Treatment Recommendations for People Who Act Out Their Dreams While Asleep


Summary: REM sleep behavior disorder, or parasomnia, affects more than 80 million people worldwide. The disorder causes sufferers to experience nightmare-like violent dreams. Sufferers act on their dreams while sleeping, often resulting in violent or dangerous sleep behaviors and injuries. Researchers propose new guidelines, including medical and pharmacological recommendations, to help curb symptoms of parasomnia and promote healthier sleep.

Source: American Academy of Sleep Medicine

A new clinical practice guideline developed by the American Academy of Sleep Medicine provides recommendations for the management of REM sleep behavior disorder in adults.  

The guideline, available online as an accepted paper in the Journal of Clinical Sleep Medicine, updates the AASM’s previous guidance published in 2010. Several clinical trials conducted in the last decade have contributed new evidence to the published literature, providing additional support for the recommendations.  

“REM sleep behavior disorder is common, affecting more than 80 million people worldwide,” said lead author Dr. Michael Howell, chair of the AASM task force and a professor and division head of sleep medicine in the department of neurology at the University of Minnesota in Minneapolis.

“This clinical practice guideline provides clinicians with insight on how best to prevent sleep-related injury and how to provide patients with a risk assessment for neurological disease. The task force assembled by the AASM diligently reviewed thousands of clinical studies to provide an up-to-date guideline for clinicians managing REM sleep behavior disorder.” 

REM sleep behavior disorder is classified as a parasomnia, a group of sleep disorders involving undesirable physical events or experiences that happen while falling asleep, sleeping, or waking from sleep. REM sleep is characterized by rapid eye movements and dream activity, and it normally involves skeletal paralysis.

This paralysis — or muscle atonia — is lost in REM sleep behavior disorder, causing individuals to act out their dreams with potentially injurious behaviors. These dreams tend to be unpleasant, action-filled, or violent, with the dreamer being confronted, attacked, or chased by unfamiliar people or animals.

The symptoms of REM sleep behavior disorder are often ignored for years, usually until an injury occurs to the dreamer or the bed partner. REM sleep behavior disorder often occurs due to an underlying neurological disorder, such as dementia with Lewy bodies, Parkinson’s disease, multiple system atrophy, narcolepsy, or stroke. 

The guideline provides recommendations for specific medications, such as clonazepam and immediate-release melatonin, that clinicians should consider when treating REM sleep behavior disorder in adults.

All of the recommendations are conditional, requiring the clinician to use clinical knowledge and experience, and to strongly consider the patient’s values and preferences, to determine the best course of action.

Treatment options also depend on whether the case of REM sleep behavior disorder is isolated, secondary to another medical condition, or drug induced.  

A Link Between Traffic Noise and Tinnitus


Summary: People exposed to noise pollution as a result of heavy traffic close to their homes are at greater risk of developing tinnitus, a new study reports.

Source: University of Southern Denmark

If you live near a busy road, it may increase your stress levels and affect your sleep. When we are under stress and sleep poorly, we may be at a higher risk of developing tinnitus.

 In a new study with data from 3.5 million Danes, researchers from the Department of Clinical Research and the Mærsk Mc-Kinney Møller Institute at the University of Southern Denmark (SDU) have found that the more traffic noise Danish residents are exposed to in their homes, the more they are at risk of developing tinnitus.

Tinnitus is most clearly manifested by annoying whistling tones in the ears, which are disturbing for many.

Risk increases with noise levels

It is the first time that researchers have found a link between residential traffic noise exposure and hearing-related outcomes.

-In our data, we have found more than 40,000 cases of tinnitus and can see that for every ten decibels more noise in people’s home, the risk of developing tinnitus increases by six percent, says Manuella Lech Cantuaria, PhD., Assistant Professor at the Mærsk Mc-Kinney-Møller Institute and affiliated to the the Department of Clinical Research at SDU.

She and her colleague Jesper Hvass Schmidt, Associate Professor at the Department of Clinical Research   and Chief Physician at Odense University Hospital (OUH) are concerned about the many health problems that traffic noise seems to cause. In 2021, they found a correlation between traffic noise and dementia.

-There is a need for more focus on the importance of traffic noise for health. It is alarming that noise seems to increase the risk of tinnitus, cardiovascular diseases and dementia, among other diseases, says Jesper Hvass Schmidt.

Tip of the iceberg

It is at hearing clinics, such as the one at OUH, where Jesper Hvass Schmidt works, that patients can get the diagnosis of tinnitus. But only the worst cases are referred from their own doctor or an otorhinolaryngologist . The high number of reported cases of tinnitus are probably only the tip of the iceberg, he believes.

-In general, about ten percent of the population experience tinnitus from time to time. It is associated with stress and poor sleep, which can be worsened by traffic noise, and here we have a potential cycle.

More studies are needed so that researchers can be sure that traffic noise causes tinnitus, and how this happens.

-But we know that traffic noise can make us stressed and affect our sleep. And that tinnitus can get worse when we live under stressful situations and we do not sleep well, Jesper Hvass Schmidt says.

Noise at night is worse

The researchers believe that noise at nighttime can be even worse for health

 – It affects our sleep, which is so important for restoring both our physical and mental health. Therefore, it is worth considering whether you can do something to improve your sleep if you live next to a busy road, Manuella Lech Cantuaria says.

What to do

In the study, higher associations were found when noise was measured at the quiet side of their houses, that is, the side facing away from the road. This is where most people would place their bedroom whenever possible, therefore researchers believe this is a better indicator of noise during sleep.

-There are different things one can do to reduce noise in their homes, for example by sleeping in a room that does not face the road or by installing soundproof windows.

But not everyone has those options.

-It is therefore necessary that traffic noise is considered a health risk that must be taken into account in urban planning and political decisions, says Manuella Lech Cantuaria.

Facts about traffic noise:

 The Danish guidance level for harmful traffic noise is 58 decibels. It is estimated that 1.4 million Danes are exposed to noise over 58 decibels in their homes. You can see the noise level for your place of residence here: dingeo.dk

It is a myth that replacing fuel cars by electric cars can significantly reduce traffic noise exposure at people’s houses. The noise comes mainly from the contact between the tires and the road.

This shows a busy street full of traffic
It is the first time that researchers have found a link between residential traffic noise exposure and hearing-related outcomes. Image is in the public domain

In Germany, speed limits have been lowered in some places at night, in order to minimize the disturbance of sleep for residents near roads.

Another way to reduce traffic noise is by placing noise barriers along the road or changing the road surface to one that dampens the tire noise.

Facts on tinnitus:
Tinnitus is a subjective experience of sound that does not come from an external source. It can be described as a ringing, buzzing, humming or other form of sound in the ears or in the head. Tinnitus can be a symptom of an underlying disease or injury, but can also be idiopathic, which means the cause is not known. Very often tinnitus occurs in connection with hearing loss. Tinnitus can have a negative impact on quality of life as it can cause sleep problems, difficulty concentrating, and depression. There are several possibilities to reduce tinnitus symptoms, including psychological treatment and hearing aids.

Abstract

Transportation Noise and Risk of Tinnitus: A Nationwide Cohort Study from Denmark

Background:

There is a growing body of evidence linking residential exposure to transportation noise with several nonauditory health outcomes. However, auditory outcomes, such as tinnitus, are virtually unexplored.

Objectives:

We aimed to investigate the association between residential transportation noise and risk of incident tinnitus.

Methods:

We conducted a nationwide cohort study including all residents in Denmark age ≥30y≥30y, of whom 40,692 were diagnosed with tinnitus. We modeled road traffic and railway noise at the most (LdenmaxLdenmax) and least (LdenminLdenmin) exposed façades of all Danish addresses from 1990 until 2017. For all participants, we calculated 1-, 5-, and 10-y time-weighted mean noise exposure and retrieved detailed information on individual- and area-level socioeconomic covariates. We conducted analyses using Cox proportional hazards models.

Results:

We found positive associations between exposure to road traffic noise and risk of tinnitus, with hazard ratios of 1.06 [95% confidence interval (CI): 1.04, 1.08] and 1.02 (95% CI: 1.01, 1.03) per 10-dB increase in 10-y LdenminLdenmin and LdenmaxLdenmax, respectively. Highest risk estimates were found for women, people without a hearing loss, people with high education and income, and people who had never been in a blue-collar job. The association with road LdenminLdenmin followed a positive, monotonic exposure–response relationship. We found no association between railway noise and tinnitus.

Discussion:

To our knowledge, this is the first study to show that residential exposure to road traffic noise may increase risk of tinnitus, suggesting noise may negatively affect the auditory system. If confirmed, this finding adds to the growing evidence of road traffic noise as a harmful pollutant with a substantial health burden.

10 Herbs That Help Boost Immunity: Current Studies


(Fitzke/Shutterstock)

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Our immune system is complex and protects us from infection and disease. Many parts of the body work separately and together to keep us healthy, but stress, lack of sleep, poor nutrition, and other factors can wear down our natural defenses.

Let’s look at 10 natural and easily obtained herbs that can boost our immunity to help keep us healthy as we push through the last months of winter cold.

1. Astragalus

Epoch Times Photo
Astragalus root (Shutterstock)

Astragalus, also called Huangqi, is a root used in ancient Chinese medicine to strengthen and regulate the immune system. It was given for many conditions, including respiratory infection, hay fever, asthma, and chronic kidney disease.

A systematic review of studies finds that astragalus regulates our immune function, promotes the proliferation of immune cells, stimulates the release of cytokines (which control the growth of immune cells), and influences the secretion of immunoglobulin (antibodies) and conduction of immune signals.

The National Institutes of Health (NIH) reports that astragalus may be safe when used “orally and appropriately,” and doses up to 60 grams daily for up to four months have been used without reported adverse effects. Possible but uncommon side effects include rash, itching, nasal symptoms, or stomach discomfort.

2. Cinnamon

Epoch Times Photo
Cinnamon is the inner bark of the “true” cinnamon tree. (Shutterstock)

Cinnamon is a powerful antibacterial and antifungal spice that can help our immune system fight off infection. This aromatic spice can also relieve symptoms of autoimmune disorders.

One study finds that cinnamon offers significant relief of rheumatoid arthritis and multiple sclerosis symptoms, while findings from another one show cinnamon and its ingredients can be recommended to manage COVID-19 infection.

3. Black Pepper

Epoch Times Photo
Black pepper. (anna1311/iStock)

One of the most common spices and used almost every day in cooking, black pepper has also shown promise against cancer.

A study confirmed that black pepper extract significantly enhances the cytotoxic activity of natural killer (NK) cells, and strongly suggests that it can exert immunomodulatory and antitumor action that can promote the maintenance of a healthy immune system.

Another in vitro study found that the active ingredient in pepper, called piperine, boosts the immune system to slow the replication of breast, prostate, and colon cancer cells, and could induce cancer cell death.

4. Garlic

Garlic,Cloves,On,Rustic,Table,In,Wooden,Bowl.,Fresh,Peeled
Garlic is a versatile plant that counts as an herb, a spice, and a vegetable. (Krasula/Shutterstock)

Used as both a spice and food for thousands of years, researchers have found that garlic offers a broad range of health benefits, especially as an immune system booster.

A systematic review of studies finds that garlic appears to enhance immune function by stimulating certain immune cell types, including macrophages, lymphocytes, and natural killer cells.

Another randomized controlled trial looked for evidence that aged garlic extract could boost human immune function against respiratory infection.

While the number of study participants who caught a cold or flu wasn’t significantly different, researchers found that the garlic group reduced cold and flu severity. Participants also experienced a reduction in the number of symptoms, and the number of work or school days missed.

5. Holy Basil

Epoch Times Photo
Holy basil leaves. (bdspn/iStock)

Different from common basil, holy basil is native to India and is a component of Ayurvedic medicine. Research finds holy basil can inhibit the growth of multidrug-resistant bacteria that include Staphylococcus, Enterococcus, and Pseudomonas.

A different randomized controlled trial also confirmed that holy basil boosted crucial immune factors in the participants’ blood.

6. Rosemary

Epoch Times Photo
Rosemary. (Nataliia K/Shutterstock)

Rosemary contains rosmarinic acid, which has been shown to modulate our immune response to have anti-allergy and decongestant properties. In a study with 29 participants, those given rosmarinic acid had decreased amounts of immune cells in nasal mucus, which reduced nasal congestion.  

A review of studies concluded that rosemary has significant antimicrobial, anti-inflammatory, antioxidant, and neuroprotective properties.

7. Ashwagandha

Ashwagandha root
Roots and powder of Ashwagandha (Eskymaks/Shutterstock)

Ashwagandha is a small woody plant native to India and North Africa that is used in Ayurvedic medicine. A clinical trial found that five participants who took 6 milliliters of ashwagandha root extract twice daily for 96 hours showed significant increases in immune cell activity.

A randomized, double-blind, placebo-controlled trial found that ashwagandha extract significantly improved the immune profile of healthy subjects by modulating their innate and adaptive immune systems.

Researchers concluded that ashwagandha could be used to boost the immune system of people at risk for infection and during “widespread infections.”

8. Black Cumin Seeds

Epoch Times Photo
Black cumin (nigella sativa or kalonji) seeds (Ulada/Shutterstock)

Black cumin seeds, also called black caraway, have a long tradition of use for therapeutic purposes.

A study identified compounds in black cumin seeds that can positively affect our immune signaling pathways, showing that this could be used as a dietary supplement to activate our immune responses.

A comprehensive review concluded that through a compound called thymoquinone, black cumin seed promotes immunity and cell survival, acts as an antitoxin, and can lessen the side effects of certain drugs.

9. Black Elderberry

Epoch Times Photo
Black elderberry (TYNZA/Shutterstock)

Black elderberry, also called Sambucus nigra, refers to several varieties of the Sambucus tree, which has clusters of white flowers and black or blue-black berries.

A  placebo-controlled, double-blind study of 312 plane travelers concluded that those who took elderberry supplements had significantly reduced cold duration and severity compared with passengers given a placebo instead.

A systematic review of studies from 2018 found that black elderberry supplements were effective to treat the symptoms of upper respiratory infection.

10. Echinacea

Epoch Times Photo
Echinacea flowers. (Shutterstock)

Echinacea refers to a group of flowering plants belonging to the daisy family. There are different species, but Echinacea purpurea is the most common.

A review of 16 studies found that echinacea was more effective than a placebo in preventing and treating upper respiratory infections.

Another review that looked at 14 studies found echinacea reduced the odds of catching a cold by almost 60 percent and decreased the symptom duration by nearly one-and-a-half days.

Are Immune-Boosting Herbal Supplements Safe to Use?

It’s important to get herbal supplements from a reputable brand.

“Echinacea and most herbal products are extremely variable,” Dr. Nima Majlesi, director of medical toxicology at Staten Island University Hospital, part of Northwell Health in New York, told The Epoch Times. He added that the labeling of products in health food stores can be incorrect due to a lack of FDA regulation.

People with allergic reactions to the contents of these supplements are the most obvious group that should avoid them.

“The fallacy of ‘it’s natural so it’s safe’ is truly concerning and we need to change the way we think about this,” said Majlesi.

Many drugs are based on natural compounds, and those compounds could have toxicity and potential for adverse effects just like prescription or over-the-counter drugs, he noted.

But overall, “these products are generally very safe, especially if taken for a short duration,” Majlesi said.

Majlesi advises that the best way to use most of these products is:

  1. Discuss whether it is safe with your health care providers, especially if you have medical issues or take medications daily.
  2. If they feel it is safe, and you want to try to improve your symptoms, consider a short course during specific times at recommended doses.

Wildfire smoke exposure in pregnancy may increase risk of preterm birth: Study



Study says wildfire smoke exposure in pregnancy may raise risk of preterm birth Photograph.

STORY HIGHLIGHTS

To assess the daily amounts of wildfire smoke in the participants’ ZIP codes during their pregnancies, the researchers first collected data from hospital records of pregnant women from 2007 to 2012. The results suggested that just one day of exposure to smoke moderately raised the risk of spontaneous preterm birth — medically defined as before the 37th week of pregnancy.  

Those exposed to wildfire smoke for at least one day have a higher chance of giving birth prematurely, according to a study of more than 2.5 million women who are pregnant in California. The results, which are still undergoing peer review, were presented on Saturday at the annual conference of the Society for Maternal-Fetal Medicine, and would be published in the American Journal of Obstetrics and Gynecology.

To assess the daily amounts of wildfire smoke in the participants’ ZIP codes during their pregnancies, the researchers first collected data from hospital records of pregnant women from 2007 to 2012.

The results suggested that just one day of exposure to smoke moderately raised the risk of spontaneous preterm birth — medically defined as before the 37th week of pregnancy. 

“Most pregnant persons are having well over one day of exposure, and the chronicity of this exposure, which continues to increase, is really the worrisome relationship with wildfire smoke,” said Dr Anne Waldrop, the study’s lead author and a maternal-fetal medicine fellow at Stanford University told NBC news. 

During their first or second trimesters, or the four weeks preceding conception, 86 per cent of the pregnant women tested in California, according to Waldrop’s research, had been exposed to fine particulate matter from wildfire smoke. Over the course of that period, the research subjects were exposed to smoke on average for more than seven days.

Only preterm births occurring within the first 20 weeks of pregnancy were linked to exposure; preconception exposure was not.

Another study discovered that air pollution likely caused roughly six million preterm births globally in 2019. According to Rakesh Ghosh, an epidemiologist at the University of California, San Francisco, and the author of that paper, who spoke to NBC news, inhaling smoke from wildfires during the first trimester may cause the amniotic sac to rupture early as a result of inflammation.

Water on Mars? Here’s what NASA’s Curiosity Rover found


“Billions of years ago, waves on the surface of a shallow lake stirred up sediment at the lake bottom, over time creating rippled textures left in rock,” NASA said.

nasa curiosity rover, nasa news, mars

The Curiosity Rover was traversing through an area of Mars called the “sulfate-bearing unit” (Source: NASA)

The National Aeronautics and Space Administration (NASA)’s Curiosity Rover has discovered new evidence that an ancient lake existed in a region of Mars, which was earlier believed to be drier.

The rover was traversing through an area of Mars called the “sulfate-bearing unit”, and researchers previously thought would show evidence of “mere trickles of water, as scientists believed the rocks there formed as the surface of the red planet was drying out”. Instead, they found some of the clearest event of ancient waters.

As I climb up Mt. Sharp, I’m exploring layers of the Martian timeline. Currently, I’m in the “Marker Band.” Up ahead, I can see something like a landslide, so I’m hoping to get a closer look at some “younger” material later this year.

Still curious? –> https://t.co/7cZGWF86Jc

— Curiosity Rover (@MarsCuriosity) February 8, 2023

“This is the best evidence of water and waves that we’ve seen in the entire mission,” said Ashwin Vasavada, Curiosity’s project scientist at NASA’s Jet Propulsion Laboratory in Pasadena, California, in a statement. “We climbed through thousands of feet of lake deposits and never saw evidence like this — and now we found it in a place we expected to be dry.”

“Billions of years ago, waves on the surface of a shallow lake stirred up sediment at the lake bottom, over time creating rippled textures left in rock,” NASA said.

Having climbed nearly a half-mile above the Mount Sharp’s base, the rover found that these rippled rock textures preserved in what’s nicknamed the “Marker Band” – a thin layer of dark rock that stands out from the rest of Mount Sharp, the agency said. As it climbed higher, it travelled over rocks that would have formed more recently. That’s why researchers didn’t expect to see such clear markers of a large body of water, the agency added.

Curiosity has attempted to extract samples from some of the rocks, but they proved too hard for the rover’s drill, according to NASA.

Millets in diabetes management: Know how these regulate blood sugar spikes


2023 is declared as the international year of millets

Government of India’s proposal for the International Year of Millets was accepted by the United Nations General Assembly (UNGA) and 2023 is being celebrated as the year of millets.‘Millets’ were among the first crops to be domesticated in India with several evidence of its consumption during the Indus valley civilization and are currently the traditional and staple food for people of several regions.In India, 2018 was declared as the National Year of millets and these wonder crops were branded as nutri cereals.

02/6Millets are good for the health

Millets are rich in antioxidants, fiber and protein. These are extremely easy to cook and can be made into delicious dishes within no time. Nutrition content, proper cultivation condition, the ease of cooking makes millets superior to processed foods. These wonder foods are extremely good in regulating cholesterol and blood sugar level, two of the major diseases which most of the population is dealing with currently.Millets are gluten free, and are hence good for those who find it difficult to process gluten loaded wheats and other flour.Millet consumption reduces triglycerides and C-reactive protein, which are known to cause cardiovascular disease.

03/6Millets for diabetes management

A 2021 research study led by the Smart Food Initiative at ICRISAT had found that those with diabetes who consumed millets daily saw a drop in the blood glucose level by 12-15%.The researchers said that millet consumption dropped the blood sugar level of diabetics to pre-diabetics levels.In case of pre-diabetic individuals the HbA1c lowered up to 17% and returned to the normal level.The study titled “A Systemic Review and Meta-Analysis of the Potential of Millets for Managing and Reducing the Risk of Developing Diabetes Mellitus” was published in the ‘Frontiers in Nutrition’. The study was a meta analysis of about 1,000 human subjects done from October 2017 to February 2021.READMORE

04/6Millets have low GI

The suitability of a food for diabetics is measured through GI or the glycemic index. The researchers found that millets have a low GI of 52.7. This is almost 30% lower than the GI of polished rice and refined wheat. It is even less than that of maize, another popular crop in the country. It was found that even during cooking, the GI of millets remained much lower than rice and maize.

05/6Know your millets

Millets are a group of small grained cereal crops. Millets comprise of Sorghum (jowar), pearl millet (bajra), finger millet (cheena), Kodo millet (kodo), Barnyard millet (sawa, sanwa, jhangora), little millet (kutki), brown top millet, buckwheat millet (kuttu) and amaranth (chaulai).Sorghum, pearl millet and finger millet are known as major millets. Foxtail millet, kodo millet, barnyard millet, little millet and proso millets are known as minor millets.Amaranth and buckwheat are known as pseudo millets.

06/6How to add millets to diet to control diabetes?

What makes millet a good food is its availability and the ease of cooking.Cooking millets does not take much time and can be easily prepared within minutes.One can make delicious khichdi using millets.Millet flour can be used to make pancakes and rotis.

The weirdness of quantum mechanics forces scientists to confront philosophy


Though quantum mechanics is an incredibly successful theory, nobody knows what it means. Scientists now must confront its philosophical implications.

KEY TAKEAWAYS

  • Despite the tremendous success of quantum physics, scientists and philosophers still disagree on what it’s telling us about the nature of reality. 
  • Central to the dispute is whether the theory is describing the world as it is or is merely a mathematical model. 
  • Attempts to reconcile the theory with reality have led physicists to some strange places, forcing scientists to grapple with matters of philosophy.

The world of the very small is like nothing we see in our everyday lives. We do not think of people or rocks being in more than one place at the same time until we look at them. They are where they are, in one place only, whether or not we know where that place is. Nor do we think of a cat locked in a box as being both dead and alive before we open the box to check. But such dualities are the norm for quantum objects like atoms or subatomic particles, or even larger ones like a cat. Before we look at them, these objects exist in what we call a superposition of states, each state with an assigned probability. When we measure many times their position or some other physical property, we will find it in one of such states with certain probabilities. 

The crucial question that still haunts or inspires physicists is this: Are such possible states real — is the particle really in a superposition of states — or is this way of thinking just a mathematical trick we invented to describe what we measure with our detectors? To take a stance on this question is to choose a certain way of interpreting quantum mechanics and our take on the world. It is important to stress that quantum mechanics works beautifully as a mathematical theory. It describes the experiments incredibly well. So we are not debating whether quantum mechanics works or not, because we are well past that point. The issue is whether it describes physical reality as it is or whether it does not, and we need something more if we are to arrive at a deeper understanding of how nature operates in the world of the very small.

States of thinking about the quantum world

Even though quantum mechanics works, the debate about its nature is fierce. The subject is vast, and I could not possibly do it justice here. My goal is to give a flavor of what is at stake. (For more details, see The Island of Knowledge.) There are many schools of thought and many nuanced arguments. But in its most general form, the schools line up along two ways of thinking about reality, and they both depend on the protagonist of the quantum world: the famous wavefunction.

In one corner stands those who think that the wavefunction is an element of reality, that it describes reality as it is. This way of thinking is sometimes called the ontic interpretation, from the term ontology, which in philosophy means the stuff that makes up reality. People who follow the ontic school would say that even though the wavefunction does not describe something palpable, like the particle’s position or its momentum, its absolute square represents the probability of measuring this or that physical property — the superpositions that it does describe are a part of reality. 

In the other corner stand those who think that the wavefunction is not an element of reality. Instead, they see a mathematical construct that allows us to make sense of what we find in experiments. This way of thinking is sometimes called the epistemic interpretation, from the term epistemology in philosophy. In this view, measurements taken as objects and detectors interact and people read the results are the only way we can figure out what goes on at the quantum level, and the rules of quantum physics are fantastic at describing the results of these measurements. There is no need to attribute any kind of reality to the wavefunction. It simply represents potentialities — the possible outcomes of a measurement. (The great physicist Freeman Dyson once told me that he considered the whole debate a huge waste of time. To him, the wavefunction was never intended to be a real thing.) 

Note the importance in all this of measurements. Historically, the epistemic view goes back to the Copenhagen interpretation, the hodgepodge of ideas spearheaded by Niels Bohr and carried forward by his younger, powerhouse colleagues such as Werner Heisenberg, Wolfgang Pauli, Pascual Jordan, and many others. 

This school of thought is sometimes unjustly called the “shut up and calculate approach” due to its insistence that we do not know what the wavefunction is, only what it does. It tells us we accept the superpositions of possible states, coexisting before a measurement is made, as a pragmatic description of what we cannot know. Upon measurement, the system collapses into just one of the possible states: the one that is measured. Yes, it is weird to state that a wavy thing, spread across space, instantaneously goes into a single position (a position that lies within what is allowed by the Uncertainty Principle). Yes, it is weird to contemplate the possibility that the act of measurement somehow defines the state in which the particle is found. It introduces the possibility that the measurer has something to do with determining reality. But the theory works, and for all practical purposes, that is what really matters.

Forks in the quantum road

At its essence, the ontic vs. epistemic debate hides the ghost of objectivity in science. Onticists deeply dislike the notion that observers could have anything to do with determining the nature of reality. Is an experimenter really determining whether an electron is here or there? One ontic school known as the Many Worlds interpretation would say instead that all possible outcomes are realized when a measurement is performed. It’s just that they are realized in parallel worlds, and we only have direct access to one of them — namely, the one we exist in. In Borgean style, the idea here is that the act of measurement forks reality into a multiplicity of worlds, each realizing a possible experimental outcome. We do not need to speak of the collapse of the wavefunction since all outcomes are realized at once.

Unfortunately, these many worlds are not accessible to observers in different worlds. There have been proposals to test the Many Worlds experimentally, but the obstacles are huge, for example requiring the quantum superposition of macroscopic objects in the laboratory. It is also not clear how to assign different probabilities to the different worlds related to the outcomes of the experiment. For example, if the observer is playing a game of Russian roulette with options triggered by a quantum device, he will only survive in one world. Who would be willing to be the subject of this experiment? I certainly would not. Still, Many Worlds has many adherents.

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Other ontic approaches require, for example, adding elements of reality to the quantum mechanical description. For example, David Bohm proposed expanding the quantum mechanical prescription by adding a pilot wave with the explicit role of guiding the particles into their experimental outcomes. The price for experimental certainty, here, is that this pilot wave acts everywhere at once, which in physics means that it has nonlocality. Many people, including Einstein, have found this impossible to accept.

The agent and the nature of reality 

On the epistemic side, interpretations are just as varied. The Copenhagen interpretation leads the pack. It states that the wavefunction is not a thing in this world, but rather a mere tool to describe what is essential, the outcomes of experimental measurements. Views tend to diverge on the meaning of the observer, about the role the mind exerts on the act of measuring and thus on defining the physical properties of the object being observed, and on the dividing line between classical and quantum. 

Due to space, I will only mention one more epistemic interpretation, Quantum Bayesianism, or as it is now called, QBism. As the original name implies, QBism takes the role of an agent as central. It assumes that probabilities in quantum mechanics reflect the current state of the agent’s knowledge or beliefs about the world, as he or she makes bets about what will happen in the future. Superpositions and entanglements are not states of the world, in this view, but expressions of how an agent experiences the world. As such, they are not as mysterious as they may sound. The onus of quantum weirdness is transferred to an agent’s interactions with the world. 

A common criticism levied against QBism is its reliance on a specific agent’s relation to the experiment. This seems to inject a dose of subjectivism, placing it athwart the usual scientific goal of observer-independent universality. But as Adam Frank, Evan Thompson, and myself argue in The Blind Spot, a book to be published by MIT Press in 2024, this criticism relies on a view of science that is unrealistic. It is a view rooted in an account of reality outside of us, the agents that experience this reality. Perhaps that is what quantum mechanics’ weirdness has been trying to tell us all along. 

What really matters

The beautiful discoveries of quantum physics reveal a world that continues to defy and inspire our imaginations. It continues to surprise us, just as it has done for the past century. As said by Democritus, the Greek philosopher who brought atomism to the forefront over 24 centuries ago, “In reality we know nothing, for truth is in the depths.” That may very well be the case, but we can keep trying, and that is what really matters.

Intermittent Fasting–is It Right for You?


Is intermittent fasting right for you? (Shutterstock)

Is intermittent fasting right for you? (Shutterstock)

Intermittent fasting as a means of weight loss and improving overall health has become a popular practice. The diet involves eating only during specific times and fasting for longer periods between meals. Is intermittent fasting right for you? Understanding fasting and an evaluation of your current state of health can help you know.

Some benefits of intermittent fasting

  1. Reduces inflammatory reactions in the body.
  2. Reduces blood sugar levels in Type 2 diabetes.
  3. Lowers blood pressure, cholesterol, and triglycerides.
  4. Assists weight loss.
  5. Anti-aging.
  6. Improves recovery from acute disseminated encephalomyelitis.
  7. Improves immune rheumatic diseases, such as asthma, multiple sclerosis, and polyarthritis.
  8. Improves side effects of chemotherapy, prevents cancer, and improves survival rates for certain cancers.
  9. Enhances the quality of sleep, skin condition, temper, and digestive function.
  10. Lowers satiety and hunger.
  11. Reduces the risk of tumors and inhibits tumor growth.

During fasting, the body’s function changes from “production mode” to “survival mode,” burning sugar and fat stores. Fasting detoxifies the body, promotes clarity of mind, and boosts energy levels.

In ancient times, human beings hunted and gathered wild fruits and vegetables. Without continual food supplies, they were often in a state of fasting. The development of agriculture and animal husbandry created a stable food supply and the evolution of the three-meals-a-day concept.

Who should avoid fasting?

Intermittent fasting is not recommended for:

  • Children.
  • Underweight or weak people.
  • Pregnant or lactating women.
  • People with conditions such as anorexia, and bulimia.
  • People with stomach problems, hyperacidity, and cholecystitis
  • People with diabetes or low sugar blood.
  • People with hyperlipidemia, kidney disease, or gout should not do long-term fasting.

Introduce fasting gradually

After 12 hours of fasting, blood ketone levels will gradually rise, and the body will start burning fat. Modern people are well-fed and seldom suffer from hunger—thus a good choice for them is “intermittent fasting,” also known as “light fasting.” Light fasting means choosing a fixed period of the day to not eat and only drink water, or non-caloric beverages such as plain coffee or tea.

The practice of fasting should be introduced gradually and take into consideration your current state of health, your workload, how much time you have to rest, social commitments, etc. Adapt fasting as a lifestyle step by step—if hunger causes adverse effects, shift the number of hours not eating to fewer, and gradually increase as the body adjusts.

Light fasting should not cause muscle loss—if it does there may be insufficient protein intake. Replenishing premium protein and moderate exercise can ensure no muscle loss during fasting.

The discomforts of fasting

Fasting usually does not cause major discomfort. However, some of the following may be experienced:

  • Feeling cold or chilled. As fat is burned in the body thyroid function may drop temporarily causing cold hands and feet.
  • Mood swings may occur as a symptom of low blood sugar and are usually temporary.
  • Headache. Transitioning from burning sugar to burning fat may cause a temporary headache.
  • Burning sensation in the stomach. If the accumulation of stomach acid causes too much discomfort you can eat something to slow down the fasting pace.
  • Nausea. Usually, the symptoms of nausea will ease naturally.
  • Dizziness. Be sure to sit down, and consider eating a bit if it persists.
  • Hair loss or fatigue. Be sure that when you are in times of eating that your diet is balanced and healthy to meet all the nutritional needs of the body .

In short, if the symptoms are not serious, they will usually improve within a few days—but you should stop fasting if the symptoms are not relieved.

Good Sleep Onset Timing Can Lower Risk of Cardiovascular Disease


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Cardiovascular disease (CVD) is one of the leading causes of death worldwide. That includes myocardial infarction, heart failure, chronic ischemic heart disease, and stroke. Studies have found that falling asleep during a specific period is associated with a lower risk of CVD.

A study in the UK showed there is a U-shaped relationship (first decreasing and then increasing, or vice versa) between daily sleep time and CVD risk. Participants who went to bed between 10 p.m. and 11 p.m. had a lower risk of heart disease than those who went to bed either earlier or later. This phenomenon was more pronounced in women. The paper was published in a 2021 edition of the European Heart Journal.

Sleep Onset Timing and CVD Risk

The research team analyzed data from 88,026 people aged 43 to 79 without CVD, with 51,214 (57.9 percent) women and 36,812 (41.6 percent) men. Participants used a wrist-worn accelerometer to record data on when they fell asleep and when they woke up during normal life for seven days. The results found that 3,172 participants (3.6 percent) developed CVD disease during an average follow-up period of about 5.7 years.

Among participants who fell asleep at different times, those who fell asleep at or after midnight had the highest risk of CVD, followed by those before 10 p.m. And those who fell asleep between 11 p.m. and 11:59 p.m., and those between 10 p.m. and 10:59 p.m. had the lowest risk of CVD.

The results of the experiment also showed a more distinct association between the time of falling asleep and the risk of CVD in women.

The research team then adjusted for factors such as sleep duration and sleep irregularity and found that the time of falling asleep was still associated with CVD risk. In addition, the researchers found that the overall association between sleep onset time and CVD risk still holds after adjustment for important CVD risk factors such as hypertension, diabetes, body mass index, and smoking.

Best Sleep Onset Timing at Midnight

Unlike western medicine, which interprets from the perspectives of all aspects visible to the naked eye, such as nerves and endocrine, traditional Chinese medicine (TCM) believes that “man and nature are one integrated entity,” and that heaven, earth, and the human body are unified and function in cohesion. The theory of yin and yang in the basic theory of TCM believes that all things or phenomena in nature have two corresponding characteristics of “yin” and “yang.” They are opposite in nature, but they are also mutually interdependent and intrinsically indispensable.

TCM believes that normal sleep is the result of the harmony and coordination of yin and yang in the human body. Yang dominates awakening and yin dominates sleep. From the perspective of TCM, Zishi (11 p.m. to 1 a.m.) is the time when the yin energy is the strongest. Therefore, people should follow the law of the growth and decline of both yin and yang in the universe, and it is best to be in a deep sleep state during Zishi. This is also consistent with Western science’s understanding of the circadian rhythm.

TCM believes that qi is the “energy” or “vitality” that constitutes life within the body, and they generally refer to the substances that replenish nutrients in the body as blood. Qi and blood are interdependent, flow throughout the whole body, nourish the organs and tissues, and maintain the vital activities of the human body.

TCM has also discovered that the human body has a “meridian” system that is responsible for transporting “qi” and “blood” throughout the body. There are 12 main meridians that follow specific timing and paths. The 12 hours period (shichen) of a day (one hour is two hours a day) corresponds to the 12 main meridians of the human body. In each hour, the qi and blood on the corresponding meridian will be particularly affluent, and the viscera governed by the corresponding meridian is also more active.

Dr. Yang Jingduan, the founder and medical director of the Yang Institute of Integrative Medicine in Pennsylvania, said that Zishi (11 p.m. to 1 a.m.) is the rule of the gallbladder meridian. Choushi (1 a.m. to 3 a.m.) belongs to the liver. During these two periods, the energy of the human body is concentrated in the liver, gallbladder, and meridian system. The liver and gallbladder mainly regulate the digestion, endocrine, heart rate, emotion, brain, and detoxification of the whole body.

Study Finds Obese People Might Have Alzheimer’s-Like Brain Atrophy


Obesity may put you at risk for cognitive decline. (Creativa Images/Shutterstock)

Obesity may put you at risk for cognitive decline

Obesity has long been linked to many health conditions, including cardiovascular disease, Type 2 diabetes, and some cancers. New research adds another concern: cognitive decline.

The study, published in the Journal of Alzheimer’s Disease, found obesity was associated with decreased brain mass similar to that seen in Alzheimer’s disease patients.

Obesity Causes Similar Changes to Brain as Alzheimer’s Disease

Researchers compared patterns of brain atrophy and amyloid-β/tau protein accumulation (hallmarks of Alzheimer’s) in patients with obesity and Alzheimer’s disease. They used a sample of over 1,300 individuals from four groups—Alzheimer’s disease patients, healthy people, obese but otherwise healthy people, and lean people.

The study was conducted using two large cohorts: the UK Biobank and the Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Researchers used PET brain scans to investigate what mechanisms might be responsible for similarities between obesity-related brain atrophy and Alzheimer’s-related amyloid-beta accumulation. They also looked for overlapping areas among patients with these conditions.

The scans showed these groups experienced similar brain thinning in areas associated with learning, memory, and judgment.

Additional data were included from a previous study involving over 20,000 participants, which showed that increased body mass index (BMI), body fat percentage, and waist-to-hip ratio were associated with worse fluid intelligence (ability to solve problems) and working memory.

Earlier research also found that obesity can change the body in ways that are linked to increased Alzheimer’s risk, particularly damage to blood vessels in the brain and accumulation of abnormal proteins in the brain.

Obesity is related to many health problems, such as Type 2 diabetes, hypertension, and high cholesterol.

“All those affect the brain in a negative way,” study author Filip Morys, who holds a doctorate in cognitive neuroscience and who is a postdoctoral researcher at McGill University in Montreal, Canada, told The Epoch Times. “For example, through changes in the brain’s vascular system or the blood-brain barrier, this might in turn lead to neuronal loss.”

How Obesity Increases Risk for Neurodegenerative Diseases

Obesity rates have increased alarmingly in the last decades, reaching global epidemic levels.

Obesity has tripled worldwide since 1975. World Health Organization (WHO) data from 2016 show that nearly 40 percent of adults 18 years and older were overweight, and 13 percent were obese.

From 1999 to 2000, through 2017 to March 2020, obesity prevalence in the United States rose from almost 31 percent to about 42 percent

In the same period, the prevalence of severe obesity also nearly doubled.

Obesity is believed to increase neurodegenerative disease risk by two means—“promoting insulin resistance and the production of inflammatory molecules in the body called cytokines,” said Dr. Jonathan J. Rasouli, director of complex and adult spinal deformity surgery at Staten Island University Hospital, part of Northwell Health in New York.

The combination of these factors can mean an increased risk of cardiovascular, pulmonary, musculoskeletal, and neurologic diseases, he continued.

There’s evidence showing insulin plays a role in brain health, and insulin resistance, which is associated with overweight and obesity, is significantly associated with Alzheimer’s risk.

A study published in Frontiers in Neuroscience shows that in addition to metabolic functions, insulin also modifies neuronal activity that improves memory in mammals and promotes the health of synapses in the brain.

When the brain can’t use insulin properly, cognition can become impaired.

A recent study stated that insulin signaling is impaired in the brains of Alzheimer’s patients, and brain insulin resistance appears to be an early and common feature of Alzheimer’s disease.

‘An Ounce of Prevention Is Worth a Pound of Cure’

Can weight loss reverse or prevent cognitive decline; is it ever too late? The impact of weight loss on cognitive function in older adults, specifically, is still not understood fully, and it’s likely that more research will be needed.

However, there is encouraging evidence that it may help.

A recent study finds that even modest weight loss can lead to improved cognitive function in older adults. Furthermore, lifestyle changes, like exercise and a healthy diet, will likely have a positive impact on cognitive function and overall health at any age.

When it comes to cognitive decline, “an ounce of prevention is worth a pound of cure,” said Rasouli.

Although the progression of cognitive decline—including memory loss—can be slowed or temporarily stopped, he warned that as soon as the process starts, it is very difficult to fully “return to normal” afterward.

Reducing sources of inflammation is one of the things Rasouli encourages patients to do.

Normal aging is associated with increased and prolonged inflammation throughout the body—and the brain.

There is evidence that persistent, increased levels of inflammation are strongly associated with neurodegeneration, impaired neuron growth (neurogenesis), and chronic diseases.

Metaflammation is a metabolic inflammatory state associated with obesity that directly contributes to insulin resistance, metabolic syndrome, and Type 2 diabetes. Evidence shows that losing weight can reverse this process.

Morys said the “key takeaway” is that obesity is a major risk factor for Alzheimer’s disease and other types of dementia.

“In line with this, we think that obesity prevention and weight loss might play a very important role in decreasing the risk for Alzheimer’s disease,” he concluded.