Kisspeptin injection could treat low libido, bring back desire for men and women


A new hormone injection could treat low sex drive in both women and men, according to researchers in the United Kingdom. A team from Imperial College London says kisspeptin can boost sexual responses in men and women suffering distress as a result of their low libido.

Two studies, both published in JAMA Network Open, show that giving patients kisspeptin can boost sexual responses in people who have hypoactive sexual desire disorder (HSDD) – a condition where patients experience psychological distress due to their low sexual desire. Women taking part in the trial reported feeling “more sexy” during the kisspeptin treatment.

HSDD affects up 10 percent of women and roughly one in 12 men worldwide. It can have “devastating” psychological and social impacts. Study authors explain that kisspeptin is a naturally-occurring hormone which stimulates the release of other reproductive hormones in the body. The team previously demonstrated that kisspeptin can enhance responses to sexual stimuli and boost attraction brain pathways independent of other reproductive hormones like testosterone in men with intact sexual desire. Now, they’re investigating the effects in women and men with low sexual desire for the first time.

The two clinical trials involved 32 pre-menopausal women between the ages of 19 and 48, and 32 men with HSDD. In both studies, researchers scanned participants using brain MRI imaging, as well as blood and behavioral tests. Taking kisspeptin improved sexual brain processing in both women and men. This resulted in positive boosts in each person’s sexual behavior compared to those who did not receive the injections.

The clinical trials are the first to explore the ability of kisspeptin to boost sexual pathways in people suffering distress from low libido. The researchers believe that the results provide the groundwork for kisspeptin-based therapies for people with HSDD.

“Low sexual desire can be distressing and so result in HSDD. This can have a major detrimental impact on relationships, mental health, and fertility. Even though it is relatively common, treatment options in women are limited, carry significant side-effects and in some cases can be harmful to even try. And unfortunately, these treatments have limited effectiveness. In men there are currently no licensed treatments and none on the horizon. Therefore, there is a real unmet need to find new, safer and more effective therapies for this distressing condition for both women and men seeking treatment,” says Dr. Alexander Comninos from the Department of Metabolism, Digestion and Reproduction at Imperial College London in a media release.

“Our two studies provide proof-of-concept for the development of kisspeptin treatments, as we provide the first evidence that kisspeptin is a potentially safe and effective therapy for both women and men with distressing low sexual desire,” Dr. Comninos continues.

“Additionally in men, we demonstrate that kisspeptin can have positive effects not only in the brain but also in the penis by increasing rigidity. Furthermore, kisspeptin was well-tolerated by both women and men with no side-effects reported, which is crucial from a drug development point of view. We now plan to take things forward to hopefully realize the potential of kisspeptin therapeutics in psychosexual disorders – sexual problems which are psychological in origin, such as unexplained low libido.”

“Our studies build on our previous work to assess the effectiveness of kisspeptin and its boosting effects in terms of arousal and attraction. It is highly encouraging to see the same boosting effect in both women and men, although the precise brain pathways were slightly different as might be expected,” adds Professor Waljit Dhillo, an NIHR Senior Investigator and co-senior study author.

“Collectively, the results suggest that kisspeptin may offer a safe and much-needed treatment for HSDD that affects millions of people around the world and we look forward to taking this forward in future larger studies and in other patient groups.”

The treatment creates more ‘happiness about sex’

During kisspeptin or placebo treatments, female participants underwent functional MRI scans while watching erotic videos and viewing male faces to see how these videos affected brain activity. Non-erotic exercise videos served as a control in the experiment. The team found that kisspeptin improved sexual and attraction brain activity in key brain areas in women.

Results also show that women suffering from distress due to low sexual function had greater kisspeptin-enhanced brain activity in the hippocampus — a key structure that scientists say plays a role in female sexual desire. Researchers found that the more kisspeptin activated the posterior cingulate cortex — another key behavioral brain area — when participants saw attractive male faces, the less sexual aversion the women had.

In the second study, 32 heterosexual men between 21 and 52 with HSDD underwent a similar study. However, the team also measured penile rigidity between January and September 2021. The study demonstrated that kisspeptin significantly boosted brain activity in the “sexual brain network,” while also increasing penile rigidity by up to 56 percent in comparison to taking a placebo.

Similar to the study with women, kisspeptin had greater effects in key brain regions in men who were more distressed by their low sexual desire. Psychometric analyses reveal that kisspeptin improved “happiness about sex” among men.

What do the patients say about the treatment?

“I got involved in the trial because I had previous problems with my sexual appetite and performance,” says a 44-year-old man named “Peter,” who took part in the trails.

“The issue had always been detrimental to sustaining relationships. I would often make excuses as to why my sexual appetite was low. For example, I would blame stress at work or tiredness as a reason instead of being honest. I had tried other performance supporting medication like Viagra. However, this proved ineffective as the issue was simply one of low desire. It was highly embarrassing and not something I felt able to talk to my previous partners about. I feared they would confuse it with lack of attraction to them,” the trial participant continues.

“I was keen to learn whether there was a solution to my problem and learn more about my condition.”

“I received the kisspeptin infusion in June 2021 and I noticed a difference in terms of my sexual desire. The week I had the kisspeptin infusion we conceived our son, who was born in March 2022. I had the best possible outcome as a result of the trial.”

“I also learnt a lot more about myself and my condition. I am really pleased to have contributed to this trial, which has been life-changing for me. I’m glad that others in a similar position could benefit from the treatment.”

“I took part in the trial as I was experiencing low sexual libido. Initially, I put it down to having small children and being exhausted as a result. However, this continued and started to impact my wellbeing. I wanted to see whether there was another reason for why I was feeling this way,” adds another trial participant and 43-year-old mom named “Eve.”

“I had two study visits in 2020 where I received the placebo and the kisspeptin infusions without knowing which one I was getting at the time. I did notice a bit of a difference once I received the kisspeptin infusion and it was fascinating to be part of the process,” Eve adds.

“I am glad that I took part in the study as many women wouldn’t like to admit they are experiencing this and may not seek help. I’m glad to know that kisspeptin could be a treatment option for other women.”

Dr. Comninos and Prof. Dhillo now plan larger studies in order to develop kisspeptin as a realistic treatment for both men and women dealing with sexual disorders.

The Perfect Food for Hormone Imbalance, Anxiety, Energy, Sleep, and Libido


Maca Powder is a magnificent mix of fibre, carbohydrates & minerals consumed by the Incan warriors prior to battle. This superfood helped increase their fighting spirit, libido, stamina and strength. Maca powder has undoubtedly become very popular among athletes because of its rich content of nutrients.

What is Maca Powder?

 Maca powder comes from a plant native to the high Andes of Peru. It is abundant with minerals, vitamins, enzymes and essential amino acids. In Peru, it is known as ‘aphrodisiac of the Andes’.

Maca powder contains:

  • Vitamins B1, B2, C, E,
  • Minerals and trace elements including potassium, iodine, zinc, calcium, magnesium, phosphorus, iron, iodine, sulphur, bismuth, silicon, boron, tin and silica.
  • Fatty acids, complex alkaloids, and sterols.

Maca Powder Can Boost Your Sex Drive Naturally: Health Benefits

Maca powder has the ability to improve fertility. According to lab studies conducted on rats, after being fed Maca males rats increased their sperm count, and female increased egg follicle development. In Peru, Maca is used to improve strength as well as fertility.

This powder contains unique compounds as macamides and macaenes which can significantly boost your health energy levels. Moreover, Maca powder has a high content of iron, manganese, and phosphorus, and can fight fatigue.

 This incredible powder works directly on your endocrine system and helps balance the hormones in your body. It can encourage the body to produce its own hormones in order to restore balance and we all know that hormonal regulation is extremely important for almost all processes of the body. Maca powder is also beneficial for easing PMS symptoms because it provides the body with the needed nutrients so it can be able to naturally produce hormones.

It is a great source of unique alkaloids and numerous vitamins and minerals. Furthermore, it possesses adaptogenic properties which produce an adaptive response to stress, thus strengthening the body and improving stamina.

This powder also has the ability to increase libido in both men and women. According to many studies, maca powder can boost your sex drive naturally.

Maca: Superfood for Energy, Stamina and Libido


Maca: Superfood for Energy, Stamina and Libido

Thanks to the efforts of a single Peruvian researcher, a neglected and little known ancient plant was saved from certain extinction about 50 years ago.  Today that resurrected root is considered a superfood that improves energy, stamina and libido, and can help menopausal women balance their hormones naturally.

Maca is a root vegetable (belonging to the Brassica family) that has been cultivated in the Peruvian Andes for over 2,600 years.  Growing at about 10,000 feet above sea level, it is the highest altitude crop in the world.

Back from the brink, maca is enjoying a resurgence in popularity as a result of the research ofGloria Chacon de Popovici, Ph.D., a Peruvian biologist, who conducted studies beginning in the 1960’s showing that maca increases fertility in rats, dogs, guinea pigs, rams, cows and humans.

Among traditional peoples in Peru, maca has long been treasured for it aphrodisiac qualities.  Modern research is now lending scientific support to the wisdom of the ancients.

Studies in men have found that maca supplementation can improve a man’s subjective perception of his general and sexual well-being, as well as increase his sexual desire.

In postmenopausal women, it’s been found to reduce psychological symptoms, including anxiety and depression, and improve libido.

Although maca grabs headlines for its aphrodisiac qualities and its reputation as a natural Viagra, it has many other health benefits.

Maca is an adaptogen

According to David “Avocado” Wolfe, author of Superfoods: The Food and Medicine of the Future, maca is a powerful adaptogen or nutritive substance that counters adverse sources of stress and allows the body to adapt naturally to stressful conditions. Adaptogens also help to improve the body’s natural balance or homeostasis.

As a result Wolfe says, maca “increases energy, endurance, oxygen in the blood, physical strength, neurotransmitter production, and libido. It supports the endocrine system, the adrenals, and the thyroid, typically improves one’s mood, and helps support healthy hormone production.”

Maca has been recommended for everything from impotence and infertility to depression, hot flashes, stress and memory loss.

How does maca work?

How does maca work its magic? One way is that it stimulates the hypothalamus and pituitary glands which in turn regulate the other glands in the body, and can bring balance to the adrenal, thyroid, pancreatic, ovarian and testicular glands.

Typically dried and powdered, maca is rich in calcium, magnesium, phosphorous, potassium, sulfur, sodium and iron as well as vitamins B1 (thiamin), B2 (riboflavin), C and E. It also contains zinc, iodine, copper, selenium, manganese and silicon.

Compared to the potato which also originated in the Andes, maca contains five times more protein and four times more fiber.

How much maca can you take? 

Wolfe recommends 1 to 2 tablespoons of maca daily and points out that studies have shown no toxicity or pharmacological effects.

Maca has a butterscotch aroma but a funky turnip flavor that can be a little strong for some. Don’t let that stop you.  Add powdered maca to smoothies, salad dressings, soups, broth, tea or coffee.

When buying maca, look for the organic, raw, dried, powdered root. You can find it in local health foods or on-line.

Low Sex Drive? What Your Hormones Have To Do With It + How To Improve Libido


Dr. Sara Gottfried is a Harvard-trained MD, best-selling author, and leading expert on hormones. That’s why we’re thrilled to team up with her for a new series this week on balancing your hormones for better health. If you’re inspired to learn more, check out her new course, How to Balance Your Hormones for Glowing Skin, Deeper Sleep & Better Digestion.

How Your Hormones Really Affect Your Sex Drive + What To Do About It Hero Image

This statistic troubles me: 57 percent of women prefer Facebook to sex. While the data doesn’t come from a scientific source (Cosmopolitan), it reflects a general feeling of “meh” that many of my patients have toward sex.

I see it daily in my functional medicine practice, and the symptom points to a larger, more disturbing problem.

I consider sex drive to be the canary in the coal mine of overall physical and mental health—and sadly, the state of women’s health, longevity, and happiness is declining in many ways. As a result, low libido is common, but few understand that the root cause is hormonal, not some intrinsic problem or lack of love and connection. Or people know hormones and sex go together but don’t really know which hormones matter or how they interact to create sexual interest, toe-curling orgasms, or robust health. Or even more important: what to do about it.

I believe that sexuality is a portal to other areas of your life, and when you optimize your sex life, there are many downstream benefits that you may not realize. You’ll find freedom in other aspects of your life where there once was struggle. And when you upgrade your sexual energy, you heal from the inside out, which is far better and more sustainable than seeking the latest Band-Aid. This is true for single folks as well as people in long-term relationships.

After years of working with people who want to get their mojo back, I know that low sex drive, poor energy, lousy sleep, skin problems, and bloating aren’t diseases that can be fixed fast with a pill or shot. These are usually hormonal problems, meaning our bodies are trying to tell us that something is wrong.

The Root Causes of Low Sex Drive

I’d estimate that 70 percent of low sex drive cases are due to misfiring hormones. Of course, there are other considerations, such as communication and intimacy, emotional currency, sexual variety, mismatch of expectations and style, frequency and type of sexual connection. For a healthy, deepening sexual connection, these areas need to be explored, mined, and renegotiated.

Many women believe as I did that they don’t have to worry about their hormones until menopause, but the truth is that your hormones start to change in your 20s. DHEA and testosterone begin to decline. Cortisol, the main stress hormone, can start to climb and rob your other sex hormones. For some women, estrogen and/or progesterone can drop, leading to estrogen dominance or PMS. You may experience high testosterone (such as with polycystic ovarian syndrome) or low testosterone (as a result of excess stress or aging). Or your thyroid may start to sputter.

Other hormones get in on the act—including oxytocin, insulin, and ghrelin—but these are the main hormonal problems I see daily as part of the story of low libido. Here, I’ll share what symptoms you might experience with each hormone. Note that I’ve included only a partial list for each—to learn more, check out my new mindbodygreen course.

1. Cortisol is too high, too low, or a combination.

It’s important to understand that dysfunctional stress in the body is the root cause of most, if not all, hormone imbalances. You may or may not be aware of how stress is being generated in the body, and one of the earliest signs can be lower sexual interest or desire.

The underlying reason for wayward cortisol varies from person to person, but it’s important to know if cortisol is off for you. For me, cortisol crashed in my mid-30s after having a baby—I was trying to be all things to all people, running myself ragged as a working mom and OB/GYN, and chasing a dream that didn’t belong to me as a surgeon and academic. My poor husband felt neglected and rejected as my libido tanked, and it took taking on my own hormones to understand the central role of cortisol in sex drive and my more global energy.

Signs of unbalanced cortisol:

  • Feeling wired but tired
  • Running from task to task, feeling overwhelmed
  • Sugar or carb cravings
  • Difficulty falling or staying asleep
  • Feeling burned out or fatigued, particularly under stress
  • Increased belly fat or weight gain
  • Unstable blood sugar—too high, too low, or both
  • Skin conditions, such as eczema

2. Estrogen is too high, too low, or a combination.

Estrogen is the main female hormone. It causes the female body to grow breasts and hips (in men, too much can lead to man boobs and estrogenic fat deposits at the hips). When it’s in balance with its counter hormone, progesterone, your period arrives on time, your skin is clear, and your mood is stable. When it’s too high or low, you may experience one or more of the following symptoms.

Signs of unbalanced estrogen:

  • Bloating or water retention
  • Abnormal Pap smears
  • Heavy or excessively light (even absent) periods
  • Breast tenderness or cysts
  • Mood swings or PMS
  • Rapid weight gain, particularly at the breasts or hips
  • Migraines
  • Red flush of the face, or rosacea
  • Vaginal dryness or atrophy

3. Thyroid is too low.

When your thyroid gland in your neck is underperforming, you feel flat and lackluster in most areas. Your hair thins, particularly eyelashes and the outer third of the eyebrow. The origin varies from person to person, and could stem from autoimmune destruction (Hashimoto’s thyroiditis) or be secondary to high cortisol, or even result from exposure to endocrine disrupters like bisphenol A or flame retardants.

Signs of low thyroid:

  • Fatigue, particularly in the morning
  • Weight gain
  • Mood problems, such as low-grade depression
  • Headaches
  • Dry, strawlike hair that tangles easily
  • Hair loss or thinning (particularly lashes and outer third of eyebrow)
  • Decreased sweating
  • Cold hands and feet, or intolerance of cold
  • Constipation

4. Testosterone is too high, too low, or a combination.

Testosterone begins to decline in your 20s, which is why you don’t respond to weight training with the same gusto that you did as a teenager. But the worst culprit when it comes to low testosterone is taking oral contraception. The Pill raises your sex-hormone-binding globulin, which is like a sponge that soaks up the free (and therefore biologically available) testosterone in the body. As a result, you may experience low sex drive, vaginal dryness, and even pain with insertion. Even worse, the problem may not resolve when you go off the Pill: One study showed that up to one year later, your hormones may still be out of whack.

High testosterone is one of the defining characteristics of polycystic ovarian syndrome, which affects about 10 percent of American women. Low testosterone is very common with age, contributing to depression in both men and women, low sex drive, and grumpiness—but it doesn’t have to be.

Signs of unbalanced testosterone:

  • Acne or greasy skin
  • Rogue hairs, especially on face, chest, or arms
  • Skin tags
  • Anxiety or depression
  • Fatigue
  • Loss of confidence and agency
  • Poor muscular response to high-intensity or weight training
  • Irregular menstruation (every 35 days or less often)
  • Infertility or subfertility

How to Regain Your Sex Drive

For far too long, there has been this prevailing belief that declining sex drive is simply inevitable, that it’s a part of being a modern and busy woman (or man), that it’s part of aging, that it’s part of life after childbearing years, that it’s part of long-term monogamous relationships, etc. I disagree. It’s not normal.

Nothing annoys me more than a doctor who brushes aside pain points like low libido as simply a “symptom of aging.” I believe it’s both possible and important for a woman to maintain a strong sex drive long past her childbearing years. It takes a little work—maintaining balanced hormones, trying some proven botanicals, a little self-love, and a steady diet of quality orgasms—but is more than worth it in the long run. Of course, libido will naturally wax and wane. Ultimately, it’s your choice.

Every day we hear about a different method to boost your sexual energy, your life force, your libido. Take this supplement! Read 50 Shades of Grey! Increase variety! Drink green tea. Don’t have any caffeine. Have sex in the morning only! Try this fantastic new lubricant! Eat fewer carbs. Eat more carbs. Eat carbs before protein. Eat carbs at night. Eat oysters! Drink less. Drink more. It’s totally confusing and often not based on any scientific research.

Instead, here are some of the most proven ways you can rev up a flagging sex drive:

1. Add an adaptogen.

If your cortisol is too high, too low, or both within the same day, I recommend taking a double adaptogen like ashwagandha. I mix a pure organic powder with hot water and drink it twice per day as a tonic for stress.

2. Change up a boring sexual routine.

You may need to bring in some variety along with resetting your hormones. My favorite is orgasmic meditation (OM), a cross between mindfulness and genital stroking, for 15 minutes as popularized by Tim Ferriss in The 4-Hour Body.

I find that OM is a wonderful practice for people who are tired of sex, or tired of how fat they feel, or just tired. It fills your tank with oxytocin, and we all need more of that! Oxytocin raises testosterone in men and lowers cortisol. In women, it raises estrogen and helps the thyroid work better.

3. Make a medicinal maca shake.

I’m a fan of occasionally drinking your nutrition, especially if you’re on the go and find it hard to eat well. I found during my hormonal recovery that my blood sugar is most stable when I started my day with yummy protein shakes. (You can hear more about my personally formulated medicinal shakes in my new mbg course.)

Maca is a libido-boosting herb native to Peru that’s proven to nourish endocrine glands. Studies show that it raises sex drive in women and reduces anxiety and depression. It’s my herb of choice for women with low estrogen.

4. Visit your health professional.

If you’d rather mop the floor than have sex, there’s a good chance there’s a hormone problem. Get help with sending a search-and-rescue operation after your lost libido by visiting a collaborative functional medicine doctor who will work with you to identify the root cause and find a natural solution.

Sometimes the culprit is overwork and high stress; sometimes it’s a medication, like the Pill or an antidepressant. Get the help you need to test your hormones and come up with a smart plan.

My hope is that you prefer sex to Facebook, and that starts with getting your hormones back on track. It’s important to your health that you make sexual pleasure a priority but not the stuff of Hollywood movies. Instead, choose the real, organic, yummy approach to sex that is your birthright and underpins optimal physiology.

Keep your focus on the natural remedies, the proven potions that truly work for you and that truly stick. Then it’s a matter of keeping your hormones in balance so that you can keep the fire stoked.

Low Testosterone and Heart Disease Linked—But What’s Really Causing Them?


Story at-a-glance

  • After age 30, a man’s testosterone levels begin to decline, and continue to do so as he ages, leading to symptoms such as decreased sex drive, erectile dysfunction, depressed mood, and difficulties with concentration and memory
  • According to a recent analysis, low testosterone may increase a man’s risk for cardiovascular disease. The mechanism of harm in still unknown, and both low testosterone and heart disease may simply be the result of poor overall health
  • Estrogen, the female sex hormone, plays a much bigger role in men’s heath than previously thought. Both hormones have been found to be important for sexual function, and a deficiency in either has a negative impact on a man’s libido
  • While testosterone deficiency accounts for decreases in lean mass, muscle size and strength, estrogen deficiency in men is the primary culprit when it comes to increases in body fat
  • Dietary and exercise changes, particularly limiting sugar/fructose, eating healthy saturated fats and engaging in high-intensity exercises, Power Plate, and strength training, can be very effective at boosting testosterone levels naturally.
  • Heart Problems

Testosterone is an androgenic sex hormone produced by a man’s testicles, and to a lesser degree, in smaller amounts, by the ovaries in women. While testosterone is stereotypically associated with virility, it also plays a role in maintaining muscle mass, bone density, red blood cells, and a general sense of well-being. 

Beginning around age 30, a man’s testosterone levels begin to decline, and continue to do so as time goes on—unless you proactively address your lifestyle.

Chemical exposures, including prescription drugs like statins, can also have an adverse effect on your testosterone production. Symptoms of decliningtestosterone levels include:

  • Decreased sex drive
  • Erectile dysfunction and/or problems urinating
  • Depression
  • Difficulties with concentration and memory
  • Weight gain and/or breast enlargement

According to a recent analysis,1 low testosterone may also increase a man’s risk for cardiovascular disease. As reported in the featured article:2

“To arrive at their findings, the research team examined previous studies that analyzed cardiovascular disease and testosterone levels between 1970 and 2013. The review of the studies revealed modest evidence that low testosterone levels are linked to an increased risk of cardiovascular disease.

However, the researchers note there was little evidence of a link between low testosterone and artherosclerosis – the hardening and narrowing of the arteries that can lead to heart attacks and strokes, and there was no evidence of a specific link between heart attacks and testosterone levels.”

The Importance of Testosterone for General Health

While the exact mechanism linking low testosterone to heart disease could not be ascertained, the researchers suggest the effect might be related to thrombosis or arrhythmia. Thrombosis is when a blood clot develops, and arrhythmia is basically a condition in which your heart beats erratically. Previous research has linked low testosterone with both of these conditions, plus a number of others, including:

  • Increased blood pressure
  • Dyslipidemia
  • Endothelial dysfunction
  • Impaired left ventricular function

Interestingly enough however, they also found that testosterone replacement therapy did NOT have any positive effect on cardiovascular health. This could potentially indicate that low testosterone does not in and of itself promote heart disease, but rather that low T and heart disease are both caused by something else. As stated by lead researcher, Dr. Johannes Ruige:3

“Based on current findings, we cannot rule out that low testosterone and heart disease both result from poor overall health.”

Indeed, I know first-hand that low testosterone is not an automatic outcome of aging, provided you incorporate certain lifestyle strategies that can naturally boost your testosterone levels, which I’ll review below. These strategies are part and parcel of an overall healthy lifestyle, so they also automatically reduce your risk of most chronic disease, including heart disease.

It actually makes logical sense that failure to incorporate these foundational health-promoting strategies could be the root cause of low testosterone, heart disease, and all the heart-related adverse effects listed above.

The Role of Estrogen in the Aging Male

Both men and women make estrogen out of testosterone. As a result, some men can actually end up with close to twice the amount of estrogen found in postmenopausal women. Still, the levels of both testosterone and estrogen both tend to decline with age, and as they do, your body changes. So far, researchers have almost exclusively focused on estrogen’s effect on women, and testosterone’s impact on men. But that may soon change.

A recent article in the New York Times4 highlighted research demonstrating the intricate play of women’s sex hormones in aging men’s health—a factor that has so far been largely ignored:

“Estrogen, the female sex hormone, turns out to play a much bigger role in men’s bodies than previously thought, and falling levels contribute to their expanding waistlines just as they do in women’s. The discovery of the role of estrogen in men is ‘a major advance,’ said Dr. Peter J. Snyder, a professor of medicine at the University of Pennsylvania, who is leading a big new research project on hormone therapy for men 65 and over. Until recently, testosterone deficiency was considered nearly the sole reason that men undergo the familiar physical complaints of midlife. “

The study in question, published in the New England Journal of Medicine5 (NEJM), found that there were significant individual variations in the amount of testosterone required for any particular man to maintain lean body mass, strength, and sexual function.

However, they were able to determine that testosterone deficiency accounted for decreases in lean mass, muscle size and strength, while estrogen deficiency was the primary culprit when it came to increases in body fat. Both hormones were found to be important for sexual function, and a deficiency in either had a negative impact on the men’s libido. According to the lead author, Dr. Joel Finkelstein, an endocrinologist at Harvard Medical School:

“Some of the symptoms routinely attributed to testosterone deficiency are actually partially or almost exclusively caused by the decline in estrogens.”

Despite individual variations, Dr. Finkelstein’s research offers valuable insight into the function and behavior of estrogen and testosterone at different levels in a man’s body. For example, they found that less testosterone is actually needed for muscle maintenance than previously thought. They also found that:

  • In young men, the average testosterone level is about 550 nanograms per deciliter (ng/dl)
  • Muscle size and strength does not become adversely affected until testosterone levels drop below 200 ng/dl, which has previously been considered extremely low
  • Fat accumulation, however, increases at testosterone levels of 300-350 ng/dl, due to its impact on estrogen
  • Libido increases steadily with simultaneous increases in testosterone and estrogen

Please note that men are NOT advised to take estrogen replacement therapy, as this could cause feminization, such as enlarged breasts. As your testosterone levels rise, your body will automatically produce more estrogen, so the key is to maintain your testosterone level—ideally by incorporating the strategies I will discuss below.

How to Raise Your Testosterone Levels Naturally Through Exercise

Personally, I do not recommend using testosterone hormone replacement. If you indeed have low testosterone, you can consider trans rectal DHEA cream, which I’ll discuss below. DHEA is the most abundant androgen precursor prohormone in the human body, meaning it’s the largest raw material your body uses to produce other vital hormones, including testosterone in men and estrogen in women. However, I believe many of you may not even need that, were you to take full advantage of your body’s natural ability to optimize hormones like testosterone and human growth hormone (HGH).

Just like testosterone, your HGH levels also sharply decline after the age of 30, as illustrated in the graph above. Both of these hormones are also boosted in response to short, intense exercise. As I do not take any hormone or prohormone supplements, I’ve been doing Peak exercises for just over three years now, and at the age of 59, my testosterone level (done last month) and HGH levels (listed below) are still well within the normal range for a young adult male without the aid of ANY prescriptions, hormones and hormone precursor supplements:

  • Total testosterone: 982 ng/dl (normal test range: 250-1,100 ng/dl)
  • Free testosterone: 117 pg/ml (normal test range: 35-155 pg/ml)
  • HGH: 14,000 pg, more than three times the normal test range of 1,000-4,000 pg/24 hours

Below is a summary and video demonstration of what a typical high-intensity Peak Fitness routine might look like. As you can see, the entire workout is only 20 minutes, and 75 percent of that time is warming up, recovering or cooling down. You’re really only working out intensely for four minutes. It’s hard to believe if you have never done this, that you can actually get that much benefit from only four minutes of intense exercise, but that’s all you need!

  • Warm up for three minutes
  • Exercise as hard and fast as you can for 30 seconds. You should feel like you couldn’t possibly go on another few seconds
  • Recover at a slow to moderate pace for 90 seconds
  • Repeat the high intensity exercise and recovery 7 more times.

Four Additional Ways to Boost Testosterone and HGH

Besides high intensity exercise, there are several other strategies that will also boost your testosterone levels naturally. These are appropriate for virtually anyone, male or female, as they carry only beneficial “side effects.” For even more tips, please see my previous article, “9 Body Hacks to Naturally Increase Testosterone.”

    • Weight training. When you use strength training to raise your testosterone, you’ll want to increase the weight and lower your number of reps. Focus on doing exercises that work a wider number of muscles, such as squats or dead lifts. You can take your workout to the next level by learning the principles of Super-Slow Weight Training. For more information on how exercise can be used as a natural testosterone booster, read my article “Testosterone Surge After Exercise May Help Remodel the Mind.”
    • Whole body vibration training (WBVT) using a Power Plate. In addition to the Peak Fitness exercises, I do 10 minutes of Power Plate training twice a day and this likely also improved my hormones. WBVT in some ways simulate high intensity exercise by stimulating your white (fast-twitch) muscle fiber. This kick-starts your pituitary gland into making more growth hormone, which helps you build lean body mass and burn fat.
    • Address your diet. This is critical for a number of reasons. First of all, if you’re overweight, shedding the excess pounds may increase your testosterone levels, according to recent research.6 Testosterone levels also decrease after you eat sugar. This is likely because sugar and fructose raises your insulin level, which is another factor leading to low testosterone. Ideally, keep your total fructose consumption below 25 grams per day. If you have insulin resistance and are overweight, have high blood pressure, diabetes or high cholesterol, you’d be well advised to keep it under 15 grams per day.

The most efficient way to shed excess weight and normalize your insulin levels at the same time is to strictly limit the amount of sugar/fructose and grains in your diet, and replacing them with vegetables and healthy fats, such as organic pastured egg yolks, avocado, coconut oil, butter made from raw grass-fed organic milk, and raw nuts.

Saturated fats are in fact essential for building testosterone. Research shows that a diet with less than 40 percent of energy as fat (and that mainly from animal sources, i.e. saturated) lead to a decrease in testosterone levels.7 My personal diet is about 70-80 percent healthy fat, and other experts agree that the ideal diet includes somewhere between 50-70 percent fat. I’ve detailed a step-by-step guide to this type of healthy eating program in my optimizednutrition plan.

  • Intermittent fasting. Another effective strategy for enhancing both testosterone and HGH release is intermittent fasting. It helps boost testosterone by improving the expression of satiety hormones, like insulin, leptin, adiponectin, glucacgon-like peptide-1 (GLP-1), cholecystokinin (CKK), and melanocortins, which are linked to healthy testosterone function, increased libido, and the prevention of age-induced testosterone decline.

Why I Recommend DHEA Over Testosterone Replacement

I personally do not use any hormone or prohormone treatments as I’ve been successful in getting my hormone levels within the healthy young adult range using the protocols described above. However, if you chose to use hormones it is really crucial to use bioidentical versions. There are synthetic and bioidentical hormone products out on the market, but I advise using bioidentical hormones like DHEA if you opt for this route. DHEA is a hormone secreted by your adrenal glands. Again, this substance is one of the most abundant precursor hormones in your body, and it’s crucial for the creation of hormones, including testosterone and other sex hormones.

Production of this prohormone peaks during your late 20s or early 30s. With age, DHEA production begins to decline, right along with your testosterone and HGH levels. Your adrenal glands also manufacture the stress hormone cortisol, which is in direct competition with DHEA for production because they use the same hormonal substrate known as pregnenolone. Chronic stress basically causes excessive cortisol levels, thereby impairing DHEA production, which is why stress is another factor for low testosterone levels.

It’s important to use any DHEA product with the supervision of a professional. Find a qualified health care provider who will monitor your hormone levels and determine if you actually require supplementation.

Also, rather than using an oral hormone supplementation, I recommend trans-mucosal (vagina or rectum) application. Skin application may not be wise, as it makes it difficult to measure the dosage you receive. This may cause you to end up receiving more than what your body requires. Applying a trans-mucosal DHEA cream to your rectum (or if you are a woman, your vagina) will allow the mucous epithelial membranes that line your mucosa to perform effective absorption. These membranes regulate absorption and inhibit the production of unwanted metabolites of DHEA. That said, I do NOT recommend prolonged supplementation of hormones, even bioidentical ones. Doing so can trick your body into halting its own DHEA production and may cause your adrenals to become impaired.

Other Helpful Supplements

Besides DHEA, there are also nutritional supplements that can not only address some of the symptoms commonly associated with low testosterone, but may help boost your testosterone levels as well. These include:

    • Saw palmetto. Besides addressing symptoms of low testosterone, this herb may also help to actually increase testosterone levels by inhibiting up-conversion to dihydrotestosterone.8 Research has also shown it can help reduce your risk of prostate cancer. When choosing a saw palmetto supplement, you should be wary of the brand, as there are those that use an inactive form of the plant. According to industry expert Dr. Rudi Moerck, what you want to look for is an organic supercritical CO2 extract of saw palmetto oil, which is dark green in color. Since saw palmetto is a fat-soluble supplement, taking it with eggs will enhance the absorption of its nutrients.
    • Astaxanthin in combination with saw palmetto. There is also solid research indicating that if you take astaxanthin in combination with saw palmetto, you may experience significant synergistic benefits. A 2009 study published in theJournal of the International Society of Sports Nutrition found that an optimal dose of saw palmetto and astaxanthin decreased both DHT and estrogen while simultaneously increasing testosterone.9
    • Ashwagandha. This ancient Indian herb is known as an adaptogen, which can help boost stamina, endurance, and sexual energy. Research published in 201010 found that men taking the herb Ashwagandha experienced a significant increase in testosterone levels.

Ashwagandha also helps promote overall immune function, and can help increase your resistance to occasional stress.11 It also supports healthful levels of total lipids, cholesterol, and triglycerides already in the normal range. While some adaptogens are stimulants in disguise, this is not the case with Ashwagandha. It can give your morning exercise routine a boost, and when taken prior to bed, it can help you get a good night’s sleep as well. I recommend using only 100% organic Ashwagandha root, free of fillers, additives and excipients, to ensure quality.

Low Testosterone Is Not an Inevitable Fate for Aging Men

I strongly recommend implementing lifestyle strategies that are known to optimize testosterone levels naturally before you do anything else to address the symptoms associated with low testosterone. If you’re still deficient in testosterone after implementing high intensity exercise and strength training, along with the dietary strategies detailed above and, ideally, intermittent fasting, then you could try trans-mucosal DHEA. Again, remember to confer with a qualified health care practitioner and get your levels tested before supplementing with DHEA or any other hormone, including testosterone.

Personally, I’ve been able to maintain both testosterone and HGH levels comparable to that of a young healthy male, simply by implementing high intensity exercise, Power Plate exercises, and intermittent fasting, along with my standarddietary recommendations. I would strongly encourage you to review my nutrition plan if you haven’t already done so.

Add to that some regular sun exposure, and you’ll be well ahead of most people. Vitamin D, a steroid hormone, also helps to naturally increase testosterone levels. In one study,12 overweight men who were given vitamin D supplements had a significant increase in testosterone levels after one year. As in most instances, given half a chance, your body will actively and automatically strive to maintain optimal health. So as long as you incorporate the foundational basics of a healthy lifestyle, you can stay healthy and strong well into your old age.

Sex Drive and Menopause: 50 Shades of Normal.


Desire may decline with estrogen levels

Sex and menopause may seem like odd bedfellows. Especially if you’re one of the 15 to 70 percent of menopausal or postmenopausal women with sexual dysfunction, such as low desire or painful intercourse.

Why do studies report such varying percentages?

Perhaps because when it comes to sex, there are 50 shades of “normal,” according to Judith M. Volkar, MD, an OB/GYN for Cleveland Clinic’s Center for Specialized Women’s Health. There are no standards on how often you should have — or desire — sex. Sexual dysfunction simply refers to any issue that causes distress or interpersonal difficulty in the bedroom. So if you’re not desiring or having sex and you’re not distressed by it, then you’re not dysfunctional.

But if you are distressed, you’re not alone. And there are plenty of things you can do to make your sex life satisfying during menopause and beyond.

Improve function — even without hormone help

As women go through menopause, their estrogen levels drop. Lower levels of estrogen cause a decrease in blood flow to the vagina, which can make it less sensitive to touch and less receptive to physical arousal. Less estrogen also can mean less vaginal lubrication. All of that can make intercourse less desirable, more difficult or downright uncomfortable.

Fortunately, several things can help women, says Dr. Volkar:

  • Over-the-counter vaginal lubricants can supplement natural lubrication.
  • Vaginal moisturizers are like lubricants, but they stay in the vagina longer and cling to vaginal walls. Use them a couple of times a week (not at the time of intercourse).
  • Vaginal estrogen can help if lubricants and moisturizers are not enough. As a vaginal cream, dissolvable tablet or long-term insert, estrogen can restore vaginal mucosa to the way it was before menopause.
  • An FDA-approved clitoral therapy device works like a gentle vacuum that can increase blood flow to the clitoris. In addition to increasing vaginal lubrication, it can enhance the ability to achieve orgasm.

While some drugs are being tested, currently there is no Viagra®-type drug to treat low libido in women.

Try increasing your receptivity instead of your sex drive

Hormones aren’t the only factor in a woman’s sex life. Emotions play a big role, too. While men can use sex as a stress reliever, women usually prefer to relieve stress before having sex. Tension, fatigue and relationship issues all can affect a woman’s sexual desire.

But here’s an interesting fact: Women don’t necessarily need to desire sex in order to enjoy it. It’s like going to the gym. You may not feel like working out on a particular day. But once you start on the treadmill, you get into it, enjoy it and feel better afterward.

So, instead of trying to increase your sex drive, try increasing your receptivity — your willingness or ability to enjoy sex once you get into it. You might try:

  • Reading erotic books or articles that make you start thinking about sexual things
  • Watching erotic videos
  • Talking to your partner about things that arouse you
  • Scheduling a romance night — and thinking beforehand about what you’ll do

You’re never too old! Talk to your doctor

If these tips don’t help and you are bothered by your sexual function, see a physician. You are never too old. Even if you haven’t had sex in years, a doctor can guide you in restoring enjoyment.

 menopause-women-sexual-dysfunction-2-190x155Source: clevelandclinic.org