Each year, interpersonal violence is experienced and perpetrated by millions of people worldwide. In 2010, it was the 27th cause of death globally, causing an estimated 456,268 deaths worldwide [1]. Violence against women has been shown to be highly prevalent globally, with partner violence affecting one in three women, and one in 15 women (7%) having been raped by a man who was not a partner [2],[3]. Recognising this huge global burden, the 67th World Health Assembly adopted the resolution “Strengthening the Role of the Health System in Addressing Violence, in Particular against Women and Girls, and against Children” [4] and mandated countries globally to develop violence prevention through their health sector. The goal of reducing violence by 50% over the next 30 years has been mooted by the World Health Organization as a rallying point for the global violence prevention community and was the subject of critical debate at the recent Global Violence Reduction Conference 2014 at King’s College, Cambridge University, UK, which was hosted by the Institute of Criminology Violence Research Centre and the World Health Organization [5]. Whilst ostensibly ambitious, several high-income countries, including the United States, have reduced rates of some forms of violence by 50% or more over a very short period of time, and such reductions are supported by historical trends of reduced homicide over several centuries in several European countries[6]–[8]. There is no real evidence, however, that violence against women is reducing in low- and middle-income countries [3]. Indeed, in South Africa, where there has been considerable gender activism and growth in women’s empowerment, non-fatal rape and intimate partner violence seem quite resistant to change, notwithstanding the measured reductions in female homicide [9],[10]. The key question, then, is how can we secure substantial reductions in violence against women in low- and middle-income countries?

Reducing Fragmentation of Research Efforts

One challenge for the violence research community is to build a stronger knowledge base comprised of research from across multiple research disciplines and relevant to different forms of violence. Currently, knowledge production is largely siloed, with researchers focused on specific forms of violence, yet there are enormous overlaps between forms of violence. For example, knowledge sharing between the fields of youth violence prevention and gender-based violence prevention is limited, and yet rape is an important form of youth violence [11],[12]. The same was true, until fairly recently, between the child abuse prevention and gender-based violence fields. Here there are increasing moves—for example, by the Sexual Violence Research Initiative and donors such as the UK Department for International Development—to address the two problems together, recognising that childhood adversity is an important risk factor for violence against women, as well as the conceptual difficulties of imposing a distinction between rape of younger and older females [13],[14].

Different research disciplines have, over the years, brought different strengths and insights to the field of violence prevention, and have their own limitations. Inter-disciplinary research is needed to build on the strengths of, and avoid conceptual stunting by boundaries of thought within, particular research disciplines. For example, standard epidemiological approaches to research have often served to accentuate differences (e.g., in types of violence and types of risk factors and behaviour) through the reduction of violence, factors, and behaviour into measurable units for surveys, and have rarely encouraged avenues of analysis that deepen understanding of latent (unmeasurable) constructs, such as constructions of masculinity and femininity. One of the most important advances in understanding violence causation has been at the nexus of sociology and epidemiology, through the application of gender theory—in particular, understanding patterns of risk factors stemming from underlying groups of behaviours that map onto constructions of masculinity [12],[15],[16].

Prioritising Evidence-Based Approaches

Stakeholders must give more recognition to the science of preventing violence against women. Gender-based violence has been an underdeveloped and underfunded field, notwithstanding the systematic development and remarkable innovation of some violence prevention interventions [17]–[19]. Recent reviews of evidence have highlighted that gender-based violence prevention interventions and strategies are often developed ad hoc, with limited opportunity to learn from intervention success or failure. Furthermore, adoption of interventions in different settings often has more to do with effective marketing than with scientific evidence[20]. Building evidence-based interventions and prevention strategies requires theory to be applied at multiple levels [15], including understanding risk factors and understanding the theory of the problem to be tackled, for example, understanding in a broad theoretical sense how gender inequity or social norms operate. Application of theory also requires an understanding of what drives and enables change, for example, how approaches that view social settings or institutions ecologically (i.e., as systems that have social norms that influence behaviour, as well as individual factors and policies/laws and institutional practices) may be necessary to secure change in them [21]. It also requires an understanding of methods that are effective for achieving changes (e.g., awareness raising or behaviour change) in specific populations and settings. There is a need to develop packages of interventions or intervention strategies that can be applied at scale. However, a balance needs to be struck so that local innovation and acknowledgment of complexity and differences between contexts can be accommodated.

Where there are more rigorous evaluations, the shortage of funds has resulted in a literature that is characterised by under-powered studies, and heated debate over whether interventions would have “worked” if they had been larger [22],[23]. There is no recognisable product pipeline, and only a handful of organisations globally have ever produced (or adapted) more than one theoretically grounded intervention to reduce violence against women. It’s hard to see how these problems can be addressed without large and long-term funding for centres of excellence in gender-based violence intervention development—centres that develop and improve multiple interventions, coordinate testing and trials so that evaluations are comparable, and focus on development of appropriate human resources.

Funding a Violence Prevention Pipeline

There is a pressing need to change the global architecture of the violence prevention field to foster the science of gender-based violence prevention, and there are important lessons to learn here from fields like drug discovery. The limited funding for violence prevention has been largely responsible for the fragmentation of the field, and to date, there has been limited support from very large donors. The Department for International Development’s £25 million research and innovation fund “What Works to Prevent Violence against Women and Girls” is the first large investment to systematically build the field. Substantial advances in intervention development require proper investment and deployment of highly trained, creative minds. Perhaps there is a need to replicate the product pipeline seen in, for example, microbicide development, with some form of equivalent of scientifically based progress from early stage concepts, to pre-clinical research, to phase 1–3 trials. The microbicide development field has been coordinated by the Alliance for Microbicide Development in a way that is completely unparalleled in violence prevention, and this coordination has been essential for the speed and scale of R&D that has been undertaken [24]. A strong prevention knowledge platform requires large donors to come to the table in violence prevention and provide sustainable funding for the architecture of the field, so that physical or virtual centres of excellence can be established, research can be coordinated, and the skills, knowledge, and experience required can be nurtured and sustained.

Changes in the violence prevention field needed to reach ambitious targets for reducing violence against women require a much deeper understanding across policy makers and donors of the preventability of violence. The evidence of change from the United States and other countries in this regard is crucial [6],[7]. We have to build recognition that reducing rates of violence globally by 50% within 30 years is not just something that must happen, but it’s something that can happen. Achieving this requires significant changes to the gender-based violence prevention field, and a new era of large-scale funding and coordination.