Diarrhoea is a condition of passing loose or watery stools three or more times a day. This can result in a big loss of fluid and electrolytes from the body. Therefore, medications for stopping the loose motion are often required. For that purpose, drugs like Racecadotril and Loperamide are sometimes used in the treatment of acute diarrhoea. 

Racecadotril selectively inhibits the enzyme neutral endopeptidase, whose normal activity is to promote secretion. Racecadotril is an antisecretory agent that may prevent fluid/electrolyte depletion from the bowel due to acute diarrhoea without affecting intestinal motility.^[1]Racecadotril administration is supposed to decrease stool frequency within 24 hours to reduce symptoms of acute diarrhoea. 

Loperamide is used in the treatment of traveler’s diarrhoea, irritable bowel syndrome associated with chronic diarrhoea, and other types of diarrhoea. It is a synthetic phenylpiperidine opioid that acts on mu-opioid receptors on intestinal muscles and inhibits peristalsis.^[2]Loperamide also prevents loss of electrolytes and increases rectal tone. Loperamide can thus decrease stool frequency and is recommended only in the initial stage of acute diarrhoea associated with frequent watery stool.