The superbug that doctors have been dreading just reached the U.S.


The Post’s Lena Sun visited Walter Reed Army Institute of Research in Silver Spring, Md., where scientists there identified a strain of bacteria resistant to the last-resort antibiotic, colistin. The bacteria was found in a Pennsylvania woman. Microbiologist Patrick McGann explains how his team identified the gene that gives the bacteria this resistance
For the first time, researchers have found a person in the United States carrying bacteria resistant to antibiotics of last resort, an alarming development that the top U.S. public health official says could mean “the end of the road” for antibiotics.

The antibiotic-resistant strain was found last month in the urine of a 49-year-old Pennsylvania woman. Defense Department researchers determined that she carried a strain of E. coli resistant to the antibiotic colistin, according to a study published Thursday in Antimicrobial Agents and Chemotherapy, a publication of the American Society for Microbiology. The authors wrote that the discovery “heralds the emergence of a truly pan-drug resistant bacteria.”

Colistin is the antibiotic of last resort for particularly dangerous types of superbugs, including a family of bacteria known as CRE, which health officials have dubbed “nightmare bacteria.” In some instances, these superbugs kill up to 50 percent of patients who become infected. The Centers for Disease Control and Prevention has called CRE among the country’s most urgent public health threats.

Health officials said the case in Pennsylvania, by itself, is not cause for panic. The strain found in the woman is still treatable with other antibiotics. But researchers worry that its colistin-resistance gene, known as mcr-1, could spread to other bacteria that can already evade other antibiotics.

It’s the first time this colistin-resistant strain has been found in a person in the United States. In November, public health officials worldwide reacted with alarm when Chinese and British researchers reported finding the colistin-resistant strain in pigs and raw pork and in a small number of people in China. The deadly strain was later discovered in Europe and elsewhere.

“It basically shows us that the end of the road isn’t very far away for antibiotics — that we may be in a situation where we have patients in our intensive care units, or patients getting urinary-tract infections for which we do not have antibiotics,” CDC Director Tom Frieden said in an interview Thursday.

[1 in 3 antibiotics prescribed in U.S. are unnecessary]

“I’ve been there for TB patients. I’ve cared for patients for whom there are no drugs left. It is a feeling of such horror and helplessness,” Frieden added. “This is not where we need to be.”
Separately, researchers at the Agriculture Department and the Department of Health and Human Services reported that testing of hundreds of livestock and retail meats turned up the same colistin-resistant bacteria in a sample from a pig intestine in the United States. USDA said it is working to identify the farm the pig came from.

CDC officials are working with Pennsylvania health authorities to interview the patient and family to identify how she may have contracted the bacteria, including reviewing recent hospitalizations and other health-care exposures. The CDC hopes to screen the patient and her contacts to see if others might be carrying the organism. Local and state health departments also will be collecting cultures as part of the investigation.

[‘A nightmare superbug’: What is it? And what are the risks?]

The woman was treated in an outpatient military facility in Pennsylvania, according to a Defense Department blog post about the findings. Samples were sent to the Walter Reed National Military Medical Center for initial testing. Additional testing was done by a special Defense Department system that tracks multi-drug-resistant organisms.

Thursday’s study did not disclose further details about the Pennsylvania woman or the outcome of her case. The authors could not be reached for comment. A spokesman at the Pennsylvania Department of Health was not immediately available to comment on the case.

Pennsylvania Gov. Tom Wolfe (D) issued a statement saying his administration immediately began working with the CDC and the Defense Department to coordinate “an appropriate and collaborative” response.

[Feds ramp up efforts to deal with antibiotic resistance]

“We are taking the emergence of this resistance gene very seriously,” he said, adding that authorities will take all necessary actions to prevent it from becoming a widespread problem with “potentially serious consequences.”

Sen. Robert P. Casey Jr. (D-Pa.) said he is concerned about the reports. In a statement, Casey said he supported legislation for and participated in hearings about antibiotic-resistant bacteria, which he said “present an urgent public health problem that we must focus on intensively.” He said he planned to get a full briefing on the case in the coming days.

Colistin is widely used in Chinese livestock, and this probably led bacteria to evolve and gain a resistance to the drug. The gene probably leaped from livestock to human microbes through food, said Yohei Doi, an infectious-disease doctor at the University of Pittsburgh who has studied the problem.
“Food handlers may be at higher risk,” he said. In places like China, where live animal markets are often in close proximity to food stalls, it may be more likely for the bacteria to spread from animals to humans.

He and other experts in infectious diseases called for speedier action to curb the overuse of antibiotics in livestock worldwide.

“It’s hard to imagine worse for public health in the United States,” Lance Price, director of the Antibiotic Resistance Action Center and a George Washington University professor, said Thursday in a statement about the case. “We may soon be facing a world where CRE infections are untreatable.”

Scientists rang the alarm bells about the gene in November, but not enough attention was paid. “Now we find that this gene has made its way into pigs and people, and people in the U.S.,” Price said. “If our leaders were waiting to act until they could see the cliff’s edge — I hope this opens their eyes to the abyss that lies before us.”

Scientists and public health officials have long warned that if the resistant bacteria continue to spread, treatment options could be seriously limited. Routine operations could become deadly. Minor infections could become life-threatening crises. Pneumonia could be more and more difficult to treat.

Already, doctors had been forced to rely on colistin as a last-line defense against antibiotic-resistant bacteria. The drug is hardly ideal. It is more than half a century old and can seriously damage a patient’s kidneys. And yet, because doctors have run out of weapons to fight a growing number of infections that evade more-modern antibiotics, it has become a critical tool in fighting off some of the most tenacious infections.
Bacteria develop antibiotic resistance in two ways. Many acquire mutations in their own genomes that allow them to withstand antibiotics, although that ability can’t be shared with pathogens outside their own family.

[Scientists discover why pancreatic cancer resists chemotherapy drug]

Other bacteria rely on a shortcut: They get infected with something called a plasmid, a small piece of DNA, carrying a gene for antibiotic resistance. That makes resistance genes more dangerous because plasmids can make copies of themselves and transfer the genes they carry to other bugs within the same family as well as jump to other families of bacteria, which can then “catch” the resistance directly without having to develop it through evolution.

The colistin-resistant E. coli found in the Pennsylvania woman has this type of resistance gene.

Public health officials say they have been expecting this resistance gene to turn up in the United States.

“This is definitely alarming,” said David Hyun, a senior officer leading an antibiotic-resistance project at the Pew Charitable Trust. “The fact that we found it in the United States confirms our suspicions and adds urgency to actions we need to work on antibiotic stewardship and surveillance for this type of resistance.”

Late last year, as part of a broader budget deal, Congress agreed to give hundreds of millions of dollars to the federal agencies engaged in the battle against antibiotic-resistant bacteria.

The largest chunk of that money, more than $150 million, was slated to go to the CDC as part of an effort to build and strengthen capacity at state and local health departments to prevent and monitor superbug outbreaks.

Other funding went to the National Institutes of Health for research on combating antimicrobial resistance, as well as to an agency known as BARDA, which works on national preparedness for chemical and biological threats, including developing new therapies.

Researchers find unsafe levels of industrial chemicals in drinking water of 6 million Americans


Drinking water supplies serving more than six million Americans contain unsafe levels of a widely used class of industrial chemicals linked to potentially serious health problems, according to a new study from Harvard University researchers.

The chemicals — known as polyfluoroalkyl and perfluoroalkyl substances, or PFASs — have been used for decades in a range of industrial and commercial products, including non-stick coatings on pans, food wrappers, water-repellent clothing and firefighting foam. Long-term exposure has been linked to increased risks of kidney cancer, thyroid problems, high cholesterol and hormone disruption, among other issues.

“Virtually all Americans are exposed to these compounds,” said Xindi Hu, the study’s lead author. “They never break down. Once they are released into the environment, they are there.”

As part of the study, which was published Tuesday in Environmental Science & Technology Letters, the researchers examined concentrations of six types of PFAS chemicals in drinking water supplies around the country. The data came from more than 36,000 samples collected by the Environmental Protection Agency between 2013 and 2015.

They also looked at sites where the chemicals are commonly found — industrial plants that use them in manufacturing, military bases and civilian airports where fire-fighting foam is used and wastewater treatment plants.

What they found: 194 of 4,864 water supplies across nearly three dozen states had detectable levels of the chemicals. Sixty-six of those water supplies, serving about six million people, had at least one sample that exceeded the EPA’s recommended safety limit of 70 parts per trillion for two types of chemicals — perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA).

“It’s a big problem in a lot of communities,” said Richard Clapp, professor emeritus at Boston University’s school of public health. “It’s happening in a lot of places.”

From Decatur, Ala., to Merrimack, N.H., residents have been wrestling with high levels of the potentially harmful chemicals, and public officials have been scrambling to figure out how to prevent them from contaminating drinking water supplies.

The federal government does not currently regulate PFAS chemicals. But they are on the EPA’s list of “unregulated contaminants” that the agency monitors, with the goal of restricting those that most endanger public health. Partly because the rules that it must follow are complicated and contentious, officials have failed to successfully regulate any new contaminant in two decades.

Only once since the 1990s has the EPA come close to imposing a new standard — for perchlorate, a chemical that sometimes occurs naturally but also is found in explosives, road flares and rocket fuel. It has turned up in the drinking water of over 16 million people.

Joel Beauvais, who leads the EPA’s Office of Water, told the Post earlier this year that the system mandated by Congress demands the agency move deliberately. “It’s a rather intensive process to get one of these drinking-water regulations across the finish line,” he said.

Could your drinking water be contaminated?

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There are reasons for that, Beauvais said at the time. A substance may occur in only a very small number of drinking-water systems or might occur only in extremely low levels. Before the EPA imposes new limitations on the nation’s water utilities, it has to prove that there is a meaningful opportunity to improve public health. “These are very consequential regulations,” Beauvais said. “They are consequential from a health perspective. They are consequential from an economic perspective.”

In the wake of that advisory, at least one Alabama community declared its tap water unfit to drink and told residents to avoid it until officials could install a temporary, high-powered filter for the water supply. Some communities in New Hampshire received bottled water while authorities considered ways to address high levels of the contaminants in nearby groundwater. A company in upstate New York agreed to install carbon filters in private homes where high levels of the chemicals had been detected.

Clapp said that as evidence has mounted about the potential health risks posed by PFAS compounds and how ubiquitous they are, few people would argue that they should remain unregulated.

“We’re definitely overdue,” he said. “It’s not a question of whether, but rather at what level should they be regulated.”

Separately on Tuesday, another Harvard-led study, published in Environmental Health Perspectives, examined the effect of PFAS exposure in about 600 adolescents from the Faroe Islands off the coast of Denmark. Individuals exposed to the substances at a young age displayed lower-than-expected levels of antibodies to tetanus and diphtheria after being immunized, raising the prospect that the chemical exposure could be reducing the effectiveness of childhood vaccines.

The opioid addict next door: Drug abuse where you least expect it


Sarah Wilson, wife and mother of four, became addicted to opioid pain medications after she suffered severe injuries from getting hit by an intoxicated driver about eight-years-ago.

She was almost three years into her recovery from addiction to hydrocodone before anyone outside of her immediate family knew.

Wilson said that people are always surprised to learn that she was an addict. She said many have a certain image that people who suffer from addiction are junkies, or in her words “people like that.”

“But I’m ‘people like that,’“ she said.

And she’s not alone.

Some 2.1 million people abused prescription pain opioid pain relievers in 2012 alone, according to a Substance Abuse and Mental Health Services Administration report.

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Many organizations are working to combat opioid use disorder, a medical condition defined by the Diagnostic and Statistical Manual of Mental Disorders. Others aren’t sure what to do, and some feel as though it’s not their battle to fight, claiming that using drugs is a choice made by the user.

Tom Hill, senior adviser on addiction and recovery at the Substance Abuse Treatment Center of the Substance Abuse and Mental Health Services Administration, said addiction affects everyone in some way.

Hill said that there needs to be a change in attitudes regarding addiction, and openly discussing the subject will help. He noted that diseases like cancer and HIV/AIDSwere once taboo subjects as well.

The stigma of addiction may prevent people from openly talking about it, which creates a “culture of secrecy,” as Hill put it.

Wilson started recovery when she became a patient in clinical trials that tested several types of delivery methods of buprenorphine, a medication that’s used to treat opioid addiction.

In January, Wilson spoke in Washington at the open public hearing to support FDA approval of Probuphine, a form of treatment for people with opioid use disorder. It works as an implant in the arm that provides a constant, low-level dose of buprenorphine for six months.

Wilson has openly shared her story with others when no one else would. She said that because of the stigma behind addiction, people are unwilling to talk about it.

“I began to realize if I’m not speaking out, and no one else is speaking out, who’s going to fix it?” she said.

Hill, who is 24 years substance-free, also has also experienced judgment similar to Wilson, hearing phrases like “you don’t look like that” or “you’re not one of them.” He said that people make wrong assumptions about people who suffer from addiction.

Groups like FORCE, which stands for Female Opioid-addiction Research and Clinical Experts, have banded together with the mission to reduce the negative stigma and treatment barriers surrounding opioid addiction.

Behshad Sheldon, a member of FORCE, said that people often think of opioid addiction as a moral failure, which she said isn’t the case. Sheldon is also the CEO and president of Braeburn Pharmaceuticals, the company behind Probuphine.

“It can happen to anyone and it does happen to anybody,” she said, referring to opioid addiction.

Wilson said despite what she’s gone through and the fact that she’s recovered, it doesn’t make her more deserving of respect or special consideration than others with different circumstances who suffer from the same disease as her. She said she also has to account for the “terrible things” she did while in the peak of her addiction.

“To somebody they are everything, no matter how many bad things they’ve done,” she said. “Somebody loves them, and their lives are valuable, period.”

This alcohol substitute could get you drunk without the hangover


Thanks to science, you may soon be able to get drunk without feeling the effects the next morning.

A British scientist and longtime drug researcher has developed an alcohol substitute that still gives imbibers that sought-after buzz without the unsavory side effects of a hangover the next day. More importantly, at least from a public-health perspective, the substitute could also reduce instances of alcoholism and eliminate the damage that alcohol toxins have on bodily organs.

Oh, and it doesn’t have calories.

Cheers!

Alcarelle is the brainchild of David Nutt, a neuropsychopharmacology professor at Imperial College London and former adviser on substance abuse to the British government. It’s the brand name for a pair of alcohol substitutes that contain chemical compounds, which Nutt calls “alcosynths,” that mimic the fun of alcohol without the consequences.

Alcarelle has not undergone a regulatory or scientific peer review, Nutt said.

Nutt has pursued patents for roughly 90 chemical compounds that have the effect of knocking a couple back, and two of those lab creations have already been tested in humans. They could come to a bar near you if his newly formed company, also called Alcarelle, can raise the money needed to bring it to market, he said. The substitute would be sold as a liquid and added to your favorite cocktail or nonalcoholic beverage in lieu of vodka, rum, gin or other libations.

“I’ve gone from this stage of being just me, the mad scientist, to having business partners,” Nutt said in a phone interview. “They’re the people who are hopefully going to get me the investors.”

The various compounds that Nutt has developed work in one of two ways. Some replicate the direct effects of alcohol, specifically affecting the area of the brain that makes you feel loose but not the area that makes you fall-down drunk. Others mimic the indirect effects of alcohol, altering your serotonin or dopamine levels so that you might feel happier or more energetic.

Researchers can also engineer the chemical compounds so that their effect on the brain maxes out after so many drinks, reducing the desire to drink excessively and the risk of alcohol poisoning or blacking out, he said.

“My ambition would be for my grandchildren to never be exposed to alcohol,” Nutt said.

Tackling the harmful effects of alcohol has been Nutt’s focus since his days as a doctoral student in the 1970s. It was also part of his work during a stint in the 1980s as clinical science chief in the National Institutes of Health’s alcohol abuse and alcoholism division. The challenge, he said, is that alcohol is fundamentally toxic to the human body. Indeed, health professionals have long warned that excessive and prolonged alcohol consumption can be detrimentalto the brain, heart and liver, among other organs.

So 10 years ago, Nutt authored a paper for the British government calling for greater research into alcohol alternatives.

“Over the last couple of years, this research has come to some fruition. We now have found substances that can do what alcohol does in terms of giving people a relaxing experience and social experience, but without having the downsides of anger and aggression and addiction,” Nutt said.

What drunk looks like on YouTube

 

Play Video2:04
A University of Pittsburgh study finds 70 of the most popular videos that show people intoxicated on YouTube accounted for more than 330 million views. Researchers are now looking at the social media videos as an opportunity to teach about the dangers of alcohol.

The Arctic is being utterly transformed — and we’re just starting to grasp the consequences


A collage of melting sea ice in the Kane Basin between Greenland and Canada’s Ellesmere Island in August of 2016.
It’s the fastest-warming part of the planet — and the impacts will be felt far, far afield. Among many other assorted impacts, the rapidly melting Arctic is expected to flood shorelines as Greenland loses ice more and more rapidly (it contains some 20 feet of potential sea level rise), further pump greenhouse gases into the atmosphere as permafrost thaws, and become a global heat sink as a once ice-covered ocean exposes more and more dark water.

No wonder, perhaps, that on Wednesday, the outgoing Obama administration convened top science policymakers from 25 other Arctic and non-Arctic nations, as well as representatives of Arctic indigenous peoples, in a first-ever Arctic Science Ministerial to coordinate study of what the consequences will be as the Arctic heats up much more rapidly than the more temperate latitudes or the equator.

“The temperature is increasing between 2 and 5 times as fast, depending on where in the Arctic you are,” said physicist John Holdren, who heads the White House’s Office of Science and Technology Policy and is Obama’s science adviser, and is chairing the meeting.

We know this in broad outline, Holdren said, but our knowledge comes up short in many areas when it comes to more precisely observing what is happening in the remote and at times dangerous Arctic region, and being able to run simulations, or computer models, to chart the consequences.

“Basically, the whole Arctic is under-instrumented,” said Holdren. “The observation networks are too sparse in geographic extent, they’re too discontinuous in time, they’re not measuring everywhere all the things they should be measuring. We can’t say, for example, how much CO2 and methane emissions from the Arctic are actually going up. We know they are going up but we don’t really have a good handle on how fast and from precisely where.”

In conjunction with the ministerial, the White House announced the release of a new satellite-based dataset that maps elevations across the Arctic at a resolution of 8 meters, with an expected further improvement to 2 meters next year. This is highly scientifically valuable because it will mean that researchers will be able to remotely detect the slumping of glaciers and permafrost and the vulnerability of different locations to rising seas.

[These gorgeous new Alaska maps could transform our understanding of the Arctic]

Also on Wednesday, global ministers announced a number of science projects including a new Integrated Arctic Observing System to be put in place by the European Union and a U.S. National Science Foundation project, called “Eyes North,” to record and evaluate the large volume of environmental changes being observed by the Arctic’s indigenous peoples in and around their communities.
The U.S. Office of Naval Research, meanwhile, is starting a project next year called the Arctic Mobile Observing System to deploy measuring devices atop floating sea ice, or autonomous submersibles below it, to gather better ice and ocean measurements. This, too, was announced Wednesday.

Representatives came to the meeting not only from all the nations with Arctic territory — the United States, Canada, Denmark, Finland, Iceland, Norway, Sweden, Russia are all members of the Arctic Council, which the U.S. is chairing this year — but also from countries in warmer latitudes, including China, Japan, and many European Union states. After all, researchers from around the world are deploying to the Arctic every summer (and sometimes in harsher seasons) to conduct increasingly urgent studies.

In a statement from all these nations’ science ministers and Arctic indigenous leaders released by the White House, they stated that “We resolve that all nations conducting research in this region must work together to enhance and deepen scientific knowledge and understanding of the Arctic.”

Scientific observers say the show of unity is very important. “The White House [Arctic Science Ministerial] is an important opportunity to focus attention on and mobilize resources for the critical issue of the global consequences of climate change in the Arctic,” said Phillip Duffy, the president of the Woods Hole Research Center. “These global consequences are potentially calamitous, yet are little known to the public, and the scale of resources being used to address them is no where near commensurate to the threat.”

To give an example, Holdren discussed in detail, in an interview with the Post, why we don’t know precisely how much the Arctic is now contributing to the global burden of greenhouse gases through emissions from thawing permafrost, both on land and, in some places, potentially from beneath the sea.

“We would want to put a large number of sensors to detect local concentrations,” he said. “If you get a dense enough picture of local concentrations, you can back calculate to figure out where it must be coming from.” That would require, he said, also knowing the atmospheric circulation and making sure instruments are in the right places. It also involves continually measuring the temperatures of permafrost itself.
“If you look at monitoring the temperatures in the permafrost, that monitoring network is much too sparse to understand what’s happening overall,” Holdren said. “It would be great to be able to predict what the emissions of the permafrost are, or are going to be.”
Timed for the ministerial, the World Wildlife Fund Tuesday released a briefing paper by a group of Arctic experts who contemplated what the Arctic would look like in a world where the global average temperature has reached one of the two Paris climate agreement targets — 1.5 or 2 degrees Celsius above pre-industrial levels.

In the Arctic, the researchers note, that could translate into an increase of “roughly 4 and even up to 5 degrees C,” thanks to the now clearly operative process of Arctic amplification, in which the top of the Earth warms the most rapidly due to feedback processes involving the loss of sea ice and the storage of more warmth in the Arctic ocean.

“For all emissions scenarios, warming and substantial ice loss are projected for the next 20 to 30 years, along with other major physical, biological, and societal changes,” the paper notes.

“Without immediate action, the Arctic will continue to unravel, leading to an unstable future, difficult-to-predict interactions with global impacts, and dramatic changes from white, ice-covered, and stable to a new future of instability with abrupt, disruptive changes, difficult-to-predict interactions, and global chain reactions,” it later continues.

Studying the Arctic is one thing — ceasing to melt it is something very different. That won’t happen soon, if it actually happens in our lifetimes. But it is likely that as the changes accelerate, so will our ability to observe them in near real time — providing a scientific front seat to some of the biggest alterations to a fundamental Earth system that humans have ever seen.

Scientists may have solved a key riddle about Antarctica — and you’re not going to like the answer


Sirius Group exposures near Mount Fleming, Antarctica, circa 1986. The snow pattern behind rocks shows prevailing winds across the East Antarctic Ice Sheet.
This story has been updated.

It’s one of the great — and unresolved — debates of Antarctic science.

In 1984, a team of Ohio State University researchers reported a surprising fossil find: More than a mile above sea level, in Antarctica’s freezing Transantarctic mountain range, fossilized deposits of tiny marine organisms called diatoms were found in rock layers dated to the Pliocene era, some 2 million to 5 million years ago. But how did they get all the way up there? Diatoms, ubiquitous marine microorganisms whose tiny shells coat the ocean floor when they die, wouldn’t show up in high, inland mountain rocks unless something rather dramatic happened, long ago, to transport them.

So began a storied debate over this rock formation, dubbed the “Sirius Group” after Mount Sirius, one of the range’s many peaks. It was between the “dynamicists,” on the one hand, and the “stabilists” on the other. The dynamicists argued that the enormous ice sheet of East Antarctica had dramatically collapsed in the Pliocene, bringing the ocean far closer in to the Transantarctic range, and that subsequent upthrusts of the Earth and re-advances of glaciers had then transported the diatoms from the seafloor to great heights. No way, countered the stabilists: The ice sheet had stayed intact, but powerful winds had swept the diatoms all the way from the distant sea surface and into the mountains.

“It became very much split into two camps,” remembers Reed Scherer, an Antarctic researcher at Northern Illinois University. “It got really nasty.” Some researchers even tried to resolve matters by suggesting that a meteorite, and subsequent cataclysms unleashed by it, could account for the odd fossil locations.

But the decades have given way to new research tools and new perspectives. And Scherer has now paired up with two researchers behind what is arguably the hottest (and most troubling) new computer simulation of how Antarctica’s ice behaves, using their model to revisit the tale of those pesky diatoms. Their solution, published Tuesday in Nature Communications, isn’t good news — for it suggests that large parts of East Antarctica can indeed collapse, and moreover, can do so in conditions not too dissimilar from those we’re creating today with all of our greenhouse gas emissions.

If we steer the Earth back to those Pliocene-type conditions — when sea levels are believed to have been radically higher around the globe — oddly located diatoms will be the least of our problems.


The new study is co-authored by Rob DeConto of the University of Massachusetts, Amherst, and David Pollard of Pennsylvania State University, who recently published a new ice sheet model of Antarctica that predicts the ice continent can melt and raise sea levels by nearly a meter, on its own, during this century. They reached this result by adding several new dynamic ice collapse processes to glacial models that, in the past, had been slow to melt East Antarctica even in quite warm conditions. These models had lent weight to the views of the stabilists in the debate over the Sirius fossils, while also seeming to suggest that we needn’t worry about truly radical sea-level rise from Antarctica.

The new study suggests otherwise. In the Pliocene — and especially the mid-Pliocene warm period, when atmospheric carbon dioxide was at about the level where it is now, 400 parts per million, but global temperatures were 1 or 2 degrees Celsius warmer than at present — the model not only collapses the entirety of West Antarctica (driving some 10 feet of global sea-level rise) but also shows the oceans eating substantially into key parts of East Antarctica. In particular, the multi-kilometer thick ice that currently fills the extremely deep Aurora and Wilkes basins of the eastern ice sheet retreats inland for hundreds of miles — which would have driven global seas to a much higher level than a West Antarctic collapse alone.
From Scherer et al, Nature Communications. The image depicts a computer simulation of what Antarctica may have looked like in the Pliocene era, with West Antarctica gone and major retreat of the ice in the Wilkes Basin (WB) and Aurora Basin (AB) of East Antarctica. The red spots indicate locations where diatoms have been found in Sirius Group rocks in the Transantarctic range. Brown areas depict previously below sea level regions that rebounded after ice retreat.
Not only is this the world we could be headed to if global warming continues. It’s also a world that can hurl diatoms up into the Transantarctic Mountains, the new study argues. Here’s how that would work.

At first, in the wake of ice retreats in the Aurora and Wilkes basins, what would be left behind are ocean bays filled with life — and many, many diatoms. But Scherer and his colleagues do not believe that winds simply scooped them out of the water and lifted them into the mountains — living, wet diatoms suspended in water would have been too heavy to travel so far, Scherer says.

So instead, the study postulates another development. After a few thousand years of seas filled with happy diatoms, dying and lining the ocean floor in front of the remnant glaciers of the Wilkes and Aurora basins, the once submerged Earth would slowly rebound in some spots (a process sometimes called “isostatic uplift” or “postglacial rebound”). This would create an archipelago of islands, new landmasses free to rise to the surface now that so much ice has sloughed off their backs.

These islands rising from the sea, then, were the source of the diatoms, the study postulates.

The computer model “did show the ice retreated along the margins of East Antarctica, and isostatic uplift would then expose these areas that become new seaways, and with it would have been highly productive for plankton,” says Scherer. “So you would have been accumulating massive numbers of diatoms across this new basin, and with the loss of the ice, the land flexed upward, became exposed to winds, and the wind carried them to the mountains.”

Scherer notes that this new scenario doesn’t really proclaim either the dynamicists or the stabilists the victors. Rather, it merges their perspectives. His view is clearly reliant on a substantial amount of dynamics, but it also doesn’t suggest that the East Antarctica ice retreated nearly as far back as earlier proposals did. Nor does it use glacial processes to move the deposited diatoms. Rather, it borrows the stabilist idea of windblown transport, albeit only after ice has retreated and land has risen in its wake.

Commenting on this new compromise proposal Monday, one Antarctic researcher praised the work as representing an advance on old ways of thinking. “The paper is a great example of how much (paleo)climate modeling has improved in the last decade(s), particularly in the last few years,” said Simone Galeotti, an Antarctic researcher at the Università degli Studi di Urbino in Italy, by email.

The research also earned praise from David Harwood, one of the original dynamicists and now a professor at the University of Nebraska-Lincoln.
“This paper’s integration of climate, ice sheet, and atmospheric models provides interesting new perspective on potential source regions for the Antarctic, marine Pliocene diatoms present in glacial sediments of the Transantarctic Mountains, from interior basins of East Antarctica,” said Harwood in an emailed statement. “Their origin from deglaciated, exposed, rebounded marine basin floors in the Aurora and Wilkes basins is plausible, and the new model-derived wind patterns support their trajectory toward the [Transantarctic Mountains].”

Harwood therefore said that the study “comes close” to resolving the old debate between “dynamicists” and “stabilists” over the fossils.

“Bottom line, this paper suggests that marine diatoms in the Sirius Group do reflect dynamic ice behavior and Pliocene ice sheet retreat, just not of the scale suggested initially by Webb/Harwood,” he said, referring to the initial study that started off the debate. “Kind of like being right for the wrong reason.”

But beyond solving the riddle of the Sirius deposits in the Transantarctic Mountains, the new study also speaks strongly to the present moment. After all, the warm Pliocene, with its much higher seas, is one of the key past eras that scientists look to for an analogue for where we are currently driving the planet with our greenhouse gases.

Why researchers nearly doubled sea level rise estimates for the year 2100 Play Video1:13
[Why the Earth’s past has scientists so worried about sea level rise]

And thus, the new work suggests that if we keep pushing the system, we’ll not only have to worry about the loss of Greenland’s and West Antarctica’s ice, but also major losses from the biggest ice sheet of them all, East Antarctica.

Scherer, DeConto, and Pollard also have a fourth author on the study, the noted Penn State glaciologist Richard Alley, who has become more and more outspoken of late about his concerns that the world’s great ice sheets could be unstable. In a media statement accompanying the study’s release, Alley had this to say:

This is another piece of a jigsaw puzzle that the community is rapidly putting together, and which appears to show that the ice sheets are more sensitive to warming than we had hoped. If humans continue to warm the climate, we are likely to commit to large and perhaps rapid sea-level rise that could be very costly. No one piece of the puzzle shows this, but as they fit together, the picture is becoming clearer.

In other words, solving this key scientific problem from Antarctica’s past turns out to immediately raise major concerns about its future.
“We have now reached a point where atmospheric CO2 levels are as high as that during the Pliocene, 400 ppm, when geological evidence and new model results suggest substantial retreat of the EAIS [East Antarctic Ice Sheet] margin into interior basins. These perspectives bear fundamentally on predictions of future EAIS behavior,” said Harwood by email.

Granted, on a scientific and individual level, there’s also the satisfaction of finally being able to unify quite a lot of information into an explanation that fits the data and also matches our growing present day understanding of Antarctic vulnerability.
“Personally, I find the story rather cathartic, because it does explain the observations, I think, in a much better way than had been done before,” says Scherer.

scientists just confirmed a key new source of greenhouse gases


Countries around the world are trying to get their greenhouse gas emissions under control — to see them inch down, percentage point by percentage point, from where they stood earlier in the century. If everybody gets on board, and shaves off enough of those percentage points, we just might be able to get on a trajectory to keep the world from warming more than 2 degrees Celsius above the temperature where it stood prior to industrialization.

But if a new study is correct, there’s a big problem: There might be more greenhouse gases going into the atmosphere than we thought. That would mean an even larger need to cut.

The new paper, slated to be published next week in BioScience, confirms a  significant volume of greenhouse gas emissions coming from a little-considered place: Man-made reservoirs, held behind some 1 million dams around the world and created for the purposes of electricity generation, irrigation, and other human needs. In the study, 10 authors from U.S., Canadian, Chinese, Brazilian, and Dutch universities and institutions have synthesized a considerable body of prior research on the subject to conclude that these reservoirs may be emitting just shy of a gigaton, or billion tons, of annual carbon dioxide equivalents. That would mean they contributed 1.3 percent of the global total.

Moreover, the emissions are largely in the form of methane, a greenhouse gas with a relatively short life in the atmosphere but a very strong short-term warming effect. Scientists are increasingly finding that although we have begun to curb some emissions of carbon dioxide, the principal greenhouse gas, we are still thwarted by methane, which comes from a diversity of sources that range from oil and gas operations to cows.

How greenhouse gas behaves in the atmosphere

Play Video0:43
This high-resolution animation shows carbon dioxide emitted from fires and megacities over a five day period in June 2006. The model is based on real emission data so that scientists can observe how the greenhouse gas behaves once it has been emitted. (Global Modeling and Assimilation Office, NASA’s Goddard Space Flight Center)

The new research concludes that methane accounted for 79 percent of carbon dioxide equivalent emissions from reservoirs, while the other two greenhouse gases, carbon dioxide and nitrous oxide, accounted for 17 percent and 4 percent.

“There’s been kind of an explosion in research into efforts to estimate emissions from reservoirs,” said Bridget Deemer, the study’s first author and a researcher with Washington State University. “So we synthesized all known estimates from reservoirs globally, for hydropower and other functions, like flood control and irrigation.

“And we found that the estimates of methane emissions per area of reservoir are about 25 percent higher than previously thought, which we think is significant given the global boom in dam construction, which is currently underway,” she continued.

As Deemer’s words suggest, the study does not single out dams used to generate electricity — it focuses on all reservoirs, including those that are created for other purposes. It drew on studies on 267 reservoirs around the world, which together have a surface area of close to 30,000 square miles, to extrapolate global data.

Reservoirs are a classic instance of how major human alteration’s to the Earth’s landscape can have unexpected effects. Flooding large areas of Earth can set off new chemical processes as tiny microorganisms break down organic matter in the water, sometimes doing so in the absence of oxygen — a process that leads to methane as a byproduct. One reason this happens is that the flooded areas initially contain lots of organic life in the form of trees and grasses.

Meanwhile, as nutrients like nitrogen and phosphorus flow into reservoirs from rivers — being poured in by human agriculture and waste streams — these can further drive algal growth in reservoirs, giving microorganisms even more material to break down. The study finds that for these reasons, reservoirs emit more methane than “natural lakes, ponds, rivers, or wetlands.”

“If oxygen is around, then methane gets converted back to CO2,” said John Harrison, another of the study’s authors, and also a researcher at Washington State. “If oxygen isn’t present, it can get emitted back to the atmosphere as methane.”And flooded areas, he said, are more likely to be depleted of oxygen. A similar process occurs in rice paddies, which are also a major source of methane emissions.

In fact, Harrison said that based on the new study, it appears that reservoir emissions and rice paddy emissions are of about the same magnitude on a global scale — but rice paddy emissions have been taken into account for some time. Reservoir emissions often have not.
‘There are inventory compilers in each country that are responsible for compiling information about greenhouse gases to the atmosphere,” Harrison explained. “The [United Nations’ Intergovernmental Panel on Climate Change] writes the guidance, the cookbook that’s supposed to be used by these inventory compilers, and that guidance currently includes reservoirs only as an appendix, not an official part of any nation’s inventory. But that is likely to change as those guidelines get revised over the next two years.”

The research, said Deemer, complicates the idea that hydropower is a carbon-neutral source of energy, although she stresses that the authors aren’t saying that they’re against using large bodies of water to generate energy through dams. Rather, they’re arguing that the greenhouse gas calculus has to be included in evaluating such projects.

This problem is not an entirely new one: A major 2000 study in BioScience raised this issue, and the International Hydropower Association on its website acknowledges that “While hydropower is a very low-carbon technology, it is known that some reservoirs in certain conditions can release quantities of methane, a greenhouse gas. Reservoirs can also, in other circumstances, act as carbon sinks.”
But what is new about the current study is its synthesis of a large number of studies since 2000, and the determination that these emissions add up to something that is big enough to be taken seriously as part of the global carbon budget. It also finds that while some reservoirs are indeed “sinks” for carbon dioxide or nitrous oxide — meaning, they take up more of these gases than they emit — that was not true for methane.

The authors acknowledge the study does not represent a full “life cycle analysis” of reservoirs, taking into account how much carbon was stored (or emitted from) lands prior to their being flooded, and also what happens after reservoirs are decommissioned. Nor does it attempt to weigh the methane emissions from reservoirs used to generate hydropower against the amount of greenhouse gas emissions that would presumably be created if that electricity was instead generated by burning coal or natural gas.
But it clearly suggests a need to take these emissions seriously, and conduct further research.

“We’re trying to provide policymakers and the public with a more complete picture of the consequences of damming a river,” said Harrison.

How often do children need to wash their hair


When children are between the ages of 8 and 12, parents often ask dermatologists this question. If you’re a parent trying to answer this question, you’ve come to the right place.

In three easy steps, you can figure out how often a child between 8 and 12 years of age needs to shampoo.

Step 1: Consider your child’s traits
To determine how often your child needs to shampoo, you first need to consider your child’s:

  • Hair type (straight, curly, oily, dry)
  • Age
  • Activity level

Step 2: Find your child’s traits on the following chart

Shampoo guidelines: Children 8 to 12 years old

Shampoo every other day or daily
  • 12 years of age or starting puberty
  • Oily, straight hair
  • Active: Plays outdoors, plays sports, or swims

Exception: Hair is dry, curly, or African American

Shampoo 1 or 2 times per week
  • 8 to 11 years of age

Exception: Hair is dry, curly or African American

Shampoo every 7 to 10 days
  • Dry, curly, or African American hair, even hair with braids or weaves
  • After heavy sweating or swimming, rinse and condition the hair

 

Step 3: Fine tune to get it just right
Once your child is shampooing as often as shown above, you may need to adjust the frequency a bit. Each child is different. Changes in weather also can affect how often your child needs to shampoo.

To fine tune, look at your child’s hair and scalp between washings. The following chart shows you what to look for and how to fine tune.

Shampoo guidelines: How To tell if your child is shampooing too often or not enough

Shampoo more often if you notice that your child’s:
  • Hair is oily
  • Scalp is oily

Continue to add one shampoo per week until you no longer see oiliness

Shampoo less often if you notice that your child’s:
  • Hair is dull and shedding
  • Hair feels dry

Continue to remove one shampoo per week until you no longer see dullness, shedding, or dryness

When to see a dermatologist

For most children, these guidelines work well. If your child’s hair or scalp seems too oily or dry after following these guidelines, you should see a dermatologist. Your dermatologist can explain why this is happening and offer a solution.

How often do children need to take a bath


If getting your child to take a bath often means a struggle, you’ll be glad to know that a daily bath may not be necessary. How often your child needs a bath depends on your child’s age and activities.

These guidelines from dermatologists can help you figure out how often a child 6 years of age or older needs a bath. You’ll also find dermatologists’ tips that can help you:

  • Make bath time fun a child at any age.
  • Teach your child healthy hand-washing habits.

 

Children ages 6 to11: Guidelines for bathing

If your child is in this age group, taking a daily bath is fine. Children in this age group, however, may not need a daily bath. Children aged 6 to 11 need a bath:

  • At least once or twice a week.
  • When they get dirty, such as playing in the mud.
  • After being in a pool, lake, ocean, or other body of water.
  • When they get sweaty or have body odor.
  • As often as directed by a dermatologist if getting treated for a skin disease .

 

Tweens and teens: Guidelines for bathing

Thankfully, most kids want to bathe daily once they hit puberty. Dermatologists tell parents that once puberty starts, kids should:

  • Shower or take a bath daily.
  • Wash their face twice a day to remove oil and dirt.
  • Take a bath or shower after swimming, playing sports, sweating heavily.

 

How to make bath time fun

By making bath time fun, children often start to enjoy it. Bath time can be fun when it becomes the time your child gets to:

  • Play with a favorite (waterproof) toy.
  • Listen to favorite stories.
  • Read a book made especially for taking into the bathtub.
  • Have fun with an adventure that you create to make bath time fun.

 

How to teach healthy hand-washing habits

There is no getting around the importance of frequent hand washing. Children need to wash their hands before eating. Hand washing also is essential after they use the bathroom, blow their noses, and touch pets and other animals.

You can help your child develop healthy hand-washing habits by teaching them these steps:

  1. Wet hands with clean, warm water.
  2. Soap up, rubbing the hands together to make a lather. The lather should go all over the hands and in between the fingers.
  3. Continue rubbing for about 20 seconds. To help younger children count the time, you can ask them to sing “Happy Birthday” to you two times.
  4. Rinse with warm, running water.
  5. Dry hands on a clean towel.

Watch the video. URL:https://youtu.be/KxT1hpkstLE

Scientists build embryos with non-egg cells


Researchers at the University of Bath were able to turn non-egg cells into a viable embryo — and living offspring — for the first time.
Scientists at the University of Bath have done what many thought impossible. They’ve turned non-egg cells into a viable, life-producing embryo.

Parthenogenotes are egg cells that have been “tricked” into becoming an embryo without actually being ferti,

lized by sperm. Parthenogenotes die after only a few days.

Researchers previously thought parthenogenotes were not viable vehicles for life. But as part of the latest research effort, scientists injected the parthenogenotes with mouse sperm. The non-traditional embryos produced mice offspring 24 percent of the time.

“This is first time that full term development has been achieved by injecting sperm into embryos,” Tony Perry, a researcher at the University of Bath, said in a news release. “It had been thought that only an egg cell was capable of reprogramming sperm to allow embryonic development to take place.”

The newborn mice are all healthy and were able to produce an additional two generations of mice.

However, their DNA development was marked by different epigenetic signatures than those observed during traditional fertilization. The findings, detailed in the journal Nature Communications, suggest successful mammalian birth can be achieved via at least two different epigenetic pathways.

“Our work challenges the dogma, held since early embryologists first observed mammalian eggs around 1827 and observed fertilization 50 years later, that only an egg cell fertilized with a sperm cell can result in a live mammalian birth,” added Perry.