Sperm stem cells restore male fertility.


Men who lose the ability to produce sperm after chemotherapy might one day be able to regain their fertility. That’s because, for the first time, infertility has been reversed in a male primate using an injection of stem cells.

Cancer drugs often work by destroying rapidly dividing cells, as these are a typical feature of cancer. Unfortunately, the drugs can also kill other rapidly dividing cells, including those that produce sperm. Some men choose to freeze sperm samples before therapy so they can use them for artificial insemination at a later date, but this is not an option for boys who have not yet reached puberty.

Kyle Orwig at the University of Pittsburgh School of Medicine in Pennsylvania may have a solution. He says that while boys don’t make sperm cells, they do possess “spermatogonial” stem cells that will eventually produce them.

To see if these stem cells could be used to restore fertility, Orwig and his team took samples of the cells from the testes of prepubescent and adult male rhesus macaques, and froze them. The monkeys were then given chemotherapy agents known to shut down sperm production. A few months later, the researchers injected each monkey’s own spermatogonial stem cells back into its testes.

 

Sperm production was re-established in nine of the 12 adult animals and started normally in three out of five prepubescent animals once they reached maturity. The resulting sperm were used to fertilise eggs and produce healthy embryos.

“I think this is the best option we have ever had,” says Renee Reijo Pera, director of Stanford University’s Center for Human Embryonic Stem Cell Research and Education, who wasn’t involved in the study. “I know a lot of people have thought about doing this before but no has ever been able to successfully demonstrate this in a clinical setting with a species genetically very similar to us.”

Orwig says there are some concerns that implanting stem cells could reintroduce cancer cells that may have been present in the original tissue. However, centres in the US and Europe are already banking testicular tissue for boys in the hope that new stem cell-based therapies will become available.

“In the most optimistic scenario our research suggests a man could have his own stem cells transplanted, giving him the opportunity to have children via natural intercourse,” Orwig says. It’s not yet ready for clinical translation, he says, “but it’s an important step forward”.

Source: Cell

8 different forms of Ancient Indian Martial Arts.


Martial arts is a part of India’s ancient culture and a traditional games.Originally a traditional form of martial art that started in South India, and now it has different names and different forms in the culture of the regions in India. Khusti The Indian Wrestling is also a part of Indian Martial arts found throughout the India. Indian martial arts has an important influence in the development of modern Asian martial arts. Nowadays a sense of self-defense and for fitness lots of people are opting for martial arts.As in other respects of Indian culture, Indian martial arts can be roughly divided into northern and southern styles.

Kalarippayattu:

Kalarippayattu is a famous Indian martial art from land of attraction Kerala and one of the oldest fighting systems in existence. It is practiced in most of the part of south India. A kalari is the school or training hall where martial arts are taught. It includes strikes, kicks and some weapon based practiced, Footwork patterns is most important key in Kalarippayattu. It is the best Indian martial art that has been used in many movies to make it popular, like Ashoka and The myth.

 

Silambam:

Silambamis a weapon-based Indian martial art from Tamil Nadu. Every states has it own style of martial arts. A wide variety of weapons are used in silamban, some of which are not found anywhere else in the world. Silambam art also used animal movements of snake, tiger, eagle forms and footwork patterns is play a key role here as well. Another part of Silambam is Kuttu varisai, it is the unarmed kind of martial art.

 

Gatka:

Gatkais weapon-based Indian martial art basically created by the Sikhs of Punjab.There are many weapons used in Gatka like, Stick, Talwar, kirpan and kataar. The attacking and defense methods are based upon the positions of the hands feet and nature of weapons used. It is also displayed during the different celebrations or at fairs in Punjab.

 

Musti yuddha:

It is unarmed martial art from the oldest city of India “Varanasi“. Technique used in this martial arts are punches, kicks, knees and elbow strikes. This style is a complete art of physical, mental and spiritual development. This art is very rarely visible but was very popular in middle age.

 

Thang Ta:

Thang Ta is popular term for the ancient Manipuri Martial Art also known as HUYEN LALLONG. Manipuri martial arts with swords and spears, is a strong yet gracefully sophisticated art.

 

Lathi:

Lathi is an ancient armed martial art of India. It also refers one of the world’s oldest weapons used in martial arts. Lathi or stick martial arts practiced in Punjab and Bengal region of India. Lathi still remains a popular sport in Indian villages.

 

Mardani Khel:

Mardani Khel is an armed method of martial art created by the Maratha. This traditional martial art of Maharashtra is practiced in kolhapur.

 

Pari-khanda:

Pari-khandaa style of sword and shield fighting from Bihar. This art is created by the rajputs. Pari-khanda steps and techniques are also used in Chau dance.

 

Source:  http://www.walkthroughindia.com

 

 

Ancient Solar Observatory.


The oldest solar observatory in the Americas has been discovered in coastal Peru, archeologists announced today.

The 2,300-year-old ceremonial complex featured the Towers of Chankillo, 13 towers running north to south along a low ridge and spread across 980 feet (300 meters) to form a toothed horizon that was used for solar observations.

 

Researchers excavated the solar observatory between 2000 and 2003. They found buildings-in exact mirror position of each other-to the east and west of the towers with observation points for watching the Sun rise and set over the toothed horizon.

 

How it works

In addition to the daily east to west motion, our Sun appears to move eastward through the stars in a path known as the ecliptic over the course of a year. Also, the Earth’s axis is not perpendicular to the ecliptic but slanted by an angle of a little over 23 degrees. The combinations of these positions determine where the Sun is above our horizon day by day.

At different times of the year one can observe the Sun rise and set in different spots with respect to our horizon and for different lengths of time. For example, in the Northern Hemisphere, around the summer solstice-which falls on June 21-the Sun rises highest in the sky and stays up longer.

As viewed from the two observing points of Chankillo [image], the spread of towers along the horizon corresponds very closely to the range of movement of the rising and setting positions of the Sun over the year, the authors write in the March 2 issue of the journal Science.

Once the Sun started to move away from any of its extreme positions, like the solstices or equinoxes, the towers and gaps between them provided a means to track the progress of the Sun up and down the horizon, to within a couple of days accuracy.

“Chankillo is arguably the oldest solar calendar that can be identified as such with confidence within the Americas,” said lead study author Ivan Ghezzi from Pontificia Universidad Catolica del Peru.

Tree-ring samples dated these structures back to the fourth century B.C.

“Many indigenous American sites have been found to contain one or a few putative solar orientations,” Ghezzi said. “Chankillo, in contrast, provides a complete set of horizon markers and two unique and indisputable observation points.”

 

How Weather Changed History

Other discoveries

At the end of a 131-foot-long corridor in the building to the west of the towers, the researchers found pottery, shells, and stone artifacts in an area possibly for commoners who participated in rituals linked to solar observations.

Previous studies showed that the Incas-South American Indians who established an empire that once ranged from northern Ecuador to central Chile from 1100 to the 1530s-had built sites to mark solar observations by 1500.

In comparison, the earliest portion of Stonehenge-megalithic ruins in southern England purported to correlate with the rising and setting of the Sun and the Moon-is said to have been completed around 3000 B.C.

The new finding, however, puts Sun cults in the Americas at an earlier date than the Incans.

“Chankillo was built approximately 1,700 years before the Incas began their expansion,” Ghezzi said. “Now we know these practices are quite a bit older and were highly developed by Chankillo’s time.”

 

Beijing Ancient Observatory:

 

museum looks like a turreted tower set in Beijing’s ancient city walls. It is located on the southeast corner of Jianguomen Street in Beijing. When it was originally built, in the Guo Shoujing (1231-1316) period of the Yuan dynasty, it had a slightly different name but the same intent: to explore the heavens. Over the course of more than five hundred years, through Ming and Qing dynasties and on into the period after the Xinhai Revolution (1911), this location has been used to observe phenomena of the skies. This is the longest historical record of using any such observatory for so long. At present, eight large bronze implements for viewing the heavens are arrayed on the top of the museum’s tower; these date from the Qing dynasty. Under the tower is a hall built between the years 1442 and 1446, during the Ming dynasty. To the east and west are subsidiary rooms and other ancient structures.

 

The observatory’s platform, rebuilt in recent years, is 17 meters high and holds exhibition rooms inside. If you walk through the door with the three characters for the observatory carved above it, you find a three-level exhibition space devoted to China’s ancient astronomical accomplishments. A stone-carved star map from Suzhou is exhibited here, as well as the ceiling astronomical map from Longfu Temple, two rare treasures. The former was done in the Song dynasty in the year 1247. It depicts 1,434 stars and is recognized as one of the best early star maps in the world. The latter was accomplished in the Ming period, but from the characters carved on the side of the map one can see that the underlying information already existed in the Tang dynasty. In the courtyard of the museum, surrounded by ancient trees, the hall and east gate areas exhibit early astronomical instruments and the methods and changes in making them. In the western chamber some 150 early methods of calculating calendars in China are exhibited. Archaic as well as more recent astronomical water clocks and contemporary astronomical clocks are exhibited. Eight bronze astronomical instruments are arranged on the top of the platform, as per the Qing-dynasty emperor Qianlong’s instructions.

 

Ancient solar observatory discovered in Peru:

 

The oldest solar observatory in the Americas may have been uncovered in coastal Peru. The ceremonial site provides evidence of sophisticated ‘cults of the Sun’ operating in South America as early as 2300 years ago.

Other ancient structures around the world – such as Stonehenge, which is estimated to be 5000 years old – are aligned with the rising and setting of the Sun on certain days called the solstices. These occur twice a year, around 21 June and 22 December, when the Sun appears to reach its highest point above or below the equator.

Previously, archaeologists had uncovered 4000-year-old gourd fragments in Peru showing images of a “staff god” with rays emanating from its head, perhaps like the Sun (see America’s oldest religious icon revealed).

Historical records also describe “Sun pillars” suggesting that South America’s Incan civilisation was observing the Sun – possibly to help mark when to plant crops – around 1500 AD, though those pillars have since been destroyed. The Incas also held public rituals to observe the Sun rise or set at marked positions on the horizon, and Incan leaders claimed authority to rule through kinship to the Sun.

Now, Ivan Ghezzi of the Instituto Nacional de Cultura in Lima, Peru, and Clive Ruggles of the University of Leicester, UK, say earlier civilisations in Peru may also have been observing the Sun as early as the fourth century BC.

 

Tower ridge

They base their conclusion on ruins at a walled coastal Peruvian site known as Chankillo. Once thought to be part of a fort, ceremonial centre or fortified temple, the researchers now argue the ruin’s central complex may have actually been used as a solar observatory.

Within Chankillo, 13 regularly spaced rectangular towers run the length of a 300-metre ridge like a spine, creating an artificial horizon from some vantage points.

On either side of the ridge are the remains of a western observatory and, lesser so, an eastern observatory, which scientists say were used to watch the Sun rise or set between those towers. On the summer solstice, the Sun rose between Tower 1 and a nearby mountain, Cerro Mucho Malo, and on the winter solstice, the Sun rose around Tower 13.

The Sun appeared for only one or two days in each gap between towers, taking six months to go from one end of the structure to the other. So it is possible the different towers were meant to divide the year into regular intervals lasting about 10 days – the time it takes for sunrises to occur between adjacent towers in the central part of the structure.
Seasonal feasts

The site may have been a place for public rituals and feasts associated with the seasons and the Sun. Excavations have revealed offerings of pottery, shells and other artifacts near an opening at the western observing point.

Researchers say the inhabitants of this site may have been involved in ritualistic practices of passing through a 40-metre-long exterior corridor and standing at the opening to observe the towers.

The specialists who actually tracked the Sun’s motions likely did their work in private while watching the Sun’s light fall onto a wall or through a window, however. “Entry to the observing points themselves appears to have been highly restricted,” the authors write.
Elite class

“Individuals with the status to access them and conduct ceremonies would have had the power to regulate time, ideology, and the rituals that bound this society together,” they continue. “Thus, Sun worship and related cosmological beliefs at Chankillo could have helped to legitimise the authority of an elite class, just as they did within the Inca empire two millennia later.”

David Dearborn, a physicist at Lawrence Livermore National Laboratory in California, US, says the study is very interesting.

“With this abundant evidence for Inca interest in astronomy, and for its use in social organisation, archaeologists have long suspected that earlier cultures also may have engaged in such activities,” he told New Scientist. “Finally, in this work, material evidence is presented that strongly supports such suspicions.”

 

Source: Science

Diabetes linked to flu.


The flu virus has another trick up its sleeve – it may trigger diabetes. The good news is that this discovery may give us a way to prevent some forms of the disease.

In diabetes, cells do not take up sugar from the blood. This can happen because cells have lost sensitivity to the hormone insulin, leading to what is called type 2 diabetes. Linked to diet and lifestyle, this form of the disease is rapidly becoming more common worldwide. Another cause of diabetes happens when the immune system destroys the pancreatic cells that produce insulin. People inherit a genetic predisposition for this condition, called type 1 diabetes, but an environmental trigger is also needed for it to appear.

Since the 1970s, researchers have suspected that viruses may provide this trigger, as type 1 diabetes often sets in suddenly after an infection. Enteroviruses and rotaviruses were both implicated; something about these infections confuses the immune system enough to make it attack the pancreas. But the picture remained unclear.

Then Ilaria Capua, of the World Organisation for Animal Health reference lab for bird flu in Legnaro, Italy, and her team decided to infect turkeys with flu. They did this because they knew birds with flu often have an inflamed pancreas, even when they have strains of the virus that do not normally spread outside the lungs. The team found that many of the turkeys developed severe pancreatic damage and diabetes.

Next, the researchers infected human pancreatic tissue with two common flu viruses. Both “grew really well” in the tissue, including in insulin-producing cells, says Capua.

 

Inflammatory response

Crucially, the presence of flu in the pancreatic cells triggered production of a set of inflammatory chemicals that have been shown to be central to the autoimmune reactions that lead to type 1 diabetes. One theory is that immune cells present bits of the infected tissue to destructive T-cells, to teach them to recognise the virus. But in the process the T-cells also learn to recognise the cells that make insulin, and to destroy them.

Can flu reach the pancreas? In humans, the virus is normally restricted to the lungs and gut, but can sometimes get into the blood. The virus might also travel up the duct that links the small intestine to the pancreas, Capua suspects. “Either way, when it gets to the pancreas it finds a good place to replicate.”

Capua is now testing the effects of flu on mouse models of type 1 diabetes. She is also looking for signs of recent flu infection in people with newly diagnosed diabetes. She suspects the H1N1 swine flu virus that caused the pandemic of 2009, and is still circulating, could be a particularly good trigger. Doctors in Japan and Italy have reported many newly diagnosed cases of type 1 diabetes in people who had recently had flu, and an upsurge in type 1 diabetes after the 2009 pandemic.

 

Real impact

“The great thing is that even if flu only causes a few per cent of type 1 diabetes cases, we can vaccinate and prevent flu in people who are genetically predisposed, and that can have a real impact,” says Capua. There are 65,000 new cases of type 1 diabetes worldwide annually, and that figure is growing by 3 to 5 per cent each year.

The link between diabetes and flu adds to growing evidence that many diseases considered non-infectious are actually caused by infection – and can therefore spread.

There is also new evidence that flu can cause heart attacks. Previously, this was suspected, because of the surge in heart attacks that regularly follows the annual flu season. But researchers at the University of Toronto, Canada, have now demonstrated the effect in individual patients. They reported this week that vaccinating adults for flu, whether they already have cardiac problems or not, makes them half as likely to have a heart attack or stroke in the following year (Canadian Journal of Cardiology, doi.org/jnr).

Source: Journal of Virology