Thrombotic Complications Still a Problem in APS


Events and related deaths persist in patients with antiphospholipid syndrome.

Morbidity and mortality are improving but remain high among patients with the systemic autoimmune condition known as antiphospholipid syndrome (APS), a large, prospective European study found.

Among 1,000 patients enrolled in the Europhospholipid project, 17% of patients developed thrombotic events during the years 1999 to 2004, as did 15% of patients during the years 2004 to 2009, according to Ricard Cervera, MD, PhD, of the University of Barcelona in Spain, and colleagues.

In addition, the standardized mortality ratio during the 10-year study was 1.8 (95% CI 1.5-2.1) compared with the general population, and the mean age at death was 59, the researchers reported in the June Annals of the Rheumatic Diseases.

“Therefore, it is imperative to increase the effort in determining the optimal prognostic markers and therapeutic measures to prevent these important complications of the APS,” they stated.

Among the clinical features of APS are stroke, transient ischemic attacks (TIA), deep vein thrombosis (DVT), and pulmonary embolism (PE), as well as obstetric complications including preeclampsia and early pregnancy loss. The condition also is associated with high titers of antiphospholipid antibodies and multiple other non-thrombotic manifestations such as seizures.

The syndrome can be primary or associated with another disease, usually systemic lupus erythematosus (SLE).

Little is known about how treatment has influenced the long-term outcomes of APS, with previous studies being small and of short duration.

Cervera and colleagues instituted the Euro-Phospholipid project in 1999 to chronicle the “real world” disease course of European patients with APS. Twenty participating centers each enrolled 50 consecutive patients who fulfilled the criteria for “definite APS.”

A total of 82% of the cohort was female, and almost all were white. Mean age at the time of enrollment was 42.

The syndrome was primary in 53%, associated with SLE in 36%, and associated with other conditions such as lupus-like syndrome in the remainder.

During the 10 years of follow-up, which were divided into two 5-year periods, 42% of patients were lost to follow-up.

Among the thrombotic events that occurred, strokes were seen in 5% of patients, TIA in 5%, DVT in 4%, and PE in 4%.

In contrast, during a median of 6 years’ follow-up before the study period, stroke had occurred in 20%, TIA in 11%, DVT in 39%, and PE in 14%.

A total of 16% of women became pregnant during the decade-long study, and 73% of the pregnancies were successful. That represented a significant improvement over baseline, when the rate of live births was only 48%.

The most frequent obstetric complication was fetal loss before 10 weeks in 17% of the pregnancies. Intrauterine growth restriction was seen in 26% and premature birth in 48%.

In comparing primary APS patients with SLE-related APS, the researchers found that the SLE subgroup more often had arthritis (21% versus 3%), hemolytic anemia (16% versus 2%), livedo reticularis (21% versus 7%), and myocardial infarction (4% versus 1%).

Most patients received antithrombotic treatment with aspirin or other antiplatelet agents. During the first 5 years of the study, 35% of patients were on low-dose anti-aggregant medications, as were 28% in the next 5 years.

Oral anticoagulants were being taken by 40% of patients during the first 5 years and by 37% during the second 5 years. In 62% of anticoagulant users, the target international normalized ratio (INR) was 2 to 3, and in 38% the target was 3 to 4.

In the second 5-year period, 25% of patients on antithrombotic therapy and 5% of those not on the treatment developed thrombosis, while 8% and 2%, respectively, developed an obstetric complication.

There were 61 major bleeding events during the 10-year follow-up among patients on antithrombotic medications, with 25% being cerebral, 16% being gastrointestinal, and 8% being intra-abdominal. Ten were fatal.

The most common causes of death were serious thrombotic events, with myocardial infarction, strokes, and PE accounting for 37%. Infection, primarily bacterial, was the cause in 27% and hemorrhage in 11%.

The probability of survival at 5 years was 94%, decreasing to 91% at 10 years.

The observation that arterial events continue to occur despite current treatment strategies suggests that “this particular group of patients may need a higher anticoagulation target (INR 3-4) as well as strict control of comorbidities and prothrombotic factors,” the investigators wrote.

“This long-term study provides updated information on APS morbidity and mortality characteristics. Patients with APS still develop significant morbidity and mortality despite current treatment (mainly oral anticoagulants and/or anti-aggregant agents),” Cervera and colleagues concluded.

College watercraft project Jet Blade has three-ski design


A four-person team from Calvin College in Grand Rapids, Michigan, have come up with a unique personal watercraft dubbed The Jet Blade. In terms of being durable, stable and agile, which were the project’s goals, the Jet Blade prototype looks promising as a product that could provide good rider experiences in water sports.

The Jet Blade is a single-rider personal watercraft with a three-ski design—two in the front of the craft and one ski in the rear. Why choose a three-ski design? The creators said they did so “because it was determined it would increase the maneuverability of the PWC [personal watercraft]. With two skis located in the front it would then allow for two edges to be in contact with the water while turning at all times giving more control over a one ski design. Having two skis on the Jet Blade will allow for increased stability and allow for easier use for the end user.”

The skis are located below an aluminum hull. They can lift the Jet Blade to cruise position by the relative water flow on the undersides of the skis. The rear ski is attached to a horizontal jet pump powered by a 650cc water-cooled engine. The front suspension implements an Active Tilt steering design.

The four-person team are Josh Vanderbyl, Nico Ourensma, Ryan DeMeester and Zak DeVries. Each is part of the mechanical concentration of the engineering program at Calvin College.

They consider Jet Blade to be unique in that conventional personal watercraft rely on a directional water jet to steer, whereas in the Jet Blade, they said, the jet is fixed and steering is accomplished by turning the front skis. For maximum turning performance, both skis must remain in contact with the water at all times.

Their Design Report said that Jet Blade is “for use on small inland lakes where waves should not exceed 1-2′ in amplitude. Like most watercraft, it is a seasonal vehicle. It is able to operate in water temperatures down to 32oF; however this is well below comfortable riding temperatures. Conversely, the liquid cooled 650cc engine allows the Jet Blade to stay cool even on the hottest summer days, operating in water temperatures up to 90oF.”

They completed the task of manufacturing a functional Jet Blade prototype. The report stated, “After the preliminary design decisions, calculations, and budgeting Team 6 has decided that the project is feasible.”

What’s next? In working out a business plan, the team said that “Currently there is nothing on the market that is identical to the Jet Blade. The Jet Blade is a unique product with a target market comprised of individuals that have some discretionary income, as it is a luxury item. Specifically individuals or those individual’s kids that have an interest in extreme sport and have access to a body of water to ride the Jet Blade. The key marketing strategy for the Jet Blade is to create superior customer value by means of differentiation.”

Wounded Sea Turtle Gets A 3D-Printed Jaw .


Titanium Turtle Jaw

Titanium Turtle Jaw

Btech Innovations

In an earlier era, colliding with a boat’s propeller could have been the end of a sea turtle’s life. This is not that grim dark era, so a sea turtle found with a broken jaw was rescued and then brought to Pamukkale University’s Sea Turtle Research, Rescue and Rehabilitation center in Denizli, Turkey. Thanks to a collaboration with Turkish company Btech Innovation, the turtle received a custom-designed, 3D-printed titanium jaw.

To make the jaw, the company scanned the turtle, and then converted those scans into 3D models. Then, they printed the jaw out of medical-grade titanium and mailed it to the rescue center, where surgeons attached the jaw to the turtle. The turtle is still in recovery–scientists have to make sure it doesn’t reject the prosthetic–but thanks to modern technological marvels and the efforts of rescuers, it should be free to return to the seas soon.

Watch the video. URL: https://youtu.be/NKgFSNXb0lQ

Reclaiming The Self – Is Your Sense Of Self An Illusion?


If there is one concept which has been under constant attack by psychologists and philosophers over the last few decades, it is the idea of ‘you’ – that you are a real entity or ‘self’. Many modern philosophers and scientists suggest that this sense of being ‘someone’ is illusory, or just a simple product of brain activity. Somehow the billions of neurons in your brain work together to produce it, and all of the thoughts and feelings which it incorporates.

This view was expressed very graphically by the scientist Francis Crick, who wrote: “You, your joys and your sorrows, your memories and your ambitions, your sense of personal identity and free will, are in fact no more than the behavior of a vast assembly of nerve cells and their associated molecules.”

From a less biological perspective, the philosopher Daniel Dennett speaks of the illusion of the ‘Cartesian Theatre’,  the sense that there is ‘someone’ in our heads looking out at a world ‘out there’, and also watching our own thoughts pass by. In reality, says Dennett, there are only mental processes. There are streams of thoughts, sensations and perceptions passing through our brains, but there is no central place where all of these phenomena are organised.

Similarly, the psychologist Susan Blackmore has suggested that the self is just a collection of what she calls ‘memes’ – units of cultural information such as ideas, beliefs and habits. We are born without a self, but slowly, as we are exposed to environmental influences, the self is ‘constructed’ out of the memes we absorb.

Modern neuroscience seems to reinforce such views. Neuroscientists claim to be able to ‘locate’ the parts of the brain responsible for mental phenomena such as aesthetic appreciation, religious experience, love, depression and so on, but they haven’t found a part of the brain associated with our underlying sense of self.Therefore, they feel justified in concluding that this doesn’t exist.

‘Ghosts Don’t Exist’, says the Ghost

There are many problems with the attempt to ‘reduce’ our sense of self to brain activity. This is related to the ‘hard problem’ of explaining the origins of conscious experience, so-called to distinguish it from the ‘easy problems’ of mental abilities and functions such as memory, concentration and attention. Whilst we might be able to understand these phenomena, the problem of how the brain might produce consciousness is on a completely different level. The brain is just a soggy clump of grey matter – how could that soggy mass possibly give rise to the richness and depth of consciousness? To think that it could is a ‘category error’ – the brain and consciousness are entirely distinct phenomena, which can’t be explained in terms of each other.

And on a more practical basis, after decades of intensive theorising and research, no-one has yet put forward any feasible explanation of how the brain might produce consciousness. The ‘hard problem’ seems completely insurmountable.

There is a basic absurdity in these attempts to show that the ‘self’ is illusory. They always feature a self trying to prove that it doesn’t exist. They are caught in a loop. If the self is an illusion to begin with, how can we trust its judgements? It’s a bit like a ghost trying to prove that ghosts don’t exist. Perhaps it may be right, but its illusory nature doesn’t inspire confidence. Dennett and Blackmore are presuming that there is a kind of reliable, objective observer inside them which is able to pass judgement on consciousness – and that presumption contradicts their own arguments. That is the very thing whose existence they are trying to disprove.

Related to this, there is a problem of subject/object confusion. All of these theories attempt to examine consciousness from the outside. They treat it like a botanist examining a flower, as an object to scrutinize and categorize. But of course, with consciousness there is no subject and no object. The subject  is  the object. You  are  consciousness. So it is fallacious to examine it as if it is something ‘other.’ Again, you are caught in a loop. You can’t get outside consciousness. And so any ‘objective’ pronouncements you make about are fallacious from the start.

An interesting question to ponder is:  why  do human beings invest so much energy into trying to prove that they don’t exist? Why do scientists and philosophers seem so intent on proving that they themselves are illusions? Perhaps there is a kind of repressed suicidal impulse at work here. Perhaps the individuals in question experience a deep-rooted self-hatred and an impulse for self-destruction which, at conscious level, has been translated into an impulse to negate their own identity and existence. More likely, though, these views are symptom of the general nihilism of our culture, the collapse of values which has followed from materialistic science. The fact that these theories have become prevalent, despite being fallacious, shows how well they fit to the present ‘zeitgeist’.

Subjective Investigation

So  does  the self exist? Is there really anybody there inside your own mental space?

I think the best way to answer the question is to take a different approach. Rather than attempting to analyse consciousness from the outside as if it is an object, the best approach is to embrace subjectivity, and delve into your own consciousness. Try meditation, for example. In deep meditation, you might find yourself in a state of complete mental quietness and emptiness, with no thoughts, no perceptions, no information processing, no concentration. In fact, this state can be seen as the ‘goal’ of meditation (at least according to some traditions). The philosopher Robert Forman has called it the ‘pure consciousness event’ – a state in which consciousness exists without content, and rests easefully within itself. I have experienced this state myself, and am familiar with its qualities. Paradoxically, although consciousness is empty, it has a quality of  fullness  too. It appears to be full of  energy –  a powerful energy which has a quality of well-being, or even bliss. (This is what Indian Vedanta philosophy describes as  satchitananda  – being-consciousness-bliss.) There is also a quality of spaciousness – somehow my own consciousness seems to become wider and larger, to spread beyond my own brain or body. This can lead to a sense of connection or even oneness – a feeling that my consciousness is merging with a force or energy which somehow seems fundamental to the world, or the cosmos.

But most importantly in terms of my argument in this article, in these moments, one of the qualities of consciousness is a sense of ‘I’. There is still a sense of identity, even if this sense may be different to the identity of a normal state of consciousness.   This identity does not feel separate or boundaried. It feels part of a greater unity, but still has a sense of I-ness. You could compare it to a wave having a sense of its own existence of a wave but at the same time being aware of itself as a part of the sea. There is still an ‘I’ which has awareness of itself and of its situation. From this point of view, it appears that consciousness or identity is not an illusion. In this state, there are no ‘memes’ and no streams of mental processes, but consciousness still appears to exist. I would therefore say that the sense of self is fundamental to us, from the deepest levels of our being. Of course, this fundamental sense of ‘I’ is acted on by all kinds environmental, social and psychological influences, and becomes ‘constructed’ to a large degree. You could compare it to how a Roman fort is built upon and expanded over centuries until eventually develops into a modern city. But there is a fundamental kernel of ‘I-ness’ which is always there, underlying all of the activity and all the construction.

Of course, this is just my own subjective experience. I shouldn’t make any universal claims for it – although, as Robert Forman has pointed out, the ‘pure consciousness event’ seems to be universal in the sense that human beings from culture to culture have independently described experiences of it throughout history. Ultimately, however, the only real way to substantiate this is for you to try it out yourself – to reach a deep state of meditation, and see if your own experience accords with mine.

13 rare medical syndromes you won’t believe are true!


Science and its inventions have changed the world and medical science in particular has changed the way we live. Yet scientists are making discoveries about the human body every day, and there’s still so much more we don’t know. Click through for some rare but real medical syndromes that people are living with right now.

1: Alien Hand Syndrome

Alien Hand SyndromeThe Alien Hand Syndrome, also known as Strangelove syndrome after the 1964 movie, is a condition where a person’s hand takes on what seems like a life of its own. Sufferers may pick up and handle objects without wanting to, or being able to control themselves. The syndrome, first discovered in 1909, is extremely rare. There is no known cure. (Pictured) Peter Sellers in Dr Strangelove. In the movie, his character suffered from the syndrome.

2: Foreign Accent Syndrome

Foreign Accent Syndrome

A sudden and dramatic shift in the sufferer’s voice, resulting in people developing a foreign accent. Fewer than 100 cases have been reported so far: a well-known example occurred in 1941 when a Norwegian woman developed a strong German accent after being injured in an air-raid.

3: Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

The name of this syndrome comes from the 1865 classic in which Alice experiences magical shrinking and expanding. A patient suffering from this syndrome experiences distorted perception of sizes and shapes: they think things are smaller, larger, nearer or further than they really are. It can cause acute disorientation and affect the patient’s senses of touch and hearing.

4: Cotard Syndrome

 

French neurologist Jules Cotard identified this in 1880: it’s also known as Cotard Syndrome. The affected person believes the he or she has died and stops eating, bathing and some even start living in a cemetery. Sufferers of this extremely rare condition can also believe that their body is rotting, or that they have lost body parts.

5: Werewolf Syndrome

Werewolf Syndrome

Abnormal growth of hair on body is known as hypertrichosis lanuginosa or werewolf syndrome. There are two types of this syndrome: a congenital (or inherited) form and an acquired form. There is no known cure for the syndrome itself, but the hair can be reduced with laser treatment. (Pictured) Jesus Fajardo poses for a photograph at a cultural center in Zapopan, Mexico. Fajardo started working in a circus at age 13 but quit after acting as a werewolf for 20 years. He now works in a carpentry firm.

6: Moebius Syndrome

Moebius Syndrome

Another extremely rare syndrome, the patients affected by moebius syndrome suffer complete facial paralysis. They cannot close their eyes and are unable to form facial expressions. (Pictured) A patient undergoes acupuncture treatment to cure facial paralysis in Beijing.

7: Geographic Tongue Syndrome

Geographic Tongue Syndrome

Though it may be not as extreme as other syndromes, the sufferers of this syndrome experience painful lesions. These lesions resemble geographical patterns on a map, hence the name. The exact cause of this syndrome is unknown and it appears be harmless, if occasionally uncomfortable.

8: Laughing Death

The disease, also known as Kuru, was exclusive to the Fore tribe in New Guinea. In 1950s, the world came to know about the disease after people started dying following bouts of maniacal laughter. American physician Carleton Gajdusek unlocked the mystery and discovered that the condition was caused by funerary cannibalism (eating of dead tribe members). Gajdusek won the 1976 Nobel Prize for his work on the disease.

9: Jerusalem Syndrome

Jerusalem Syndrome

Regardless of religion or faith, this syndrome can affect anyone. A visit to the Holy Land can trigger a belief that the sufferer is the Messiah, or receiving communications directly from God. Local doctors have been quoted as saying that the best treatment is simply to leave Jerusalem.

10: Fibrodysplasia Ossificans Progressiva

A rare condition affecting one in two million, this genetic disorder – sometimes known as Stone Man Syndrome – changes soft muscles into hard bones and fuses joints. There is no treatment and surgical removal of new bones can exacerbate the condition.

11: Fish Odour Syndrome

Fish Odour Syndrome

Trimethylaminuria also known as fish odour syndrome is caused due to the deficiency of an enzyme that prevents breakdown of trimethylamine (TMA). It cause extreme foul odour in breath, sweat and urine. A TMA-free diet may reduce the symptoms.

12: Exploding Head Syndrome

Exploding Head Syndrome

Essentially harmless but extremely distressing, sufferers experience imagined loud sounds such as gunshots, bomb blasts and explosions. Insomnia, anxiety can aggravate the condition.

13: Water Allergy

Water Allergy

Aquagenic urticaria, also known as water allergy, is so rare that only 30 cases have been reported so far. Hormonal imbalance may trigger the allergy where a person is unable to even drink water. case was reported in 2008, where a British girl could only drink Diet Coke and had 10-second-long showers to survive.

Climate Engineers Can No Longer Suppress El Niño


Stratospheric Aerosol Geoengineering (SAG) is a term for the ongoing global climate modification programs being conducted by major powers around the world. A primary stated goal of the geoengineering programs is to provide a “solar shield” to slow “runaway climate change”, and numerous geoengineering patents have a stated goal of slowing global warming. Geoengineering patents also call for spraying tens of millions of tons of highly toxic metal nano particulates into the atmosphere all over the planet.

Is the spraying of metal particulates only for “solar radiation management”? Based on available data, there are a number of other objectives including but not limited to Solar Radiation Management (SRM), weather warfare, over-the-horizon radar enhancement, controlling food production, and probable biological testing. There are likely many more aspects and agendas related to the atmospheric spraying which we can not yet know.

From every conceivable direction, the climate engineers continue to wreak total havoc on the planet and its life support systems. Their documented attempt to “own the weather” has now put virtually all life on Earth in the balance.

The periodic “El Niño” phenomenon is the planet’s process of releasing excess heat from the oceans. El Niño events are directly associated with record warm global temperatures as the seas release this excess heat. Even without an El Niño, 2014 was the warmest year ever recorded on our planet as rapidly rising ocean temperatures shattered records.

Since at least 2007, geoengineers have done everything they could to prevent El Niño from forming, resulting in a highly destructive attempt to keep global temperatures down. In recent years the El Niño has been described as being “elusive” and “super weird“. How could the geoengineers actually affect the El-Niño process? By maintaining the “ridiculously resilient ridge” of high pressure over the US west coast — which scientists just “can’t figure out”, since they are forbidden to even mention the effects of climate engineering.

But the climate engineering elephant in the room is becoming bigger and harder to hide by the day. This constant ridge of high pressure is a phenomenon which is fueled by ionosphere heaters like “HAARP” along with the constant spraying of atmospheric aerosols. The “ridiculously resilient ridge” they have created has in effect altered the trade winds normally associated with the development of El Niño and thus contained the rapidly building heat on our planet within the now-record warm oceans. In turn, the warming oceans are also fueling an unfolding methane release global catastrophe, and the now altered wind and ocean currents (and ocean stratification) are pushing us toward a “Canfield ocean” scenario.

The Climate Engineers Can No Longer Suppress El Niño - Sea Surface Temperature Anomalies

This ridge of high pressure continues to bake California in record shattering heat and drought. Even if El Niño does form, the geoengineers can still keep the rain cut off to the now parched US West if they choose to do so, which it seems is what they have planned.

What happens when the El Niño process is actively suppressed? As should be expected, interference with Earth’s life support systems can only bring about very bad consequences. Now the bottled up heat is so extreme that is contributing (along with numerous other factors) to mass marine ecosystem die-off and ocean dead zones in the Pacific. Active hurricane suppression in the Atlantic basin by the geoengineers has contributed to built up heat and dead zones there as well. Oceans around the globe are dying, marine ecosystem collapse is accelerating at an ever more rapid pace.

Human activity has completely altered the biosphere in countless ways, especially in regard to the climate system. Of all the anthropogenic factors affecting the climate, the ongoing climate engineering programs are the single most significant source of disruption and decimation. To say the changes to our biosphere are “natural” would be like pushing someone off a cliff and then saying “people die, it’s natural”.

Global climate engineering is the absolute epitome of human arrogance and insanity. Not only is geoengineering contaminating the entire web of life, these programs are making an already bad planetary warming scenario far worse overall, not better (though the climate engineers can and are creating short term toxic cooling in some regions, especially the eastern US). The battle to expose and stop the ongoing geoengineering is nothing short of a fight for life, make your voice heard in this critical fight.

Teenager kept awake for week to stop parasite burrowing into eyeball.


Jessica Greaney has eyedrops administered every ten minutes for seven days after doctors find small worm-like creature in her left eye from contact lens

Jessica Greaney's eye which got an infection which nearly blinded her.

Jessica Greaney’s eye which got an infection which nearly blinded her.
Medics forced a student to stay awake for a week to prevent a parasite from burrowing into her eyeball.

Jessica Greaney, 18, had eyedrops administered every ten minutes for seven days in a row after doctors found a small worm-like creature in her left eye from a contact lens.

Miss Greaney, a first-year English student at the University of Nottingham, was told she got the parasite – acanthamoeba keratitis – in her eye after a drop of tap water splashed on her contact lens.

At first, she thought she had an eye infection as her eyelid was dropping, which was then mis-diagnosed as an ulcer by doctors.

She said: “But, by the end of the week, my eye was bulging, and it looked like a huge red golf ball. It was swollen, and extremely painful, and they admitted me into hospital.

“I had an intensive treatment of eyedrops every ten minutes because my cornea was being eaten away from the inside by the parasite.”


Jessica Greaney got the parasite from her contact lens (SWNS)

Miss Greaney, originally from Birmingham, was finally diagnosed with the parasite after doctors clamped open her eye and scraped off a layer with a scalpel, which was then sent away for testing.

She said: “Apparently, all water has tonnes of different types of bacteria and the acanthamoeba just happens to be one of them. One of my contact lenses got contaminated, and the parasite survived in the area between the lens and my eye.”

If untreated, the parasite causes sight problems and paralysis or even death as it eats its way through the eye and into the spinal cord.

Speaking to student newspaper The Tab, she said: “They had to keep me awake for a week. It was torture – she had to hold my eye open and squirt a few droplets in.

“Even if I had managed to nod off, I could only get a couple of minutes’ sleep before I was woken again. This parasite was still eating my eye and even worse, my immune system was shutting down because of my lack of sleep.”

Miss Greaney has been wearing contact lenses for just two years and had no idea that she could contract an eye parasite from normal water.

She said: “I want to raise awareness about this parasite and tell people they need to be very careful with their contact lenses.

“If so much as a droplet of water gets into contact with the lens, problems can occur. I got my infection by just leaving my contact lenses near my sink, in a glass of solution.”

Miss Greaney, who was admitted to hospital on March 26, still has to continue taking 21 droplets a day.

A New Weapon in Colombia’s War on Drugs: Cocaine-Eating Moths | GOOD


The government of Colombia is trying to recruit cocaine’s biggest fan—no, not Rick James—to help them finally clear the country of the illegally grown drug. The favorite food of the Cocaine Tussock Moth larva is, as its name implies, the leaves of the coca plant. Alberto Gomez, head of the Quindio Botanical Garden, (a Colombian preserve with a building shaped like a giant butterfly), has suggested a plan to flood the country with a horde of the hungry little insects as an alternative to spraying pesticides.

According to the Associated Press, US-backed efforts to beat back the growth of cocaine in the country’s remote regions have mostly relied on airborne herbicides that use glyphosate, a chemical that the World Health Organization classifies as carcinogenic. At an event in Bogotá, the nation’s capital last week, President Juan Manuel Santos announced an end to the use of the fumigation chemical, citing a recommendation from the country’s Health Ministry.

In Colombia, much of the coca trade is run by rebel groups who protect the crops, making attempts to eradicate the plants with government personnel a dangerous proposition. But per the AP,

The decision to end fumigation program could have a side effect of somewhat easing ongoing peace talks with the country’s main rebel group, the Revolutionary Armed Forces of Colombia, which has demanded an end to the spraying as part of any deal.

Building at the Quindio Botanical Garden. 

This is not the first time the country has considered using these moths as a non-toxic means of curbing la cocaina; the plan has been floating around for about a decade, but authorities have been reluctant to take it up out of fear of unknown ecological externalities. In 2005, Ricardo Vargas, director of Colombian environmental organization Andean Action, told NBC, “With a plan like this, the chance for ecological mischief is very high and very dangerous.”

Only now, in light of heightened awareness of glyphosate’s potential risks, are the moths being reconsidered as an option. And while insects chomping through the Andes’ coca supply might, indeed, seem like a safer, or more natural solution than spraying hazardous chemicals, it would be prudent to remember Vargas’ warning about “ecological mischief”—there’s no telling what a swarm of angry, fiending moths are going to do after all that cocaine wears off.

Discovery lays the foundation for yeast-based drug synthesis


Fans of homebrewed beer and backyard distilleries already know how to employ yeast to convert sugar into alcohol. But a research team led by bioengineers at the University of California, Berkeley, has gone much further by completing key steps needed to turn sugar-fed yeast into a microbial factory for producing morphine and potentially other drugs, including antibiotics and anti-cancer therapeutics.

Over the past decade, a handful of synthetic-biology labs have been working on replicating in microbes a complex, 15-step chemical pathway in the poppy plant to enable production of . Research teams have independently recreated different sections of the poppy’s drug pathway using E. coli or yeast, but what had been missing until now were the final steps that would allow a single organism to perform the task from start to finish.

In a new study to appear in the Monday, May 18, advanced online publication of the journal Nature Chemical Biology, UC Berkeley bioengineer John Dueber teamed up with microbiologist Vincent Martin at Concordia University in Québec to overcome that hurdle by replicating the early steps in the pathway in an engineered strain of yeast. They were able to synthesize reticuline, a compound in poppy, from tyrosine, a derivative of glucose.

“What you really want to do from a fermentation perspective is to be able to feed the yeast glucose, which is a cheap sugar source, and have the yeast do all the chemical steps required downstream to make your target therapeutic drug,” said Dueber, the study’s principal investigator and an assistant professor of bioengineering. “With our study, all the steps have been described, and it’s now a matter of linking them together and scaling up the process. It’s not a trivial challenge, but it’s doable.”

Paving the path from plants to microbes

The qualities that make the poppy plant pathway so challenging are the same ones that make it such an attractive target for research. It is complex, but it is the foundation upon which researchers can build new therapeutics. Benzylisoquinoline alkaloids, or BIAs, are the class of highly bioactive compounds found in the poppy, and that family includes some 2,500 molecules isolated from plants.

Perhaps the best-known trail in the BIA pathway is the one that leads to the opiates, such as codeine, morphine and thebaine, a precursor to oxycodone and hydrocodone. All are controlled substances. But different trails will lead to the antispasmodic papaverine or to the antibiotic precursor dihydrosanguinarine.

“Plants have slow growth cycles, so it’s hard to fully explore all the possible chemicals that can be made from the BIA pathway by genetically engineering the poppy,” said study lead author William DeLoache, a UC Berkeley Ph.D. student in bioengineering. “Moving the BIA pathway to microbes dramatically reduces the cost of drug discovery. We can easily manipulate and tune the DNA of the yeast and quickly test the results.”

The researchers found that by repurposing an enzyme from beets that is naturally used in the production of their vibrant pigments, they could coax yeast to convert tyrosine, an amino acid readily derived from glucose, into dopamine.

With help from the lab of Concordia University’s Vincent Martin, the researchers were able to reconstitute the full seven-enzyme pathway from tyrosine to reticuline in yeast.

“Getting to reticuline is critical because from there, the molecular steps that produce codeine and morphine from reticuline have already been described in yeast,” said Martin, a professor of microbial genomics and engineering. “Also, reticuline is a molecular hub in the BIA pathway. From there, we can explore many different paths to other potential drugs, not just opiates.”

Red flag for regulators

The study authors noted that the discovery dramatically speeds up the clock for when homebrewing drugs could become a reality, and they are calling for regulators and law enforcement officials to pay attention.

“We’re likely looking at a timeline of a couple of years, not a decade or more, when sugar-fed yeast could reliably produce a controlled substance,” said Dueber. “The time is now to think about policies to address this area of research. The field is moving surprisingly fast, and we need to be out in front so that we can mitigate the potential for abuse.”

In a commentary to be published in Nature and timed with the publication of this study, policy analysts call for urgent regulation of this new technology. They highlight the many benefits of this work, but they also point out that “individuals with access to the and basic skills in fermentation would be able to grow the yeast using the equivalent of a homebrew kit.”

They recommend restricting engineered yeast strains to licensed facilities and to authorized researchers, noting that it would be difficult to detect and control the illicit transport of engineered strains.

While such controls may help, Dueber said, “An additional concern is that once the knowledge of how to create an opiate-producing strain is out there, anyone trained in basic molecular biology could theoretically build it.”

Another target for regulation would be the companies that synthesize and sell DNA sequences. “Restrictions are already in place for sequences tied to pathogenic organisms, like smallpox,” said DeLoache. “But maybe it’s time we also look at sequences for producing controlled substances.”

13 Evidence-Based Medicinal Properties of Coconut Oil.


While coconut oil has dragged itself out of the muck of vast misrepresentation over the past few years, it still rarely gets the appreciation it truly deserves.   Not just a “good” saturated fat, coconut oil is an exceptional healing agent as well, with loads of useful health applications.

Some examples of “good” saturated fat include

1. Fat-burning

Ironic, isn’t it? A saturated fat which can accelerate the loss of midsection fat (the most dangerous kind). Well, there are now two solid, human studies showing just two tablespoons a day (30 ml), in both men and women, is capable of  reducing belly fat  within 1-3 months.

2. Brain-Boosting

A now famous study, published in 2006 in the journal  Neurobiology of Aging, showed that the administration of medium chain triglycerides (most plentifully found in coconut oil) in 20 subjects with Alzheimer’s disease or mild cognitive impairment, resulted in significant increases in ketone bodies (within only 90 minutes after treatment) associated with measurable cognitive improvement in those with less severe cognitive dysfunction.[i]

3. Clearing Head Lice

When combined with anise spray, coconut oil was found to be superior to the insecticide permethrin (.43%).[ii]

4. Healing Wounds

Coconut has been used for wound healing  since time immemorial. Three of the identified mechanisms behind these healing effects are its ability to accelerate re-epithelialization, improve antioxidant enzyme activity, and stimulate higher collagen cross-linking within the tissue being repaired.[iii]   Coconut oil has even been shown to work synergistically with traditional treatments, such as silver sulphadizine, to speed burn wound recovery.[iv]

5. NSAID Alternative

Coconut oil has been demonstrated to have anti-inflammatory, analgesic and fever-reducing properties.[v]

6. Anti-Ulcer Activity

Interestingly, coconut milk (which includes coconut oil components), has been shown to be as effective as the conventional drug sucralfate as an NSAID-associated anti-ulcer agent.  [vi]

7. Anti-Fungal

In 2004, 52 isolates of Candida species were exposed to coconut oil. The most notorious form, Candida albicans, was found to have the highest susceptibility. Researchers remarked: “Coconut oil should be used in the treatment of fungal infections in view of emerging drug-resistant Candida species.”  [vii]

8. Testosterone-Booster

Coconut oil was found to reduce oxidative stress in the testes of rats, resulting in significantly higher levels of testosterone.  [viii]

9. Reducing Swollen Prostate

Coconut oil has been found to reduce testosterone-induced benign prostate growth in rats.  [ix]

10. Improving Blood Lipids

Coconut oil consistently  improves the LDL:HDL ratio  in the blood of those who consume it. Given this effect, coconut oil can nolonger be dismissed for being ‘that saturated fat which clogs the arteries.’

11. Fat-Soluble Nutrient Absorption

Coconut oil was recently found to be superior to safflower oil in enhancing tomato carotenoid absorption.  [x]

12. Bone Health

Coconut oil has been shown to reduce oxidative stress within the bone, which may prevent structural damage in osteoporotic bone.  [xi]  [Note:  Osteoporosis is a Myth, as presently defined by the T-Score]

13. Sunscreen

Coconut oil has been shown to block out UV rays by 30%. Keep in mind that this is good, insofar as UVA rays are damaging to the skin, whereas UVB rays are highly beneficial (when exposure is moderate).  [i]   Make sure to check this list of other  sun-blocking oils.

Of course, when speaking about coconut oil, we are only looking at one part of the amazing coconut palm.  Each component, including  coconut hull fiber,  coconut protein  and  coconut water  has experimentally confirmed therapeutic applications.