Does Exposure to Certain Industrial Chemicals Increase the Risk for Liver Cancer?


Researchers at the University of Southern California Keck School of Medicine have discovered a potential link between exposure to a group of long-lasting chemicals and nonviral hepatocellular carcinoma. According to Veronica Wendy Setiawan, PhD, and colleagues, greater exposure to polyfluoroalkyl and perfluoroalkyl substances (PFAS) greatly increased the risk for developing this type of liver cancer, and the likely mechanisms centered on alterations in glucose, amino acid, and bile acid metabolism. These research findings were published in JHEP Reports, an open-access companion to the Journal of Hepatology.

“We believe our work is providing important insights into the long-term health effects that these chemicals have on human health, especially with respect to how they can damage normal liver function,” stated coauthor Lida Chatzi, MD, PhD, in a Keck School of Medicine press release.

Plasma PFAS were measured in 50 patients with hepatocellular carcinoma and 50 carefully selected control participants, and the risk was calculated using a conditional logistic regression. Additionally, a metabolome-wide association study and pathway enrichment analysis were performed for PFAS exposure and its correlation to hepatocellular carcinoma.

Through these methods, it was determined that high levels of perfluorooctane sulfonic acid (PFOS) contributed the most to the risk of developing hepatocellular carcinoma. The 90th percentile for PFOS concentration (determined by the National Health and Nutrition Examination Survey), measured at approximately 55 µg/L, correlated to 4.5 times the risk for developing this type of liver cancer. Through this study, it was also seen that PFOS exposure likely caused alterations in the metabolism of glucose, bile acid, and branched chain amino acids in the liver, which may contribute to the onset of nonalcoholic fatty liver disease; patients with this disease have a significantly higher risk of developing liver cancer. This study is reportedly the first to look at the effects of PFAS exposure in humans, and more research is needed to confirm these findings.

Researchers find unsafe levels of industrial chemicals in drinking water of 6 million Americans


Drinking water supplies serving more than six million Americans contain unsafe levels of a widely used class of industrial chemicals linked to potentially serious health problems, according to a new study from Harvard University researchers.

The chemicals — known as polyfluoroalkyl and perfluoroalkyl substances, or PFASs — have been used for decades in a range of industrial and commercial products, including non-stick coatings on pans, food wrappers, water-repellent clothing and firefighting foam. Long-term exposure has been linked to increased risks of kidney cancer, thyroid problems, high cholesterol and hormone disruption, among other issues.

“Virtually all Americans are exposed to these compounds,” said Xindi Hu, the study’s lead author. “They never break down. Once they are released into the environment, they are there.”

As part of the study, which was published Tuesday in Environmental Science & Technology Letters, the researchers examined concentrations of six types of PFAS chemicals in drinking water supplies around the country. The data came from more than 36,000 samples collected by the Environmental Protection Agency between 2013 and 2015.

They also looked at sites where the chemicals are commonly found — industrial plants that use them in manufacturing, military bases and civilian airports where fire-fighting foam is used and wastewater treatment plants.

What they found: 194 of 4,864 water supplies across nearly three dozen states had detectable levels of the chemicals. Sixty-six of those water supplies, serving about six million people, had at least one sample that exceeded the EPA’s recommended safety limit of 70 parts per trillion for two types of chemicals — perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA).

“It’s a big problem in a lot of communities,” said Richard Clapp, professor emeritus at Boston University’s school of public health. “It’s happening in a lot of places.”

From Decatur, Ala., to Merrimack, N.H., residents have been wrestling with high levels of the potentially harmful chemicals, and public officials have been scrambling to figure out how to prevent them from contaminating drinking water supplies.

The federal government does not currently regulate PFAS chemicals. But they are on the EPA’s list of “unregulated contaminants” that the agency monitors, with the goal of restricting those that most endanger public health. Partly because the rules that it must follow are complicated and contentious, officials have failed to successfully regulate any new contaminant in two decades.

Only once since the 1990s has the EPA come close to imposing a new standard — for perchlorate, a chemical that sometimes occurs naturally but also is found in explosives, road flares and rocket fuel. It has turned up in the drinking water of over 16 million people.

Joel Beauvais, who leads the EPA’s Office of Water, told the Post earlier this year that the system mandated by Congress demands the agency move deliberately. “It’s a rather intensive process to get one of these drinking-water regulations across the finish line,” he said.

Could your drinking water be contaminated?

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There are reasons for that, Beauvais said at the time. A substance may occur in only a very small number of drinking-water systems or might occur only in extremely low levels. Before the EPA imposes new limitations on the nation’s water utilities, it has to prove that there is a meaningful opportunity to improve public health. “These are very consequential regulations,” Beauvais said. “They are consequential from a health perspective. They are consequential from an economic perspective.”

In the wake of that advisory, at least one Alabama community declared its tap water unfit to drink and told residents to avoid it until officials could install a temporary, high-powered filter for the water supply. Some communities in New Hampshire received bottled water while authorities considered ways to address high levels of the contaminants in nearby groundwater. A company in upstate New York agreed to install carbon filters in private homes where high levels of the chemicals had been detected.

Clapp said that as evidence has mounted about the potential health risks posed by PFAS compounds and how ubiquitous they are, few people would argue that they should remain unregulated.

“We’re definitely overdue,” he said. “It’s not a question of whether, but rather at what level should they be regulated.”

Separately on Tuesday, another Harvard-led study, published in Environmental Health Perspectives, examined the effect of PFAS exposure in about 600 adolescents from the Faroe Islands off the coast of Denmark. Individuals exposed to the substances at a young age displayed lower-than-expected levels of antibodies to tetanus and diphtheria after being immunized, raising the prospect that the chemical exposure could be reducing the effectiveness of childhood vaccines.

The ‘mystery ingredients’ in fast food are actually industrial chemicals


Many people are aware of how bad fast food is for them – or at least, they kind of are. But the faults in fast food do not lie solely in the exorbitant calories, excess fat and copious use of salt and sugar. In fact, it turns out that these aspects may indeed be the more innocent parts of the dangers inherent in the fast food industry.

Fast food is surely not nutritionally sound (far from it), but there are many other secret ingredients lurking in those meat-shaped patties, and most of them are hidden because  people would not eat the food if they knew what was actually in it .

 Image: The ‘mystery ingredients’ in fast food are actually industrial chemicals

MSG, or monosodium glutamate, is a perfect example of this. While there are many people who will concede that MSG is harmful to  some people, they insist that it is not harmful to the majority. But, as  Food Renegade discusses, it is a cumulative compound, which means it can build up in your body over time. Even if you aren’t sensitive to it now, if you consume it regularly, eventually you will be. MSG is associated with a lot of side effects, including headaches. In fact, research has shown that it can even cause brain damage and lead to neurological disorders.

No one uses that stuff anymore though, right? Wrong. In fact, nearly every item on the KFC menu contains MSG, except for desserts and drinks. It is not uncommon for MSG to even be used in salads in the fast food industry. In addition, MSG has a host of alternative names that we should all be on the lookout for, including “yeast extract” and “hydrolized soy protein.”

High fructose corn syrup is another star of fast food and convenience items alike. While many people associate this ingredient with sweets like sodas and apple pies, HFCS is also added to salad dressings and other items. Despite claims that HFCS is “just like regular sugar,” evidence indicates that this is not true. As Natural News reports, “[T]his substance does not stimulate insulin secretion or reduce the hunger hormone ghrelin, people continue to eat while the body converts what they consume into fat.”

As a result of the growing concerns about HFCS, many manufacturers have taken to renaming HFCS with more innocent-sounding terms, such as “corn sugar.”

Another of the toxic ingredients hiding in your favorite fast food items is dimethylpolysiloxane, an anti-foaming agent with a variety of uses that are not at all food-related. For example, dimethylpolysiloxane is used in caulk, sealants and Silly Putty. It’s also featured in multiple items from McDonald’s, KFC and Wendy’s.

Of course, this just the beginning. There are many other harmful additives in fast foods. Sodium benzoate, sodium aluminum phosphate and acrylamide are just a few of the things you can find in your favorite takeaway meals. Next time you think you want a cheeseburger, do yourself a favor and make it yourself.