University of California Santa Barbara

DNA clamp to grab cancer before it develops.

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As part of an international research project, a team of researchers has developed a DNA clamp that can detect mutations at the DNA level with greater efficiency than methods currently in use. Their work could facilitate rapid screening of those diseases that have a genetic basis, such as cancer, and provide new tools for more advanced nanotechnology. The results of this research is published this month in the journal ACS Nano.

Toward a new generation of screening tests

An increasing number of genetic mutations have been identified as risk factors for the development of cancer and many other diseases. Several research groups have attempted to develop rapid and inexpensive screening methods for detecting these mutations. “The results of our study have considerable implications in the area of diagnostics and therapeutics,” says Professor Francesco Ricci, “because the DNA clamp can be adapted to provide a fluorescent signal in the presence of DNA sequences having mutations with high risk for certain types cancer. The advantage of our fluorescence clamp, compared to other detection methods, is that it allows distinguishing between mutant and non-mutant DNA with much greater efficiency. This information is critical because it tells patients which cancer(s) they are at risk for or have.”

“Nature is a constant source of inspiration in the development of technologies,” says Professor Alexis Vallée-Bélisle. “For example, in addition to revolutionizing our understanding of how life works, the discovery of the DNA double helix by Watson, Crick and Franklin in 1953 also inspired the development of many diagnostic tests that use the strong affinity between two complementary DNA strands to detect mutations.”

“However, it is also known that DNA can adopt many other architectures, including triple helices, which are obtained in DNA sequences rich in purine (A, G) and pyrimidine (T, C) bases,” says the researcher Andrea Idili, first author of the study. “Inspired by these natural triple helices, we developed a DNA-based clamp to form a triple helix whose specificity is ten times greater than a double helix allows.”

“Beyond the obvious applications in the diagnosis of genetic diseases, I believe this work will pave the way for new applications related in the area of DNA-based nanostructures and nanomachines,” notes Professor Kevin Plaxco, University of California, Santa Barbara. “Such nanomachines could ultimately have a major impact on many aspects of healthcare in the future.”

“The next step is to test the clamp on human samples, and if it is successful, it will begin the process of commercialization,” concludes Professor Vallée-Bélisle.

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Artist’s rendering of the discovery: the research team took advantage of the ability of certain DNA sequences to form a triple helix, in order to develop a DNA clamp. This nanometer-scale clamp recognizes and binds DNA sequences more strongly and more specifically, allowing the development of more effective diagnostic. Professor Alexis Vallée-Bélisle, Department of Chemistry, Université de Montréal worked with the researcher Andrea Idili and Professor Francesco Ricci of the University of Rome Tor Vergata, and Professor Kevin W. Plaxco, University of California Santa Barbara, to develop this diagnostic nanomachine

Accumulating ‘microplastic’ threat to shores.

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Debris on shoreline (Image: AP)
Concentrations of microplastic were greatest near coastal urban areas, the study showed

Microscopic plastic debris from washing clothes is accumulating in the marine environment and could be entering the food chain, a study has warned.

Researchers traced the “microplastic” back to synthetic clothes, which released up to 1,900 tiny fibres per garment every time they were washed.

Earlier research showed plastic smaller than 1mm were being eaten by animals and getting into the food chain.

The findings appeared in the journal Environmental Science and Technology.

“Research we had done before… showed that when we looked at all the bits of plastic in the environment, about 80% was made up from smaller bits of plastic,” said co-author Mark Browne, an ecologist now based at the University of California, Santa Barbara.

“This really led us to the idea of what sorts of plastic are there and where did they come from.”

Dr Browne, a member of the US-based research network National Center for Ecological Analysis and Synthesis, said the tiny plastic was a concern because evidence showed that it was making its way into the food chain.

“Once the plastics had been eaten, it transferred from [the animals’] stomachs to their circulation system and actually accumulated in their cells,” he told BBC News.

In order to identify how widespread the presence of microplastic was on shorelines, the team took samples from 18 beaches around the globe, including the UK, India and Singapore.

“We found that there was no sample from around the world that did not contain pieces of microplastic.”

Scanning microscope image of nylon fibres
The smallest fibres could end up causing huge problems worldwide

Dr Browne added: “Most of the plastic seemed to be fibrous.

“When we looked at the different types of polymers we were finding, we were finding that polyester, acrylic and polyamides (nylon) were the major ones that we were finding.”

The data also showed that the concentration of microplastic was greatest in areas near large urban centres.

In order to test the idea that sewerage discharges were the source of the plastic discharges, the team worked with a local authority in New South Wales, Australia.

“We found exactly the same proportion of plastics,” Dr Browne revealed, which led the team to conclude that their suspicions had been correct.

As a result, Dr Browne his colleague Professor Richard Thompson from the University of Plymouth, UK carried out a number of experiments to see what fibres were contained in the water discharge from washing machines.

“We were quite surprised. Some polyester garments released more than 1,900 fibres per garment, per wash,” Dr Browne observed.

“It may not sound like an awful lot, but if that is from a single item from a single wash, it shows how things can build up.

“It suggests to us that a large proportion of the fibres we were finding in the environment, in the strongest evidence yet, was derived from the sewerage as a consequence from washing clothes.”

Just Thinking about Science Triggers Moral Behavior.

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Psychologists find deep connection between scientific method and morality.

 

 
 just-thinking-about-science-triggers-moral-behavior_1

Public opinion towards science has made headlines over the past several years for a variety of reasons — mostly negative. High profile cases of academic dishonesty and disputes over funding have left many questioning the integrity and societal value of basic science, while accusations of politically motivated research fly from left and right. There is little doubt that science is value-laden. Allegiances to theories and ideologies can skew the kinds of hypotheses tested and the methods used to test them. These, however, are errors in theapplication of the method, not the method itself. In other words, it’s possible that public opinion towards science more generally might be relatively unaffected by the misdeeds and biases of individual scientists.  In fact, given the undeniable benefits scientific progress yielded, associations with the process of scientific inquiry may be quite positive.

Researchers at the University of California Santa Barbara set out to test this possibility. They hypothesized that there is a deep-seated perception of science as a moral pursuit — its emphasis on truth-seeking, impartiality and rationality privileges collective well-being above all else. Their new study, published in the journal PLOSOne, argues that the association between science and morality is so ingrained that merely thinking about it can trigger more moral behavior.

The researchers conducted four separate studies to test this. The first sought to establish a simple correlation between the degree to which individuals believed in science and their likelihood of enforcing moral norms when presented with a hypothetical violation. Participants read a vignette of a date-rape and were asked to rate the “wrongness” of the offense before answering a questionnaire measuring their belief in science. Indeed, those reporting greater belief in science condemned the act more harshly.

Of course, a simple correlation is susceptible to multiple alternative explanations. To rule out these possibilities, Studies 2-4 used experimental manipulations to test whether inducing thoughts about science could influence both reported, as well as actual, moral behavior. All made use of a technique called “priming” in which participants are exposed to words relevant to a particular category in order to increase its cognitive accessibility. In other words, showing you words like “logical,” “hypothesis,” “laboratory” and “theory” should make you think about science and any effect the presentation of these words has on subsequent behavior can be attributed to the associations you have with that category.

Participants first completed a word scramble task during which they either had to unscramble some of these science-related words or words that had nothing to do with science. They then either read the date-rape vignette and answered the same questions regarding the severity of that transgression (Study 2), reported the degree to which they intended to perform a variety of altruistic actions over the next month (Study 3), or engaged in a behavioral economics task known as the dictator game (Study 4). In the dictator game the participant is given a sum of money (in this case $5) and told to divide that sum however they please between themselves and an anonymous other participant.  The amount that participants give to the other is taken to be an index of their altruistic motivation.

Across all these different measures, the researchers found consistent results. Simply being primed with science-related thoughts increased a) adherence to moral norms, b) real-life future altruistic intentions, and c) altruistic behavior towards an anonymous other. The conceptual association between science and morality appears strong.

Though this finding replicates across different measures and methods, there’s one variable that might limit the generalizability of the effect. There is some evidence suggesting that attitudes towards science vary across political parties with conservatives having become decreasingly trustworthy of science over the past several decades. Though the researchers did include measures of religiosity in their studies, which did not affect the relationship between science and morality, ideally they would have also controlled for political affiliation. It’s not a stretch to imagine that undergraduate students at the University of Santa Barbara disproportionately represent liberals. If so, the relationship between science and morality found here might be stronger in self-described liberals.

That said, there’s also reason to believe that the general public, liberal or conservative, can draw a distinction between the scientific process and its practitioners. In the same way that people might mistrust politicians but still see nobility in the general organizing principles of our political structure, we could hold charitable views of science independent of how it might be conducted.

These results might seem encouraging, particularly to fans of science. But one possible cost of assigning moral weight to science is the degree to which it distorts the way we respond to research conclusions. When faced with a finding that contradicts a cherished belief (e.g. a new study suggesting that humans have, or have not, contributed to global warming), we are more likely to question the integrity of the practitioner. If science is fundamentally moral, then how could it have arrived at such an offensive conclusion? Blame the messenger.

How can we correct this thought process?  A greater emphasis on, and better understanding of, the method might do the trick. It’s significantly harder to deny the import of challenging findings when you have the tools necessary to evaluate the process by which scientists arrived at their results. That new study on global warming is tougher to dismiss when you know (and care enough to check) that the methods used are sound, regardless of what you think the authors’ motivations might be. In the absence of such knowledge, the virtue assigned to “science” might also be a motivational force for ideological distortion, the precise opposite of impartial truth-seeking.

Source: scientificamerican.com

Vitamins Offer Hope for Alzheimer’s.

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Story at-a-glance

  • Alzheimer’s disease is currently at epidemic proportions, with 5.4 million Americans—including one in eight people aged 65 and over—living with it. There is no known cure, and few truly effective treatments
  • Research suggests the best hope is in prevention focusing on diet, exercise and staying mentally active.
  • Two recent studies show that compounds in cinnamon, and vitamins B12, B6, and folate may delay the onset and/or slow progression of the disease
  • Vitamin treatment consisting of 0.8 mg folic acid, 20 mg vitamin B6 and 0.5 mg vitamin B12 slowed shrinkage of the whole brain volume over the course of two years
  • The vitamin treatment also reduced, by as much as seven-fold, the cerebral atrophy in certain brain regions that are particularly vulnerable to damage associated with Alzheimer’s disease
  • Research suggests that being exposed to general anesthesia can increase the risk of dementia in the elderly by as much as 35 percent.
  • cinnamon

In the United States, Alzheimer’s disease is currently at epidemic proportions, with 5.4 million Americans—including one in eight people aged 65 and over—living with the disease, according to the Alzheimer’s Association’s 2011 Alzheimer’s Disease Facts and Figures1.

By 2050, this is expected to jump to 16 million, and in the next 20 years, it is projected that Alzheimer’s will affect one in four Americans, rivaling the current prevalence of obesity and diabetes.

There is still no known cure for this devastating disease, and very few treatments.Alzheimer’s drugs are often of little to no benefit at all, which underscores the importance of prevention throughout your lifetime.

Research repeatedly suggests the best hope for patients lies in prevention through optimal diet, exercise and staying socially and mentally active. As recently reported by Forbes2:

“[A] new study in Science suggested that last year’s ‘breakthrough’ pharmaceutical, bexarotene (Targretin) – a cancer drug that had initially received wide publicity for helping break up the plaques in Alzheimer’s – doesn’t seem to do this very well at all, and can have significant adverse side effects for the patient.

‘Something happened in that initial report – either something technically or otherwise, which we can’t put our hands on at this point in time,” study author Sangram Sisodia told US News & World Report. ‘Something is seriously wrong.’

While memory loss is common among Westerners, it is NOT a “normal” part of aging. Research has shown that even mild “senior moments” are caused by the same brain lesions associated with Alzheimer’s disease and other forms of dementia. These cognitive changes are by no means inevitable!

People who experience very little decline in their cognitive function up until their deaths have been found (post-mortem) to be free of brain lesions, showing that it’sentirely possible to prevent the damage from occurring in the first place. At the end of this article, I share my best tips for maintaining healthy brain function well into old age.

In recent years, researchers studying natural compounds have offered new hope. For example, two recent studies suggest that compounds in cinnamon, as well as vitamins B12, B6, and folate may delay the onset and/or slow progression of the disease.

The Promise of Cinnamon and Vitamins in the Fight Against Alzheimer’s Disease

The first study in question, published in the Journal of Alzheimer’s Disease3,found that cinnamaldehyde and epicatechin, two compounds found in cinnamon, have an inhibitory effect on the aggregation of a particular protein called tau. Tau plays a large role in the structure and function of neurons.

But while a normal part of cell structures, this protein can begin to accumulate, forming “neurofibrillary tangles” that are a hallmark of Alzheimer’s disease. Both compounds were found to protect tau from oxidative damage that can lead to dysfunction.

Donald Graves, adjunct professor in UCSB‘s Department of Molecular, Cellular, and Developmental Biology and co-author of the study explained the protective process to Medical News Today4:

“‘Take, for example, sunburn, a form of oxidative damage. If you wore a hat, you could protect your face and head from the oxidation. In a sense this cinnamaldehyde is like a cap. While it can protect the tau protein by binding to its vulnerable cysteine residues, it can also come off,’ Graves added, which can ensure the proper functioning of the protein.”

It’s interesting to note that there’s a high correlation between type 2 diabetes and Alzheimer’s disease. Some even believe Alzheimer’s may be a form of brain diabetes. Insulin and insulin receptors in your brain are crucial for learning and memory, and it’s known that these components are lower in people with Alzheimer’s disease.

In addition to the above findings, cinnamon has also been found to have beneficial effects on blood glucose management in type 2 diabetics. This is one of the reasons I include cinnamon in my healthy coconut candy recipe.

B Vitamins Again Show Promise in Alzheimer’s Prevention

The other study, published in Proceedings of the National Academy of Sciences5, found that vitamins B6, B12, and folic acid may help slow the progression of the disease, confirming and supporting previous studies. As reported in the featured article6:

“The fact that B-family vitamins may play a significant role in dementia, or more specifically in warding it off has been consistently illustrated. What is news from the current study, however, is that high-dose B-vitamin treatment in people at risk for the disease ‘slowed shrinkage of whole brain volume,’ and especially reduced shrinkage in areas known to be affected in Alzheimer’s disease.”

The 156 study participants, all of whom were over the age of 70, were diagnosed with mild cognitive impairment. This, along with midlife hypertension, midlife obesity and diabetes, is a known risk factor for Alzheimer’s. One group of participants received a placebo while the other received high-dose B-vitamin treatment consisting of:

  • 0.8 mg folic acid
  • 20 mg vitamin B6
  • 0.5 mg vitamin B12

It is important to note that vitamin B12 comes in many forms and it is typically injected because it is not absorbed well by most people, especially in the elderly who need it most. This is due to it being one of the largest vitamins known. The most common form is cyanocobalamin but a better from would be methylcobalamin. A better alternative to B12 injections would also be sublingual sprays, which are absorbed very similarly to the injections.

The treatment effectively slowed shrinkage of the whole brain volume over the course of two years. It also reduced, by as much as seven-fold, the cerebral atrophy in certain brain regions that are particularly vulnerable to damage associated with Alzheimer’s disease. Another major boon: The supplements cost less than 50 cents a day and are readily available in pharmacies and health-food stores. In the placebo group, higher homocysteine levels at baseline were associated with faster atrophy in these same regions. According to the researchers7:

“We… show that the beneficial effect of B vitamins is confined to participants with high homocysteine… and that, in these participants, a causal Bayesian network analysis indicates the following chain of events: B vitamins lower homocysteine, which directly leads to a decrease in gray matter atrophy, thereby slowing cognitive decline.

Our results show that B-vitamin supplementation can slow the atrophy of specific brain regions that are a key component of the AD process and that are associated with cognitive decline.”

Dr. A. David Smith, professor emeritus of pharmacology at Oxford University, founding director of the Oxford Project to Investigate Memory and Ageing, and senior author of the study told Bloomberg News8 that this B-vitamin treatment is “the first and only disease-modifying treatment that’s worked. We have proved the concept that you can modify the disease.” This shouldn’t come as a surprise to anyone who understands that without proper nutrition and exercise, your brain will be increasingly vulnerable to damage with age…

Vitamin B Cocktail Already Used for Dementia Prevention in Sweden

Three years ago, the same group of researchers showed that the atrophy rate in patients’ whole brains was reduced by about 30 percent in those taking the vitamin cocktail9. The atrophy rate was even higher—53 percent—in those who had elevated homocysteine levels, a benefit that was reconfirmed in the featured study. According to Bloomberg10:

“The studies, known as Vitacog, were funded by seven charities and government agencies and vitamin maker Meda AB of Solna, Sweden. Smith is an inventor on three patents held by Oxford University for B vitamin formulations to treat Alzheimer’s disease… Vitamin B12 is found in liver, fish and milk and folic acid in fruit and vegetables. Deficiency of folate and B vitamins is already linked to dementia…

Doctors in Sweden began measuring homocysteine in people who report declining memory about two years ago, said [Johan] Lokk [professor and head physician in the geriatric department at Karolinska University Hospital in Sweden, who wasn’t involved in the study]...

Swedish patients with high homocysteine are given folic acid and B vitamins, even if they aren’t deficient. ‘We think the increased homocysteine level could be deleterious to the brain,’ Lokk said. ‘We wanted to be on the offensive in diagnosing and treating patients. In our opinion, it is harmless and cheap.’”

General Anesthesia Could Increase Risk of Dementia in Elderly by 35 Percent

Related research suggests that being exposed to general anesthesia can increase the risk of dementia in the elderly by as much as 35 percent. The research was presented at the annual congress of the European Society of Anesthesiology (ESA). As reported by Medical News Today11:

“Postoperative cognitive dysfunction, or POCD, could be associated with dementia several years later. POCD is a common complication in elderly patients after major surgery. It has been proposed that there is an association between POCD and the development of dementia due to a common pathological mechanism through the amyloid β peptide. Several experimental studies suggest that some anesthetics could promote inflammation of neural tissues leading to POCD and/or Alzheimer’s disease (AD) precursors including β-amyloid plaques and neurofibrillary tangles.”

Participants aged 65 and over were followed for a total of 10 years. Participants exposed to at least one general anesthetic over the follow-up had a 35 percent increased risk of developing a dementia compared to those who were not exposed to anesthesia. According to lead researcher Dr. Francois Sztark12:

“These results are in favor of an increased risk for dementia several years after general anesthesia. Recognition of POCD is essential in the perioperative management of elderly patients. A long-term follow-up of these patients should be planned.”

Tips for Avoiding Alzheimer’s Disease

The beauty of following my revised Nutrition Plan is that it helps treat and prevent all chronic degenerative diseases, from the common ones like heart disease, diabetes, obesity and Alzheimer’s to the ones you have never heard of or can’t even pronounce. So please read the Plan as soon as you can. It is divided into three helpful sections, Beginner, Intermediate and Advanced to help you start at the right level.

The plan is the first step in addressing Alzheimer’s disease, which is currently at epidemic proportions, with 5.4 million Americans – including one in eight people aged 65 and over – living with the disease.

Remember, while memory loss is indeed common among Westerners, it is NOT a “normal” part of aging, and cognitive changes are by no means inevitable. People who experience very little decline in their cognitive function up until their deaths have been found (post-mortem) to be free of brain lesions, showing that it’s entirely possible to prevent the damage from occurring in the first place… and one of the best ways to do this is by leading a healthy lifestyle.

  • Sugar and Fructose. Ideally, you’ll want to keep your sugar levels to a minimum and your total fructose below 25 grams per day, or as low as 15 grams per day if you have insulin resistance or any related disorders.
  • Improve magnesium levels. There is some exciting preliminary research strongly suggesting a decrease in Alzheimer symptoms with increased levels of magnesium in the brain. Unfortunately, most magnesium supplements do not pass the blood brain levels, but a new one, magnesium threonate, appears to and holds some promise for the future for treating this condition and may be superior to other forms.
  • Optimize your vitamin D levels with safe sun exposure. Strong links between low levels of vitamin D in Alzheimer’s patients and poor outcomes on cognitive tests have been revealed. Researchers believe that optimal vitamin D levels may enhance the amount of important chemicals in your brain and protect brain cells by increasing the effectiveness of the glial cells in nursing damaged neurons back to health.

Vitamin D may also exert some of its beneficial effects on Alzheimer’s through its anti-inflammatory and immune-boosting properties. Sufficient vitamin D is imperative for proper functioning of your immune system to combat inflammation that is also associated with Alzheimer’s.

  • Keep your fasting insulin levels below 3. This is indirectly related to fructose, as it will clearly lead to insulin resistance. However other sugars (sucrose is 50 percent fructose by weight), grains and lack of exercise are also important factors. Lowering insulin will also help lower leptin levels which is another factor for Alzheimer’s.
  • Vitamin B12: In addition to the research presented above, a small Finnish study published in the journal Neurology13 also found that people who consume foods rich in B12 may reduce their risk of Alzheimer’s in their later years. For each unit increase in the marker of vitamin B12, the risk of developing Alzheimer’s was reduced by two percent. Remember sublingual methylcobalamin may be your best bet here.
  • Eat a nutritious diet, rich in folate, such as the one described in my nutrition plan. Vegetables, without question, are your best form of folate, and we should all eat plenty of fresh raw veggies every day. Avoid supplements with folic acid, which is the inferior synthetic version of folate.
  • High-quality animal-based omega-3 fats, such as krill oil. (I recommend avoiding most fish because, although fish is naturally high in omega-3, most fish are now severely contaminated with mercury.) High intake of the omega-3 fats EPA and DHA help by preventing cell damage caused by Alzheimer’s disease, thereby slowing down its progression, and lowering your risk of developing the disorder.
  • Avoid and eliminate mercury from your body. Dental amalgam fillings, which are 50 percent mercury by weight, are one of the major sources of heavy metal toxicity. However you should be healthy prior to having them removed. Once you have adjusted to following the diet described in my optimized nutrition plan, you can follow the mercury detox protocol and then find a biological dentist to have your amalgams removed.
  • Avoid aluminum, such as antiperspirants, non-stick cookware, vaccine adjuvants, etc.
  • Exercise regularly. It’s been suggested that exercise can trigger a change in the way the amyloid precursor protein is metabolized14, thus, slowing down the onset and progression of Alzheimer’s. Exercise also increases levels of the protein PGC-1alpha. Research has also shown that people with Alzheimer’s have less PGC-1alpha in their brains11 and cells that contain more of the protein produce less of the toxic amyloid protein associated with Alzheimer’s. I would strongly recommend reviewing the Peak Fitness Technique for my specific recommendations.
  • Avoid flu vaccinations as most contain both mercury and aluminum, well-known neurotoxic and immunotoxic agents.
  • Eat blueberries. Wild blueberries, which have high anthocyanin and antioxidant content, are known to guard against Alzheimer’s and other neurological diseases. Like any fruit though, avoid excesses here.
  • Challenge your mind daily. Mental stimulation, especially learning something new, such as learning to play an instrument or a new language, is associated with a decreased risk of Alzheimer’s. Researchers suspect that mental challenge helps to build up your brain, making it less susceptible to the lesions associated with Alzheimer’s disease.
  • Avoid anticholinergic and statin drugs. Drugs that block acetylcholine, a nervous system neurotransmitter, have been shown to increase your risk of dementia. These drugs include certain nighttime pain relievers, antihistamines, sleep aids, certain antidepressants, medications to control incontinence, and certain narcotic pain relievers.

Statin drugs are particularly problematic because they suppress the synthesis of cholesterol, deplete your brain of coenzyme Q10 and neurotransmitter precursors, and prevent adequate delivery of essential fatty acids and fat-soluble antioxidants to your brain by inhibiting the production of the indispensable carrier biomolecule known as low-density lipoprotein.

Other Natural Treatments for Your Anti-Alzheimer’s Arsenal

Finally, there are a few other nutritional recommendations worth noting for their specific benefits in preventing and treating dementia. So, although your fundamental strategy for preventing dementia should involve a comprehensive lifestyle approach, you may want to consider adding a few of these natural dietary agents to your anti-Alzheimer’s arsenal. These four natural foods/supplements have good science behind them, in terms of preventing age-related cognitive changes:

  1. Coconut Oil: The primary fuel your brain needs for energy is glucose. However, your brain is able to run on more than a single type of fuel, one being ketones (ketone bodies), or ketoacids. Ketones are what your body produces when it convertsfat (as opposed to glucose) into energy.

The medium-chain triglycerides (MCT) found in coconut oil are GREAT source of ketone bodies, because coconut oil is about 66 percent MCTs. In fact, ketones appear to be the preferred source of brain food in patients affected by diabetes or Alzheimer’s.

  1. Astaxanthin is a natural pigment with unique properties and many clinical benefits, including some of the most potent antioxidant activity currently known. As a fat-soluble nutrient, astaxanthin readily crosses your blood-brain barrier. One study15 found it may help prevent neurodegeneration associated with oxidative stress, as well as make a potent natural “brain food.”

The molecules of astaxanthin neutralize free radicals and other oxidants without being destroyed or becoming pro-oxidants themselves in the process. It’s is a unique molecule whose shape allows it to precisely fit into a cell membrane and span its entire width. In this position, astaxanthin can intercept potentially damaging molecules before they can damage your cells.

You can get some astaxanthin by taking krill oil, which is a fantastic omega-3 fat supplement. But you can boost your astaxanthin even MORE by adding a pure astaxanthin supplement to your nutritional regimen. For optimal absorption, make sure to take krill oil and/or astaxanthin with a fat-containing meal, since both are fat-soluble.

  1. Gingko biloba: Many scientific studies have found that Gingko biloba has positive effects for dementia. Gingko, which is derived from a tree native to Asia, has long been used medicinally in China and other countries. A 1997 study from JAMAshowed clear evidence that Gingko improves cognitive performance and social functioning for those suffering from dementia.

Research since then has been equally promising. One study in 2006 found Gingko as effective as the dementia drug Aricept (donepezil) for treating mild to moderate Alzheimer’s type dementia. A 2010 meta-analysis found Gingko biloba to be effective for a variety of types of dementia.

  1. Alpha lipoic acid (ALA): ALA can stabilize cognitive functions among Alzheimer’s patients and may slow the progression of the disease.

Source: mercola.com