Adult Sinusitis Guidelines Updated


The American Academy of Otolaryngology–Head and Neck Surgery Foundation has presented an updated clinical practice guideline on adult sinusitis, with a greater focus on patient education and patient preference, published April 1 in Otolaryngology–Head and Neck Surgery.

In the United States, sinusitis affects approximately 1 in 8 adults, with more than 30 million diagnoses and $11 billion in direct costs per year. More than 1 in 5 antibiotics prescribed in adults are for sinusitis.
“More than ever before, there is a prominent role for shared decision-making between patients and clinicians when managing adult sinusitis — especially in deciding whether to use antibiotics for acute bacterial sinusitis or to instead try ‘watchful waiting’ to see if a patient can fight the infection on his or her own,” guidelines chair Richard M. Rosenfeld, MD, MPH, said in a news release.

The update recommends watchful waiting for initial management of all patients with uncomplicated acute bacterial rhinosinusitis, regardless of severity, and not just for those with “mild” illness, as in the 2007 guideline.

“Intuitively clinicians often feel that sicker patients benefit more from antibiotics, but our recommendation is that watchful waiting or antibiotics are both appropriate,” Dr Rosenfeld said. “This empowers patients and clinicians to use antibiotic judiciously, reserving antibiotics for cases that get worse or don’t improve over time.”

Another area benefitting from shared decision making is choice of symptomatic treatment, including analgesics, topical intranasal steroids, and nasal saline irrigation. The update includes a new algorithm to clarify decision-making and action statement relationships.

A multidisciplinary panel of experts in otolaryngology–head and neck surgery, infectious disease, family medicine, allergy and immunology, advanced practice nursing, and a consumer advocate updated this clinical guideline based on current evidence.

Additional changes from the 2007 guideline to the 2015 update include:

The addition of additional information regarding the role of analgesics, topical intranasal steroids, and/or nasal saline irrigation for symptomatic relief of acute bacterial sinusitis.

Changed recommendation for the preferred agent when antibiotics are prescribed. The 2007 guideline called for amoxicillin alone, whereas the 2015 update recommends amoxicillin with or without clavulanate.

Inclusion of several recommendations for management of chronic rhinosinusitis, which was not addressed in the 2007 guideline. These include addition of asthma and of polyps as chronic conditions modifying chronic rhinosinusitis management, a recommendation for use of topical intranasal therapy (saline irrigations or corticosteroids), and a recommendation against using topical or systemic antifungal agents.

“The update group made strong recommendations that clinicians (1) should distinguish presumed [acute bacterial rhinosinusitis] from acute rhinosinusitis…caused by viral upper respiratory infections and noninfectious conditions and (2) should confirm a clinical diagnosis of [chronic rhinosinusitis] with objective documentation of sinonasal inflammation, which may be accomplished using anterior rhinoscopy, nasal endoscopy, or computed tomography,” the authors write.

Kartagener Syndrome.


 

A 43-year-old man presented with cough and expectoration for 7 days. Since birth he had had recurrent episodes of respiratory tract infections, for which he used to take drugs from his family doctor. He was married for 15 years but had borne no children. On examination, apex beat was in the sixth right intercostal space with heart sounds being heard on the right side of the chest. Electrocardiogram showed evidence of dextrocardia . Cardiac apex, along with aortic arch and gastric bubble on chest radiograph were seen on the right side . High-resolution CT of chest and upper abdomen showed bronchiectasis with situs inversus totalis . Radiograph and CT of sinuses showed mucosal thickening in maxillary sinuses and hypoplastic frontal sinuses. Fibreoptic bronchoscopy showed transposition of right and left bronchus. Semen analysis (done thrice) showed decreased sperm viability with no motility. Saccharin test for mucociliary clearance gave a time of 48 min (normal <15 min).

k1k2Situs_inversus_due_to_Kartagener's_syndrome

A diagnosis of Kartagener’s syndrome was made. Kartagener’s syndrome is characterised by the triad of chronic sinusitis, bronchiectasis, and situs inversus. It is classified under the group of disorders called primary ciliary dyskinesias. Patients generally present with recurrent upper and lower respiratory tract infection because of ineffective mucociliary clearance. As sperm mortility is dependent on ciliary function, males are generally sterile.

Source: Lancet

Systemic Corticosteroid Monotherapy of No Benefit in Acute Rhinosinusitis .


Oral prednisolone is not associated with quicker resolution of facial pain in patients with clinically diagnosed rhinosinusitis, according to a double-blind trial in the Canadian Medical Association Journal.

Some 175 patients from primary care practices in the Netherlands were randomized to 7 days’ treatment with either 30 mg/day of oral prednisolone or placebo. Patients recorded symptom changes in daily diaries. By day 7, the percentage of patients recording resolution of facial pain or pressure did not differ significantly between active treatment (62.5%) and placebo (55.8%). The median duration of facial pain also did not differ between the groups.

The authors conclude: “We feel that there is no rationale for the use of corticosteroids in the broad population of patients with clinically diagnosed acute rhinosinusitis and instead advocate symptomatic treatment.”

Source: CMAJ