Why Butter Is Better


A block of fresh butter. (Shutterstock)

A block of fresh butter.

In the early 1900s, Americans consumed about 18 pounds of butter per person per year—and that doesn’t include the butterfat they got from whole milk, cream, and cheese. Today that number stands at about five pounds, a slight increase over the last few years from a low of four pounds per person per year.

What happened? Why did butter consumption in the U.S. plummet?

What happened is that America became electrified and stopped using candles. I am not kidding, this is the genesis of butter’s decline. An American company called Procter and Gamble had figured out a way to solidify liquid cottonseed oil—a waste product of the cotton industry—into a hard fat that could burn in candles. The process was called partial hydrogenation, which reconfigured the molecules in liquid oils into an unnatural type of fat called trans fats, which are hard at room temperature.

Since their candle business was declining, Procter and Gamble decided to promote partially hydrogenated cottonseed oil as a food. They called their product Crisco—short for “crystalized cotton seed oil”—and it came on the scene in 1911 along with a cookbook called “The Story of Crisco.”

The book was a masterstroke of advertising genius, which pushed all the buttons of the up-and-coming American housewife. Women who used Crisco instead of lard, the book promised, were more modern, had cleaner houses that smelled better, and had children of better character. Their cakes rose more easily, their food tasted better, and was easier to digest!

Imitation butter in the form of margarine soon followed, and since margarine contained no cholesterol or saturated fat like butter did, the ad men had the perfect handle: Claim that cholesterol and saturated fat caused heart disease and offer up cholesterol-free margarine as an alternative. Soon doctors were promoting this fake fat—remember they also promoted cigarettes—and then the government joined in.

Such was the power of vegetable oil industry influence behind the scenes that by 1973, the Senate Select Committee on Human Needs promised that Americans could solve their most serious diseases—heart disease, stroke, diabetes, cancer, high blood pressure, etc.—if they only used margarine instead of butter!

Fast forward to the present. Margarine today has come under a cloud, now that we know how bad partially hydrogenated oils are for human health. Today most Americans use “healthy,” trans-free spreads, still dutifully following government suggestions—yet, rates of serious disease have not gone down—quite the opposite, they keep going up and up.

The science of fats and oils has come a long way since the early 1900s, and we now know a lot more about butter—although we’re unlikely to read about butter’s many important components in the newspapers. Here are a few of the good things we get from butter:

Fat-soluble vitamins: The U.S. Department of Agriculture and the U.S. Food and Drug Administration claims that butter is an “empty” fat, but butter is an easy way to get fat-soluble vitamin A on a daily basis from foods we like to eat, and also provides vitamins D, K2 and E. Typical spreads contain only one form of vitamin A and none of the other fat-soluble vitamins.

Minerals: Butter contains trace amounts of important minerals, including calcium, phosphorus, magnesium, iron, and selenium. The amounts may be small but they are largely absorbed due to the presence of the fat-soluble vitamins, especially vitamin D. Butter provides a small amount of iodine, especially if the cows are grazing on iodine-rich soil, or receive an iodine teat wash, which again is efficiently absorbed.

Butyric acid: This is a very small fat molecule that is almost unique to butter. Our bodies make butyric acid when good bacteria ferment high-fiber foods in the colon, but in butter, we get butyric acid readymade. Butyric acid is important for digestion and seems to protect us against constipation, irritable bowel syndrome, Crohn’s disease, and colon cancer.

New research indicates that butyric acid in butter supports the assimilation of vitamin A. Butyric acid also supports thyroid function by making the thyroid cells more sensitive to thyroid hormones. (The combination of vitamin A, iodine, and butyric acid in butter makes it the perfect food for thyroid function.) And a fascinating line of research is exploring ways that butyric acid can help with addictions and alleviate pain.

Arachidonic acid: Unique to animal fats, arachidonic acid is important for skin health, digestion, and brain function—it is especially abundant in the brain. Arachidonic acid is critical to mental health, as our endocannabinoids are derived from it. Other feel-good chemical pathways involve arachidonic acid, vitamin A, and vitamin D. Butter is a happy-making fat, for sure!

Conjugated linoleic acid (CLA): This is a type of trans fat that is beneficial—its levels are high in butter from cows eating green grass. CLA protects against cancer and helps the body build muscle rather than store fat.

Glycosphingolipids: These are a special category of fats that support the immune system, and are also critical for a healthy nervous system.

Cholesterol: Yes, cholesterol. One thing the anti-butter folks never told us is that the amount of cholesterol we eat has no relationship to the amount of cholesterol in the blood. Babies and toddlers in particular need cholesterol because they do not make their own. Cholesterol is essential for growth, neurological health, muscle function, and hormone production.

Saturated fat: Far from posing a danger, saturated fats play many important roles in the body’s chemistry. So important are saturated fats, that the body has a backup plan if we don’t eat enough of them: It makes them out of carbohydrates, especially refined carbohydrates. Cravings for carbs often wane when you add plenty of butter to the diet. (We’ll talk more about the roles of saturated fat in a later column.)

Margarines and spreads made with vegetable oils contain none of the special fatty acids that occur mainly in animal fats. While modern spreads contain no trans fats, they do contain industrially processed seed oils, which are rancid and break down into highly reactive aldehydes. The use of soybean oil is especially concerning because it contains estrogen-like compounds. Then there are the additives, like potassium sorbate, calcium disodium, citric acid, and artificial flavorings.

You do not need to feel guilty for eating butter. Butter is the fat in nature most perfectly designed to support growth in children, and health and happiness at all ages.

The best butter comes from cows that graze on green grass. Butter from Ireland and New Zealand—available in many supermarkets—fits this category, and grass-fed butter from small dairy farms is often available locally. Use it liberally on toast, potatoes, and vegetables. Your body will thank you for it.

Researchers find why immunotherapy doesn’t work well for lung cancer treatment



https://timesofindia.indiatimes.com/world/rest-of-world/researchers-find-why-immunotherapy-doesnt-work-well-for-lung-cancer-treatment/articleshow/97585744.cms?from=mdr

Soft Tissue Sarcoma: What You Need to Know About this Rare Cancer


Soft Tissue Sarcomas account for <1% of all adult tumours and 15% of paediatric tumours. They are a complex, heterogeneous group of tumours that can occur in any part of the body, making them diagnostically challenging. 

Sarcomas can spread to other parts of your body, while aggressively destroying the soft tissues or bones.

The treatment of Soft Tissue Sarcoma depends on the type, stage, size, and other factors, as well as whether your body is suited for chemotherapy or radiotherapy. 

Let’s get a deeper insight into this rare disease.

What Is Soft Tissue and What Is Soft Tissue Sarcoma?

How-cancer-cells-grow

Our soft tissues comprise muscles, tendons, ligaments, fat, blood vessels and other tissues. They connect and surround the organs, while supporting the other structures of our body.

Tumours in the soft tissues can be benign ( non- cancerous) or malignant ( cancerous). The malignant soft tissue tumours are called soft tissue sarcomas.

Sarcoma is a type of cancer that begins in the tissues and can be found anywhere in the body. However, they are most commonly found in the head, arms, neck, abdomen, and legs. 

What Are the Types of Soft Tissue Sarcoma?

Despite having more than 30 types, Soft Tissue Sarcoma is broadly categorised based on the origin tissue. They are:

  1. Muscle tissue
  2. Fibrous tissue
  3. Peripheral nerve tissue
  4. Joint tissue
  5. Blood and lymph vessels

The most commonly identified types are Undifferentiated Pleomorphic Sarcoma (UPS), Gastrointestinal Stromal Tumour (GIST), Liposarcoma, Leiomyosarcoma, Ewing’s Sarcoma, and Synovial Sarcoma. However, in India, the two main types are Ewing’s Sarcoma and Synovial Sarcoma.

What Is Ewing’s Sarcoma?

Ewing’s sarcoma is a rare cancerous disease. It is a tumour in the bone or soft tissues. It occurs in common areas like the pelvis, the femur, the humerus, the ribs, and collarbone. Symptoms include lumps in their legs and arm, which grows over weeks or months.

Ewing’s sarcoma occurs in teenagers and young adults, with a male/female ratio of 1:6. Due to its complex nature, it is often difficult to diagnose Learn more about Ewing Sarcoma here.

What Is Synovial Sarcoma?

Synovial Sarcoma is one of the rarest types of cancer. It usually starts in the thighs, knees, feet, or forearms. It is usually diagnosed after a lump or some related pain. 

Synovial Sarcoma has a male to female ratio of 1.2:1. It can be caused due to multiple risk factors, but mostly due to inherited conditions.

What Are the Risk Factors of Soft Tissue Sarcoma?

Risk-factors-for-Soft-tissue-sarcoma

The exact cause of what causes most soft tissue sarcomas is still under research. However, there have been certain risk factors identified with it. Most of these risk factors are inherited conditions due to gene mutations, and affects the genes in the cells of the soft tissue.

Medical research states the following as risk factors for developing soft tissue sarcoma:

  1. Radiation during treatment of other cancers: Patients might develop sarcoma during treatment for breast cancer or lymphoma. However, it constitutes less than 5% of all sarcomas. The time between radiation exposure and diagnosis of sarcoma is approximately 10 years.
  2. Family Cancer Syndrome: They are disorders caused due to gene mutations. People are usually born with it, and it may increase their chances of developing soft tissue sarcoma. The main types of family cancer syndromes that may cause soft tissue sarcoma are:
    •  Neurofibromatosis, also called von Recklinghausen disease. It forms in the nerves under the skin. 5% of people with Neurofibromatosis will develop sarcoma.
    • Gardner Syndrome, that causes polyps in the colon and intestine. It increases the risk of colon cancer as well, and may also cause problems outside the colon.
    • Li-Fraumeni Syndrome, in which the susceptibility to developing cancers of the breastbrain, or blood is high. People with this syndrome are highly sensitive to radiation, and may eventually develop sarcoma in a new part of the body while being treated.
    • Retinoblastoma, a type of eye cancer prevalent in children.
    • Werner Syndrome, a condition that causes children to have age-related medical conditions like cataracts, skin changes, arteriosclerosis (clogged arteries) and an increased risk of soft tissue sarcoma.
  3. Exposure to cancer-causing chemicals, particularly vinyl chloride, presents a higher risk of developing a sarcoma. Exposure to polycyclic hydrocarbons, asbestos, and dioxin can also up the risk.
  4. Damaged Lymph System, caused due to lymph (clear fluid that contains cells from the immune system) buildup caused by damaged lymph nodes during radiation therapy. It can result in swelling and is also known as lymphedema.

What Are the Symptoms of Soft Tissue Sarcoma?

Symptoms-of-soft-tissue-sarcoma

Soft Tissue Sarcoma may not present any initial sign or symptom due to its complex nature. However, here are some of the symptoms you need to keep an eye out for:

  1. A new lump that is growing in size
  2. Chronic, degenerative pain in the abdomen
  3. Blood in your vomit or stool
  4. Black, sticky bowel (due to internal bleeding in the stomach)

However, lumps and bumps in the body necessarily do not mean Sarcoma. It is best to consult a medical expert if you’re experiencing any of the above.

How Is Soft Tissue Sarcoma Diagnosed?

Diagnosing-Soft-Tissue-Sarcoma

There are a number of tests that are used to identify Soft Tissue Sarcomas. It usually begins with the medical expert determining if the tumour is cancerous or benign and how much it has spread in the body. 

After reviewing the symptoms, the lump specifically, a computed tomography (CT) scan or magnetic resonance imaging (MRI) scan is done to obtain a detailed view of the tumour. 

To confirm the diagnosis and determine the type of tumour, a biopsy is done. A biopsy sample can be obtained by withdrawing bits of tissue from the lump with a needle. In some cases, the tissue sample may be obtained during surgery. The tissue sample is examined under the microscope by a pathologist. In addition to making the diagnosis, this specialist can determine how active the sarcoma is by estimating the number of dividing cells (mitoses) in the specimen. Cancers with a large number of mitoses have a worse prognosis and may need aggressive treatment.

If the diagnosis of malignant soft tissue tumour( Sarcoma) is established, the next step is to determine the cancer’s stage—a measure of how much it has spread. The stage is based on:

  • the tumour’s size
  • the tumour’s grade (how rapidly the cells are dividing and how abnormal they look under the microscope)
  • whether or not cancer cells are in nearby lymph nodes
  • whether or not the cancer has spread beyond its original site to other parts of the body. A positron emission tomography (PET- CT) scan may be done to identify a spread of tumour( Staging).  

PET scan  provides a more accurate picture of where cancer is located. Because PET looks at the entire body, it can be useful when your doctor thinks the cancer may have spread to the other parts of the body.

Treatment will be advised only after the stage, type, and other important factors have been determined.

What Are the Stages of Soft Tissue Sarcoma?

Doctors first determine the type of Sarcoma you have. It is then graded based on how your cancer might behave or spread to the other parts of your body ; followed by the stage it is on.

Sarcomas are graded on a scale of G1 to G3, with G1 being low-grade and almost similar to normal cells, G2, or medium-grade, and G3 or high-grade tumour which may spread readily to other parts of your body.

The general stages of a Soft tissue sarcoma are:

Stage 1: The tumour is small and low grade

Stage 2: The tumour is small but of a higher grade

Stage 3: The tumour is large and of a higher grade

Stage 4: The cancer has spread to other parts of the body

Tumour sizes are often measured in centimeters (cm) or inches. Common food items that can be used to show tumour size in cm include: a pea (1 cm), a peanut (2 cm), a grape (3 cm), a walnut (4 cm), a lime (5 cm or 2 inches), an egg (6 cm), a peach (7 cm), and a grapefruit (10 cm or 4 inches).

Treatment Options for Soft Tissue Sarcoma

Treatment-for-soft-tissue-sarcoma

There are different methods to treat the different types of soft tissue sarcoma. It is often a combination of therapies best suited for the patient. However, the four standard types of treatment are:

  • Surgery
  • Radiation therapy
  • Chemotherapy
  • Isolated regional therapy

The Prognosis for Soft Tissue Sarcoma

In general, people with localised Soft Tissue Sarcomas have a very good prognosis with a high rate of cure. The main feature of an excellent prognosis is a tumour that is completely removed by surgery and hasn’t spread beyond the margins of the tumour. Children tend to have a better prognosis than adults for both localised tumours and those that have spread.

Preventing Soft Tissue Sarcoma

There is no known way to prevent sarcomas. However, because HIV infection seems to increase the risk of some sarcomas, you should avoid behaviours that can lead to HIV infection.

If your occupation exposes you to substances that can cause soft tissue sarcomas, use proper protective equipment to reduce your exposure.

With advancements in medical science and continual research and development to treat cancers, soft tissue sarcoma, despite being a rare type of cancer, may be treated if detected early on. Overall, the 5-year survival rate for soft tissue sarcoma is more than 65%.

It is important to understand that not everyone with a risk factor will develop soft tissue sarcoma, especially due to its rare nature. However, it is best to consult your doctor if you observe any visible lumps or unmanageable pain.

What Women Should Know About Breast Density and Cancer


Urban cities in India like New Delhi, Mumbai, Ahmedabad, Kolkata, and Trivandrum have seen a rise in the cases of breast cancer over the last decade. Lifestyle factors like weight gain, lack of exercise, excessive alcohol consumption, hormone replacement therapies, stress, and erratic work timings have largely contributed to this. 

However, other non-modifiable factors like genetics, age, gender, and dense breast tissues have also contributed to this increasing number.

But what does it mean to have dense breast tissues? Why does it increase your risk of breast cancer? Can you do anything about it? Here’s everything you need to know about breast density and its implication for breast cancer in women.

What Does it Mean to Have Dense Breasts?

What-does-it-mean-to-have-dense-breasts

Breast tissues are made up of milk glands and ducts, supportive tissues (dense breast tissue) and fatty tissue (non-dense breast tissue). Dense breast tissues appear as a solid white area on a mammogram, obscuring any hidden lumps. This makes it difficult for doctors to identify any potential breast cancer threats. 4 out of 5 women who screen for breast cancer are unaware that dense breasts can increase their risk of breast cancer. 

“Women with dense breasts are 5 times more likely to develop breast cancer than women with less dense breasts.”


It is imperative for all radiologists to inform and educate their patients about breast density and what it may mean for their health.

What Causes Dense Breasts?

What-are-the-screening-options-for-dense-breasts

Breast density is usually dependent on your natural body composition. It is also affected by age and hormones. If you are undergoing hormone replacement therapy, it can increase your breast density as well. More often than not, one cannot do much to alter their breast density. 

Why Does Breast Density Matter?

Dense breasts can obscure the detection of any lumps or malformations in your breasts in a mammogram. This increases the chance of any potential breast cancer threat to go undetected.

What Are the Screening Options for Women With Dense Breasts?

Screening-methods-for-breast-cancer

Breast density cannot be diagnosed by touch. 

“A woman’s breast may feel soft but appear dense on the mammogram,” –  Renee Pinsky, M.D., associate professor, University of Michigan.

3D Mammography, also known as Tomosynthesis, is by far the best way to screen for breast cancer in women with dense breasts. During a 3D Mammography, the breasts are observed in visual slices, helping remove some of the obscure, masking effects of dense breast tissue. 3D Mammography machines can help radiologists to get deeper insights and make early detection easier and more accurate.

Breast density is categorised into four levels :

  1. Almost entirely fatty
  2. Scattered fibroglandular densities
  3. Heterogeneously dense
  4. Extremely dense

Women who have dense breasts or think they might have dense breasts should discuss with their doctor on other screening methods like an ultrasound, which can pick up other cancers that may not be detected in a mammogram. But it is to be noted that Ultrasound may also have a higher false positive rate. 

Some other screening methods for breast density include Breast MRI, and Molecular Breast Imaging (MBI). Consult your doctor on what screening method is best for you.

Furthermore, it is important to understand and discuss breast cancer risk factors with your doctor to remain compliant with the growing need for breast cancer screening.

Takeaway

The concept of breast density is an important factor in determining breast cancer risks. Here are some key factors you should keep in mind:

  1. Breast density cannot be diagnosed by touch, you need to consult your doctor for specific screening methods.
  2. Dense breasts can make it difficult to detect any signs of breast cancer in a mammogram.
  3. Breast density may change with age and conditions like pregnancy, lactation, and menopause.
  4. Dense breasts require additional screenings like Ultrasound and Breast MRI.

It is important we talk more about breast density and address this issue head-on. So #ScreenItOut and have the best chance of early cancer detection.

Vitamin B12 deficiency reduces RBCs, affects nervous system: Know what are the symptoms associated with it


Vitamin B12 or Cobalamin is a water soluble vitamin

Vitamin B12 comprises cobalt, hence it is named as cobalamin. It is a water soluble vitamin.Vitamin B12 is required for the regulation of the nervous system, formation of healthy red blood cells and DNA synthesis.Now that you know the benefits of vitamin B12, you can estimate the damage your body must be going through when it is deficient in this vitamin. Therefore it is crucial to know the symptoms of vitamin B12 deficiency and get medical treatment for it at the earliest.

02/8Pale skin

Lack of vitamin B12 in the body affects the amount of red blood cells in the body and leads to anemia. This affects the color of the skin.Due to vitamin B12 deficiency the skin appears yellowish or has a pale appearance.

03/8Frequent headache

Recurrent episodes of headache, which do not have any other reasons or causes, can be linked to vitamin B12 deficiency especially if other symptoms of it are seen.Headache is said to be a neurological effect of the deficiency of cobalamin.

04/8Gastrointestinal issues

When the body does not have adequate vitamin B12 it leads to gastrointestinal issues like diarrhea, nausea, constipation, and bloating. While these symptoms overlap with several other gastrointestinal issues, if they occur paired with other signs of vitamin B12 deficiency you should get it checked without any delay.

05/8Irritability

Lack of vitamin B12, triggers irritability in an individual. Since the vitamin is linked to the proper functioning of the central nervous system, lack of it can impact your mental health.Several studies have also associated vitamin B12 deficiency with the onset of depression and anxiety.

06/8Other signs of vitamin B12 deficiency

The other signs of vitamin B12 deficiency are: mouth ulcers, pricking sensation in the body, disturbed vision, and decline in cognitive function.Vitamin B12 induced anemia causes extreme fatigue, lethargy, breathlessness, feeling faint, palpitations and sometimes tinnitus.

Vitamin B12 deficiency: Five areas on your body that can show signs

Vitamin B12 deficiency: Signs of ‘neurologic damage’ caused by low vitamin B12 in the body

07/8Who is at more risk of having vitamin B12 deficiency?

Though vitamin B12 deficiency can happen to anyone, there are certain groups of people who are more at risk of developing this condition:The gastrointestinal health of older adults affects the body’s ability to absorb vitamin B12 as a result of which they are at a higher risk of getting deficient in the vitamin.People with pernicious anemia, an autoimmune disease are also likely to be deficient in vitamin B12.Individuals who have celiac’s disease and Crohn’s disease are also likely to be deficient in cobalamin.People who consume less or no animal products or are strictly vegetarian tend to have lower levels of vitamin B12.

08/8How to prevent vitamin B12 deficiency?

The golden method to prevent the deficiency of vitamin B12 in the body is by consuming foods that are rich in the said vitamin. Vitamin B12 is found abundantly in animal food products. Foods like red meat, fish, poultry, eggs and dairy products.If you are deficient in the vitamin you can have fortified foods that have vitamins added to them. Another way to improve the body’s ability to absorb more vitamin B12 is by checking for gastrointestinal issues like Crohn’s disease or Celiac disease.

Does type 2 diabetes require insulin?


Type 2 diabetes occurs when the body does not make enough insulin or use it correctly. Some people require insulin, while others can manage their blood sugar levels through diet and exercise.

The Centers for Disease Control and Prevention (CDC)Trusted Source state that diabetes affects 37 million people in America, and about 90–95% have type 2 diabetes. It occurs when cells in the body do not respond to the insulin produced by the pancreas.

Insulin works to regulate blood sugar in the cells for energy. The pancreas continues to produce insulin but eventually cannot keep up with the body’s needs, and blood sugar levels rise. High blood sugar can cause problems with major organs such as the heart, kidneys, and eyes.

Type 2 diabetes may be manageable with diet and exercise or with a combination of healthy eating, exercise, insulin, or other medications.

Regardless of the treatment protocol, blood sugar checks must occur regularly.

This article discusses why doctors recommend insulin for some people with type 2 diabetes. It also outlines the benefits and risks of insulin and lists other treatments for the condition.

Does type 2 diabetes require insulin?

A person with type 2 diabetes doing a finger prick test-1.

People with type 2 diabetes may require insulin but not always. Some people can manage their blood sugar with a healthy diet and exercise, according to the American Diabetes Association (ADA). However, not everyone with type 2 diabetes can go without insulin or other medication, even with diet and exercise management.

Even if insulin is not a regular partTrusted Source of an individual’s diabetes management, it may become necessary at certain times, such as during pregnancy or hospitalization.

When might doctors recommend insulin?

Once tests confirm that a person has diabetes, a doctor may prescribe certain medications to help manage blood sugar. Then, over weeks, months, or longer, while monitoring blood sugar levels, the doctor may determine that adding insulin is the best course of action to stabilize blood sugar levels.

Benefits of insulin

Insulin medication is a substitute for the insulin that the body produces. It helps move sugar from the blood to other tissues, which use it for energy. It also minimizes sugar production in the liver.

Maintaining stable blood sugar can help people avoid health conditions such as:

Potential side effects of insulin

Taking insulin requires monitoring food intake and activity. A common side effect is hypoglycemia, or low blood sugar, often caused by:

Low blood sugar can usually stabilize by eating something that contains sugar.

Other side effects related to insulin injections include:

  • itching and swelling at the injection site
  • fat buildup or breakdown at the injection site
  • weight gain
  • constipation

Treatment for type 2 diabetes

There are several treatment options for type 2 diabetes, including diet, exercise, and medications.

Diet

According to the ADA, there is no perfect diet for managing diabetes. After extensive research, they concluded that everybody responds uniquely to different foods. However, there are a few fundamental guidelines.

The ADA recommends the diabetes plate method. People with diabetes should fill half the plate with nonstarchy vegetables, one-quarter with lean protein, and one-quarter with healthy carbohydrates.

If possible, people can work with a registered dietitian or nutritionist to create a balanced, sustainable eating plan.

Exercise

One 2018 studyTrusted Source evaluated the safety and effectiveness of different types of exercise for people with type 2 diabetes. They focused on aerobic, anaerobic, and resistance training exercise.

The researchers concluded that adults with diabetes should seek to perform 150 minutes per week of moderate-intensity aerobic exercise across at least 3 days, with no more than two consecutive days without exercise. If there are no limitations, people should practice resistance training twice a week.

Medication

Doctors may prescribe different classes of drugs to lower blood sugar. These include:

  • Alpha-glucosidase inhibitors: These block the breakdown of starches and sugars to slow the increase in blood sugar following a meal.
  • Biguanides: Also known as metformin, biguanides decrease glucose produced by the liver.
  • Bile acid sequestrants: These help remove cholesterol from the body, which can rise with type 2 diabetes.
  • Dopamine-2 agonists: These lower blood sugar following meals.
  • DPP-4 inhibitors: These help the body make more insulin only when it’s needed and results in lower elevated blood sugar levels.
  • Meglitinides: People take meglitinides before meals to stimulate the release of insulin.
  • SGLT2 inhibitors: These help the body secrete excess glucose in urine.
  • Sulfonylureas: These stimulate beta cells in the pancreas to release more insulin.
  • Thiazolidinediones: These increase the insulin action in fat and muscle and lower glucose production in the liver.

Summary

Type 2 diabetes is the most common form of diabetes. It develops when the body fails to make or use insulin correctly.

Some people can manage the condition through dietary changes and exercise. Other people take prescription medications, and some take insulin if a doctor prescribes it.

A doctor may recommend insulin if a person’s blood sugar levels are unstable. Insulin has few side effects, but reactions at injection sites and weight gain may occur.

Eating a healthy diet and being physically active can help stabilize blood sugar and improve overall health and well-being.

Dormant cancer cells camouflage to resist radiotherapy


Some tumor cells were found to survive a bout of radiotherapy, eluding researchers by camouflaging as normal cells.

Cancerous cells

When Wilhelm Conrad Roentgen produced the first X-ray image in 1895, he probably did not suspect that he would win the Nobel Prize for it a mere six years later. But X-rays soon proved to be an invaluable tool not only for imaging, but also for therapy. Weeks after Roentgen’s discovery, a woman with breast cancer was irradiated and by the end of 1896, the therapeutic potential of X-rays on cancers was established by several researchers.

Today, radiotherapy is a standard treatment for several types of cancers, but a new paper in Advanced Science has discovered that radiated cells can enter a “dormant” state that makes them resistant to the therapy. The results have been shown for colon cancer both in the lab and in mice and could help design new treatments to improve the outcome of radiotherapy in patients.

The birth of radiobiology

Back when X-rays were first used, little was known about their effects on cells. The reason was simple: cell cultures, and hence the possibility to experiment directly with them in the lab, were only developed half a century later. In the 1950s, researchers started irradiating cancer cells and studying their response, and the field of radiobiology was born.

Soon after, scientists realized that irradiated cancer cells often grew much bigger than normal, as is common for cells that are about to die. This was taken to be a very good sign that radiation had the desired effect in killing tumor cells and became a textbook feature of radiotherapy. But when co-author Qian Huang was a visiting professor at Duke University ten years ago and observed this phenomenon on some colon cancer cells, she was surprised.

Huang is a cancer biologist who had never seen these “giant” cells before. “She’s not a traditional radiobiologist,” said Chuan-Yuan Li, professor of Pharmacology and Cancer Biology at Duke and co-author of the paper. So, Huang decided to isolate those cells and discovered they could actually grow again. “That’s new,” observed Li.

“Giant” cells camouflage as normal

Huang decided to investigate this further together with Li and a team at the Shanghai Jiao Tong University School of Medicine where she is now professor of pathology and oncology. Years of research showed that, indeed, these “giant” cells could survive a bout of radiotherapy. After a long enough wait, they could even repair themselves and become almost normal.

The colon cancer cells the team used are known to form tumors in immunodeficient mice that mimic human tumors very reliably, so they decided to try and verify their results in vivo. Indeed, giant cell formation occurred, but after two to three weeks, the tumor cells camouflaged as normal ones.

“In the past, when people would see [the cells] normalized after a long time, they thought they just disappeared — they’re gone! Because we didn’t look carefully in the middle, what happened [so we thought] the giant cells must have died,” explained Li. “But with new technology,” he added, “you can take movies in real time all the time, and then you can see these cells are actually alive and well, they just stay put for a while, then they split into smaller, normal-looking cells.”

A good analogy for this phenomenon can be found in chemotherapy in which this is a key feature behind relapse. “You don’t see [a dormant cell], but after a while, that cell reactivates again, it starts to grow again and produce daughter cells, it divides and so the tumor regenerates,” said Eva Galán Moya, researcher in oncology at the University of Castilla-La Mancha in Spain who was not involved in the study.

Genetic traits might be key to finding new treatments

The team at Duke and Shanghai also analyzed the genetic signatures of the newly identified cells. They found that these cells have distinct genetic traits which are also associated with the success of the radiotherapy treatment. “Cells with giant cell formation signatures can predict radiotherapy outcome,” said Li.

This opens a door towards designing a way to improve radiotherapy results. If giant cells can be targeted with drugs so that they become more sensitive to radiation, the therapy might be more successful overall. “It’s true that [these cells] should become a therapeutic target,” said Galán Moya.

A crucial complement to this strategy, she added, is to block the communication between the tumor and its surrounding cells. Sometimes, the memory in the surrounding cells can cause the cancer to reactivate, a phenomenon which is often overlooked when designing treatments.

First, though, the researchers plan to check whether the results they observed in mice with colon cancer hold in human patients across a wide range of cancers that are being actively treated with radiotherapy. They will have to take samples before and after radiation to confirm the dormant behavior and perform genetic analysis in order to find out whether the same traits hold across all cancers.

The process will be lengthy as working with human patients requires time, but the potential for avoiding relapse after radiotherapy is certainly worth the wait.

How To Improve Your Sleep with Blood Sugar?


Sometimes, you may go to bed later than you’d want since you’re trying to juggle too many things only to wake up with a bad headache or drowsiness. Over time, not getting enough sleep raises the chance of developing type 2 diabetes, cardiovascular disease, obesity, and depression.

Lack of sleep has far-reaching consequences for blood sugar levels, influencing everything from food intake to insulin sensitivity to mood.

Getting enough shut-eye is crucial to controlling your diabetes and it also benefits from feeling refreshed and improving your mood.

Ways To Improve Your Sleep with Blood Sugar

The term “sleep hygiene” is used to refer to a set of habits that may be adopted into one’s daily routine to improve your sleep quality.  You may improve your sleep hygiene with optimum blood sugars by doing simple things on your own at home.

If you want to get better sleep with diabetes, consider these suggestions.

  • Prioritise Maintaining Healthy Blood Sugar Levels

If you have trouble sleeping, controlling your high blood sugar levels may help, because persistent high blood sugars may make lead to irritable mood and need to go to toilet frequently. Doctors suggest eating low-glycemic meals to prevent the highs and lows in blood sugar that might cause insomnia.

  • Engage in Regular Physical Exercise

Regular exercise may help you get a better night’s rest. Experts claim that exercise aids in controlling blood sugar levels. Minimum 30 minutes or optimally 45-60 minutes exercise is necessary for all individuals daily.

  • Maintain a Healthy Body Mass Index

Set weight reduction and management goals with your doctor if you’re overweight. Williams claims that reducing your weight by only 10 per cent will improve your management of blood sugar, as well as lower your chances of depression and sleep apnoea.

  • Increase Your Protein Intake for More Energy

Regarding protein, researchers suggest prioritising foods like chicken, eggs, seafood and pulses may add protein in diet without any supplements. Blood sugar levels may be better controlled when protein is consumed regularly throughout the day. You may take help of your doctor and dietitian to optimise protein content in your diet.

  • Get Rid of Interruptions

The bedroom is used for sleeping and nothing else. Too much light from electronics like TVs, phones, tablets, radios and even clock might prevent you from falling asleep and staying asleep. Your mobile phone should only be used for emergency calls if you keep it beside your bed.

  • Put on Some Background Music

It’s very uncommon for some individuals to be able to sleep through the sound of a siren, a dog barking, or even a very loud television. Some people aren’t as fortunate as others and find themselves tossing and turning at the slightest sound or sensation that isn’t familiar.

Sound machines for sleep provide low-level calming noises to block out undesired noise, so you may leave the fan on or play a natural sounds CD. In addition, using thick curtains in the bedroom might assist bringing down any irritating noises from the outside.

  • Turn Down the Heat

Did you know that sleeping in a room with temperatures above 75 degrees Fahrenheit or below 54 degrees Fahrenheit might cause you to wake up? The recommended temperature range, according to experts, is between 60 to 70 degrees Fahrenheit (around 20-degree Celsius). Although researchers have not yet determined the perfect temperature for sleeping, they agree that a slightly colder environment promotes more restful sleep.

  • Make It Comfortable for Sleeping

The quality of your sleep is highly influenced by the conditions in your bedroom. Get a good pillow and mattress to help you sleep. Keep indoor temps from being too hot or too chilly. And keep the natural and artificial light levels to a minimum.

  • Aromatise the Bed

Seventy-one per cent of people report sleeping better on freshly laundered linens, but who has that much spare time? Instead, fill a spray bottle with water and a few drops of essential oil, such as lavender or chamomile, and spritz the bedding. Those two aromas may aid in achieving good quality sleep.

  • Stack Your Pillows

According to a recent National Sleep Foundation survey, sleep professionals agree that having soft pillows and a firm mattress is essential for a restful night’s sleep. If your head is bent back or elevated up, purchase a cushion that puts your head and neck in a better posture to prevent strain and cramps.

To avoid neck and back pain, it is recommended that people who sleep on their backs put an extra pillow under their knees and a small pillow under their lower back, while those who sleep on their sides should place a flat cushion in the space between their knees. Those who sleep on their stomachs should place a pillow under their hips. Additionally, it’s crucial to have a mattress that provides enough support.

Conclusion

You, as a diabetic, are undoubtedly aware of the significance of a healthy diet, regular exercise, and the proper use of medication. Getting enough sleep to have normal sugar levels is crucial for maintaining a healthy life. Suppose you regularly get fewer than six hours of sleep every night, in that case, your blood sugar levels will likely be higher than average.