A 72-year-old man was admitted to hospital with 1 month of progressive solid food dysphagia that caused a 10-kg weight loss. The patient reported alcohol and tobacco use but had no known medical conditions. An oral examination and head and neck computed tomography (CT) were normal apart from poor dentition. Laboratory investigations showed a raised C-reactive protein level (54.4 [normal < 5] mg/L) and normal leukocyte count (6.83 [normal 4.0–10.0] ×10⁹/L). Gastroscopy and barium swallow test were unremarkable. He was discharged without a diagnosis.

The patient returned to hospital 1 week later with severe oral and maxillary pain and persistent dysphagia. We found a lingual lesion with white coating (Figure 1A). The result for a repeat C-reactive protein test was 117.6 mg/L and the patient’s leukocyte count was 11.04 ×10⁹/L. Two days later, the left lingual lesion had become necrotic (Figure 1B). We suspected malignant disease and performed a panendoscopic examination and biopsied his tongue. No other lesions were found. The histopathology showed complete ischemic tissue necrosis, with no signs of malignant disease or vasculitis. We arranged a CT angiogram to determine the cause of his tongue ischemia, which showed isolated luminal narrowing of the left lingual artery. Because we suspected giant cell arteritis, we performed a temporal artery biopsy. It confirmed a granulomatous arteritis compatible with giant cell arteritis.

Figure 1:

(A) White-coated lesion of the left border of the tongue in a 72-year-old man with 5-week progressive solid food dysphagia. (B) Secondary necrosis of the left border of the patient’s tongue, 2 days later.

We started treatment with methylprednisolone (250 mg/d for 3 d) followed by prednisone (1 mg/kg/d). The patient’s tongue healed, and his pain and dysphagia resolved.

Giant cell arteritis, or temporal arteritis, has a prevalence of 1 in 500 individuals,1 and involves large and medium arteries such as carotid artery branches. Common symptoms include headache, scalp tenderness, jaw claudication, ocular ischemic manifestations and inflammatory arthralgia. Dysphagia and tongue necrosis are uncommon manifestations of giant cell arteritis associated with a high (50%) risk of recurrence.2 Tongue necrosis has many differential diagnoses in addition to vasculitis, including malignant disease, embolism and drug- or radiation-related adverse effects.1

Corticosteroid therapy should be started as soon as giant cell arteritis is suspected. Treatment with prednisone is suggested at 1 mg/kg/d for 6 weeks