Flexible Spinal Implant May Be Future Of Paralysis Treatment; Helps Paralyzed Rats Walk Again


Although any kind of injury is bad, spinal cord injuries (SCI) might just be the scariest. Our spines are an information superhighway for nerves and their signals, which travel to the rest of the body. Just one strong blow to the back can be enough to offset vertebrae, which can tear or push into the spinal cord tissue, and just like that a person can be left paralyzed. It’s estimated that about 12,500 people will have a SCI each year, and 41 percent of them will end up either paralyzed from the waist down or throughout. After years of research, however, Swiss scientists are finally on track to giving these people their lives of movement back, with the help of elastic electrical spinal implants.

E-Dura

Scientists at Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have been working on spinal cord implants for quite some time now, but a major roadblock for them has been maintaining flexibility akin to the spine. Current iterations of spinal cord implants are rigid and unable to move around if, for example, you’re bending down to tie your shoe. Over the course of a few days, these implants begin to rub against spinal tissue, causing inflammation and scar tissue build up. Eventually, the body rejects the implant.

The team’s new implant is called e-Dura. It’s named after the dura mater — one layer of the protective membrane that surrounds the spinal cord and brain — under which it’s placed. By using elastic silicone and cracked gold wiring, which created a mesh-like structure, the researchers were able to give it flexibility comparable to that of the nerve tissue surrounding it. And after two months of having the implant in their spines, paralyzed rats were able to walk, run, and jump without damage or rejection.

“This is quite remarkable. Until now, the most advanced prostheses in intimate contact with the spinal cord caused quite substantial damage to tissue in just one week due to their stiffness,” Dr. Dusko Ilic, from King’s College London, told the BBC. He was not involved in the study. “The work described here is a groundbreaking achievement of technology, which could open a door to a new era in treatment of neuronal damage.”

For the study, the researchers first tested the e-Dura against a stiffer implant and surgery alone, and found it was safe for the rats’ bodies without any adverse reactions. Then they inserted the implant in the rats’ motor cortexes to determine which signals indicated an intention to move their legs, and found that the device could indeed read signals, Live Sciencereported. Finally, they tested the device again on a group of paralyzed rats, finding that they had the ability to walk again after eight weeks, albeit with the help of an external stimulator which connected to the device with wires.

The team still has a long way to go if they want to bring this technology to humans. One of the first things they need to work on is getting the device to work independently of an external stimulator, which provides the signals for movement. “Translation of experimental treatments to humans often falters because insufficient attention is given to some of the more pragmatic aspects of translational science,” Dr. Mark Bacon, scientific director of the UK charity Spinal Research who wasn’t involved in the study, told the BBC.  “The combination of electrical and chemical stimulation has been proven in principle — in animal models at least — so it is encouraging to see the application of multidisciplinary efforts to take this one step closer to safe testing in patients.”

Source: Minev I, Musienko P, Lacour S, et al. Electronic dura mater for long-term multimodal neural interfaces. Science. 2014.

Gimball: A crash-happy flying robot.


Gimball bumps into and ricochets off of obstacles, rather than avoiding them. This 34 centimeter in diameter spherical flying robot buzzes around the most unpredictable, chaotic environments, without the need for fragile detection sensors. This resiliency to injury, inspired by insects, is what sets it apart from other flying robots. Gimball is protected by a spherical, elastic cage which enables it to absorb and rebound from shocks. It keeps its balance using a gyroscopic stabilization system. When tested in the forests above Lausanne, Switzerland, it performed brilliantly, careening from tree trunk to tree trunk but staying on course. It will be presented in public at the IREX conference in Tokyo, Japan from November 5-9, 2013.

Powered by twin propellers and steered by fins, Gimball can stay on course despite its numerous collisions. This feat was a formidable challenge for EPFL PhD student Adrien Briod. “The idea was for the robot’s body to stay balanced after a collision, so that it can keep to its trajectory,” he explains. “Its predecessors, which weren’t stabilized, tended to take off in random directions after impact.” With colleague Przemyslaw Mariusz Kornatowski, Briod developed the gyroscopic  consisting of a double carbon-fiber ring that keeps the robot oriented vertically, while the cage absorbs as it rotates.

Going sensor-free: insect-inspired design

Most robots navigate using a complex network of sensors, which allow them to avoid obstacles by reconstructing the environment around them. It’s an inconvenient method, says Briod. “The sensors are heavy and fragile. And they can’t operate in certain conditions, for example if the environment is full of smoke.”

Gimball’s robustness lies in its technological simplicity, says Briod. “Flying insects handle collisions quite well. For them, shocks aren’t really accidents, because they’re designed to bounce back from them. This is the direction we decided to take in our research.”

The flying  is prepared to deal with the most difficult terrain out there. “Our objective was exactly that – to be able to operate where other robots can’t go, such as a building that has collapsed in an earthquake. The on-board camera can provide valuable information to emergency personnel.” The scientist had an opportunity to test his prototype in a Swiss pine forest. Fitted out with just a compass and an altitude sensor, Gimball demonstrated its ability to maintain its course over several hundred meters despite colliding with several tree trunks along the way.

Gimball is the latest in a long line of colliding robots developed in the laboratory of EPFL professor Dario Floreano. But its stabilization system, spherical shape and ultralight weight – barely 370 grams – demonstrate the potential of the concept better than ever before. “The mechanics must also be intelligent, since complex obstacle avoidance systems are not sufficient,” says Briod. Even so, he insists, “we’re not yet ready to compete with our model. Insects are still superior.”

A first: Stanford engineers build computer using carbon nanotube technology.


A team of Stanford engineers has built a basic computer using carbon nanotubes, a semiconductor material that has the potential to launch a new generation of electronic devices that run faster, while using less energy, than those made from silicon chips.

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This unprecedented feat culminates years of efforts by scientists around the world to harness this promising material.

The achievement is reported today in an article on the cover of Nature magazine written by Max Shulaker and other doctoral students in electrical engineering. The research was led by Stanford professors Subhasish Mitra and H.S. Philip Wong.

“People have been talking about a new era of carbon nanotube electronics moving beyond silicon,” said Mitra, an electrical engineer and computer scientist, and the Chambers Faculty Scholar of Engineering. “But there have been few demonstrations of complete digital systems using this exciting technology. Here is the proof.”

Experts say the Stanford achievement will galvanize efforts to find successors to silicon chips, which could soon encounter physical limits that might prevent them from delivering smaller, faster, cheaper electronic devices.

“Carbon nanotubes (CNTs) have long been considered as a potential successor to the silicon transistor,” said Professor Jan Rabaey, a world expert on electronic circuits and systems at UC Berkeley.

But until now it hasn’t been clear that CNTs could fulfill those expectations.

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“There is no question that this will get the attention of researchers in the semiconductor community and entice them to explore how this technology can lead to smaller, more energy-efficient processors in the next decade,” Rabaey said.

Mihail Roco, senior advisor for Nanotechnology at the National Science Foundation, called the Stanford work “an important, scientific breakthrough.”

It was roughly 15 years ago that carbon nanotubes were first fashioned into transistors, the on-off switches at the heart of digital electronic systems.

But a bedeviling array of imperfections in these carbon nanotubes has long frustrated efforts to build complex circuits using CNTs. Professor Giovanni De Micheli, director of the Institute of Electrical Engineering at École Polytechnique Fédérale de Lausanne in Switzerland, highlighted two key contributions the Stanford team has made to this worldwide effort.

“First, they put in place a process for fabricating CNT-based circuits,” De Micheli said. “Second, they built a simple but effective circuit that shows that computation is doable using CNTs.”

As Mitra said: “It’s not just about the CNT computer. It’s about a change in directions that shows you can build something real using nanotechnologies that move beyond silicon and its cousins.”

Why worry about a successor to silicon? Such concerns arise from the demands that designers place upon semiconductors and their fundamental workhorse unit, those on-off switches known as transistors

For decades, progress in electronics has meant shrinking the size of each transistor to pack more transistors on a chip. But as transistors become tinier they waste more power and generate more heat – all in a smaller and smaller space, as evidenced by the warmth emanating from the bottom of a laptop.

Many researchers believe that this power-wasting phenomenon could spell the end of Moore’s Law, named for Intel Corp. co-founder Gordon Moore, who predicted in 1965 that the density of transistors would double roughly every two years, leading to smaller, faster and, as it turned out, cheaper electronics.

But smaller, faster and cheaper has also meant smaller, faster and hotter.

“Energy dissipation of silicon-based systems has been a major concern,” said Anantha Chandrakasan, head of electrical engineering and computer science at MIT and a world leader in chip research. He called the Stanford work “a major benchmark” in moving CNTs toward practical use. CNTs are long chains of carbon atoms that are extremely efficient at conducting and controlling electricity. They are so thin – thousands of CNTs could fit side by side in a human hair – that it takes very little energy to switch them off, according to Wong, co-author of the paper and the Williard R. and Inez Kerr Bell Professor at Stanford.

“Think of it as stepping on a garden hose,” Wong said. “The thinner the hose, the easier it is to shut off the flow.” In theory, this combination of efficient conductivity and low-power switching make carbon nanotubes excellent candidates to serve as electronic transistors.

“CNTs could take us at least an order of magnitude in performance beyond where you can project silicon could take us,” Wong said. But inherent imperfections have stood in the way of putting this promising material to practical use.

First, CNTs do not necessarily grow in neat parallel lines, as chipmakers would like.

Over time, researchers have devised tricks to grow 99.5 percent of CNTs in straight lines. But with billions of nanotubes on a chip, even a tiny degree of misaligned tubes could cause errors, so that problem remained.

A second type of imperfection has also stymied CNT technology.

Depending on how the CNTs grow, a fraction of these carbon nanotubes can end up behaving like metallic wires that always conduct electricity, instead of acting like semiconductors that can be switched off.

Since mass production is the eventual goal, researchers had to find ways to deal with misaligned and/or metallic CNTs without having to hunt for them like needles in a haystack.

“We needed a way to design circuits without having to look for imperfections or even know where they were,” Mitra said. The Stanford paper describes a two-pronged approach that the authors call an “imperfection-immune design.”

To eliminate the wire-like or metallic nanotubes, the Stanford team switched off all the good CNTs. Then they pumped the semiconductor circuit full of electricity. All of that electricity concentrated in the metallic nanotubes, which grew so hot that they burned up and literally vaporized into tiny puffs of carbon dioxide. This sophisticated technique was able to eliminate virtually all of the metallic CNTs in the circuit at once.

Bypassing the misaligned nanotubes required even greater subtlety.

So the Stanford researchers created a powerful algorithm that maps out a circuit layout that is guaranteed to work no matter whether or where CNTs might be askew.

“This ‘imperfections-immune design’ (technique) makes this discovery truly exemplary,” said Sankar Basu, a program director at the National Science Foundation.

The Stanford team used this imperfection-immune design to assemble a basic computer with 178 transistors, a limit imposed by the fact that they used the university’s chip-making facilities rather than an industrial fabrication process.

Their CNT computer performed tasks such as counting and number sorting. It runs a basic operating system that allows it to swap between these processes. In a demonstration of its potential, the researchers also showed that the CNT computer could run MIPS, a commercial instruction set developed in the early 1980s by then Stanford engineering professor and now university President John Hennessy.

Though it could take years to mature, the Stanford approach points toward the possibility of industrial-scale production of carbon nanotube semiconductors, according to Naresh Shanbhag, a professor at the University of Illinois at Urbana-Champaign and director of SONIC, a consortium of next-generation chip design research.

“The Wong/Mitra paper demonstrates the promise of CNTs in designing complex computing systems,” Shanbhag said, adding that this “will motivate researchers elsewhere” toward greater efforts in chip design beyond silicon.

“These are initial necessary steps in taking carbon nanotubes from the chemistry lab to a real environment,” said Supratik Guha, director of physical sciences for IBM’s Thomas J. Watson Research Center and a world leader in CNT research.

Journal reference: Nature

 

Microscopic ‘Tuning Forks’ Could Make the Difference Between Life and Death in the Hospital.


A patient admitted to a hospital with a serious bacterial infection may have only a few hours to live. Figuring out which antibiotic to administer, however, can take days. Doctors must grow the microbes in the presence of the drugs and see whether they reproduce. Rush the process, and they risk prescribing ineffective antibiotics, exposing the patient to unnecessary side effects, and spreading antibiotic resistance. Now, researchers have developed a microscopic “tuning fork” that detects tiny vibrations in bacteria. The device might one day allow physicians to tell the difference between live and dead microbes—and enable them to recognize effective and ineffective antibiotics within minutes.

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“It’s a brilliant method,” provided subsequent investigations confirm the researchers’ interpretation of their data, says Martin Hegner, a biophysicist at Trinity College Dublin who was not involved in the work.

The research involves tiny, flexible bars called cantilevers that vibrate up and down like the prongs of a tuning fork when they receive an input of energy. Cantilevers are an important part of atomic force microscopy, which is useful for making atomic scale resolutions of surfaces for use in nanotechnology or atomic physics research. In this technique, a minute needle attached to a cantilever moves across a surface, and the deflection of the cantilever gives information about how atoms are arranged on the surface. It can even be used to shunt atoms around. More recently, however, they have been used without the needle as tiny oscillators, allowing scientists to investigate matter directly attached to the cantilever.

Biophysicist Giovanni Longo and colleagues at the Swiss Federal Institute of Technology in Lausanne and the University of Lausanne in Switzerland immersed these cantilevers in a liquid bacterial growth medium and monitored their movement using a laser. They found that the bare cantilever moved very slightly as a result of the thermal movement of the liquid molecules in the medium. They then covered both sides of the cantilever withEscherichia coli bacteria, which can cause food poisoning, and immediately found that the oscillations became much more pronounced. The researchers believe that chemical processes that occur inside the bacteria as they metabolize energy are driving the oscillation. “What we see is that if you have some sort of a moving system on the cantilever, you are going to induce a movement on the cantilever itself,” Longo explains. “Exactly what kind of metabolic movement we see is something that we are still studying.”

To determine if the cantilevers could detect the impact of drugs, the team added ampicillin, an antibiotic that the cultured bacteria were sensitive to. The size of the cantilever’s oscillations decreased almost 20-fold within 5 minutes, the researchers report online today in Nature Nanotechnology. Fifteen minutes later, the scientists flushed the antibiotic out with fresh growth medium, but the movement of the cantilever did not increase again. This, the researchers say, suggests that the antibiotic had killed the bacteria. When they used an ampicillin-resistant strain of E. coli, however, they found that the oscillations initially decreased but returned to normal within about 15 minutes, indicating that the microbes had recovered.

Hegner cautions that the research is still “basic science. … It’s not yet an applied tool which is robust enough to be used in an ER or something.” That, he says, might take another 5 or 10 years.

Before that happens, Hegner says, researchers need to determine what the sensors are picking up and whether that signal can be conclusively linked to the bacteria and their antibiotic resistance. They also need to find out if properties of the medium affect the results, he says. “If you inject a bacterium into a medium with different viscosity and different density, this also might affect the vibration of the sensor.”

The Swiss researchers are continuing to investigate clinical applications of their system. They have recently obtained access to a more secure lab licensed to handle highly pathogenic bacteria and are working on confirming their results in these microbes. They are also thinking beyond the clinic. “Our dream is to send something like this to Mars to see if there is life,” Longo says. “It’s much faster than any other technique one can imagine—you just put some of the martian dirt inside the liquid and whatever attaches to the cantilever, if it moves it’s alive.”

Source: sciencemag.org

Contact lenses bestow telescopic vision.


Researchers have created contact lenses which, when paired with special spectacles, bestow telescopic vision on their wearers.

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The contact-lens-and-spectacles combination magnifies scene details by 2.8 times.

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Polarising filters in the spectacles allow wearers to switch between normal and telescopic vision.

The telescopic sight system has been developed to help people suffering age-related blindness.

Age-related macular degeneration is one of the most common forms of blindness and damages the part of the eye, the macula, that handles fine detail. As this area degenerates, sufferers lose the ability to recognise faces and perform tasks, such as driving and reading, that rely on picking up details.

Precise control

The contact lens created by the researchers has a central region that lets light through for normal vision. The telescopic element sits in a ring around this central region. Tiny aluminium mirrors scored with a specific pattern act as a magnifier as they bounce the light around four times within the ring before directing it towards the retina.

In ordinary use, the magnified image is not seen as it is blocked by polarising filters set in a companion pair of spectacles. Wearers can switch it on by changing the filters on the spectacles so the only light falling on their retina comes from the magnified stream.

For their filtering system, the researchers, led by Joseph Ford at UC San Diego and Eric Tremblay at Switzerland’s EPFL, adapted a pair of glasses that Samsung produces for some of its 3D TV sets. In normal use, these spectacles create a 3D effect by alternately blocking the right or left lens.

The prototype contact lens produced by the team is 8mm in diameter, 1mm thick at its centre and 1.17mm thick in its magnifying ring.

“The most difficult part of the project was making the lens breathable,” Dr Tremblay told the BBC. “If you want to wear the lens for more than 30 minutes you need to make it breathable.”

Gases have to be able to penetrate the lens to keep the parts of the eye covered by the contact, especially the cornea, supplied with oxygen, he said.

The team has solved this problem by producing lenses riddled with tiny channels that let oxygen flow through.

However, said Dr Tremblay, this made manufacturing the lenses much more difficult.

“The fabrication tolerances are quite challenging because everything has to be so precise,” he said.

Despite this, gas-permeable versions of the telescopic lens are being prepared that will be used in clinical trials in November, he said. Eventually it should be possible for those with age-related sight problems to wear the telescopic lenses all day.

The lenses are an improvement on other ways these sight problems have been tackled which has included surgery to implant a telescopic lens or wearing bulky spectacles that have telescopic lenses forming part of the main lens.

Clara Eaglen, eye health campaigns manager at the RNIB said the research looked “interesting” and praised its focus on macular degeneration.

“It is encouraging that innovative products such as these telescopic contact lenses are being developed, especially as they aim to make the most of a person’s existing vision,” she said. “”Anything that helps to maximise functioning vision is very important as this helps people with sight loss to regain some independence and get out and about again, helping to reduce isolation.”

The lenses may one day find their way into other areas as the research was being funded by Darpa, the research arm of the US military.

“They are not so concerned about macular degeneration,” he said. “They are concerned with super vision which is a much harder problem.

“That’s because the standard is much higher if you are trying to improve vision rather than helping someone whose eyesight has deteriorated,” he said.

Source: BBC