Vibrating Oral Capsule for Constipation Gets FDA Green Light


Drug-free Vibrant System cleared for treatment of chronic idiopathic constipation

FDA MARKETING Drug-Free Constipation Treatment (Vibrant) over a photo of the device in a man’s hand.

The FDA issued marketing authorization for a novel, drug-free treatment for chronic constipation.

Dubbed Vibrant System, the treatment is indicated for patients with chronic idiopathic constipation who failed to achieve bowel symptom relief after at least 1 month of taking recommended doses of laxatives.

The orally administered first-of-its-kind product involves a single-use capsule and pod that activates the vibrating capsule. Patients are directed to ingest the capsule with a glass of water and can monitor the treatment using a mobile app.

According to developer Vibrant Gastro, the “treatment is thought to enhance colonic motility by augmenting the biological clock via mechanical stimulation of the colon.”

Safety and efficacy data supporting the authorization came from 312 patients with chronic idiopathic constipation who participated in a phase III trial.

Nearly twice as many patients treated with the vibrating capsule had at least one additional complete spontaneous bowel movement each week (compared with baseline) versus a placebo group (40.5% vs 22.9%, respectively, P=0.0011). Additionally, twice as many patients on the Vibrant System had at least two additional complete bowel movements each week compared with the controls (23.4% vs 11.8%).

Adverse events with the vibrating capsule were less frequent compared with the placebo group (6.5% vs 9.4%), and no serious adverse events were reported. Two patients in the study arm reported diarrhea.

“The goal of Vibrant is to address a real problem in chronic constipation, which has made life very challenging for those who suffer from it,” said principal investigator Satish Rao, MD, PhD, of the Medical College of Georgia, in a press release from the company. “We believe the Vibrant System is a meaningful step towards achieving that goal.”

Chronic constipation is a common gastrointestinal disorder affecting approximately 16% of individuals in the U.S. It also comes with significant treatment costs. About 70% to 90% of patients experience symptoms of straining, bloating, and hard stools, which reduce individuals’ quality of life.

Vibrant is expected to be available early next year in select states, with gradual expansion nationally after that.

What should be the management of functional constipation in adults?


The treatment of functional constipation in adults depends on eliminating the underlying cause and distinguishing between different subtypes of functional constipation, such as normal transit, slow transit, or an evacuation disorder, which has substantial therapeutic implications. Adult functional constipation is treated with a combination of lifestyle modifications, pelvic floor therapies (if a rectal evacuation disorder exists), and pharmacological treatment.1

Nonpharmacologic treatment   
Lifestyle modificationstoileting after meals, increased fluid intake, increased dietary fibre intake, and increased physical activity
BiofeedbackEffective for treating constipation caused by pelvic floor dysfunction.
Pharmacological treatments   
DrugDosagesTime of onsetSide effects
Bulking agents   
Methylcellulose powder19 g/day12 to 72 hours
Polycarbophil tablets1,250 mg/day, (one to four times)12 to 72 hours
Psyllium powder1 tsp/day or 1 packet/day (one to three times)12 to 24 hoursBloating, abdominal distension
Osmotic laxatives   
Lactulose solution15 to 30 mL/day24 to 48 hoursBloating and cramping, nausea
Magnesium citrate solution150 to 300 mL, single dose or short-term daily dose30 minutes to 6 hoursIncrease in magnesium, causing lethargy, hypotension, respiratory depression
Magnesium hydroxide suspension30 to 60 mL/day30 minutes to 6 hoursIncrease in magnesium, causing lethargy, hypotension, respiratory depression
Polyethylene glycol powder17 g/day24 to 48 hoursMinimal adverse effects of cramping and gas
Sorbitol solution2 to 3 tbsp, single dose or short-term daily dose24 to 48 hoursBloating, cramping, and nausea
Stool softeners   
Docusate sodium capsules100 mg twice/day24 to 48 hours
Stimulant laxatives   
Bisacodyl tablets5 to 15 mg/day6 to 10 hoursDiarrhoea and abdominal pain in 56% in week 1 and 5% in week 4
Senna tablets15 mg/day6 to 12 hoursAbdominal pain in up to 12%
Chloride channel activators   
Lubiprostone capsules24 mcg twice/dayWithin 24 hoursNausea
Peripherally acting mu-opioid antagonists   
Methylnaltrexone solutionWeight-based subcutaneous injection, once or twice/day30 to 60 minutesDiarrhoea, abdominal pain
Other   
Linaclotide capsules145 mcg/day Diarrhoea leads to treatment cessation

Surgery is a last-resort treatment. There are no clear standards on how to manage functional constipation surgically, and techniques differ greatly between children and adults.[1]

Citation

  1. ^ Vriesman MH, Koppen IJN, Camilleri M et al. Management of functional constipation in children and adults. Nat Rev Gasteroenterol Hepatol. 2020;17:21-39.https://www.nature.com/articles/s41575-019-0222-y

Here’s Why Your Poop Can Be So Freaking Weird on Your Period


You know what we’re talking about.
Poop-And-Periods

Most people are pretty open about the “joys” that come with having a period, like cramps, bloating, and sore boobs. But there’s one period side effect people really need to discuss more often, because maybe sharing the burden can at least make the load a little lighter: period poop.

Everyone’s situation is different, but it’s not uncommon for your regular poop habits to take a temporary vacation when you’re on your period, or be suddenly replaced with a whole lot of diarrhea, or both. “Many women do get bowel changes just before or during their period,” Kyle Staller, M.D., a gastroenterologist at Massachusetts General Hospital, tells SELF.

You’ve probably noticed this and dismissed it as just one of those body things, but there’s an actual biological cause you should know about.

“The reason that this happens is largely due to hormones,” says Dr. Staller. Pre-period constipation could be a result of an increase in the hormone progesterone, which starts to increase in the time between ovulation and when you get your period. Progesterone can cause food to move more slowly through your intestines, backing you up in the process.

So what about that diarrhea, though? Hormone-like substances called prostaglandins could be to blame for that. The cells that make up the lining of your uterus (known as endometrial cells), produce these prostaglandins, which get released as the lining of your uterus breaks down right before and during your period. If your body makes a lot of prostaglandins, they can make their way into the muscle that lines your bowels. There, they can cause your intestines to contract just like your uterus and push out fecal matter quickly, causing diarrhea in the process, Ashkan Farhadi, M.D., a gastroenterologist at MemorialCare Orange Coast Medical Center and director of MemorialCare Medical Group’s Digestive Disease Project in Fountain Valley, California, tells SELF. (Fun fact: These prostaglandins are also responsible for those painful cramps you might get every month.)

Of course, this can all vary in different people. But if you notice you experience constipation or diarrhea right around your period like clockwork, this may be why.

Having certain health conditions can also exacerbate period-related bowel changes.

If you struggle with a health condition like endometriosisCrohn’s diseaseirritable bowel syndrome, or ulcerative colitis, having your period can cause a flare-up of your symptoms. Ultimately, the symptoms you experience depend on your condition, Dr. Farhadi says.

For example, if you struggle with Crohn’s disease, which can often cause diarrhea, or IBS-D (a form of IBS that causes people to have diarrhea), your body’s release of prostaglandins during your period may cause you poop even more than usual. But if you suffer from IBS-C (IBS that causes people to have constipation), you may find yourself struggling even more to have a BM on your period as progesterone further slows your bowels’ activity. Since ulcerative colitis can lead to both diarrhea and constipation, you might experience an uptick in either during your period.

And unfortunately endometriosis can lead to pain during bowel movements around your period, Christine Greves, M.D., a board-certified ob/gyn at the Winnie Palmer Hospital for Women and Babies, tells SELF. Endometriosis is a disease where endometrial tissue that normally grows inside the uterus (or, as is up for debate, tissue similar to endometrial lining) grows outside of the uterus. This tissue can attach to your bowels and start trouble. “You then have bleeding around that area, and that can cause pain when you have a bowel movement,” Dr. Greves explains.

If your poop gets weird on your period, there are a few things you can do to cope.

The most important step is knowing what’s normal for you on your period and doing what you can to minimize any additional triggers. For instance, if you always get diarrhea during your period, and you know that coffee tends to make you poop more, it’s a good idea to cut back a little when you’re actually on your period, Dr. Farhadi says. You can also take Immodium on the first day of your period in anticipation of diarrhea, or carry it with you in case it strikes, he says. If you deal with constipation during your period, try upping your fiber and water intake in the middle of your cycle, when constipation-prompting progesterone levels start rising.

It can also help to pop some non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs, a common class of pain relievers, can block certain enzymes in your body from making prostaglandins. With fewer prostaglandins roaming around, you may get some relief from an achy belly and incessant pooping.

If you’re really having a hard time with poop issues on your period, talk to your doctor. They may be able to recommend next steps or refer you to a specialist who can. Your period is already annoying enough without spending forever on the toilet, either basically pooping water or straining hard to go in the first place.

Gastroenterologists Share 7 Things to Do When You Have Painful Gas


Pain is the cruel cherry on top.
Gas-Pains

Pretty much no one is happy to have gas (with the exception of the elementary school set, who of course finds it hilarious). Gas is a normal part of having a body, but it can also be straight-up painful sometimes.

Since you probably don’t feel comfortable calling out sick from work with gas or otherwise letting it disrupt your life, you likely want to get things sorted out ASAP. As it turns out, the key to fixing painful gas is knowing why it happens in the first place.

There are a few reasons gas can develop, and, well, it has to go somewhere.

Gas often happens as a normal part of your digestive process. Your stomach and small intestine don’t entirely break down certain carbohydrates you eat, so they end up getting to your large intestine intact, according to the National Institute of Diabetes and Digestive and Kidney Diseases. There, bacteria make gas as they process these undigested sugars, fibers, and starches. Certain foods, like dairy products and cruciferous vegetables such as Brussels sprouts, are more likely to cause gas than others, but everyone’s triggers are different.

You can also get gas if you swallow a lot of air. While it’s unlikely that you’re actually trying to suck down a bunch of oxygen, certain habits like regularly using a straw, drinking carbonated beverages, eating too quickly, and chewing gum can cause you to take in more air than normal. When this causes gas, it’s typically via burping, since the air comes back up before it can go all the way to your stomach.Beyond those causes, gas can happen if you have health conditions that affect your digestive system, like irritable bowel syndromeulcerative colitis, or Crohn’s disease, or bacterial overgrowth in the small intestine, according to the Mayo Clinic.

OK, but why does gas sometimes hurt so bad that you want to cry and check yourself into the ER?

Good question. Painful gas and other bothersome symptoms like bloating can happen if gas builds up in your system because you can’t expel it (like if you’re purposely holding it in), if you eat something that really doesn’t agree with you, or if you have an underlying condition that prevents gas from moving through your system normally. All of this can cause spasms and distension in your large intestine during the digestive process, which can be pretty painful, Jamile Wakim-Fleming, M.D., a gastroenterologist at the Cleveland Clinic, tells SELF.

Unfortunately, there isn’t one magic pill that will immediately get rid of any painful gas you may be experiencing. The drug simethicone, which is an anti-foaming agent present in medicines like Gas-X, is designed to reduce bloating and pain from gas and may help, but it’s not a guarantee, Kyle Staller, M.D., M.P.H., a gastroenterologist at Massachusetts General Hospital, tells SELF.

There are, however, a few tricks you can try to either make the gas go away or, at the very least, make you feel better.

1. Sip a glass of water slowly.

Drinking water does two things, says Dr. Wakim-Fleming: It can help move any gas-causing foods in your system through the digestive process, and it makes it harder for your intestines to contract in a way that gasses you up. See, your intestines contract to move food, and if they contract too strongly or for too long, that can lead to or exacerbate gas.

2. Try to stop swallowing so much air—seriously.

Downing some water can be counterproductive if you’re doing it in a way that will only lead to more gas. Until the pain abates, avoid habits that can lead to swallowing a ton of air, like taking big gulps of water at a time, using straws, drinking fizzy beverages, sucking your food down too quickly, talking a lot while eating, and chewing gum, Dr. Wakim-Fleming says.

3. Try getting up and walking around.

Exercise isn’t just great for your overall health—it can also help clear up painful gas and bloating. While a five-mile run probably isn’t first on your to-do list when you’re doubled over in pain, if you can manage a quick walk or other gentle movement, that can make a big difference.

“Exercise helps exercise your intestines, too,” Dr. Wakim-Fleming says. Experts don’t know exactly why exercise helps move gas along, but something about physical activity helps to boost your intestines’ muscle activity, Ashkan Farhadi, M.D., a gastroenterologist at MemorialCare Orange Coast Medical Center and director of MemorialCare Medical Group’s Digestive Disease Project in Fountain Valley, Calif., tells SELF. (This is part of why exercise is recommended for constipation.)

4. Consider if dairy is actually the culprit.

If you’re currently in the fetal position dealing with gas pain, think back to how much cheese, milk, and ice cream you had recently—even if you don’t think you’re lactose intolerant. You can spend years having zero issues when you drink a venti latte in the A.M., followed by a grilled cheese sandwich at lunch…until you suddenly do. As most people age, they start making less lactase, an enzyme that breaks down lactose, the sugar in dairy products, Dr. Staller says. This is one cause of lactase deficiency and lactose intolerance. As your digestive system’s bacteria tries to break down lactose without enough lactase to do the job, you may experience annoying symptoms like more painful gas than usual.

“Many people in their 20s and 30s have symptoms and don’t suspect that it’s the dairy products,” Dr. Staller says. If you think dairy is behind your painful gas, try cutting it out for a few weeks (or at the very least, the rest of the day) and see where that gets you.

5. Have some peppermint oil or peppermint tea.

It’s not just for your breath—peppermint can act as a spasmolytic, meaning it may help stop your intestines from spasming too much (which is what increases gas), says Dr. Staller. While this mechanism has mainly been studied in regard to irritable bowel syndrome, the muscle contractions in that disorder are the same ones that can make gas feel so terrible, he says.

Doctors aren’t totally sure whether it’s better to take peppermint in a capsule form or via something more standard like a mint or peppermint tea, so feel free to try whatever you have handy (but be sure to follow the instructions if you’re ingesting peppermint oil as a pill).

6. Snuggle under a blanket with a heating pad on your abdomen.

It’s not a hard sell when you feel like crap, but cozying up under a blanket with a heating pad on your abdomen can actually help fight gas. Like peppermint, warmth can have an antispasmodic effect on your body and help your intestines to relax instead of contract too hard or too much, lessening that achy sensation that all too often comes along with gas, Dr. Wakim-Fleming says. And don’t worry that lying down means your gas is having to struggle against gravity to exit—it makes no difference either way, Dr. Farhadi says. (Though, as we said, getting up and walking around for a bit can also be helpful to do before or after you settle in with a heating pad.)

7. And lastly, commit to keeping your fiber intake in check.

Fiber is a key part of a healthy diet and digestive system. It bulks up your stool, which helps you stay regular instead of getting constipated. But on the flip side, having too much fiber can make you gassy as the bacteria in your colon works to break this tough nutrient down, Dr. Farhadi says.

If you find that you’re always in pain after you eat a salad with both broccoli and Brussels sprouts, it’s really best to avoid those foods (or whatever the fiber-heavy food may be) until you feel better—and to try to space out when you eat them in the future.

These tips should, at the very least, help make your painful gas feel a bit better. But if you’re struggling with incredibly painful gas and nothing is helping, call your doctor. They should be able to help you find the root of the issue—and how to stop it.

Constipation Emergencies on the Rise


Constipation is one of the most common bowel problems, impacting up to 19 percent of the US population (no pun intended).1 It’s defined as passing hard, dry stools that you have to strain to move, as well as having fewer than three bowel movements a week.

Constipation is uncomfortable, causing bloating, cramps, and a feeling of incomplete elimination. However, despite its ability to make you feel miserable, constipation is generally regarded as more of a nuisance than a real health threat.

This is a mistake, as chronic constipation left untreated can lead to fecal impaction,2 which is when hardened stool gets stuck in your intestines. Constipation has also been shown to increase your risk of colon cancer and has been implicated in diverticulosis and appendicitis.

Straining to have a bowel movement, which is common with constipation, is also not something to be taken lightly. This can lead to hemorrhoids, anal fissure (torn skin in your anus), and even rectal prolapse, in which a part of your intestine protrudes from your anus.

It can also be quite painful, leading to severe abdominal pain, which is likely one reason why emergency room (ER) visits for constipation have been on the rise.

ER Visits for Constipation Are on the Rise

From 2006 to 2011, there was a 42 percent increase in ER visits for constipation in the US – a significant rise that’s far greater than the 22 percent increase in overall ER visits during the same period.3 The study’s senior author, Dr. Anthony Lembo from Beth Israel Deaconess Medical Center in Boston, told Reuters:4

“Constipation is often thought of as not a serious disease – particularly among doctors. Patients complain about it but it’s often not thought of as being medically that relevant.”

The costs involved would suggest otherwise, however. From 2006 to 2011, costs of ER visits for constipation rose about 56 percent per patient, from $1,500 at the start of the study to $2,300 in 2011, after accounting for inflation. In all, about $1.6 billion was spent on ER care for constipation in 2011.5

This is an extremely high number, especially since constipation can usually be easily remedied with lifestyle changes. Ironically, one of the biggest hindrances to your success may be not realizing you’re constipated in the first place.

Conventional medicine typically defines constipation as fewer than two or three bowel movements a week. But you should really be having one bowel movement a day, and preferably two or three. So if you are having anything less than one bowel movement a day, you should consider taking some constipation remedies.

What Causes Constipation?

Regular bowel movements are extremely important for your health because, without them, toxins accumulate and are recirculated in your bloodstream. If elimination is not regular and complete, the wastes will dry and become cemented to the walls of your colon.

Some of the common causes of constipation include laxative abuse,hypothyroidism, irritable bowel syndrome (IBS), and ignoring the urge to go. If you consistently ignore the urge to have a bowel movement – for instance, to avoid using a public toilet – eventually you may stop feeling the urge.

Certain medications, like antidepressants, antacids (like calcium), blood pressure medications, and iron supplements may also contribute to constipation, as can dehydration if you’re not drinking enough pure water each day.

However, one of the primary causes of constipation has to do with your diet, particularly if you’re eating one high in processed foods and low in fiber. One of the signs that a food is a natural source of fiber is that you must chew it a good number of times before swallowing. Processed foods, which basically melt in your mouth, are not going to give you the fiber your body needs.

Unless you regularly eat whole fruits and vegetables (along with nuts and seeds), you may be missing out on the healthiest forms of fiber available – and that could be a problem. It is actually because your body can’t digest fiber that it plays such an important part in digestion. Soluble fiber, like that found in cucumbers and blueberries, dissolves into a gel-like texture, helping to slow down your digestion.

This helps you to feel full longer and is one reason why fiber may help with weight control. Insoluble fiber, found in foods like dark green leafy vegetables, green beans, celery, and carrots, does not dissolve at all and helps add bulk to your stool.

This helps food to move through your digestive tract more quickly for healthy elimination. Many whole foods, especially fruits and vegetables, naturally contain both soluble and insoluble fiber, which help to keep you regular, naturally.

Fiber Feeds Beneficial Gut Bacteria and Helps with Weight Loss

Fiber supplements have been shown to enhance weight loss among obese people,6 likely because fiber increases feelings of fullness. However, there’s more to it. When microbes in your gut digest fiber, a short-chain fatty acid called acetate is released. The acetate then travels from your gut to your hypothalamus, where it helps signal you to stop eating.

In addition, fiber can shift the makeup of microbes in your gut in a very favorable direction. Research published in the American Journal of Clinical Nutrition, for instance, showed that people taking fiber supplements had more bacteroidetes than firmicutes.7

Bacteroidetes tend to be higher in lean people. Separate research found that obese individuals had about 20 percent more firmicutes and almost 90 percent less bacteroidetes than lean people.8 Firmicutes help your body to extract calories from complex sugars and deposit those calories in fat.

While it’s becoming more widely known that supplementing with probiotics (or eating fermented foods) can favorably alter the makeup of your gut microflora, this new research is important because it shows how dietary fiber also plays a role. Hannah Holscher, a University of Illinois postdoctoral researcher, told Rodale News:9

“We’re hoping this study helps people realize that diet—what you eat every day—does affect the bacteria in your gut. We saw these dramatic shifts in bacterial populations with fiber supplementation, but then those shifts went away when people stopped using the supplements.”

Fermented Foods Are Important to Make Your Fiber Work with You, Not Against You

The human digestive system is not designed to break down fiber. Instead, it ends up undigested in your bowel, where the majority of your gut flora resides. If your gut flora is healthy, i.e. dominated by beneficial probiotic species, then these microbes will feed on the fiber and proliferate.

However, if your gut is filled with pathogenic bacteria and/or yeast and fungi, fiber may actually make your symptoms worse, as it is a non-specific growth factor for intestinal bacteria and does not discriminate between pathogenic and beneficial bacteria.

So, if your bowel is predominantly dominated by pathogenic microbes, they will feed on fiber and proliferate, making whatever health problems you have worse. Increasing fiber from vegetables is incredibly important if you’re constipated, as I’ll explain below, but so, too, is making sure you’re introducing that fiber to a healthy gut environment.

The key to doing this is to reduce your intake of excess sugar while adding naturally fermented foods into your diet, such as fermented vegetables and raw grass-fed kefir (if you tolerate dairy).

You can also add a probiotic supplement if you suspect you’re not getting enough beneficial bacteria from your diet alone. Probiotics have even been shown to help relieve constipation among one particularly constipation-prone population – pregnant women.10

Vegetables Are One of the Best Sources for Your 32 Grams of Fiber a Day

Assuming your gut is generally healthy, I believe most people need upwards of 32 grams of fiber a day. Most Americans get nowhere near this amount, which could easily contribute to chronic constipation. As the New York Times reported:11

“…the current average fiber intake in the United States is about 13 grams a day for women and 17 for men. Increasing these amounts by seven grams a day would bring them close to the recommended levels of 21 to 25 grams for women and 30 to 38 for men.

‘Seven grams a day increase is an achievable goal…’ ‘You’re talking about… increasing vegetable and fruit by two portions a day.'”

If your diet could use more fiber, resist the urge to fortify it with whole grains. Grains actually contain anti-nutrients that may damage your health, as well as sticky proteins like gluten (literally, Latin for “glue”) in the prolamine class, which are highly constipating to some individuals. If you’re constipated, try removing all sources of glutinous, prolamine-containing grains from your diet (the most common sources are wheat, barley, rye, and spelt). Instead, focus on eating more vegetables, nuts, and seeds. The following whole foods, for example, contain high levels of soluble and insoluble fiber.

Chia seeds Berries Vegetables such as broccoli and Brussels sprouts
Root vegetables and tubers, including onions and sweet potatoes Almonds Psyllium seed husk, flax, and chia seeds
Green beans Cauliflower Beans
Peas

Organic whole husk psyllium is another simple, cost-effective way to add more fiber to your diet. Taking it three times a day could add as much as 18 grams of dietary fiber (soluble and insoluble) to your diet, which brings you quite close to the recommended minimum of 20 grams a day. Ideally, you’ll want to get around 30-32 grams per day for optimal health, so you’ll want to use psyllium in addition to a healthy, veggie-rich diet. Please keep in mind that psyllium is a heavily sprayed crop, which means many sources are contaminated with pesticides, herbicides, and fertilizers.

For this reason, be sure to ONLY use organic psyllium husk, and make sure it’s 100% pure. Many supplement brands use synthetic or semi-synthetic active ingredients that do not contain psyllium, such as methylcellulose and calcium polycarbophil. Some brands even add sweeteners and other additives, which you’re better off avoiding. As an added bonus, soluble fibers such as psyllium are prebiotics that help nourish beneficial bacteria. These beneficial bacteria in turn assist with digestion and absorption of your food, and play a significant role in your immune function.

Policosanols on Vegetables Are Important for Regularity

Aside from fiber, another reason why vegetables, and green leafy vegetables, in particular are so good for regularity has to do with waxy alcohols called policosanols, which coat the leaves. Policosanols act as a natural waterproofing agent for plants and when you eat them they help speed the passage of food through your gastrointestinal (GI) tract.

As mentioned, green leafy vegetables are an excellent source of policosanols, but if you’re eating mostly processed varieties, you’re probably not getting them. Processing often destroys the natural policosanols from the food you eat. These healthy substances are also found in foods such as peanuts, pomegranate seeds, grapeseed oil, and perilla seeds and oil, as well as in supplement form if you’re not getting enough from dietary sources.

Are You Exercising? It Can Help You ‘Go’

We’ve covered the importance of nourishing a healthy gut environment with beneficial bacteria, fermented foods, and sugar avoidance, while eating plenty of fiber-rich vegetables. This is a large part of the picture, but it’s not the whole thing. Exercise is also important for regularity, in part because your abdominal and intestinal muscles work together to help move your bowels. If these muscles are weak, you’ll have a harder time with bowel movements. In addition, movement helps stimulate circulation and intestinal function, causing your bowels to move properly.

Squatting Can Help if You’re Constipated

The last thing most people think about when using the bathroom is position, but this can significantly impact the ease with which you eliminate and even increase your risk of bowel and pelvic problems, including constipation, hemorrhoids, and more. Most of you reading this probably sit to evacuate your bowel, but this requires you to apply additional force (straining), which has some unwanted biological effects, including a temporary disruption in cardiac flow.

Sitting on a modern toilet is designed to place your knees at a 90-degree angle to your abdomen. However, the time-honorednatural squat position (which is still used by the majority of the world’s population) places your knees much closer to your torso, and this position actually changes the spatial relationships of your intestinal organs and musculature, optimizing the forces involved in defecation.

Squatting straightens your rectum, relaxes your puborectalis muscle, and allows for complete emptying of your cecum and appendix without straining, which prevents fecal stagnation and the accumulation of toxins in your intestinal tract. It is instructive that non-westernized societies, in which people squat, do not have the high prevalence of bowel disease seen in developed nations; in some cultures with traditional lifestyles, these diseases are uncommon or almost unknown.

If you have trouble with bowel movements, especially constipation, I urge you to give the squat position a try. Squatting does involve strength and flexibility that adults tend to lose over time (but children have naturally). Special toilets and stools that get your body into a more “squatty” position can help you get closer to the ideal even if you’ve been sitting for decades.

Use Extreme Caution When Considering Laxatives

If you’re constipated, it may be tempting to turn to an over-the-counter laxative for relief. However, they must be used with extreme caution. Last year, the US Food and Drug Administration (FDA) released a warning following 13 deaths (12 adults and one child) that occurred after use of OTC saline laxatives (including brand name Fleet and others).12 The products contain the active ingredient sodium phosphate, which draws water into your bowel to help soften your stool, allowing it to pass easier.

However, if too much is taken, the laxatives can lead to dehydration and abnormal levels of electrolytes in your blood, which can cause kidney damage, heart problems, and death. Another crucial reason why laxatives are NOT a good option is that your body may become dependent on them. This is especially true with stimulant laxatives (such as brand name Exlax), which work by increasing the contraction of muscles in your intestines. This risk also applies to senna or cassia laxatives, which are frequently marketed as “natural.”

These laxatives may decrease your colon’s ability to contract and over time may damage your large intestine’s nerves, muscles, and other tissues. The cumulative lifetime use of commercial laxatives has even been associated with increased risk of colon cancer.13 For these reasons, and because constipation is usually easy to remedy naturally, laxatives should be avoided at all cost and used only as a last resort. If you absolutely must use a laxative, make sure it is used for only a very short period of time.

You could also try a magnesium supplement as a short-term alternative, as one of the ways to determine proper dosing is the “bowel test.” You know you have too much magnesium when your stools become loose, which is often a pleasant “side effect” for those with constipation. Magnesium deficiency may also manifest as constipation, so you might be treating the underlying cause as well. Do not, however, use an excess of magnesium for regularity purposes long-term, as this can upset your calcium/magnesium ratio and cause other problems.

New Drug May Treat Constipation Caused by Strong Painkillers.


Many people withheartburn aren’t taking their acid-reducing medicine at the right time, which makes the drugs less effective and wastes money, according to new research. Only about one-third of those buying these medications — such as NexiumPrevacid andPrilosec — over-the-counter used them properly compared to just under half of those who were prescribed the drugs by their primary care doctor. Those who were given a prescription by a gastroenterologist were most likely to use the drugs as they’re supposed to be used, with seven out of 10 taking the drugs properly, according to the study. These drugs are activated once in the body, said the study’s senior author, Dr. M. Michael Wolfe, a gastroenterologist and chair of the department of medicine at MetroHealth System. “In order to activate the medicine, you must eat. For that reason, you take it before breakfast. If you don’t take the drug correctly, you don’t do as well,” Wolfe said. Despite labels advising users to take the drugs before breakfast, people aren’t following those directions, he said. Those who aren’t taking the medicines properly “are wasting money, they’re not feeling well and they aren’t getting symptom relief,” Wolfe added. The study was published in the June issue of The American Journal of Gastroenterology. Heartburn is a painful, burning feeling just below the breastbone, experienced at least once a month by about 44 percent of U.S. adults. About 7 percent have heartburn daily. Frequent heartburn may indicate a condition called gastroesophageal reflux disease, or GERD. Food and acid from the stomach backs up, or refluxes, into the esophagus. Reflux can damage the esophagus and cause serious issues over time. Direct costs related to GERD, including acid-reducing medicines, top $10 billion each year in the United States, according to background information in the study. The medications looked at in this study are a class of drugs known as proton pump inhibitors. They work by reducing the amount of stomach acid produced, according to the U.S. National Library of Medicine. Unlike antacids, such as Tums or Rolaids, proton pump inhibitors don’t provide immediate relief of heartburn symptoms. It takes about 7 days of continuous use for the drugs to reach their maximum acid-suppressing potential, the study noted. Wolfe and his colleagues surveyed 610 patients who used heartburn medicine for their GERD. Of that group, 190 got a prescription heartburn medicine from a gastroenterologist and 223 received a prescription from their primary care doctor. The other 197 bought over-the-counter heartburn medicines. Those prescribed the medicines by their gastroenterologist did best, Wolfe noted, with 71 percent taking the medicines correctly. Only 47 percent of those who got prescriptions from their primary care doctors took them correctly. And just 39 percent of those who bought them over-the-counter used them right, the investigators found. In a previous study, only one-third of primary care doctors told patients to take the medicines before meals, but nearly all gastroenterologists did, according to the report. In his study, Wolfe found, the severity and frequency of symptoms were better in those who were prescribed the drug by a gastroenterologist compared to a primary care doctor. “If you have frequent heartburn, you have a disease, GERD,” Wolfe said. “And you really should see a physician and not treat yourself,” he explained. Dr. John Lipham is director of the Digestive Health Center at Keck Medicine of the University of Southern California. Lipham reviewed the findings but was not involved in the study. “It’s something we have known since these medications came out, that they work best if you take them 30 minutes or so before a meal,” said Lipham. However, he pointed out that the new study puts some data behind what experts knew from experience. Lipham said the new study is the first, to his knowledge, to show a difference in taking the medicine correctly depending on who prescribed it. Wolfe and Lipham both find that patients often think of the proton pump inhibitors in the same way as antacids, meant to be taken when heartburn strikes. “But these [proton pump inhibitor] medicines don’t work that way,” Lipham said. “They need to be stimulated by acid and need to build up in your system. You have to take them at the correct time each day and you also need to take them every day to get the maximum effectiveness of the medications.” As to why doctors aren’t all telling their patients how to use these drugs, Wolfe speculated that primary care doctors may be too busy and don’t have the time to read all of the drug literature. The bottom line is “it boils down to education,” said Wolfe. Physicians and consumers need to take the time to learn about the drugs. Ideally, Wolfe said, you should take the medicine in the morning, then ”eat something that causes your stomach to make acid, such as protein, an egg, a piece of cheese, yogurt.” For those who hate breakfast, he advises drinking a glass of milk or at least a cup of coffee.

Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: A Comparative Effectiveness Review..


To systematically review the evidence comparing wireless motility capsule (WMC) with other diagnostic tests used for the evaluation of gastroparesis and slow-transit constipation, in terms of diagnostic accuracy, accuracy of motility assessment, effect on treatment decisions, effect on patient-centered outcomes, harms, and effect on resource utilization. Data sources. We searched Medline ® and Embase ® from inception through July 2012. Additionally, we scanned reference lists of relevant articles and queried experts. Review methods. We included studies in any language that compared WMC with other diagnostic tests among patients with suspected gastroparesis or slow-transit constipation. Two reviewers independently assessed articles for eligibility, serially abstracted data from relevant articles, independently evaluated study quality, and graded the strength of the evidence (SOE). We summarized results qualitatively rather than quantitatively because of the heterogeneity of studies. Results. We included 12 studies (18 publications). Seven studies evaluated diagnosis of gastric emptying delay; we found low SOE that WMC alone was comparable to scintigraphy for diagnostic accuracy, accuracy of motility assessment, effect on treatment decisions, and effect on resource utilization. Sensitivity of WMC compared with gastric scintigraphy ranged from 59 to 86 percent and specificity ranged from 64 to 81 percent. We found two studies evaluating WMC as an add-on to other testing. The SOE was low for diagnostic accuracy and for the accuracy of motility assessment by WMC in combination with other modalities. The addition of WMC increased diagnostic yield. Nine studies analyzed colon transit disorders and provided moderate SOE for diagnostic accuracy, accuracy of motility assessment, and harms. WMC was comparable to radiopaque markers (ROM), with concordance ranging between 64 percent and 87 percent. Few harms were reported. The evidence was insufficient to justify conclusions about effects of WMC on treatment decisions and resource utilization. Conclusions. WMC is comparable in accuracy to current modalities in use for detection of slowtransit constipation and gastric emptying delay, and is therefore another viable diagnostic modality. Little data are available to determine the optimal timing of WMC for diagnostic algorithms.

Source: AHRQ Comparative Effectiveness Review.

Linaclotide Is Effective for Irritable Bowel Syndrome with Constipation.