. Because histamine is a molecule that can get overproduced in allergy-related conditions and can be a key player in the inflammatory process, it’s likely that the anti-inflammatory benefits we get from olives involve this anti-histamine pathway. It’s also possible that olives may have a special role to play as part of an overall anti-allergenic diet. Your circulation will improve and you’ll be able to breath easier with olive consumption. They can increase blood flow and help lessen the effects of illnesses such as asthma through its anti-inflammatory properties.

7. Digestive Tract Health

Frequent consumption of both vitamin E and the monounsaturated fats in black olives is associated with lower rates of colon cancer. These nutrients help prevent colon cancer by neutralizing free radicals. Olive oil’s protective function also has a beneficial effect on ulcers and gastritis. Olive oil activates the secretion of bile and pancreatic hormones much more naturally than prescribed drugs, thereby lowering the incidence of gallstone formation. A cup of black olives also contains 17% of the daily allowance of fiber, which promotes digestive tract health by helping to move food through the system at a healthier pace. This keeps any one part of the digestive tract from having to work too hard and supports the ideal balance of chemicals and populations of microorganisms required for a healthy digestive system.

8. Good Source of Iron

Olives, especially black are very high in iron. The ability of red blood cells to carry oxygen throughout the body is due to the presence of iron in the blood. If we suffer from a lack of iron, our tissues don’t get enough oxygen, and we may feel cold or weak. Iron also plays a vital role in the production of energy. It is a necessary part of a number of enzymes, including iron catalase, iron peroxidase, and the cytochrome enzymes. It also helps produce carnitine, a nonessential amino acid important for the utilization of fat. To top it all off, the proper function of the immune system is dependent on sufficient iron.

9. Eye Health

One cup of olives contains ten percent of the daily recommended allowance of vitamin A which, when converted into the retinal form, is crucial for healthy eyes. It enables the eye to better distinguish between light and dark, thereby improving night vision. Furthermore, Vitamin A is believed effective against cataracts, macular degeneration, glaucoma and other age-related ocular diseases.

10. Increases Blood Levels of Glutathione

Olives have shown the ability to increase blood levels of glutathione (one of the body’s premier antioxidant nutrients). Consumption of olive pulp is associated with significantly increased glutathione levels in the blood and improvement in antioxidant capacity.

How to Select Olives

While olives have been traditionally sold in jars and cans, many stores are now offering them in bulk in large barrels or bins (often called an “olive bar”). Buying bulk olives will allow you to experiment with many different types with which you may be unfamiliar and to purchase only as many as you need at one time.

While whole olives are very common, you may also find ones that have been pitted, as well as olives that have been stuffed with either peppers, garlic or almonds. If you purchase olives in bulk, make sure that the store has a good turnover and keeps their olives immersed in brine for freshness and to retain moistness. Some grocers will also use genetically modified oils such as Canola which should be avoided.

Avoid purchasing olives in cans. FDA data has shown levels of acrylamide as high as 1,925 ppb in some canned, nationally distributed brands of black pitted olives. Based on this data, higher acrylamide levels in select canned black olives may be related to specific handling, storage, processing (especially preservation and darkening methods), and heating steps that favored formation of acrylamide.

When selecting olives, beware of the label description, “hand-picked.” This description does not necessarily tell you anything helpful about the olive harvesting. Many olives are hand-picked, even though the product label makes no mention of this fact. Conversely, olives with have been mechanically harvested with a hand-held pneumatic rake are sometimes labeled as “hand-picked.”

As far olive oils go, the best processing comes from ice-pressed oils which is in the complete absence of heat; a dramatic 20-30 times colder than the cold-pressed olive oil; a critical distinction in terms of maintaining the oils’ nutritive and healing potential and to staking claim as one of the world’s only RAW producers of olive oil. Taste the distinct refreshing taste!

Source: preventdisease.com

Even More Uses of the Wonder Herb Turmeric.


Turmeric is a culinary spice widely used in Southeast Asia. Recent research reveals why this herb is such a powerful healer due to its anti-inflammatory and anti-oxidant properties.

The health benefits of Turmeric have been recognized by Chinese and Ayurvedic medicine for hundreds of years. It has been used to treat everyday problems such as indigestion and flatulence, as well as more serious problems such as arthritis, Alzheimer’s disease, cancer, diabetes, HIV, high cholesterol, heartburn, jaundice, liver disorders, and menstrual disorders. Turmeric can also be applied topically in poultices to reduce inflammation and to relieve wounds, cuts, and bruises.

Alzheimer’s Disease

Inflammation inside of the brain has been suspected to be one of the contributing factors in the development of Alzheimer’s disease. Studies have shown that Turmeric has anti-inflammatory and anti-oxidant activity. Therefore, regular daily consumption of Turmeric capsules may be an effective way to prevent the onset of Alzheimer’s.

Arthritis

Due to its anti-inflammatory and pain-relieving properties, it is not surprising that Turmeric is now being used as an effective natural remedy for Arthritis pain. Therefore, taking 500mg to 1000mg Turmeric capsules three times per day may provide significant relief from osteoarthritis pain.

Asthma

Since turmeric is an anti-inflammatory, it can help reduce the inflammation associated with asthma. Add 1 teaspoon of turmeric powder to a glass of warm milk, and drink this mixture as an effective asthma home remedy.

Cancer

Several recent studies have found that Turmeric can induce apoptosis, a process that triggers the self-destruction and elimination of damaged (cancerous) cells. Further research is still required before the full effects of Turmeric on cancer cells can be determined. However, existing studies suggest that daily Turmeric powder or supplements combined with a balanced, nutritious diet may help prevent or even destroy cancer cells.

Colds and Flu

Turmeric’s anti-bacterial, anti-viral, and anti-fungal agents can help our body fight against colds, cough and flu. Therefore, when symptoms of these infections are present, simply mix one teaspoon of Turmeric powder into a glass of warm milk once per day. Also drink plenty of water throughout the day.

Diabetes

Recent studies have shown that the antioxidant agents in Turmeric help reduce insulin resistance, which may prevent the onset of Type-2 Diabetes. Therefore, a simple preventive remedy is to take one teaspoon of turmeric powder twice a day with meals. Curcumin extracts or capsules can also be used as an alternative to the powder.

Inflammation

Turmeric’s key ingredient Curcumin is known for its anti-bacterial and anti-inflammatory properties. Therefore, Turmeric powder can help in healing cuts, wounds, and other skin infections including boils.

Heat one cup of Flax Seed Oil in a small saucepan on the stove. Thinly slice a small onion and add it to the hot oil. Fry the onions until they are dark brown and crunchy. Remove the brown onions and mix 2 tablespoons of Turmeric powder into the oil. Turn off the stove and let the oil cool down to a temperature that is comfortable to touch. Using a cotton swab, apply a small amount of the oil onto the injured or infected skin area. Apply this three times per day until the wound or infection is cured. Save the remaining oil into an airtight container for future use.

For internal injuries, fractures, sprains, and herniated disks, dip a piece of unbleached cotton fabric into the warm Turmeric oil. The fabric or cotton pad should be large enough to cover the outer skin of the affected area. Secure it in place and leave this cotton pad on overnight.

You can also add one teaspoon of turmeric powder into a warm glass of milk and drink it before going to bed to prevent internal inflammation and infections.

Weight Loss

Curcumin in Turmeric powder has been found to help increase the flow of bile, an important component in the breakdown of dietary fat. Therefore, taking one teaspoon of Turmeric powder with every meal may be an effective weight loss aid when combined with a healthy diet and exercise program.

What are the Side Effects of Turmeric?

Moderate use of Turmeric powder as part of regular diet is fairly safe, and recent studies have found that a dosage of 500mg capsules of Turmeric three times per day is safe. However, prolonged consumption of high doses of Turmeric extract may cause stomach or liver distress, as well as dehydration and constipation. Therefore, it should be avoided by people with gallstones or bile obstructions. If you are currently taking blood thinners (including Aspirin), you should consult your doctor before taking Turmeric since it is an anti-platelet (prevents blood clots).

Source:
Home Remedies and Natural Cures

 

         

         

Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives.


Glucocorticoids are widely used for their unsurpassed anti-inflammatory and immunomodulatory effects. However, the therapeutic use of glucocorticoids is almost always limited by substantial adverse outcomes such as osteoporosis, diabetes, and obesity. These unwanted outcomes are a major dilemma for clinicians because improvements in the primary disorder seem to be achievable only by accepting substantial adverse effects that are often difficult to prevent or treat. To understand the pathogenesis of glucocorticoid-induced osteoporosis, it is necessary to consider that the actions of glucocorticoids on bone and mineral metabolism are strongly dose and time dependent. At physiological concentrations, endogenous glucocorticoids are key regulators of mesenchymal cell differentiation and bone development, with additional regulatory roles in renal and intestinal calcium handling. However, at supraphysiological concentrations, glucocorticoids affect the same systems in different and often unfavourable ways. For many years, these anabolic and catabolic actions of glucocorticoids on bone were deemed paradoxical. In this Review, we highlight recent advances in our understanding of the mechanisms underlying the physiology and pathophysiology of glucocorticoid action on the skeleton and discuss present and future management strategies for glucocorticoid-induced osteoporosis.

Source: Lancet

 

 

 

12 Best Anti-Inflammatory Foods.


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Inflammation is largely caused by the foods we put in our bodies. Consuming highly processed canned, frozen and bagged foods are foreign to the natural flora of our bodies and so the body naturally fights against the products in these foods (as a part of the immune response), leading to high levels of inflammation. Effects of chronic inflammation can range from heart disease to dementia, to cancer and arthritis. Most autoimmune diseases like inflammatory bowel disease are linked to excessive inflammation in the body.

The good news is that you can control the level of inflammation in your body by simply changing the way you eat. Getting regular sleep, eating well, quitting smoking, reducing alcohol intake (or quitting altogether), stressing less and engaging in regular exercise will all help make a difference.

Here is a list of 12 amazing foods that help combat inflammation in the body:

(1) Papaya

Papaya contains the enzymes ‘papain’ and ‘chymopapain’ which help reduce inflammation  in the body (and also improve digestion). Papaya has powerful antioxidants like beta-carotene and vitamins C and E which combat free radicals in the body that trigger inflammation-related diseases.

(2) Avocado

Avocados are polyhydroxylated fatty alcohols (PFAs). PFAs are mostly present in seaweeds and other ocean plants, and are extremely rare in land plants, so this makes the avocado very unusual in this respect. The PFAs and phytosterols in avocados provide our bodies with anti-inflammatory benefits which help fight a variety of diseases. Particularly, avocado’s phytosterols prevent pro-inflammatory prostaglandin E2 synthesis by the connective tissue (and thus reducing inflammation in the joints of individuals experiencing arthritis and gout.

(3) Cranberries

Cranberries contain important anti-inflammatory phytonutrients that protect the cardiovascular system and prevent hardening of the arteries. They also prevent inflammation-associated diseases of the urinary tract (urinary tract infections), stomach (ulcers), and mouth (gingivitis).

(4) Broccoli

Broccoli is an incredible anti-inflammatory food, thanks to it’s abundant sulforaphane compounds which help the body get rid of potentially carcinogenic compounds (a cause of a highly inflamed body) and relieve inflammation and oxidative stress. It is also very high in vitamin C which is another powerful anti-inflammatory agent which cuts the levels of inflammation markers by up to 45%!

(5) Red Cabbage

If we do not ingest anti-inflammatory foods, our body cannot regulate the inflammation in our body we acquire from stress and the environment, as well as highly processed foods, wheat, and animal products. Anthocyanins found in red cabbage have been researched numerous times and time and time again they have been found to be one of the best anti-inflammatory vegetables out there!

(6) Hemp seeds

Raw hemp seeds contain an ideal ratio of omega’s 3 and 6. Omega-6 fats contain GLA which works in the body as an anti-inflammatory, decreasing inflammation and helping people suffering from things like asthma, arthritis and other body pain associated from exercising or being bruised. This healthy fat also improves the health of our skin and inhibits cancer cell growth.

(7) Blueberries

Inflammation and damage by free radicals have been linked with pretty much every disease we witness today. Many studies have found that blueberries prevent oxidative stress and inflammation. Blueberries help increase natural killer cell activity which help eradicate free radicals and fight disease. As well, they promote the production of anti-inflammatory cytokines in the body which leaves us with lower levels of inflammation and thus reduced chance of falling ill.

(8) Chia seeds

Many arthritis sufferers have reported reduced inflammation associated pain after just a few weeks of taking chia seeds. They contain important omega-3 fatty acids which are converted to prostagladins which have pain relieving and anti-inflammatory effects. Chia seeds are also a great source of antioxidants (they contain more than blueberries!), and antioxidants help keep the body healthy and reduce pain arising from inflammation in the body.

(9) Ginger

Ginger contains potent anti-inflammatory compounds called gingerols which inhibit the production of nitric oxide (which naturally forms potent and very damaging free radicals called peroxynitrites). Ginger has also been found to suppress pro-inflammatory compounds like cytokines produced by synoviocytes, chrondrocytes and leukocytes, and thus making our immune system and joints stronger.

(10) Walnuts

Walnuts contain omega-3 fatty acids, phytonutrients (tannins, phenolic acids and flavonoids), quinones and other anti-inflammatory nutrients. Consuming walnuts has been linked to decreased markers for blood vessel inflammation (reduced C-reactive protein) for those at risk for heart disease. Including walnuts as a part of your diet will ensure you gain these benefits.

(11) Turmeric

Turmeric, if you haven’t already heard, is one of the best anti-inflammatory foods out there! Thanks to the active ingredient, curcumin, this root can inhibit the activity and synthesis of COX-2 and 5-LOX, two important enzymes involved in the inflammatory response. One study found that osteoarthritis patients had significantly reduced pain and increased mobility when taking just 200 mg of curcumin per day (the control group with no curcumin had no significant improvements). Curcumin has also been found to block inflammatory pathways, and thus prevents proteins from triggering pain and swelling.

(12) Celery

A specific nutrient in celery, called “luteolin”, is particularly effective against inflammation and cancer. This compound is found in smaller amounts in peppers, parsley, thyme, basil and peppermint. It is a biofalvonoid which means that it has double the antioxidant properties of vitamin C! Luteolin essentially prevents the inflammatory pathway in the brain to get switched on, and thus helps reduce the amount of inflammatory responses triggered in the body.

Source: livelovefruit.com