Brain Regeneration: Why It’s Real and How To Do It


Have you ever wished you could regenerate those brain cells you sacrificed in college? Do you fear that your aging brain is in a perpetual state of decline? Medical science is being rewritten to show that we CAN improve the health of our brain, and that repairing damage is not only possible, it’s something anyone can do.

It is a commonly held misconception that the brain is beyond repair. Even the medical establishment has asserted that once we kill brain cells, they are gone forever. The fact is, the brain can repair itself, and as science is now proving, there is real benefit to simple practices that can help keep our brains sharp and elastic throughout our lifetime.

 

Rewriting the Story of Brain Health

The field of cognitive neuroscience is relatively new — only around one hundred years old — so it’s no surprise that we are constantly arriving at a newer and better understanding of how the neural circuitry of the human brain supports overall brain functioning.

For most of those one hundred years, it was believed that once damaged, the brain could not regenerate. Brain cells were finite, and any loss or injury would be suffered as a deficiency for the rest of that person’s life. This created a false belief that the brain is essentially in a perpetual state of decline.

Although compelling evidence to the contrary was presented as early as 1960, medical dogma was (and is) slow to change. It wasn’t until the 1980’s when Fernando Nottebohm’s research at Rockefeller University clearly indicated that neurogenesis — production of new nerve cells, aka neurons — was taking place in the adult vertebrate brain.

The next big step in this scientific evolution would take more than thirty years. However, the pace of our understanding of how the brain is wired was about to take a quantum leap.

Our Elastic Brain

The growth of new neurons in an adult, mammalian brain was first seen in 1992, when scientists isolated neural stem cells from mice in a Petri dish. This regeneration was then replicated thousands of times in a variety of published studies over the next twenty-five years.

It is now accepted in the medical scientific community that the adult brain is capable of growing new neurons and glial cells, something previously disbelieved by the medical establishment. The brain is now considered to be resilient, pliable — plastic.

The term neuroplasticity refers to the ability of the brain to “rewire” itself through practice of a desired skill. It is the combination of new cells and new learning that creates this magic. When fresh nerve cells are well-stimulated (i.e., trained through specific learning exercises) they make new connections. In other words, they become healthy brain cells that contribute to learning and the development of new skills.

Just like the muscles of the body, when the brain is well-nourished and stimulated through proper exercise, it heals and grows. And with proper care and feeding, this amazing brain regeneration can occur throughout life.

To help make this a “no-brainer”, GreenMedInfo has compiled a simple list of ways you can safeguard brain health, stimulate new brain cell growth, and even heal the brain.

1.  Get Lots of Physical Exercise

When you hear the phrase “train your brain”, you probably don’t think of lifting weights. Turns out, physical exercise is one of the best things you can do for your body, and your brain.

The brain benefits of exercise are two-fold. First, the brain is a voracious consumer of glucose and oxygen, with no ability to store excess for later use. A continual supply of these nutrients is needed to maintain optimal functioning.

Physical exercise increases the blood flow to the brain, delivering a boost of fresh oxygen and glucose to hungry brain cells. A 2014 study showed that just 30 minutes of moderate cardio was enough to boost cognitive functioning in adult brains of all ages.

But the benefits don’t stop there. Exercise is believed to stimulate hippocampal neurogenesis: new cell growth in the region of the brain associated with long-term memory and emotions. Healthy cell growth in this region is important to the aging brain, and believed to help prevent cognitive decline associated with Alzheimer’s disease and dementia.

2.  Use Stress Reduction Techniques

Our modern world runs on stress, so the need to unwind is easy to understand. What you might not be aware of, is just how damaging continual immersion in the fight or flight hormones of stress can be to your brain.

Stress is one of the top factors in age-related cognitive decline. This makes engaging in regularly scheduled leisure activities not just a fun thing to do, but an important step towards ensuring optimal brain health.

You don’t need to look far to find ways to de-stress. Let your interests guide you. The key to picking brain-healthy pastimes is to avoid passive activities like watching TV, and instead choose stimulating hobbies that engage the brain through patterns, puzzles, and problem-solving.

A 2011 study published in the Journal of Neuropsychiatry found that activities such as playing games, reading books, and crafts like quilting and knitting reduced rates of cognitive impairment by up to 50 percent.

Engaging with art also ranks high on the list of brain-healthy hobbies. Studies prove that once again, it’s not enough to be a passive observer. To get the brain-boost, we must engage.

In a German study reported in the journal PLOS One, researchers studied two groups: a group who observed art, and a group that produced art. The study concluded that compared to those who observed art, the art producers demonstrated increased interactivity between the frontal and parietal cortices of the brain. This increased brain connectivity translates to enhanced psychological resilience in the group of art producers. In other words, their ability to resist the negative effects of stress improved.

Looking for a more low-key way to unwind? How about playing beautiful music or sitting in quiet contemplation? Meditation has been shown to lower blood pressure, reduce inflammation, and even build resistance to feelings of anxiety and depression. And while listening to music may seem like a passive activity, research suggests that the act of listening to musical patterns facilitates brain neurogenesis.

Both meditation and listening to music affect the secretion of key hormones which enhance brain plasticity, thus changing the very way we respond to stress. Talk about good medicine!

3. Take Strategic Supplements

Turmeric

You probably know at least one person who raves about the health benefits of turmeric. This deep, orange root has been used as a panacea for everything from soothing joint pain and calming inflammation, to lowering the risk of heart disease. And our awareness of the benefits of this ancient medicinal herb continues to grow.

Turmeric is an example of a remyelinating compound, which denotes a substance with proven nerve-regenerative effects.

Remyelinating compounds work to repair the protective sheath around the nerve bundle known as myelin, an area often damaged in autoimmune and vaccine-induced disorders. Research shows that even small doses of these restorative substances can produce significant nerve regeneration.

The Western model of pharmaceutical intervention has created a culture that seeks to identify and isolate the “active ingredient” of an organic substance. What this fails to account for is that organic compounds often work in concert: isolates by themselves may lack a critical key that another plant element provides.

Curcumin is the isolated active ingredient in turmeric, however, new research shows that another element found in turmeric has magical properties of its own.

In an exciting study published in the journal Stem Cell Research & Therapy, researchers found that a little-known component within turmeric, Ar-tumerone, may make “a promising candidate to support regeneration in neurologic disease.”

The study found that when brain cells were exposed to ar-tumerone, neural stem cells increased in number and complexity, indicating a healing effect was taking place. This effect was replicated in rats, who when exposed to ar-tumerone saw increased neural stem cell production and the generation of healthy new brain cells.

Green Tea

A 2014 paper studying the active compounds in green tea (known as catechins, a main class of micronutrient), determined that green tea catechins are not only antioxidant and neuroprotective, they actually stimulate the brain to produce more neurons.

Because of this therapeutic effect on damaged regions of the brain, green tea has been shown to have exciting implications in the treatment of ‘incurable’ neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s disease. This prompted researchers to declare green tea catechins “a highly useful complementary approach” in the treatment of neurodegenerative diseases.

Further investigation of green tea examined a combination of blueberry, green tea and carnosine, and found it to promote growth of new neurons and brain stem cells, in an animal model of neurodegenerative disease.

Ginkgo Biloba

Ginkgo Biloba is considered a powerhouse in the herbal medicine pharmacopoeia, and its implications for brain health are equally potent. Ginkgo has demonstrated at least 50 distinct health benefits, and its medicinal value is documented in the treatment of more than 100 different diseases.

There are numerous studies on Ginkgo’s ability to stimulate levels of a critical brain protein called BDNF: brain-derived neurotrophic factor. This protein affects healing in damaged regions of the brain and is essential in the regulation, growth and survival of brain cells, making it especially important for long-term memory.

Ginkgo is so effective that a 2006 paper published in the European Journal of Neurology found it to be as useful in the treatment of Alzheimer’s disease as the blockbuster drug, Donepezil.

Recently, a new mechanism behind Ginkgo Biloba’s brain healing properties came to light with the publication of an article in Cell and Molecular Neurobiology. Researchers determined that Ginkgo is effective, in part, due to its ability to modulate neural stem cells (NSC’s) into the type of cell that is necessary in the specific region of the brain where the BDNF proteins are active.

NSC’s are multipotent cells; they have the amazing ability to shapeshift into any of the many different phenotypes of cells that make up the brain. Ginkgo stimulates the growth of the right cell phenotype for the affected region of the brain, giving our brain exactly what’s needed, where it’s needed. Now that’s intelligent medicine!

4. Eat Your Veggies

Want to stimulate brain cell regrowth while you’re having lunch? Add some freshly steamed broccoli to your plate!

Science has added a substance called sulforaphane, found in sulfur-rich vegetables such as broccoli, to the growing list of neuritogenic substances that have been documented to stimulate nerve growth in the brain.

The study, published in the journal Genesis, reveals that sulforaphane, in addition to stimulating new nerve growth, has demonstrated significant healing properties as an antioxidant and anti-inflammatory agent, as well as preventing disease and death of healthy neurons.

Adding to the excitement surrounding these findings, researchers observed the beneficial effect on neural stem cells that results in their differentiation to specific, useful types of neurons, lending powerful support to the hypothesis that sulforaphane stimulates brain repair.

Vegetables containing sulforaphane include broccoli, Brussels sprouts, cabbage, cauliflower, horseradish, kale, kohlrabi, mustard leaves, radish, turnips, watercress, and bok choy. For therapeutic benefit, try to consume at least 3 cups per day, raw or cooked.

5. Employ Continuous Learning

Aging is often associated with cognitive decline, both in research and anecdotal evidence. However, a growing body of literature shows that retaining a sharp, lucid brain means never retiring our critical thinking skills.

The need to continually challenge and expand our thinking was demonstrated in the aforementioned 2011 study published in the Journal of Neuropsychiatry. In this study, the leisure time activities of a group of older adults (ages 70-89) were monitored for effect on mild cognitive impairment (MCI).

The study determined that the level of complexity of the activity was key to its effectiveness at preventing MCI. Working with computers, reading books, and activities associated with patterns and problem-solving contributed to a significant decrease in the odds of developing of MCI. Less stimulating activities showed no statistical effect. This stresses the importance of feeling challenged and stimulated by the activities we pursue as we age.

These findings were reinforced by a 2014 study of nearly 3,000 volunteers, spanning more than a decade. This study examined the potential long-term benefit of cognitive training in older adults. Results showed that participants demonstrated enhanced brain processing speed and reasoning skills for up to ten years after the training was completed.

These tangible brain benefits spilled over into daily life and were measured in the participant’s ability to complete normal daily tasks, such as personal finances, meal preparation, and personal care routines. Said of the study, “The idea is, the more stimulating your environment, the more you’re increasing the complexity of your brain.”

Singapore scientists uncover how neural stem cells are activated intrinsically by spindle matrix proteins


Neural progenitor cells (green) in the rat olfactory bulb 

Neural stem cells (NSCs) are self-renewing and multipotent cells that give rise to the neurons and glia of the nervous system during an animal’s embryonic development. In a mammalian brain, only a small fraction of the adult NSCs are proliferative and a majority are in a nondividing state, also known as quiescence.

The balance between NSC proliferation and quiescence is essential for brain development and emerging evidence suggests that its imbalance is linked to neurodevelopmental disorders, such as microcephaly. On the other side, the population of quiescent NSCs in the brain increases with ageing, which is associated with declining brain function.

Understanding how endogenous NSCs can be activated has huge potential in regenerative medicine. However, it is poorly understood as to how NSCs switch between proliferation and quiescence in vivo.

A multicentre research team led by Duke-NUS Medical School (Duke-NUS)’s Neuroscience and Behavioural Disorders Programme has uncovered that spindle matrix proteins can play an intrinsic role in regulating neural stem cell (NSC) reactivation and proliferation.

This discovery is an early important step towards opening up avenues for further research that could lead to potential stem cell-based therapies for neurodevelopmental and neurodegenerative disorders such as microcephaly and Alzheimer’s disease.

Study

The study, published in Nature Communicationsis a first of its kind conducted on fruit flies (Drosophila melanogaster) that demonstrates a critical role of the spindle matrix complex containing chromator (Chro) functioning as an essential nuclear factor for controlling gene expression during NSC reactivation. The study suggests that Chro plays an important role in maintaining the balance between NSC proliferation and quiescence, as it is not only critical for NSC reactivation (exit from quiescence) but also essential for preventing re-entry into inactivation.

“In this study, we have uncovered that spindle matrix proteins play a novel role in regulating reactivation of neural stem cells. It may be in its early stage, but this should help to open up avenues for further research and the development of potent therapies for neurodevelopmental disorders in the future,” said lead author Hongyan Wang, an Associate Professor and Deputy Director of Duke-NUS’ Neuroscience and Behavioural Disorders Programme.

Chromator is required for activation of neural stem cells (NSCs). Upper panels show wild-type control Drosophila larval brains with proliferating NSCs (EdU+; in red). Lower panels show NSCs from chromator- mutant brains stay in a quiescent stage (EdU-). Note that cellular extension, a hallmark of quiescent NSCs, is indicated by a yellow arrowhead. NSCs are marked by nuclear Dpn (in blue) and cortical Mira (in green).

The team employed the state-of-art genomic technique for transcriptome analysis in vivo and identified binding-sites of Chro in NSCs. The main findings from these experiments suggest that Chro is a master nuclear factor that reactivates NSCs through regulating gene expression of key transcription factors that either promote or repress the proliferation of NSCs. The study also suggests that Chro functions downstream of Insulin/PI3k pathway, which is known to promote NSC reactivation and mutations of which are found in microcephalic patients.

“Our study demonstrates that some of the players such as transcription factors Grainy Head and Prospero act downstream of Chro and identifies the likely pathway by which NSCs are activated,” added Professor Wing-Kin Sung, who is from the National University of Singapore (NUS) School of Computing and a Senior Group Leader at A*STAR’s Genome Institute of Singapore (GIS).

Human Neural Stem Cells Become Neurons in Monkey Brains.


A team of scientists based in Korea and Canada who transplanted human neural stem cells (hNSCs) into the brains of nonhuman primates (NHPs) report that the hNSCs had differentiated into neurons at 24 months and did not cause tumors. The study is scheduled to be published in Cell Transplantation.

Breakthrough: Human Neural Stem Cells Become Neurons in Monkey Brains

The hNSCs were labeled with magnetic nanoparticles to enable them to be followed by magnetic resonance imaging. The researchers, who did not use immunosuppressants, claim their study is the first to evaluate and show the long-term survival and differentiation of hNSCs without the need for immunosuppression.

“None of the grafted hNSCs were bromodeoxyuridine (BrdU)-positive in the monkey brain indicating that hNSCs did not replicate in the NHP brain and did not cause tumor-formation,” write the investigators in an unedited, available-online copy of the manuscript. “This study serves as a proof-of-principle study to provide evidence that human NSCs transplanted in NHP brain could survive and differentiate into neurons in the absence of immunosuppression, and also serves as a preliminary study in our scheduled preclinical studies of human NSC transplantation in NHP stroke models.”

The researchers maintain that hNSCs could be a key a source for cell replacement and gene transfer for the treatment of Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, spinal cord injury, and stroke.

“Stroke is the fourth major cause of death in the U.S. behind heart failure, cancer, and lower respiratory disease,” said study co-author Seung U. Kim, Ph.D., of the University of British Columbia Hospital’s department of neurology. “While tissue plasminogen activator (tPA) treatment within three hours after a stroke has shown good outcomes, stem cell therapy has the potential to address the treatment needs of those stroke patients for whom tPA treatment was unavailable or did not help.”

Dr. Kim and colleagues injected hNSCs into the frontal lobe and the putamen of the monkey brain because they are included in the middle cerebral artery (MCA) territory, which is the main target in the development of the ischemic lesion in animal stroke models. “Thus, research on survival and differentiation of hNSCs in the MCA territory should provide more meaningful information to cell transplantation in the MCA occlusion stroke model,” he explained.

The researchers said that they chose NSCs for transplantation because the existence of multipotent NSCs “has been known in developing rodents and in the human brain with the properties of indefinite growth and multipotent potential to differentiate” into the three major CNS cell types (neurons, astrocytes, and oligodendrocytes).

Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenografts


 

Treatment of glioblastoma remains a challenge in neuro-oncology. We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma. Glioma cells showed resistance to soluble TRAIL and proteasome inhibitors alone, but responded well to their combined treatment. In co-culture with NSCs-mTRAIL, glioma cells appeared to be more prone to apoptosis than to treatment with soluble TRAIL, which was enhanced by proteasome inhibitor bortezomib. In vivo, the survival of animals bearing intracranial glial xenografts was significantly improved by NSCs-mTRAIL. The addition of bortezomib further enhanced the efficacy of NSCs-TRAIL treated group in one of examined tumor models. These data demonstrate that therapy with NSCs-mTRAIL is a potent cell based approach for treatment of glioma. Such an approach warrants further search for therapeutics capable of increasing sensitivity of glioma cells to mTRAIL in vivo.

source: cancer letter