Treatment of Benzodiazepine Dependence.



What are some of the basic approaches to the treatment of benzodiazepine dependence?

The first benzodiazepine to be approved and introduced into clinical practice was chlordiazepoxide, which was introduced to the market in 1960. Today, approximately 35 benzodiazepine derivatives exist, 21 of which have been approved internationally. They all bind to specific sites on the γ-aminobutyric acid (GABA) type A receptor, increasing the receptor’s affinity for GABA, an inhibitory neurotransmitter. A new Clinical Practice Review Article elaborates.

Clinical Pearl

  • What are the indications for benzodiazepines?

Benzodiazepines can be divided into anxiolytic agents and hypnotic agents on the basis of their clinical effects. In principle, however, all benzodiazepines have anxiolytic, hypnotic, muscle-relaxant, anticonvulsant, and amnesic effects. They are used as sedatives and to treat withdrawal symptoms, including alcohol withdrawal delirium.

Clinical Pearl

  • What side effects are associated with benzodiazepines?

The main disadvantages and dose-dependent side effects of benzodiazepines are drowsiness, lethargy, fatigue, excessive sedation, stupor, “hangover effects” the next day, disturbances of concentration and attention, development of dependence, symptom rebound (i.e., recurrence of the original disorder, most commonly a sleep disorder) after discontinuation, and hypotonia and ataxia. Benzodiazepines can seriously impair driving ability and are associated with increased risks of traffic accidents, as well as falls and fractures.

Morning Report Questions

Q: What are some of the symptoms of benzodiazepine withdrawal?
A: The mildest form of withdrawal is symptom rebound and is particularly common with withdrawal from benzodiazepines that are used for sleep disorders. The most common physical symptoms of withdrawal are muscle tension, weakness, spasms, pain, influenza-like symptoms (e.g., sweating and shivering), and “pins and needles.” The most common psychological withdrawal symptoms are anxiety and panic disorders, restlessness and agitation, depression and mood swings, psychovegetative symptoms (e.g., tremor), reduced concentration, and sleep disturbances and nightmares. Disorders of perception are relatively common and range from hyperacusis to photophobia to dysesthesia; these symptoms are not pathognomonic but are characteristic of benzodiazepine withdrawal. Seizures are quite common, especially if the agent is discontinued abruptly.

Q: What are some of the basic approaches to the treatment of benzodiazepine dependence?
A: The overall consensus is that benzodiazepines should be discontinued gradually over a period of several weeks (e.g., 4 to 6 weeks or more for diazepam doses >30 mg per day), to prevent seizures and avoid severe withdrawal symptoms. The use of several benzodiazepines should be converted to the use of one, preferably diazepam. Withdrawal from short-acting benzodiazepines is associated with higher dropout rates than withdrawal from longer-acting agents, but switching from a drug with a short half-life to one with a longer half-life is not associated with a better outcome. Withdrawal is sometimes successful on an outpatient basis, but patients should be hospitalized for withdrawal from very high doses (a dose equivalent to ≥100 mg of diazepam daily). In patients receiving opioid maintenance therapy, the dose of the opioid (e.g., methadone) should be kept stable throughout the benzodiazepine-reduction period and high enough to prevent symptoms of opioid withdrawal. In general, the prognosis for patients who undergo withdrawal treatment for benzodiazepine dependence is fairly good.

source:resident360.nejm.org

Are gravitational waves kicking this black hole out of its galaxy?


Astronomers have just spied a black hole with a mass 1 billion times the sun’s hurtling toward our galaxy. But scientists aren’t worried about it making contact: It’s some 8 billion light-years away from Earth and traveling at less than 1% the speed of light. Instead, they’re wondering how it got the boot from its parent galaxy, 3C186 (fuzzy mass in the Hubble telescope image, above). Most black holes lie quietly—if voraciously—at the center of their galaxies, slurping up the occasional passing star.

But every once in a while, two galaxies merge, and the black holes in their centers begin to swirl around each other in a pas des deux that eventually leads to a devastating merger. The wandering black hole (bright spot above), may be the result of one such merger. Based on the wavelengths of spectral lines emitted by the luminous gas surrounding the black hole, the object is traveling at a speed of about 7.5 million kilometers per hour—a rate that would carry it from Earth to the moon in about 3 minutes. If the most likely scenario is true, then a massive kick from the merger of two black holes some 1.2 billion years ago would have created a ripple of gravitational waves, the researchers suggest in a forthcoming issue of Astronomy & Astrophysics. And if the precollision black holes didn’t have the same mass and rotation rate as each other, the waves would have been stronger in some directions than others, giving the resulting object a jolt equivalent to the energy of 100 million supernovae exploding simultaneously, the researchers estimate. Other runaway black holes have been proposed, but none of them has yet been confirmed.

This physicist says consciousness could be a new state of matter.


‘Perceptronium’.

 

Consciousness isn’t something scientists like to talk about much. You can’t see it, you can’t touch it, and despite the best efforts of certain researchersyou can’t quantify it. And in science, if you can’t measure something, you’re going to have a tough time explaining it.

But consciousness exists, and it’s one of the most fundamental aspects of what makes us human. And just like dark matter and dark energy have been used to fill some otherwise gaping holes in the standard model of physics, researchers have also proposed that it’s possible to consider consciousness as a new state of matter.

 To be clear, this is just a hypothesis, and one to be taken with a huge grain of salt, because we’re squarely in the realm of the hypothetical here, and there’s plenty of room for holes to be poked.

But it’s part of a quietly bubbling movement within theoretical physics and neuroscience to try and attach certain basic principles to consciousness in order to make it more observable.

The hypothesis was first put forward in 2014 by cosmologist and theoretical physicist Max Tegmark from MIT, who proposed that there’s a state of matter – just like a solid, liquid, or gas – in which atoms are arranged to process information and give rise to subjectivity, and ultimately, consciousness.

The name of this proposed state of matter? Perceptronium, of course.

As Tegmark explains in his paper, published in the journal Chaos, Solitons & Fractals:

“Generations of physicists and chemists have studied what happens when you group together vast numbers of atoms, finding that their collective behaviour depends on the pattern in which they are arranged: the key difference between a solid, a liquid, and a gas lies not in the types of atoms, but in their arrangement.

In this paper, I conjecture that consciousness can be understood as yet another state of matter. Just as there are many types of liquids, there are many types of consciousness.

However, this should not preclude us from identifying, quantifying, modelling, and ultimately understanding the characteristic properties that all liquid forms of matter (or all conscious forms of matter) share.”

In other words, Tegmark isn’t suggesting that there are physical clumps of perceptronium sitting somewhere in your brain and coursing through your veins to impart a sense of self-awareness.

Rather, he proposes that consciousness can be interpreted as a mathematical pattern – the result of a particular set of mathematical conditions.

 Just as there are certain conditions under which various states of matter – such as steam, water, and ice – can arise, so too can various forms of consciousness, he argues.

Figuring out what it takes to produce these various states of consciousness according to observable and measurable conditions could help us get a grip on what it actually is, and what that means for a human, a monkey, a flea, or a supercomputer.

The idea was inspired by the work of neuroscientist Giulio Tononi from the University of Wisconsin in Madison, who proposed in 2008 that if you wanted to prove that something had consciousness, you had to demonstrate two specific traits.

According to his integrated information theory (IIT), the first of these traits is that a conscious being must be capable of storing, processing, and recalling large amounts of information.

“And second,” explains the arXiv.org blog, “this information must be integrated in a unified whole, so that it is impossible to divide into independent parts.”

This means that consciousness has to be taken as a whole, and cannot be broken down into separate components. A conscious being or system has to not only be able to store and process information, but it must do so in a way that forms a complete, indivisible whole, Tononi argued.

If it occurred to you that a supercomputer could potentially have these traits, that’s sort of what Tononi was getting at.

As George Johnson writes for The New York Times, Tononi’s hypothesis predicted – with a whole lot of maths – that “devices as simple as a thermostat or a photoelectric diode might have glimmers of consciousness – a subjective self”.

In Tononi’s calculations, those “glimmers of consciousness” do not necessarily equal a conscious system, and he even came up with a unit, called phi or Φ, which he said could be used to measure how conscious a particular entity is.

Six years later, Tegmark proposed that there are two types of matter that could be considered according to the integrated information theory.

The first is ‘computronium’, which meets the requirements of the first trait of being able to store, process, and recall large amounts of information. And the second is ‘perceptronium’, which does all of the above, but in a way that forms the indivisible whole Tononi described.

In his paper, Tegmark explores what he identifies as the five basic principles that could be used to distinguish conscious matter from other physical systems such as solids, liquids, and gases – “the information, integration, independence, dynamics, and utility principles”.

He then spends 30 pages or so trying to explain how his new way of thinking about consciousness could explain the unique human perspective on the Universe.

As the arXiv.org blog explains, “When we look at a glass of iced water, we perceive the liquid and the solid ice cubes as independent things even though they are intimately linked as part of the same system. How does this happen? Out of all possible outcomes, why do we perceive this solution?”

It’s an incomplete thought, because Tegmark doesn’t have a solution. And as you might have guessed, it’s not something that his peers have been eager to take up and run with. But you can read his thoughts as they stand in the journal Chaos, Solitons & Fractals.

That’s the problem with something like consciousness – if you can’t measure your attempts to measure it, how can you be sure you’ve measured it at all?

More recently, scientists have attempted to explain how human consciousness could be transferred into an artificial body – seriously, there’s a start-up that wants to do this – and one group of Swiss physicists have suggested consciousness occurs in ‘time slices’that are hundreds of milliseconds apart.

As Matthew Davidson, who studies the neuroscience of consciousness at Monash University in Australia, explains over at The Conversation, we still don’t know much about what consciousness actually is, but it’s looking more and more likely that it’s something we need to consider outside the realm of humans.

“If consciousness is indeed an emergent feature of a highly integrated network, as IIT suggests, then probably all complex systems – certainly all creatures with brains – have some minimal form of consciousness,” he says.

“By extension, if consciousness is defined by the amount of integrated information in a system, then we may also need to move away from any form of human exceptionalism that says consciousness is exclusive to us.”

Two pints of beer better for pain relief than paracetamol, study says


But health experts warn to drink moderately

 Your head is pounding, the room’s spinning and your stomach is lurching – when you’re hungover, reaching for painkillers can often seem like a good idea.

But according to a new study, hair of the dog really could do the trick.

And not just for dealing with a hangover – according to new research, drinking two beers is more effective at relieving pain than taking painkillers.

Over the course of 18 studies, researchers from the University of Greenwich found that consuming two pints of beer can cut discomfort by a quarter.

By elevating your blood alcohol content to approximately 0.08 per cent, you’ll give your body “a small elevation of pain threshold” and thus a “moderate to large reduction in pain intensity ratings”.

The researchers explained: “Findings suggest that alcohol is an effective analgesic that delivers clinically-relevant reductions in ratings of pain intensity, which could explain alcohol misuse in those with persistent pain, despite its potential consequences for long-term health.”

It’s not clear, however, whether alcohol reduces feelings of pain because it affects brain receptors or because it just lowers anxiety, which then makes us think the pain isn’t as bad.

Dr Trevor Thompson, who led the study at London’s Greenwich University, told The Sun: “[Alcohol] can be compared to opioid drugs such as codeine and the effect is more powerful than paracetamol.

“If we can make a drug without the harmful side-effects, then we could have something that is potentially better than what is out there at the moment.”

However experts are also speaking out to clarify that the results of the new study don’t mean alcohol is good for us.

Rosanna O’Connor, director of Alcohol and Drugs at Public Health England, said: “Drinking too much will cause you more problems in the long run. It’s better to see your GP.”

Government guidelines recommend no more than 14 units of alcohol a week for both men and women, which equates to six pints of beer, or six 175ml glasses of wine.

New Research Shows That Time Travel Is Mathematically Possible


IN BRIEF

Physicists have developed a new mathematical model that shows how time travel is theoretically possible. They used Einstein’s Theory of General Relativity as a springboard for their hypothetical device, which they call a Traversable Acausal Retrograde Domain in Space-time (TARDIS).

BENDING TIME

Even before Einstein theorized that time is relative and flexible, humanity had already been imagining the possibility of time travel. In fact, science fiction is filled with time travelers. Some use metahuman abilities to do so, but most rely on a device generally known as a time machine. Now, two physicists think that it’s time to bring the time machine into the real world — sort of.

The Future According to H. G. Wells [INFOGRAPHIC]

“People think of time travel as something as fiction. And we tend to think it’s not possible because we don’t actually do it,” Ben Tippett, a theoretical physicist and mathematician from the University of British Columbiasaid in a UBC news release. “But, mathematically, it is possible.”

Essentially, what Tippet and University of Maryland astrophysicist David Tsang developed is a mathematical formula that uses Einstein’s General Relativity theory to prove that time travel is possible, in theory. That is, time travel fitting a layperson’s understanding of the concept as moving “backwards and forwards through time and space, as interpreted by an external observer,” according to the abstract of their paper, which is published in the journal Classical and Quantum Gravity.

Oh, and they’re calling it a TARDIS — yes, “Doctor Who” fans, hurray! — which stands for a Traversable Acausal Retrograde Domain in Space-time.

FEASIBLE BUT NOT POSSIBLE. YET.

“My model of a time machine uses the curved space-time to bend time into a circle for the passengers, not in a straight line,” Tippet explained. “That circle takes us back in time.” Simply put, their model assumes that time could curve around high-mass objects in the same way that physical space does in the universe.

For Tippet and Tsang, a TARDIS is a space-time geometry “bubble” that travels faster than the speed of light. “It is a box which travels ‘forwards’ and then ‘backwards’ in time along a circular path through spacetime,” they wrote in their paper.

Unfortunately, it’s still not possible to construct such a time machine. “While is it mathematically feasible, it is not yet possible to build a space-time machine because we need materials — which we call exotic matter — to bend space-time in these impossible ways, but they have yet to be discovered,” Tippet explained.

Image credit: Tippet and Yang

Indeed, their work isn’t the first to suggest that time traveling can be done. Various other experiments, including those that rely on photon stimulation, suggest that time travel is feasible. Another theory explores the potential particles of time.

However, some think that a time machine wouldn’t be feasible because time traveling itself isn’t possible. One points to the intimate connection between time and energy as the reason time traveling is improbable. Another suggests that time travel isn’t going to work because there’s no future to travel to yet.

Whatever the case may be, there’s one thing that these researchers all agree on. As Tippet put it, “Studying space-time is both fascinating and problematic.”

Metallic Hydrogen Is The Holy Grail Of High-Pressure Physics, And One Team Says They’ve Made It


For more than 80 years, physicists have dreamed of the ability to produce metallic hydrogen. In 2016, one team claimed to have finally done it. To understand why science wants metallic hydrogen so badly—and why the 2016 announcement caused so much drama—you have to first understand the potential of this elusive material.

The heart of a diamond anvil cell.

To Infinity And Beyond

 We all know hydrogen: it’s the first element on the periodic table, and the most abundant in the universe. It appears most commonly as a gas. If you cool it to very low temperatures, as rocket scientists are wont to do, it becomes a liquid. Liquid hydrogen makes great rocket fuel because it’s light and it burns with extreme intensity. Specifically, when you combine it with something like liquid oxygen, liquid hydrogen yields the highest specific impulse—efficiency, basically—of any rocket fuel.

You can imagine, then, what you could accomplish if you squeezed hydrogen with enough pressure to turn it into a metal. High-pressure researchers first predicted this was possible in 1935. They theorized that not only would metallic hydrogen conduct electricity (that’s what metals do, after all) but it might do it without resistance, which would mean it was a superconductor. What’s more, it could do that at room temperature—no supercooling necessary for this supermaterial! But that’s not all it could help accomplish, as Nature’s Davide Castelvecchi points out: “By making metallic hydrogen, physicists might also be able to explore planetary science at their lab bench: gas-giant planets such as Jupiter are theorized to have metallic hydrogen in their cores, which would perhaps explain how they can sustain a magnetic field.”

More Like Metallic Hy-Drama

 In October of 2016, two physicists announced that they had actually squeezed hydrogen between diamonds at such low temperatures and high pressure that it turned metallic. As Gizmodo reports, “As the scientists cranked up the pressure, they observed transparent hydrogen turn black. Finally, at a pressure 5 million times our own air pressure, the hydrogen turned reflective. The researchers presented this as proof that the hydrogen atoms had arranged into a regular, 3D structure like a metal.” Other physicists did not take this lying down. “I don’t think the paper is convincing at all,” French physicist Paul Loubeyre told Nature. “We express a doubt that [the physicists] were even in a close vicinity of the claimed pressure,” wrote Carnegie Institute staff scientist Alexander Goncharov in a response paper.
Why are other scientists so skeptical? There are a few reasons. For one thing, there’s little evidence that the material was even hydrogen in the first place; it could have been the aluminum oxide that coats the tips of the diamonds themselves. The researchers also took just a single measurement of the sample at its very highest pressure, which makes it hard to see how the pressure changed as the hydrogen turned metallic. Worst of all, further testing led them to lose the sample. “Basically, it’s disappeared,” team leader Isaac F. Silvera told ScienceAlert. “It’s either someplace at room pressure, very small, or it just turned back into a gas. We don’t know.” And you thought losing your keys was rough.

Why men might have a point about ‘man flu’ – viruses want to kill men more than women, scientists find


A man lies ill on a sofa
Men are right, viruses really do affect them more than women 

Historically men have been mocked for their inability to handle even mild viruses, with the term ‘man flu’ often used to describe the male experience of the common cold.

But a new study suggests men might have a point. Some viruses really are out to get them.

Researchers at Royal Holloway University have discovered that certain viral infections have evolved to be more virulent in men.

They appear to be particularly nasty if they are the sort of virus that is transmitted from mother to child, such as rubella, chickenpox, zika and hepatitis.

Put simply, women are more valuable to the virus than men are because they can pass it on to more people.

“Viruses may be evolving to be less dangerous to women, looking to preserve the female population,” said Dr Francisco Úbeda, of the School of Biological Sciences at Royal Holloway.

“The reason why these illnesses are less virulent in women is that the virus wants to be passed from mother to child, either through breastfeeding, or just through giving birth.”

A woman blows her nose
Viruses are keen to keep women alive because they are more likely to pass them on to their children 

Researchers looked at the virus Human T-cell Lymphotropic Virus Type 1 (HTLV-1), which can cause leukaemia in infected individuals.

Infected women tend to develop leukaemia less often than men when there is more mother-to-child transmission.

Death due to infectious diseases is often higher in men than in women, but it has previously been attributed to differences in the immune system of each sex.

The study suggests it is the virus itself which prevents women becoming too ill.

“It has already been established that men and women react to illness differently, but evidence shows that viruses themselves have evolved to affect the sexes differently,” said Professor Vincent Jansen, from the School of Biological Sciences at Royal Holloway, University of London.

The researchers used mathematical modelling to show that natural selection favours viruses that have a lower rate of fatality in women than in men, if the virus can be passed from person to person and from mother to child, either in childbirth, breast-feeding, or close contact in infancy.

The HIV virus under a microscope 
HIV is another virus which appears to more virulent in men more than women  

They also looking at how HTLV-1 affects people in Japan and the Caribbean. The research showed that HTLV-1 is about 2 to 3.5 times more likely to progress to become Adult T-cell Leukaemia (ATL), which is lethal, in Japanese men than women.

In the Caribbean, however, the likelihood of HTLV-1 progressing to leukaemia is roughly equal in men and women.

The researchers believe that because breastfeeding is more prolonged in Japan, giving more opportunity for it to be passed onto offspring, the HTLV-1 virus has evolved to become less fatal to women than in the Caribbean where breastfeeding is shorter.

Women are more valuable as hosts for the pathogens when they are able to pass on the pathogen in more ways than men, who are only capable of transmission from person to person.

“Pathogens are adapting to be less virulent in women to increase their chances of being passed on to the next generation during pregnancy, birth and infancy,” added Dr Úbeda.

 “Survival of the fittest is relevant to all organisms, not just animals and humans.

It’s entirely probable that this sex-specific virulent behaviour is happening to many other pathogens causing diseases. It’s an excellent example of what evolutionary analysis can do for medicine.”

Source: Nature Communications.

Cryogenically Frozen Brains Will Be ‘Woken up’ and Transplanted in Donor Bodies Within Three Years, Neurosurgeon Claims


IN BRIEF

After he attempts the world’s first human head transplant, neurosurgeon Sergio Canavero plans to attempt another world first: reawakening a brain that has been cryogenically frozen.

ONE WORLD’S FIRST AFTER ANOTHER

Given the remarkable advances that have been made in medicine in recent years, it’s hard to believe anything is still truly impossible. Artificial intelligences are diagnosing diseasesreal-life cyborgs walk among us, and we’re finding promising new clues on our quest for immortality. Even more remarkable breakthroughs are on the way,  but if any one research team truly faces seemingly insurmountable odds, it has to be that of Professor Sergio Canavero, Director of the Turin Advanced Neuromodulation Group.

An Exponential Timeline of Organ Transplants

Four years ago, the acclaimed neurosurgeon announced his plan to complete the world’s first human head transplant, and this week, in an interview with OOOM, he confirmed that the controversial operation will take place within the next 10 months. According to Canavero, the operation will occur in Harbin, China, with Xiaoping Ren of Harbin Medical University leading the surgical team, and contrary to previous reports, a Chinese citizen, not Russian Valery Spiridonov, will be the recipient of a donor body.

However, the most remarkable news to come out of Canavero’s interview doesn’t have anything to do with the head transplant at all, but what he plans to do afterwards: “As soon as the first human head transplant has taken place, i.e., no later than in 2018, we will be able to attempt to reawaken the first frozen head.”

LIFE AFTER DEATH?

Canavero plans to remove the brain from a head that has been frozen at -196 degrees Celsius (-320 degrees Fahrenheit) and submerged in liquid nitrogen. He’ll then place the brain in a donor body in an attempt to effectively bring the patient back from the dead and, in the process, clear up humanity’s questions about the afterlife.

“If we bring this person back to life, we will receive the first real account of what actually happens after death,” said Canavero. “The head transplant gives us the first insight into whether there is an afterlife, a heaven, a hereafter, or whatever you may want to call it or whether death is simply a flicking off of the light switch and that’s it.”

Watch the video discussion. URL:

Clearly, this is the stuff of science fiction, and the medical community — and society at large — has every reason to be very skeptical of its potential for success.

“The advocates of cryogenics are unable to cite any study in which a whole mammalian brain … has been resuscitated after storage in liquid nitrogen,” Clive Coen, Professor of Neuroscience at King’s College London, told The Telegraph, adding, “Irreversible damage is caused during the process of taking the mammalian brain into sub-zero temperatures.”

Even if it did work and the frozen brain did “wake up,” there’s no telling what kinds of complications the patient could experience, from decreased mental faculties to unimaginable mental trauma. Though we do now live in a world in which the seemingly impossible is becoming possible, some experiments might be better suited for works of sci-fi than modern hospitals.

Couple of alcoholic drinks a day could protect heart, say scientists


Red wine is poured into a glass 
Women who raised their alcohol intake by two drinks per day lowered their risk of heart disease 

Acouple of glasses of wine or beer each night lowers the risk of developing coronary heart disease, new research has shown.

Although alcohol was found to raise the risk of breast cancer for women, it appears to have a protective effect on the heart.

A study of 22,000 post-menopausal women in Denmark found those who increased their alcohol intake by two drinks per day over five years had a 20 per cent decreased risk of coronary heart disease and a 30 per cent increased risk of breast cancer.

In January Dame Sally Davies, the Chief Medical Officer, issued new alcohol guidelines which drastically cut the safe level of consumption to a maximum of 14 units a week for both men and women, which equates to less than two glasses of wine per night.

Dame Sally also told women to think about the risks of  breast cancerbefore deciding whether to have a glass of wine. Alcohol is responsible for about 11 per cent of female breast cancers in the UK.

Although the new research did find a link to cancer, it also showed that alcohol may be beneficial for other health conditions. Experts believe that alcohol can bring down the risk of heart disease by raising levels of ‘good’ cholesterol

The study, by the University of Southern Denmark, also found that lowering alcohol intake did not lower the risk for either disease.

“We found that an increased alcohol intake over a five year period resulted in a higher risk of breast cancer and a lower risk of coronary heart disease among postmenopausal women, compared with a stable alcohol intake,” said lead author Professor Janne Tolstrup .

“The results support the hypotheses that alcohol is associated with breast cancer and coronary heart disease in opposite directions.”

There are 80,000 deaths from heart disease each year and it will cause the deaths of one in five men and one in seven women.

A breast scan 
Increasing alcohol intake does increase the risk of breast cancer 

Research by the Mediterranean Neurological Institute published this week also found that drinking two small cans of beer a day protects against heart disease by around one quarter.

The authors looked at 150 studies into the link between heart disease and beer and came to the conclusion that moderate drinking is likely to be beneficial.

“Unless they are at high risk for alcohol-related cancers or alcohol dependency there is no reason to discourage healthy adults who are already light or moderate beer consumers from continuing,” they said.

In February Dame Sally told the House of Commons science and technology committee that evidence suggesting wine could protect the heart was less robust than had previously been thought.

And she said the NHS had “done so much with statins” and other medical treatments for heart disease that the case for drinking wine to protect the heart was weaker than it used to be.

Professor Tim Key, Deputy Director, Cancer Epidemiology Unit at the University of Oxford also said there were better ways to lower heart disease risk than drinking alcohol.

“There may be some benefit with low to moderate intakes of alcohol, but this could be outweighed by an increased risk of breast cancer and other morbidities.

“The risk of heart disease can be reduced substantially by other lifestyle changes, as well as by drugs such as statins shown to be effective in primary prevention.”

Charities also warned that it was still important to lower alcohol intake.

Sally Greenbrook, Policy Manager at Breast Cancer Now, said: “When it comes to an individual’s risk of developing breast cancer, it is difficult to separate out the real impact of food from other lifestyle factors and so we would encourage everyone to be as active as possible and to limit alcohol intake, in addition to eating a healthy diet.”

Metallic Hydrogen Is The Holy Grail Of High-Pressure Physics, And One Team Says They’ve Made It


For more than 80 years, physicists have dreamed of the ability to produce metallic hydrogen. In 2016, one team claimed to have finally done it. To understand why science wants metallic hydrogen so badly—and why the 2016 announcement caused so much drama—you have to first understand the potential of this elusive material.

The heart of a diamond anvil cell.
 We all know hydrogen: it’s the first element on the periodic table, and the most abundant in the universe. It appears most commonly as a gas. If you cool it to very low temperatures, as rocket scientists are wont to do, it becomes a liquid. Liquid hydrogen makes great rocket fuel because it’s light and it burns with extreme intensity. Specifically, when you combine it with something like liquid oxygen, liquid hydrogen yields the highest specific impulse—efficiency, basically—of any rocket fuel.

You can imagine, then, what you could accomplish if you squeezed hydrogen with enough pressure to turn it into a metal. High-pressure researchers first predicted this was possible in 1935. They theorized that not only would metallic hydrogen conduct electricity (that’s what metals do, after all) but it might do it without resistance, which would mean it was a superconductor. What’s more, it could do that at room temperature—no supercooling necessary for this supermaterial! But that’s not all it could help accomplish, as Nature’s Davide Castelvecchi points out: “By making metallic hydrogen, physicists might also be able to explore planetary science at their lab bench: gas-giant planets such as Jupiter are theorized to have metallic hydrogen in their cores, which would perhaps explain how they can sustain a magnetic field.”

More Like Metallic Hy-Drama

In October of 2016, two physicists announced that they had actually squeezed hydrogen between diamonds at such low temperatures and high pressure that it turned metallic. As Gizmodo reports, “As the scientists cranked up the pressure, they observed transparent hydrogen turn black. Finally, at a pressure 5 million times our own air pressure, the hydrogen turned reflective. The researchers presented this as proof that the hydrogen atoms had arranged into a regular, 3D structure like a metal.” Other physicists did not take this lying down. “I don’t think the paper is convincing at all,” French physicist Paul Loubeyre told Nature. “We express a doubt that [the physicists] were even in a close vicinity of the claimed pressure,” wrote Carnegie Institute staff scientist Alexander Goncharov in a response paper.

Why are other scientists so skeptical? There are a few reasons. For one thing, there’s little evidence that the material was even hydrogen in the first place; it could have been the aluminum oxide that coats the tips of the diamonds themselves. The researchers also took just a single measurement of the sample at its very highest pressure, which makes it hard to see how the pressure changed as the hydrogen turned metallic. Worst of all, further testing led them to lose the sample. “Basically, it’s disappeared,” team leader Isaac F. Silvera told ScienceAlert. “It’s either someplace at room pressure, very small, or it just turned back into a gas. We don’t know.” And you thought losing your keys was rough.

Did Scientists Really Make Metallic Hydrogen?