US Coronavirus, Covid Cases In US, US Covid Deaths, US Covid Numbers: US Sets World Daily Record of Over 1 Million Cases


US Coronavirus, Covid Cases In US, US Covid Deaths, US Covid Numbers: US Sets World Daily Record of Over 1 Million Cases https://www.ndtv.com/world-news/us-coronavirus-covid-cases-in-us-us-covid-deaths-us-covid-numbers-us-sets-world-daily-record-of-over-1-million-cases-2687743

florona disease in israel symptoms – Coronavirus Outbreak News


florona disease in israel symptoms – Coronavirus Outbreak News https://www.indiatoday.in/coronavirus-outbreak/story/florona-disease-in-israel-symptoms-1894912-2022-01-01

#Omicron is highly transmissible. Scientists are looking for clues as to why.


Omicron is highly transmissible. Scientists are looking for clues as to why : Goats and Soda : NPR https://www.npr.org/sections/goatsandsoda/2021/12/31/1067702355/omicron-is-spreading-like-wildfire-scientists-are-trying-to-figure-out-why

#CRISPR Fixes “Duplication Mutation” in Live Animal


CRISPR Fixes “Duplication Mutation” in Live Animal https://www.freethink.com/health/duplication-mutation?utm_source=facebook&utm_medium=social&utm_campaign=BigThinkdotcom

“Superhuman immunity” in some COVID 19 individuals


Immunity

Shane Crotty, an immunologist, considers “hybrid immunity”; or “superhuman immunity” or “bulletproof as coined by other scientists, to be impressively potent against SARS-CoV-2. Whatever might be the name, this type of immunity brings a ray of hope amidst the COVID-19 crisis.

Recent researches have found an extraordinarily powerful immune response against SARS-CoV-2, in some people, by producing very high levels of antibodies with great flexibility. These antibodies have the capacity to fight off the prevailing as well as future emerging coronavirus variants.

Paul Bieniasz, a virologist at Rockefeller University, says that these people might be quite well protected against all or most of the SARS-CoV-2 variants that may emerge in future. Bieniasz and his colleagues, in a study, found antibodies in individuals with hybrid immunity that have the potential of strongly neutralizing the six variants of concern tested [delta, beta, and several other viruses related to SARS-CoV-2, including one in bats, two in pangolins and the one responsible for first coronavirus pandemic, SARS-CoV-1].

They also shared the probability of these individuals having some degree of protection against the SARS-like viruses that are yet to infect humans.

This “superhuman” or “hybrid” immune response can develop in individuals having a “hybrid” exposure to the virus, specifically, people with prior infection with the coronavirus in 2020, followed by immunization with mRNA vaccines. 

Theodora Hatziioannou, a virologist at Rockefeller University, considers these people to have amazing responses to the vaccine and be in the best position to fight the virus. He further explained these antibodies to have the potential to even neutralize SARS-CoV-1, the first coronavirus, which emerged 20 years ago, which is very different from SARS-CoV-2.

These antibodies even showed the potential to deactivate an engineered virus, highly resistant to neutralization. This virus suffered 20 mutations that can prevent SARS-CoV-2 antibodies from binding to it. Antibodies from people who were only vaccinated or priorly coronavirus infected persons (non-vaccinated) could not fight against this mutant virus. But antibodies of people with the “hybrid immunity” neutralized it, proving the strength of mRNA vaccines in people with prior exposure to SARS-CoV-2.

Another study, published in The New England Journal of Medicine, supports this hypothesis. In this study, the researchers’ analyzed antibodies of people priorly infected with the original SARS virus -SARS-CoV-1 (back in 2002 or 2003) and who then received an mRNA vaccine this year. Interestingly, these people too demonstrated a high level of antibodies that could neutralize a whole range of variants and SARS-like viruses.

What for people who arent infected with SARS-CoV-2 to date?

John Wherry, an Immunologist at the University of Pennsylvania, stated that they can see some of this antibody evolution happening in people who are just vaccinated, although it is faster in people who have been infected.

A recent study by Wherry et al. published online in late August showed that over time, people with two doses of the vaccine (and no prior infection) produce more flexible antibodies that can better recognize many of the variants of concern. Thus a third dose of the vaccine can give a boost and push the evolution of the antibodies further. 

COVID care in children and adolescents-latest Indian guidelines


Immunity and COVID

India is the world’s largest democracy having a population of more than 1.2 billion. The covid-19 pandemic has badly affected the country’s socio-economic conditions. Less than 12% of the total infected people are below 20 yrs of age. 1

It was reported that among adults with confirmed COVID-19 infection, 80% experience mild illness, about 14-15% experience moderate-severe disease and 5% are critically ill. As is evident from the current scenario, children have not been affected so much by this fast-spreading infection. The available serosurvey data prior to the launch of the vaccination drive, states that children of 10-17 years had seropositivity similar to that in adults but the proportion of  <20  yr olds was lower among confirmed  COVID-19  cases than expected.  This suggests that children are also susceptible as adults to infection, but mostly remain asymptomatic. Further, children who have symptoms have the milder infection as compared to adults. 2

Besides the spread of the Coronavirus, the fear has impacted the normal life of people greatly. Hence, necessary precautions and care is the best way to prevent infection and reduce the burden on the health care system. The common symptoms in both children and adolescents include sore throat, throat irritation, cough, fever, headache, body pains, rhinorrhoea, diarrhoea Malaise/weakness, and loss of sense of smell and/or taste. 2

Enhancing the existing COVID care facilities to provide care to children with acute infection is necessary. These should have facilities where parents can accompany the child.  In paediatric hospitals, separate arrangements for COVID-care need to be set up. Additional pediatric-specific equipment, infrastructure, and pediatric formulations, more doctors and nurses and health workers should be provided.  

Children infected by COVID and having MIS-C, need to have cared more. For children who test negative for acute COVID, care has to be provided by the existing pediatric facilities.

 As per the management protocols developed by the MoHFW for children with acute COVID and MIS-C most of the drugs used in adults such as Ivermectin/ HCQ/ Favipiravir/ Antibiotics such as Doxycycline or Azithromycin are not recommended.

Children mostly have asymptomatic or mild illness and can be kept in home isolation and managed by parents. Symptomatic Treatment includes administering paracetamol for fever, throat smoothening and hot saline water gargles for sore throat and throat irritation, good monitoring and measuring of the respiratory rates, difficulty in respiration, oral intake and oxygen saturation are essential criteria’s to be followed.

Collaborative works between district hospitals, medical colleges and other health care facilities are necessary for improving the quality of care and for capacity. Few centers may be designated as the Regional Centres of Excellence for COVID care as well as research. These centers may help in providing guidance and leadership in clinical management and training. Telemedicine could be emphasized and practiced to reach out to the majority of the population and help different facilities providing COVID care.

Data collection at all levels and transmission from community to higher centers is very essential. A national registry should be launched for pediatric COVID. Encouraging and facilitating research in the area of pediatric COVID, optimal treatment for MIS-C, its management and its study through clinical trials is also important, Proper IEC campaign should be launched and encouraged to provide correct information and strict actions should be undertaken for communicating wrong information or misinformation in media and social media.  

Thus, following the proper guidelines and monitoring constantly, children, as well as adolescents, can prevent and protect themselves.

References:

  1. https://www.worldbank.org/en/country/india/coronavirus
  2. https://www.mohfw.gov.in/pdf/GuidelinesonOperationalizationofCoVIDCareServicesforChildrenandAdolescents

The Mystery at the Heart of Physics That Only Math Can Solve


The accelerating effort to understand the mathematics of quantum field theory will have profound consequences for both math and physics.87

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Olena Shmahalo/Quanta Magazine

Over the past century, quantum field theory has proved to be the single most sweeping and successful physical theory ever invented. It is an umbrella term that encompasses many specific quantum field theories — the way “shape” covers specific examples like the square and the circle. The most prominent of these theories is known as the Standard Model, and it is this framework of physics that has been so successful.

“It can explain at a fundamental level literally every single experiment that we’ve ever done,” said David Tong, a physicist at the University of Cambridge.

But quantum field theory, or QFT, is indisputably incomplete. Neither physicists nor mathematicians know exactly what makes a quantum field theory a quantum field theory. They have glimpses of the full picture, but they can’t yet make it out.

Quanta Science Podcast

Quantum Field Theory is the most important idea in physics. A major effort is underway to translate it into pure mathematics.


00:10/36:55

“There are various indications that there could be a better way of thinking about QFT,” said Nathan Seiberg, a physicist at the Institute for Advanced Study. “It feels like it’s an animal you can touch from many places, but you don’t quite see the whole animal.”

Mathematics, which requires internal consistency and attention to every last detail, is the language that might make QFT whole. If mathematics can learn how to describe QFT with the same rigor with which it characterizes well-established mathematical objects, a more complete picture of the physical world will likely come along for the ride.

“If you really understood quantum field theory in a proper mathematical way, this would give us answers to many open physics problems, perhaps even including the quantization of gravity,” said Robbert Dijkgraaf, director of the Institute for Advanced Study (and a regular columnist for Quanta).

Every other idea that’s been used in physics over the past centuries had its natural place in mathematics. This is clearly not the case with quantum field theory.

Nathan Seiberg, the Institute for Advanced Study

Nor is this a one-way street. For millennia, the physical world has been mathematics’ greatest muse. The ancient Greeks invented trigonometry to study the motion of the stars. Mathematics turned it into a discipline with definitions and rules that students now learn without any reference to the topic’s celestial origins. Almost 2,000 years later, Isaac Newton wanted to understand Kepler’s laws of planetary motion and attempted to find a rigorous way of thinking about infinitesimal change. This impulse (along with revelations from Gottfried Leibniz) birthed the field of calculus, which mathematics appropriated and improved — and today could hardly exist without.

Now mathematicians want to do the same for QFT, taking the ideas, objects and techniques that physicists have developed to study fundamental particles and incorporating them into the main body of mathematics. This means defining the basic traits of QFT so that future mathematicians won’t have to think about the physical context in which the theory first arose.

The rewards are likely to be great: Mathematics grows when it finds new objects to explore and new structures that capture some of the most important relationships — between numbers, equations and shapes. QFT offers both.

“Physics itself, as a structure, is extremely deep and often a better way to think about mathematical things we’re already interested in. It’s just a better way to organize them,” said David Ben-Zvi, a mathematician at the University of Texas, Austin.

For 40 years at least, QFT has tempted mathematicians with ideas to pursue. In recent years, they’ve finally begun to understand some of the basic objects in QFT itself — abstracting them from the world of particle physics and turning them into mathematical objects in their own right.

Yet it’s still early days in the effort.

“We won’t know until we get there, but it’s certainly my expectation that we’re just seeing the tip of the iceberg,” said Greg Moore, a physicist at Rutgers University. “If mathematicians really understood [QFT], that would lead to profound advances in mathematics.”

Fields Forever

It’s common to think of the universe as being built from fundamental particles: electrons, quarks, photons and the like. But physics long ago moved beyond this view. Instead of particles, physicists now talk about things called “quantum fields” as the real warp and woof of reality.

These fields stretch across the space-time of the universe. They come in many varieties and fluctuate like a rolling ocean. As the fields ripple and interact with each other, particles emerge out of them and then vanish back into them, like the fleeting crests of a wave.

“Particles are not objects that are there forever,” said Tong. “It’s a dance of fields.”

To understand quantum fields, it’s easiest to start with an ordinary, or classical, field. Imagine, for example, measuring the temperature at every point on Earth’s surface. Combining the infinitely many points at which you can make these measurements forms a geometric object, called a field, that packages together all this temperature information.

In general, fields emerge whenever you have some quantity that can be measured uniquely at infinitely fine resolution across a space. “You’re sort of able to ask independent questions about each point of space-time, like, what’s the electric field here versus over there,” said Davide Gaiotto, a physicist at the Perimeter Institute for Theoretical Physics in Waterloo, Canada.

Quantum fields come about when you’re observing quantum phenomena, like the energy of an electron, at every point in space and time. But quantum fields are fundamentally different from classical ones.

While the temperature at a point on Earth is what it is, regardless of whether you measure it, electrons have no definite position until the moment you observe them. Prior to that, their positions can only be described probabilistically, by assigning values to every point in a quantum field that captures the likelihood you’ll find an electron there versus somewhere else. Prior to observation, electrons essentially exist nowhere — and everywhere.

“Most things in physics aren’t just objects; they’re something that lives in every point in space and time,” said Dijkgraaf.

A quantum field theory comes with a set of rules called correlation functions that explain how measurements at one point in a field relate to — or correlate with — measurements taken at another point.

Each quantum field theory describes physics in a specific number of dimensions. Two-dimensional quantum field theories are often useful for describing the behavior of materials, like insulators; six-dimensional quantum field theories are especially relevant to string theory; and four-dimensional quantum field theories describe physics in our actual four-dimensional universe. The Standard Model is one of these; it’s the single most important quantum field theory because it’s the one that best describes the universe.

There are 12 known fundamental particles that make up the universe. Each has its own unique quantum field. To these 12 particle fields the Standard Model adds four force fields, representing the four fundamental forces: gravity, electromagnetism, the strong nuclear force and the weak nuclear force. It combines these 16 fields in a single equation that describes how they interact with each other. Through these interactions, fundamental particles are understood as fluctuations of their respective quantum fields, and the physical world emerges before our eyes.

It might sound strange, but physicists realized in the 1930s that physics based on fields, rather than particles, resolved some of their most pressing inconsistencies, ranging from issues regarding causality to the fact that particles don’t live forever. It also explained what otherwise appeared to be an improbable consistency in the physical world.

“All particles of the same type everywhere in the universe are the same,” said Tong. “If we go to the Large Hadron Collider and make a freshly minted proton, it’s exactly the same as one that’s been traveling for 10 billion years. That deserves some explanation.” QFT provides it: All protons are just fluctuations in the same underlying proton field (or, if you could look more closely, the underlying quark fields).

But the explanatory power of QFT comes at a high mathematical cost.

“Quantum field theories are by far the most complicated objects in mathematics, to the point where mathematicians have no idea how to make sense of them,” said Tong. “Quantum field theory is mathematics that has not yet been invented by mathematicians.”

Too Much Infinity

What makes it so complicated for mathematicians? In a word, infinity.

When you measure a quantum field at a point, the result isn’t a few numbers like coordinates and temperature. Instead, it’s a matrix, which is an array of numbers. And not just any matrix — a big one, called an operator, with infinitely many columns and rows. This reflects how a quantum field envelops all the possibilities of a particle emerging from the field.

“There are infinitely many positions that a particle can have, and this leads to the fact that the matrix that describes the measurement of position, of momentum, also has to be infinite-dimensional,” said Kasia Rejzner of the University of York.

And when theories produce infinities, it calls their physical relevance into question, because infinity exists as a concept, not as anything experiments can ever measure. It also makes the theories hard to work with mathematically.

“We don’t like having a framework that spells out infinity. That’s why you start realizing you need a better mathematical understanding of what’s going on,” said Alejandra Castro, a physicist at the University of Amsterdam.

The problems with infinity get worse when physicists start thinking about how two quantum fields interact, as they might, for instance, when particle collisions are modeled at the Large Hadron Collider outside Geneva. In classical mechanics this type of calculation is easy: To model what happens when two billiard balls collide, just use the numbers specifying the momentum of each ball at the point of collision.

When two quantum fields interact, you’d like to do a similar thing: multiply the infinite-dimensional operator for one field by the infinite-dimensional operator for the other at exactly the point in space-time where they meet. But this calculation — multiplying two infinite-dimensional objects that are infinitely close together — is difficult.

“This is where things go terribly wrong,” said Rejzner.

Smashing Success

Physicists and mathematicians can’t calculate using infinities, but they have developed workarounds — ways of approximating quantities that dodge the problem. These workarounds yield approximate predictions, which are good enough, because experiments aren’t infinitely precise either.

“We can do experiments and measure things to 13 decimal places and they agree to all 13 decimal places. It’s the most astonishing thing in all of science,” said Tong.

One workaround starts by imagining that you have a quantum field in which nothing is happening. In this setting — called a “free” theory because it’s free of interactions — you don’t have to worry about multiplying infinite-dimensional matrices because nothing’s in motion and nothing ever collides. It’s a situation that’s easy to describe in full mathematical detail, though that description isn’t worth a whole lot.

“It’s totally boring, because you’ve described a lonely field with nothing to interact with, so it’s a bit of an academic exercise,” said Rejzner.

But you can make it more interesting. Physicists dial up the interactions, trying to maintain mathematical control of the picture as they make the interactions stronger.

This approach is called perturbative QFT, in the sense that you allow for small changes, or perturbations, in a free field. You can apply the perturbative perspective to quantum field theories that are similar to a free theory. It’s also extremely useful for verifying experiments. “You get amazing accuracy, amazing experimental agreement,” said Rejzner.

But if you keep making the interactions stronger, the perturbative approach eventually overheats. Instead of producing increasingly accurate calculations that approach the real physical universe, it becomes less and less accurate. This suggests that while the perturbation method is a useful guide for experiments, ultimately it’s not the right way to try and describe the universe: It’s practically useful, but theoretically shaky.

“We do not know how to add everything up and get something sensible,” said Gaiotto.

We’ve been using QFT as an outside stimulus, but it would be nice if it were an inside stimulus.

Dan Freed, the University of Texas, Austin

Another approximation scheme tries to sneak up on a full-fledged quantum field theory by other means. In theory, a quantum field contains infinitely fine-grained information. To cook up these fields, physicists start with a grid, or lattice, and restrict measurements to places where the lines of the lattice cross each other. So instead of being able to measure the quantum field everywhere, at first you can only measure it at select places a fixed distance apart.

From there, physicists enhance the resolution of the lattice, drawing the threads closer together to create a finer and finer weave. As it tightens, the number of points at which you can take measurements increases, approaching the idealized notion of a field where you can take measurements everywhere.

“The distance between the points becomes very small, and such a thing becomes a continuous field,” said Seiberg. In mathematical terms, they say the continuum quantum field is the limit of the tightening lattice.

Mathematicians are accustomed to working with limits and know how to establish that certain ones really exist. For example, they’ve proved that the limit of the infinite sequence 12 + 14 +18 +116 … is 1. Physicists would like to prove that quantum fields are the limit of this lattice procedure. They just don’t know how.

“It’s not so clear how to take that limit and what it means mathematically,” said Moore.

Physicists don’t doubt that the tightening lattice is moving toward the idealized notion of a quantum field. The close fit between the predictions of QFT and experimental results strongly suggests that’s the case.

“There is no question that all these limits really exist, because the success of quantum field theory has been really stunning,” said Seiberg. But having strong evidence that something is correct and proving conclusively that it is are two different things.

It’s a degree of imprecision that’s out of step with the other great physical theories that QFT aspires to supersede. Isaac Newton’s laws of motion, quantum mechanics, Albert Einstein’s theories of special and general relativity — they’re all just pieces of the bigger story QFT wants to tell, but unlike QFT, they can all be written down in exact mathematical terms.

“Quantum field theory emerged as an almost universal language of physical phenomena, but it’s in bad math shape,” said Dijkgraaf. And for some physicists, that’s a reason for pause.

“If the full house is resting on this core concept that itself isn’t understood in a mathematical way, why are you so confident this is describing the world? That sharpens the whole issue,” said Dijkgraaf.

Outside Agitator

Even in this incomplete state, QFT has prompted a number of important mathematical discoveries. The general pattern of interaction has been that physicists using QFT stumble onto surprising calculations that mathematicians then try to explain.

“It’s an idea-generating machine,” said Tong.

At a basic level, physical phenomena have a tight relationship with geometry. To take a simple example, if you set a ball in motion on a smooth surface, its trajectory will illuminate the shortest path between any two points, a property known as a geodesic. In this way, physical phenomena can detect geometric features of a shape.

Now replace the billiard ball with an electron. The electron exists probabilistically everywhere on a surface. By studying the quantum field that captures those probabilities, you can learn something about the overall nature of that surface (or manifold, to use the mathematicians’ term), like how many holes it has. That’s a fundamental question that mathematicians working in geometry, and the related field of topology, want to answer.

“One particle even sitting there, doing nothing, will start to know about the topology of a manifold,” said Tong.

In the late 1970s, physicists and mathematicians began applying this perspective to solve basic questions in geometry. By the early 1990s, Seiberg and his collaborator Edward Witten figured out how to use it to create a new mathematical tool — now called the Seiberg-Witten invariants — that turns quantum phenomena into an index for purely mathematical traits of a shape: Count the number of times quantum particles behave in a certain way, and you’ve effectively counted the number of holes in a shape.

“Witten showed that quantum field theory gives completely unexpected but completely precise insights into geometrical questions, making intractable problems soluble,” said Graeme Segal, a mathematician at the University of Oxford.

Another example of this exchange also occurred in the early 1990s, when physicists were doing calculations related to string theory. They performed them in two different geometric spaces based on fundamentally different mathematical rules and kept producing long sets of numbers that matched each other exactly. Mathematicians picked up the thread and elaborated it into a whole new field of inquiry, called mirror symmetry, that investigates the concurrence — and many others like it.

“Physics would come up with these amazing predictions, and mathematicians would try to prove them by our own means,” said Ben-Zvi. “The predictions were strange and wonderful, and they turned out to be pretty much always correct.”

But while QFT has been successful at generating leads for mathematics to follow, its core ideas still exist almost entirely outside of mathematics. Quantum field theories are not objects that mathematicians understand well enough to use the way they can use polynomials, groups, manifolds and other pillars of the discipline (many of which also originated in physics).

For physicists, this distant relationship with math is a sign that there’s a lot more they need to understand about the theory they birthed. “Every other idea that’s been used in physics over the past centuries had its natural place in mathematics,” said Seiberg. “This is clearly not the case with quantum field theory.”

I like to say the physicists don’t necessarily know everything, but the physics does.

David Ben-Zvi, the University of Texas, Austin

And for mathematicians, it seems as if the relationship between QFT and math should be deeper than the occasional interaction. That’s because quantum field theories contain many symmetries, or underlying structures, that dictate how points in different parts of a field relate to each other. These symmetries have a physical significance — they embody how quantities like energy are conserved as quantum fields evolve over time. But they’re also mathematically interesting objects in their own right.

“A mathematician might care about a certain symmetry, and we can put it in a physical context. It creates this beautiful bridge between these two fields,” said Castro.

Mathematicians already use symmetries and other aspects of geometry to investigate everything from solutions to different types of equations to the distribution of prime numbers. Often, geometry encodes answers to questions about numbers. QFT offers mathematicians a rich new type of geometric object to play with — if they can get their hands on it directly, there’s no telling what they’ll be able to do.

“We’re to some extent playing with QFT,” said Dan Freed, a mathematician at the University of Texas, Austin. “We’ve been using QFT as an outside stimulus, but it would be nice if it were an inside stimulus.”

Make Way for QFT

Mathematics does not admit new subjects lightly. Many basic concepts went through long trials before they settled into their proper, canonical places in the field.

Take the real numbers — all the infinitely many tick marks on the number line. It took math nearly 2,000 years of practice to agree on a way of defining them. Finally, in the 1850s, mathematicians settled on a precise three-word statement describing the real numbers as a “complete ordered field.” They’re complete because they contain no gaps, they’re ordered because there’s always a way of determining whether one real number is greater or less than another, and they form a “field,” which to mathematicians means they follow the rules of arithmetic.

“Those three words are historically hard fought,” said Freed.

In order to turn QFT into an inside stimulus — a tool they can use for their own purposes — mathematicians would like to give the same treatment to QFT they gave to the real numbers: a sharp list of characteristics that any specific quantum field theory needs to satisfy.

Kevin Costello of the Perimeter Institute is creating a framework that may eventually put quantum field theory on rigorous mathematical grounds.Gabriela Secara/Perimeter Institute

A lot of the work of translating parts of QFT into mathematics has come from a mathematician named Kevin Costello at the Perimeter Institute. In 2016 he coauthored a textbook that puts perturbative QFT on firm mathematical footing, including formalizing how to work with the infinite quantities that crop up as you increase the number of interactions. The work follows an earlier effort from the 2000s called algebraic quantum field theory that sought similar ends, and which Rejzner reviewed in a 2016 book. So now, while perturbative QFT still doesn’t really describe the universe, mathematicians know how to deal with the physically non-sensical infinities it produces.

“His contributions are extremely ingenious and insightful. He put [perturbative] theory in a nice new framework that is suitable for rigorous mathematics,” said Moore.

Costello explains he wrote the book out of a desire to make perturbative quantum field theory more coherent. “I just found certain physicists’ methods unmotivated and ad hoc. I wanted something more self-contained that a mathematician could go work with,” he said.

By specifying exactly how perturbation theory works, Costello has created a basis upon which physicists and mathematicians can construct novel quantum field theories that satisfy the dictates of his perturbation approach. It’s been quickly embraced by others in the field.

“He certainly has a lot of young people working in that framework. [His book] has had its influence,” said Freed.

Costello has also been working on defining just what a quantum field theory is. In stripped-down form, a quantum field theory requires a geometric space in which you can make observations at every point, combined with correlation functions that express how observations at different points relate to each other. Costello’s work describes the properties a collection of correlation functions needs to have in order to serve as a workable basis for a quantum field theory.

The most familiar quantum field theories, like the Standard Model, contain additional features that may not be present in all quantum field theories. Quantum field theories that lack these features likely describe other, still undiscovered properties that could help physicists explain physical phenomena the Standard Model can’t account for. If your idea of a quantum field theory is fixed too closely to the versions we already know about, you’ll have a hard time even envisioning the other, necessary possibilities.

“There is a big lamppost under which you can find theories of fields [like the Standard Model], and around it is a big darkness of [quantum field theories] we don’t know how to define, but we know they’re there,” said Gaiotto.

Costello has illuminated some of that dark space with his definitions of quantum fields. From these definitions, he’s discovered two surprising new quantum field theories. Neither describes our four-dimensional universe, but they do satisfy the core demands of a geometric space equipped with correlation functions. Their discovery through pure thought is similar to how the first shapes you might discover are ones present in the physical world, but once you have a general definition of a shape, you can think your way to examples with no physical relevance at all.

And if mathematics can determine the full space of possibilities for quantum field theories — all the many different possibilities for satisfying a general definition involving correlation functions — physicists can use that to find their way to the specific theories that explain the important physical questions they care most about.

“I want to know the space of all QFTs because I want to know what quantum gravity is,” said Castro.

A Multi-Generational Challenge

There’s a long way to go. So far, all of the quantum field theories that have been described in full mathematical terms rely on various simplifications, which make them easier to work with mathematically.

One way to simplify the problem, going back decades, is to study simpler two-dimensional QFTs rather than four-dimensional ones. A team in France recently nailed down all the mathematical details of a prominent two-dimensional QFT.

Other simplifications assume quantum fields are symmetrical in ways that don’t match physical reality, but that make them more tractable from a mathematical perspective. These include “supersymmetric” and “topological” QFTs.

The next, and much more difficult, step will be to remove the crutches and provide a mathematical description of a quantum field theory that better suits the physical world physicists most want to describe: the four-dimensional, continuous universe in which all interactions are possible at once.

“This is [a] very embarrassing thing that we don’t have a single quantum field theory we can describe in four dimensions, nonperturbatively,” said Rejzner. “It’s a hard problem, and apparently it needs more than one or two generations of mathematicians and physicists to solve it.”

But that doesn’t stop mathematicians and physicists from eyeing it greedily. For mathematicians, QFT is as rich a type of object as they could hope for. Defining the characteristic properties shared by all quantum field theories will almost certainly require merging two of the pillars of mathematics: analysis, which explains how to control infinities, and geometry, which provides a language for talking about symmetry.

“It’s a fascinating problem just in math itself, because it combines two great ideas,” said Dijkgraaf.

If mathematicians can understand QFT, there’s no telling what mathematical discoveries await in its unlocking. Mathematicians defined the characteristic properties of other objects, like manifolds and groups, long ago, and those objects now permeate virtually every corner of mathematics. When they were first defined, it would have been impossible to anticipate all their mathematical ramifications. QFT holds at least as much promise for math.

“I like to say the physicists don’t necessarily know everything, but the physics does,” said Ben-Zvi. “If you ask it the right questions, it already has the phenomena mathematicians are looking for.”

And for physicists, a complete mathematical description of QFT is the flip side of their field’s overriding goal: a complete description of physical reality.

“I feel there is one intellectual structure that covers all of it, and maybe it will encompass all of physics,” said Seiberg.

Now mathematicians just have to uncover it.

How Many Numbers Exist? Infinity Proof Moves Math Closer to an Answer.


For 50 years, mathematicians have believed that the total number of real numbers is unknowable. A new proof suggests otherwise.

A man looking at a tower with infinity signs on it.
There are an infinite number of infinities. Which one corresponds to the real numbers?Olena Shmahalo/Quanta Magazine

In October 2018, David Asperó was on holiday in Italy, gazing out a car window as his girlfriend drove them to their bed-and-breakfast, when it came to him: the missing step of what’s now a landmark new proof about the sizes of infinity. “It was this flash experience,” he said.

Asperó, a mathematician at the University of East Anglia in the United Kingdom, contacted the collaborator with whom he’d long pursued the proof, Ralf Schindler of the University of Münster in Germany, and described his insight. “It was completely incomprehensible to me,” Schindler said. But eventually, the duo turned the phantasm into solid logic.

Their proof, which appeared in May in the Annals of Mathematics, unites two rival axioms that have been posited as competing foundations for infinite mathematics. Asperó and Schindler showed that one of these axioms implies the other, raising the likelihood that both axioms — and all they intimate about infinity — are true.

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“It’s a fantastic result,” said Menachem Magidor, a leading mathematical logician at the Hebrew University of Jerusalem. “To be honest, I was trying to get it myself.”

Most importantly, the result strengthens the case against the continuum hypothesis, a hugely influential 1878 conjecture about the strata of infinities. Both of the axioms that have converged in the new proof indicate that the continuum hypothesis is false, and that an extra size of infinity sits between the two that, 143 years ago, were hypothesized to be the first and second infinitely large numbers.

“We now have a coherent alternative to the continuum hypothesis,” said Ilijas Farah, a mathematician at York University in Toronto.

It’s one of the most intellectually exciting, absolutely dramatic things that has ever happened in the history of mathematics.

Juliette Kennedy

The result is a victory for the camp of mathematicians who feel in their bones that the continuum hypothesis is wrong. “This result is tremendously clarifying the picture,” said Juliette Kennedy, a mathematical logician and philosopher at the University of Helsinki.

But another camp favors a different vision of infinite mathematics in which the continuum hypothesis holds, and the battle between these sides is far from won.

“It’s an amazing time,” Kennedy said. “It’s one of the most intellectually exciting, absolutely dramatic things that has ever happened in the history of mathematics, where we are right now.”

An Infinity of Infinities

Yes, infinity comes in many sizes. In 1873, the German mathematician Georg Cantor shook math to the core when he discovered that the “real” numbers that fill the number line — most with never-ending digits, like 3.14159… — outnumber “natural” numbers like 1, 2 and 3, even though there are infinitely many of both.

Infinite sets of numbers mess with our intuition about size, so as a warmup, compare the natural numbers {1, 2, 3, …} with the odd numbers {1, 3, 5, …}. You might think the first set is bigger, since only half its elements appear in the second set. Cantor realized, though, that the elements of the two sets can be put in a one-to-one correspondence. You can pair off the first elements of each set (1 and 1), then pair off their second elements (2 and 3), then their third (3 and 5), and so on forever, covering all elements of both sets. In this sense, the two infinite sets have the same size, or what Cantor called “cardinality.” He designated their size with the cardinal number ℵ0 (“aleph-zero”).

But Cantor discovered that natural numbers can’t be put into one-to-one correspondence with the continuum of real numbers. For instance, try to pair 1 with 1.00000… and 2 with 1.00001…, and you’ll have skipped over infinitely many real numbers (like 1.000000001…). You can’t possibly count them all; their cardinality is greater than that of the natural numbers.

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Sizes of infinity don’t stop there. Cantor discovered that any infinite set’s power set — the set of all subsets of its elements — has larger cardinality than it does. Every power set itself has a power set, so that cardinal numbers form an infinitely tall tower of infinities.

Standing at the foot of this forbidding edifice, Cantor focused on the first couple of floors. He managed to prove that the set formed from different ways of ordering natural numbers (from smallest to largest, for example, or with all odd numbers first) has cardinality ℵ1, one level up from the natural numbers. Moreover, each of these “order types” encodes a real number.

His continuum hypothesis asserts that this is exactly the size of the continuum — that there are precisely ℵ1 real numbers. In other words, the cardinality of the continuum immediately follow ℵ0, the cardinality of the natural numbers, with no sizes of infinity in between.

A black and white photo of a man with a beard.
The German mathematician Georg Cantor would, in the decade following this 1870 portrait, develop set theory and discover the infinite hierarchy of infinite sets.

But to Cantor’s immense distress, he couldn’t prove it.

In 1900, the mathematician David Hilbert put the continuum hypothesis first on his famous list of 23 math problems to solve in the 20th century. Hilbert was enthralled by the nascent mathematics of infinity — “Cantor’s paradise,” as he called it — and the continuum hypothesis seemed like its lowest-hanging fruit.

To the contrary, shocking revelations last century turned Cantor’s question into a deep epistemological conundrum.

The trouble arose in 1931, when the Austrian-born logician Kurt Gödel discovered that any set of axioms that you might posit as a foundation for mathematics will inevitably be incomplete. There will always be questions that your list of ground rules can’t settle, true mathematical facts that they can’t prove.

As Gödel suspected right away, the continuum hypothesis is such a case: a problem that’s independent of the standard axioms of mathematics.

These axioms, 10 in all, are known as ZFC (for “Zermelo-Fraenkel axioms with the axiom of choice”), and they undergird almost all of modern math. The axioms describe basic properties of collections of objects, or sets. Since virtually everything mathematical can be built out of sets (the empty set {} denotes 0, for instance; {{}} denotes 1; {{},{{}}} denotes 2, and so on), the rules of sets suffice for constructing proofs throughout math.

In 1940, Gödel showed that you can’t use the ZFC axioms to disprove the continuum hypothesis. Then in 1963, the American mathematician Paul Cohen showed the opposite —you can’t use them to prove it, either. Cohen’s proof, together with Gödel’s, means the continuum hypothesis is independent of the ZFC axioms; they can have it either way.

A German manuscript.
Cantor first posed the continuum hypothesis in this manuscript, dated July 11, 1877. The paper was published the following year.Courtesy Göttingen State and University Library

In addition to the continuum hypothesis, most other questions about infinite sets turn out to be independent of ZFC as well. This independence is sometimes interpreted to mean that these questions have no answer, but most set theorists see that as a profound misconception.

They believe the continuum has a precise size; we just need new tools of logic to figure out what that is. These tools will come in the form of new axioms. “The axioms do not settle these problems,” said Magidor, so “we must extend them to a richer axiom system.” It’s ZFC as a means to mathematical truth that’s lacking — not truth itself.

Ever since Cohen, set theorists have sought to shore up the foundations of infinite math by adding at least one new axiom to ZFC. This axiom should illuminate the structure of infinite sets, engender natural and beautiful theorems, avoid fatal contradictions, and, of course, settle Cantor’s question.

Gödel, for his part, believed that the continuum hypothesis is false — that there are more reals than Cantor guessed. He suspected there are ℵ2 of them. He predicted, as he wrote in 1947, “that the role of the continuum problem in set theory will be this, that it will finally lead to the discovery of new axioms which will make it possible to disprove Cantor’s conjecture.”

Source of Light

Two rival axioms emerged that do just that. For decades, they were suspected of being logically incompatible. “There was always this tension,” Schindler said.

To understand them, we have to go back to Paul Cohen’s 1963 work, where he developed a technique called forcing. Starting with a model of the mathematical universe that included ℵ1 reals, Cohen used forcing to enlarge the continuum to include new reals beyond those of the model. Cohen and his contemporaries soon found that, depending on the specifics of the procedure, forcing lets you to add however many reals you like — ℵ2 or ℵ35, say. Aside from new reals, mathematicians generalized Cohen’s method to conjure up all manner of other possible objects, some logically incompatible with one another. This created a multiverse of possible mathematical universes.

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“His method creates an ambiguity in our universe of sets,” said  Hugh Woodin, a set theorist at Harvard University. “It creates this cloud of virtual universes, and how do I know which one I’m in?”

What was virtual and what was real? Which of two conflicting objects, dreamed up by different forcing procedures, should be permitted? It wasn’t clear when or even whether an object, just because it could be conceived of with Cohen’s method, really exists.

To address this problem, mathematicians posed various “forcing axioms” — rules that established the actual existence of specific objects rendered possible by Cohen’s method. “If you can imagine an object to exist, then it does; this is the guiding intuitive principle that leads to forcing axioms,” Magidor explained. In 1988, Magidor, Matthew Foreman and Saharon Shelah took this ethos to its logical conclusion by posing Martin’s maximum, which says that anything you can conceive of using any forcing procedure will be a true mathematical entity, so long as the procedure satisfies a certain consistency condition.

For all the expansiveness of Martin’s maximum, in order to simultaneously permit all those products of forcing (while satisfying that constancy condition), the size of the continuum jumps only to a conservative ℵ2— one cardinal number more than the minimum possible value.

Besides settling the continuum problem, Martin’s maximum has proved to be a powerful tool for exploring the properties of infinite sets. Proponents say it fosters many sweeping statements and general theorems. By contrast, assuming that the continuum has cardinality ℵ1 tends to yield more exceptional cases and roadblocks to proofs — “a paradise of counterexamples,” in Magidor’s words.

Martin’s maximum became massively popular as an extension of ZFC. But then in the 1990s, Woodin proposed another compelling axiom that also kills the continuum hypothesis and pins the continuum at ℵ2 but by a totally different route. Woodin named the axiom (*), pronounced “star,” because it was “like a bright source — a source of structure, a source of light,” he told me.

(*) concerns a model universe of sets that satisfies the nine ZF axioms plus the axiom of determinacy, rather than the axiom of choice. Determinacy and choice logically contradict each other, which is why (*) and Martin’s maximum seemed irreconcilable. But Woodin devised a forcing procedure by which to extend his model mathematical universe into a larger one that is consistent with ZFC, and it’s in this universe that the (*) axiom holds true.

What makes (*) so illuminating is that it lets mathematicians make statements of the form “For all X, there exists Y, such that Z” when referring to properties of sets within the domain. Such statements are powerful modes of mathematical reasoning. One such statement is: “For all sets of ℵ1 reals, there exist reals not in those sets.” This is the negation of the continuum hypothesis. Thus, according to (*), Cantor’s conjecture is false. The fact that (*) lets mathematicians conclude this and assert many other properties of sets of reals makes it an “attractive hypothesis,” Schindler said.

With two highly productive axioms floating around, proponents of forcing faced a disturbing surplus. “Both the forcing axiom [Martin’s maximum] and the (*) axiom are beautiful and feel right and natural,” Schindler said, so “which one do you choose?”

If the axioms contradicted each other, then adopting one would mean sacrificing the other’s nice consequences, and the judgment call might feel arbitrary. “You would have had to come up with some reasons why one of them is true and the other one is false — or maybe both should be false,” Schindler said.

Instead, his new work with Asperó shows that Martin’s maximum++ (a technical variation of Martin’s maximum) implies (*). “If you unify these theories, as we did,” Schindler said, “I would say that you can take it as a case in favor of: Maybe people got something right.”

Asperó and Schindler were young researchers together at an institute in Vienna 20 years ago. Their proof germinated several years later, when Schindler read a manuscript, handwritten as usual, by the set theorist Ronald Jensen. In it, Jensen invented a technique called L-forcing. Schindler was impressed by it and asked a student of his to try to develop it further. Five years later, in 2011, he described L-forcing to Asperó, who was visiting him in Münster. Asperó immediately suggested that they might be able to use the technique to derive (*) from Martin’s maximum++.

They announced that they had a proof the next year, in 2012. Woodin immediately identified a mistake, and they withdrew their paper in shame. They revisited the proof often in the years that followed, but they invariably found that they lacked one key idea — a “missing link,” Asperó said, in the logical chain leading from Martin’s maximum++ to (*).

Two men standing up and drinking from coffee cups.
The set theorists Ralf Schindler (left) and David Asperó, authors of a new proof uniting rival axioms of infinite math, pictured in 2001.Thoralf Raesch

Their plan of attack for deriving the latter axiom from the former was to develop a forcing procedure similar to L-forcing with which to generate a type of object called a witness. This witness verifies all statements of the form of (*). So long as the forcing procedure obeys the requisite consistency condition, Martin’s maximum++ will establish that the witness, since it can be forced to exist, exists. And thus (*) follows.

“We knew how to build such forcings,” Asperó said, but they couldn’t see how to guarantee that their forcing procedure would meet the key requirement of Martin’s maximum. Asperó’s “flash experience” in the car in 2018 finally showed the way: They could break up the forcing into a recursive sequence of forcings, each satisfying necessary conditions. “I remember feeling very confident that this ingredient would in fact make the proof work,” he said, though it took further flashes of insight from both Asperó and Schindler to work it all out.

Other Stars

The convergence of Martin’s maximum++ and (*) creates a solid foundation for a tower of infinities in which the cardinality of the continuum is ℵ2. “The question is, is it true?” asks Peter Koellner, a set theorist at Harvard.

According to Koellner, knowing that the strongest forcing axiom implies (*) can count as evidence either for or against it. “Really that depends on what your take on (*) is,” he said.

The convergence result will focus scrutiny on (*)’s plausibility, since (*) allows mathematicians to make those powerful “for all X, there exists Y” statements that have consequences for the properties of the real numbers.

Despite (*)’s extreme usefulness in permitting those statements, seemingly without contradiction, Koellner is among those who doubt the axiom. One of its implications — a mirroring of the structure of a certain large class of sets with a much smaller set — strikes him as strange.

Notably, the person who might have been most enthusiastic about (*)’s correctness has also turned against it. “I’m considered a traitor,” Woodin said in one of our Zoom conversations this summer.

Twenty-five years ago, when he posed (*), Woodin thought the continuum hypothesis was false, and thus that (*) was a source of light. But about a decade ago, he changed his mind. He now thinks that the continuum has cardinality ℵ1 and that (*) and forcing are “doomed.”

Woodin called Asperó and Schindler’s proof “a fantastic result” that “deserves to be in the Annals” — the Annals of Mathematics is widely considered to be the top math journal — and he acknowledged that this kind of convergence result “is usually taken as evidence of some kind of truth.” But he doesn’t buy it. There’s the issue mentioned by Koellner, and another even bigger problem that he identified in a flash experience of his own in 2019, shortly after reading the preprint of Asperó and Schindler’s paper. “It’s an unexpected twist in the story,” Woodin said.

ABSTRACTIONS BLOG

How Gödel’s Proof WorksJULY 14, 2020

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When he posed (*), Woodin also posed stronger variants called (*)+ and (*)++, which apply to the full power set (the set of all subsets) of the reals. It’s known that, in various models of the mathematical universe if not in general, (*)+ contradicts Martin’s maximum. In a new proof, which he began to share with mathematicians in May, Woodin showed that (*)+ and (*)++ are equivalent, which means (*)++ contradicts Martin’s maximum in various models also.

(*)+ and (*)++ far outshine (*), for one reason: They permit mathematicians to make statements of the form “There exists a set of reals …” and thus to describe and analyze properties of any and all sets of reals. (*) does not provide such an “existential theory” of sets of reals. And because Martin’s maximum seems to contradict (*)+ and (*)++, it seems that existential statements about sets of reals might not be possible in the Martin’s maximum framework. For Woodin, this is a deal breaker: “What this is saying is, it’s doomed.”

The other main players are all still digesting Woodin’s proof. But a few stressed that his arguments are conjectural. Even Woodin acknowledges that a surprising discovery could change the picture (and his opinion), as has happened before.

Many in the community await the results of Woodin’s attempt to prove the “ultimate L” conjecture: that is, the existence of an all-encompassing generalization of Gödel’s model universe of sets. If ultimate L exists — Woodin has good reason to think it does, and he is 400 pages into a proof attempt now — he’ll consider it obvious that the “dream axiom” to add to ZFC must be the ultimate L axiom, or the statement that ultimate L is the universe of sets. And in ultimate L, Cantor is right: The continuum has cardinality ℵ1. If the proof works out, the ultimate L axiom will be, if not an obvious choice of extension for ZFC, at least a formidable rival for Martin’s maximum.

Ever since Gödel and Cohen established the independence of the continuum hypothesis from ZFC, infinite math has been a choose-your-own-adventure story in which set theorists can force the number of reals up to any level — ℵ35, or ℵ1000, say — and explore the consequences. But with Asperó and Schindler’s result pointing compellingly to ℵ2, and Woodin building the case for ℵ1, a clear dichotomy has established itself, and an outright winner seems newly possible. Most set theorists would like nothing more than to exit the mathematical multiverse and coalesce behind a single picture of Cantor’s paradise, one that’s beautiful enough to call true.

Kennedy, for one, thinks we may soon return to that “prelapsarian world.” “Hilbert, when he gave his speech, said human dignity depends upon us being able to decide things in mathematics in a yes-or-no fashion,” she said. “This was a matter of redeeming humanity, of whether mathematics is what we always thought it was: to establish the truth. Not just this truth, that truth. Not just possibilities. No. The continuum is this size, period.”

Expecting or Not?: How COVID-19 May Affect Your Decision


Historically, natural disasters, terrorist attacks and blackouts have affected the birth rate. Similarly, initial signs during the COVID-19 pandemic point to fewer babies in the coming years, continuing a trend that first gained noticeable momentum during the Great Recession. You may be wondering if you should have a baby during the pandemic or if you’re Being Practical About Having Babies or Should I Keep My Firstborn an Only Child? or if  Mothers With One Child Are Happiest.

A recent survey from the Guttmacher Institute, a reproductive-health research and policy organization, found that “about a third of women in the United States ages 18 to 49 were planning to postpone pregnancy or forgo adding a child to their family because of the pandemic.”

More Requests for Birth Control

Since the pandemic started, Nurx, a telehealth company that provides women’s reproductive health care prescribed online and delivered to their homes, has seen a spike in the demand for contraception. Dr. Julie Graves, a family medicine and public health doctor and the Associate Director of Clinical Services at Nurx, notes there’s been a 50% increase in birth control requests and a 40% uptick in requests for the morning-after pill. 

Many on the fence, wondering, should you have a baby or not during COVID, have found it difficult to get contraceptives or get in to see a physician due to the priority being given to treating patients with COVID-19. Others have tried to avoid going to the pharmacy during the pandemic.

Baby-Making Decisions in a Shaky Economy

The trajectory of this virus remains unknown, but its economic devastation is affecting how people think about family size. They worry about starting or expanding their family for financial reasons. Fifty percent of adults have experienced their own or someone in their household’s loss of income because of the pandemic. Added financial strain could force many couples, especially millennials, to think twice about having a first child or growing their family: 

Dr. Kate Bahn, director of labor market policy at the Washington Center for Equitable Growth says, “We know that women make fertility decisions based on economic opportunities.” 

Dr. Hannes Schwandt, an economics professor at Northwestern University goes further, “The very unromantic part of fertility is that it’s really largely driven by economics,” he says. “This pandemic means that the baby bust is looking less like a blip and more like a permanent trend.” 

The pandemic has led some women to put their in vitro fertilization treatments on hold. Even with an effective, tested vaccine on its way, COVID-19 still spirals in many states and giving birth in some areas is challenging. Because labor and delivery regulations that do or don’t allow a partner into the hospital can change according to COVID-19’s prevalence at the time, and definitive studies on the risks to mother and baby during the epidemic are not yet available, couples are being appropriately cautious about becoming pregnant. 

The personal impact of life-threatening events and major life stressors vary from person to person. Some decide to hold off on making major life changes and others forge ahead reported The New York Times. 

Should you have a baby or not during COVID? Have COVID-related health or financial worries affected your family planning? I would love to hear your thoughts. Please tell me via the “contact” form at the top of this pageYour response is confidential; only I will see it.

New #coronavirus variant ‘#IHU’ identified in France


New coronavirus variant ‘IHU’ identified in France https://economictimes.indiatimes.com/news/international/world-news/new-coronavirus-variant-ihu-identified-in-france/articleshow/88689359.cms Download Economic Times App to stay updated with Business News – https://etapp.onelink.me/tOvY/135dde21