In October 2015, the Cancer Research UK Grand Challenge was launched to tackle seven of the toughest challenges in understanding and managing cancer. The second challenge in the series posed the question: is it possible to wipe out the cancers caused by an infection due to Epstein Barr Virus?
The Epstein-Barr virus is a very common viral infection affecting humans. Approximately 19 adults in every 20 carry this virus. However, in most cases, it does not cause any harm to the human body. But, in some people, it can cause cancer.
In fact, it was the first virus that was found to be responsible for causing cancer in humans. Every year, 200,000 new cases of cancer associated with EBV infections are detected.
The most common forms of cancer caused by EBV include lymphoma, cancers affecting the tissue at the back of the throat and nose, and stomach cancer.
The molecules synthesized by EBV can stimulate an uncontrolled division of the infected cells resulting in the development of cancer. However, researchers have found that diet and genetics also play a role in the development of cancer.
During the research, it was found that the incidence of EBV-linked cancers was higher in the China, sub-Saharan Africa and some parts of South-East Asia.
Professor Sir David Lane, the Scientific Director at the Ludwig Institute for Cancer Research, believes that understanding the main trigger behind cancer can help in tackling them in a more efficient ways.
Since some cancers have a known cause, which is EB virus, in this case, they can be prevented by treating the infections successfully before it causes damage to the cells.
The scientists hope that a way to avoid EBV infection would help prevent cancers caused byEpstein-Barr virus and save many lives.
Also, since the virus is known to target the immune cells like lymphocytes, the research is also directed at finding a prevention strategy against EBV-linked cancer by modifying the immune response of the body.
Research related to EBV-linked cancer has been ongoing since more than 50 years. However, Lane believes that the research conducted till now lacked the momentum needed to turn the studies into effective ways to tackle the challenge.
The Grand Challenge might prove to be a significant boost for the efforts in reducing the risk of cancer through the use of immunotherapy.